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Offspring And (Parents Or Mother)

Qi Liu, Shuna Jin, Xiaojie Sun, Xia Sheng, Zhenxing Mao, Yangqian Jiang, Hongxiu Liu, Chen Hu, Wei Xia, Yuanyuan Li, Shunqing Xu
BACKGROUND: Pregnancy hypertensive disorders have impaired neurodevelopment in offspring. We aimed to explore the association of normal range maternal blood pressure (BP) with child neurodevelopment, as well as the possible role of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) therein. METHODS: Among 1,008 mother-child pairs recruited in Wuhan, China, in 2013-2015, we measured maternal third-trimester BP (systolic and diastolic BP, SBP and DBP) and cord glucocorticoids (cortisol and cortisone), a marker reflecting placental 11β-HSD2 activity...
February 16, 2019: American Journal of Hypertension
Laurence J Howe, Gemma C Sharp, Gibran Hemani, Luisa Zuccolo, Stephen Richmond, Sarah J Lewis
BACKGROUND: High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects. METHODS: In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption...
February 5, 2019: Drug and Alcohol Dependence
Charles N Bernstein, Charles Burchill, Laura E Targownik, Harminder Singh, Leslie L Roos
BACKGROUND & AIMS: We performed a population-based study to determine whether there was an increased risk of inflammatory bowel diseases (IBD) in persons with critical events at birth and within 1 year of age. METHODS: We collected data from the University of Manitoba IBD Epidemiology Database, which contains records on all Manitobans diagnosed with IBD from 1984 through 2010 and matched controls. From 1970 individuals' records can be linked with those of their mothers, so we were able to identify siblings...
February 14, 2019: Gastroenterology
Yi Zhang, Zong-Heng Wang, Yi Liu, Yong Chen, Nuo Sun, Marjan Gucek, Fan Zhang, Hong Xu
We have previously proposed that selective inheritance, the limited transmission of damaging mtDNA mutations from mother to offspring, is based on replication competition in Drosophila melanogaster. This model, which stems from our observation that wild-type mitochondria propagate much more vigorously in the fly ovary than mitochondria carrying fitness-impairing mutations, implies that germ cells recognize the fitness of individual mitochondria and selectively boost the propagation of healthy ones. Here, we demonstrate that the protein kinase PINK1 preferentially accumulates on mitochondria enriched for a deleterious mtDNA mutation...
February 1, 2019: Molecular Cell
Xin Ren, Weitong Wang, Xuesong Zhao, Baixiang Ren, Limin Chang
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a re-emerging environmental contaminant used as a suitable substitute for brominated flame retardants. The objective of this study was to evaluate the effects of TDCIPP on thyroid disruption and growth inhibition in zebrafish (Danio rerio) offspring after chronic parental exposure, and to examine the possible molecular mechanisms involved. When adult zebrafish (4 months old) were exposed to 5.66, 25.55, or 92.8 μg TDCIPP/L for 90 days, bioconcentration of TDCIPP and its metabolic product [bis(1,3-dichloro-2-propyl) phosphate, BDCIPP] was observed in 7-day postfertilization (dpf) F1 larvae, which suggests the transfer of this compound from adult fish to their offspring...
February 7, 2019: Aquatic Toxicology
Wuding Hong, Huijuan Kuang, Xingping He, Lin Yang, Pengfei Yang, Bolu Chen, Zoraida P Aguilar, Hengyi Xu
The toxicity, especially the transgenerational toxicity of quantum dots (QDs) in vivo, is still scarcely understood in spite of great promising applications of QDs in biomedicine. In this study, the maternal status, pregnancy outcome, and fetus development of parental generation (P0) to offspring in three generations (F3) were investigated after Kunming mice perinatal (GD 13-PND 5) exposure to Cd containing QDs (CdSe/ZnS QDs) and CdCl₂. The results show CdSe/ZnS QDs induced placenta injuries in P0 and diminished placenta diameters in F1 and F2...
February 14, 2019: Nanomaterials
Iria Mendez, David Axelson, Josefina Castro-Fornieles, Danella Hafeman, Tina R Goldstein, Benjamin I Goldstein, Rasim Diler, Roger Borras, John Merranko, Kelly Monk, Mary Beth Hickey, Boris Birmaher
OBJECTIVE: To compare the prevalence and risk factors associated with Psychotic-Like-Experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents. METHOD: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a cohort study of 390 offspring of BP parents and 247 offspring of control parents aged 6-18 years old. The sample was followed up every 2.5 years on average for 8...
November 2, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Amit Shalev, John Merranko, Tina Goldstein, David J Miklowitz, David Axelson, Benjamin I Goldstein, David Brent, Kelly Monk, Mary Beth Hickey, Danella M Hafeman, Dara Sakolsky, Rasim Diler, Boris Birmaher
OBJECTIVE: To compare the longitudinal course of family functioning in offspring of parents with bipolar disorder (BD), offspring of parents with non-BD psychopathology, and offspring of healthy control parents (HC). METHOD: Offspring of BD parents (256 parents and 481 offspring), non-BD parents (82 parents and 162 offspring) and HC parents (88 parents and 175 offspring) ages 7-18 at intake, from the Bipolar Offspring Study (BIOS), were followed for an average of 4...
December 18, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Eirini Flouri, Zahra Sarmadi, Marta Francesconi
OBJECTIVE: To explore if paternal psychological distress is related to the longitudinal course of child Problem behaviour after accounting for maternal psychological distress. METHOD: We used data from the Millennium Cohort Study (MCS), a large general-population birth cohort in the UK. Maternal and paternal psychological distress was measured with the Kessler 6-item psychological distress scale (K-6) at child ages 3, 5, 7, 11 and 14 years. Problem behaviour was measured with the Strengths and Difficulties Questionnaire at these ages...
February 1, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
Josh M Colston, Ruthly Francois, Nora Pisanic, Pablo Peñataro Yori, Benjamin J J McCormick, Maribel Paredes Olortegui, Md Amran Gazi, Erling Svensen, Mondar Maruf Moin Ahmed, Esto Mduma, Jie Liu, Eric R Houpt, Robert Klapheke, Julia W Schwarz, Robert L Atmar, Robert E Black, Margaret N Kosek
BACKGROUND: Histo blood group antigens (HBGAs) such as fucosyltransferase FUT2 and 3 may act as innate host factors that differentially influence susceptibility of individuals and their offspring to pediatric enteric infections. METHODS: In three community-based birth cohorts, FUT2 and FUT3 statuses were ascertained for mother-child dyads. qPCR panels tested 3,663 diarrheal and 18,148 asymptomatic stool samples for 29 enteropathogens. Cumulative diarrhea and infection incidence were compared by child (n=520) and mothers' (n=519) HBGA status and hazard ratios (HRs) derived for all-cause diarrhea and specific enteropathogens...
February 15, 2019: Journal of Infectious Diseases
Qinrui Yang, Baonian Liu, Chengchen Shao, Yuxiang Zhou, Yining Yao, Yuyin Pan, Kuan Sun, Hongmei Xu, Chengtao Li, Ting Wei, Yueqin Zhou, Qiqun Tang, Jianhui Xie
BACKGROUND: An STR locus with tri-allelic pattern is occasionally observed in routine forensic casework. The extra copy of TPOX locus with tri-allelic pattern in populations has been assumed to be inserted into an X chromosome, which took place forth before the Bantu expansion in Africa. Nonetheless, the exact location of the duplication and the form of rearrangement in the human genome has not been clarified yet. RESULTS: In this study, we investigated the extra copy of type 2 tri-allelic pattern at TPOX in various populations...
February 14, 2019: BMC Genetics
Christina Bauch, Jelle J Boonekamp, Peter Korsten, Ellis Mulder, Simon Verhulst
Telomere length (TL) predicts health and survival across taxa. Variation in TL between individuals is thought to be largely of genetic origin, but telomere inheritance is unusual, because zygotes already express a TL phenotype, the TL of the parental gametes. Offspring TL changes with paternal age in many species including humans, presumably through age-related TL changes in sperm, suggesting an epigenetic inheritance mechanism. However, present evidence is based on cross-sectional analyses, and age at reproduction is confounded with between-father variation in TL...
February 2019: PLoS Genetics
Hamdi Mbarek, Margot P van de Weijer, Mathijs D van der Zee, Hill F Ip, Jeffrey J Beck, Abdel Abdellaoui, Erik A Ehli, Gareth E Davies, Bart M L Baselmans, Michel G Nivard, Meike Bartels, Eco J de Geus, Dorret I Boomsma
The tendency to conceive spontaneous dizygotic (DZ) twins is a complex trait with important contributions from both environmental factors and genetic disposition. In earlier work, we identified the first two genes as maternal susceptibility loci for DZ twinning. The aim of this study was to identify genetic variants influencing multiple births and to genetically correlate the findings across a broad range of traits. We performed a genome-wide association study (GWAS) in 8962 participants with Caucasian ancestry from UK Biobank who reported being part of a multiple birth, and 409,591 singleton controls...
February 13, 2019: European Journal of Human Genetics: EJHG
Ruth Feldman, Katharina Braun, Frances A Champagne
In recent decades, human sociocultural changes have increased the numbers of fathers that are involved in direct caregiving in Western societies. This trend has led to a resurgence of interest in understanding the mechanisms and effects of paternal care. Across the animal kingdom, paternal caregiving has been found to be a highly malleable phenomenon, presenting with great variability among and within species. The emergence of paternal behaviour in a male animal has been shown to be accompanied by substantial neural plasticity and to be shaped by previous and current caregiving experiences, maternal and infant stimuli and ecological conditions...
February 13, 2019: Nature Reviews. Neuroscience
Kathleen S Lynch, Lauren A O'Connell, Matthew I M Louder, Christopher N Balakrishnan, Eva K Fischer
Parental care is critical for offspring survival in many species. However, parental behaviors have been lost in roughly 1% of avian species known as the obligate brood parasites. To shed light on molecular and neurobiological mechanisms mediating brood parasitic behavior, we compared brain gene expression patterns between two brood parasitic species and one closely related non-parasitic Icterid (blackbird) species. Our analyses focused on gene expression changes specifically in the preoptic area (POA), a brain region known to play a critical role in parental behavior across vertebrates...
February 13, 2019: G3: Genes—Genomes—Genetics
Tiina Taka-Eilola Nèe Riekki, Juha Veijola, Graham K Murray, Jari Koskela, Pirjo Mäki
BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders. METHODS: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13.9% of the mothers reported themselves depressed at mid-gestation. The offspring were followed 43 years...
February 6, 2019: Journal of Affective Disorders
Abdalla Ahmed, Paul Delgado-Olguin
Obesity during pregnancy programs adult-onset heart disease in the offspring. Clinical studies indicate that exposure to an adverse environment in utero during early, as compared to late, gestation leads to a higher prevalence of adult-onset heart disease. This suggests that the early developing heart is particularly sensitive to an adverse environment. Accordingly, growing evidence from clinical studies and animal models demonstrates that obesity during pregnancy alters the function of the fetal heart, programming a higher risk of cardiovascular disease later in life...
February 10, 2019: Biochimica et biophysica acta. Molecular basis of disease
Dan-Qing Yu, Ping-Ping Lv, Yi-Shang Yan, Guan-Xin Xu, Annapurna Sadhukhan, Shan Dong, Yan Shen, Jun Ren, Xue-Ying Zhang, Chun Feng, Yi-Ting Huang, Shen Tian, Yin Zhou, Yi-Ting Cai, Zhen-Hua Ming, Guo-Lian Ding, Hong Zhu, Jian-Zhong Sheng, Min Jin, He-Feng Huang
Brown adipose tissue (BAT) is an exclusive tissue of nonshivering thermogenesis. It is fueled by lipids and glucose and involved in energy and metabolic homeostasis. Intrauterine exposure to hyperglycemia during gestational diabetes mellitus may result in abnormal fetal development and metabolic phenotypes in adulthood. However, whether intrauterine hyperglycemia influences the development of BAT is unknown. In this study, mouse embryos were exposed to the intrauterine hyperglycemia environment by injecting streptozocin into pregnant mice at 1 d post coitum (dpc)...
February 13, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Rebecca Y M Cheung, Man Chong Leung, Kevin K S Chan, Chun Bun Lam
The present study tested a theoretical model of emotion regulation between parent-offspring dynamics and emerging adults' adjustment. The mediating role of emotion regulation strategies, including cognitive reappraisal and expressive suppression, were investigated for the effects of mother-offspring and father-offspring dynamics on emerging adults' adjustment. A sample of 352 Chinese emerging adults in Hong Kong (230 female, 121 male) participated in this study. Participants were asked to complete a set of self-reported questionnaires...
2019: PloS One
Leif Christopher Lindeman, Jorke Harmen Kamstra, Jarle Ballangby, Selma Hurem, Leonardo Martín Martín, Dag Anders Brede, Hans Christian Teien, Deborah H Oughton, Brit Salbu, Jan Ludvig Lyche, Peter Aleström
Ionizing radiation is a recognized genotoxic agent, however, little is known about the role of the functional form of DNA in these processes. Post translational modifications on histone proteins control the organization of chromatin and hence control transcriptional responses that ultimately affect the phenotype. The purpose of this study was to investigate effects on chromatin caused by ionizing radiation in fish. Direct exposure of zebrafish (Danio rerio) embryos to gamma radiation (10.9 mGy/h for 3h) induced hyper-enrichment of H3K4me3 at the genes hnf4a, gmnn and vegfab...
2019: PloS One
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