keyword
https://read.qxmd.com/read/38526836/the-need-for-the-great-%C3%A2-score-to-predict-relapse-in-graves-disease-a-questionnaire-among-patients-and-internal-medicine-specialists
#1
JOURNAL ARTICLE
H I Jansen, C Heuveling van Beek, P H Bisschop, A C Heijboer, E Bruinstroop, A Boelen
PURPOSE: Graves' disease (GD) is an auto-immune cause of hyperthyroidism. First-line treatment often consists of a 12-18 month course of antithyroid drugs (ATD). After discontinuation of ATD, GD relapses in approximately 50% of patients. The 'Graves recurrent event after therapy+ ' (GREAT+) score may predict individual relapse chances after ATD discontinuation more accurately based on clinical and laboratory parameters at diagnosis. We investigated the need for the GREAT+ score through an online questionnaire among GD patients and physicians treating GD...
March 25, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38513355/value-of-follow-up-diagnostic-radioiodine-scans-in-differentiated-thyroid-cancer
#2
JOURNAL ARTICLE
Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas
BACKGROUND: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38512702/effectiveness-and-safety-of-lenvatinib-in-a-series-of-advanced-well-differentiated-thyroid-carcinomas-from-a-single-tertiary-cancer-center-and-literature-review
#3
JOURNAL ARTICLE
Inês L Damásio, Ana Figueiredo, Joana Maciel, Mariana Horta, Tiago N Silva, Joana Simões-Pereira, Sara Donato, Valeriano Leite
BACKGROUND: Treatment of advanced differentiated thyroid carcinoma (DTC) remains a challenge as 25-50% of patients with locally invasive or distant metastatic disease become refractory to radioiodine (RAI) therapy. Tyrosine kinase inhibitors (TKI) are increasingly used in this setting. The SELECT trial demonstrated that lenvatinib, a multikinase inhibitor, significantly improved progression free survival (PFS) compared to placebo. Our aim was to report the effectiveness and safety of lenvatinib in our series of patients with advanced DTC...
March 21, 2024: Minerva endocrinology
https://read.qxmd.com/read/38510823/augmentation-of-radioiodine-uptake-by-pulmonary-metastasis-of-papillary-thyroid-carcinoma-treated-with-dabrafenib-and-trametinib
#4
JOURNAL ARTICLE
Elona Malja, Asha Kandathil, Fangyu Peng
Redifferentiation therapy with Dabrafenib (a BRAF inhibitor) and Trametinib (a MEK inhibitor) restores radioiodine avidity of radioiodine-refractory papillary thyroid carcinoma (PTC). A 50-year-old man was diagnosed with radioiodine-refractory PTC pulmonary metastasis post prior total thyroidectomy and radioiodine ablation. The patient was treated with Dabrafenib and Trametinib, followed by second radioiodine ablation with I-131 sodium iodine. Diffuse increased radioiodine uptake by pulmonary metastasis was visualized on post ablation whole body scan...
April 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38509944/prognostic-factors-for-postoperative-papillary-thyroid-cancer-with-unexplained-elevated-tg-a-retrospective-study
#5
JOURNAL ARTICLE
Chenghui Lu, Na Han, Jiao Li, Guoqiang Wang, Congcong Wang, Qiang Jia, Jian Tan, Xufu Wang, Zhaowei Meng
OBJECTIVE: This study aimed to investigate the underlying reasons for unexplained elevated thyroglobulin (Tg) in postoperative papillary thyroid cancer (PTC) patients according to follow-up results post RAT and to explore the long-term clinical outcomes and prognostic factors associated with these patients. METHODS: From April 2016 to June 2019, a retrospective study was conducted on postoperative PTC patients who underwent RAT at our institution. Patients with preablative stimulated thyroglobulin (psTg) > 10 ng/mL but no structurally evident disease were enrolled...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38505561/can-ethanol-ablation-achieve-durable-control-of-neck-nodal-recurrences-in-adults-with-stage-i-papillary-thyroid-cancer
#6
JOURNAL ARTICLE
Ian D Hay, Robert A Lee, Carl C Reading, J William Charboneau
OBJECTIVE: Results of ethanol ablation (EA) for controlling neck nodal metastases (NNM) in adult patients with papillary thyroid carcinoma (APTC) beyond 6 months have rarely been reported. We now describe outcome results in controlling 71 NNM in 40 node-positive stage I APTC patients followed for 66 to 269 months. METHODS: All 40 patients were managed with bilateral thyroidectomy and radioiodine therapy and followed with neck ultrasound (US) for >48 months after EA...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38503602/theranostics-of-thyroid-cancer
#7
REVIEW
Luca Giovanella, Murat Tuncel, Atena Aghaee, Alfredo Campenni, Petra Petranović Ovčariček, Armando De Virgilio
Molecular imaging is pivotal in evaluating and managing patients with different thyroid cancer histotypes. The existing, pathology-based, risk stratification systems can be usefully refined, by incorporating tumor-specific molecular and molecular imaging biomarkers with theranostic value, allowing patient-specific treatment decisions. Molecular imaging with different radioactive iodine isotopes (ie, I131 , I123 , I124 ) is a central component of differentiated carcinoma (DTC)'s risk stratification while [18 F]F-fluorodeoxyglucose ([18 F]FDG) PET/CT is interrogated about disease aggressiveness and presence of distant metastases...
March 18, 2024: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38503312/preoperative-serum-thyroglobulin-levels-predict-radioiodine-therapy-outcome-in-papillary-thyroid-microcarcinoma-patients
#8
JOURNAL ARTICLE
Xian Cheng, Yijun Fan, Wanzhong Ye, Shichen Xu, Jing Wu, Wenjing Gao, Jiandong Bao, Huixin Yu, Li Zhang
Our previous study showed that elevated preoperative thyroglobulin (pre-Tg) level predicted the risk of developing radioiodine refractory in PTC patients. In the present study, we aimed to evaluate the prognostic value of pre-Tg in papillary thyroid microcarcinoma (PTMC). After a specific inclusion and exclusion criteria were applied, a total of 788 PTMCs were enrolled from Jiangyuan Hospital affiliated to Jiangsu Institute of Nuclear Medicine between Jan, 2015 and Dec, 2019. Among them, 107 PTMCs were treated with radioiodine therapy (RAIT) and the response to therapy was grouped as excellent response (ER), and non-excellent response (NER: indeterminate response, IDR and biochemical incomplete response, BIR)...
March 19, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38500743/unexpected-99m-tc-pertechnetate-avidity-of-lymph-node-metastases-predicts-better-response-to-radioiodine-therapy-in-differentiated-thyroid-cancer-patients-with-lymph-node-metastases
#9
JOURNAL ARTICLE
Jie Liu, Xin Li, Linfa Li, Yuhua Yin, Hu Cai, Heqing Yi
OBJECTIVE: To investigate the value of 99m Tc-pertechnetate scan in postoperative differentiated thyroid cancer (DTC) patients with lymph node (LN) metastases (LNM) uptake 99m Tc-pertechnetate, especially the predictive value to their response to radioiodine-131 (131 I) therapy. METHODS: This retrospective study collected 752 patients with DTC and LNM treated at Zhejiang Cancer Hospital between May 2012 and December 2017. Depending on the ability of LNM uptake 99m Tc-pertechnetate, the patients were grouped as the 99m Tc-pertechnetate-avid (n=88) vs...
2024: American Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38456952/false-diagnosis-of-recurrent-thyroid-carcinoma-the-importance-of-testing-for-heterophile-antibodies
#10
Leila Guastapaglia, Maria Izabel Chiamolera, José Viana Lima Junior, Claudia Maria De Francischi Ferrer, Luciana Godoy Viana, Claudia Veiga Chang, Raquel Andrade Siqueira, Rui Monteiro Barros Maciel, José Gilberto Henriques Vieira, Rosa Paula Mello Biscolla
Thyroglobulin (Tg) levels are important to predict recurrence in differentiated thyroid cancer patients.However, false-positive results can hence the request of unnecessary tests and treatments. We reported two cases of interference in thyroglobulin measurement and the workup to investigate them. Both patients achieved an excellent response to therapy after total thyroidectomy and one patient had also received radioiodine treatment. During the follow-up, Tg levels increased and there was no evidence of recurrent disease in the imaging studies...
March 7, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38455660/malignant-struma-ovarii-with-synchronous-primary-papillary-thyroid-cancer-in-the-neck-a-case-report-and-literature-review
#11
Sijian Li, Ruping Hong, Jiaxin Yang
Malignant struma ovarii (MSO) with synchronous primary thyroid cancer in the neck is extremely rare and lacks a treatment consensus. A 44-year-old woman presenting with a left ovarian cyst was admitted to Peking Union Medical College Hospital (Beijing, China) Ultrasonography showed a 6 cm solid-cystic left ovarian mass with plentiful blood signals. Other notable findings were an elevated CA125 level and a suspected malignant thyroid nodule. A unilateral salpingo-oophorectomy (USO) was conducted, and the surgical pathology was papillary thyroid cancer (PTC) arising in a struma ovarii...
April 2024: Oncology Letters
https://read.qxmd.com/read/38445804/external-beam-radiation-therapy-for-recurrent-or-residual-thyroid-cancer-what-is-the-best-treatment-time-and-the-best-candidate-for-long-term-local-disease-control
#12
JOURNAL ARTICLE
Lara Bessa Campelo Pinheiro Cavalcante, Natalia Treistman, Fabiola Maria Teresa Torres Gonzalez, Pollyanna Iemini Weyll Fernandes, Paulo Alonso Garcia Alves Junior, Fernanda Accioly Andrade, Elisa Napolitano Ferreira, Tarcisio Fontenele De Brito, Attilio Pane, Rossana Corbo, Felipe Erlich, Daniel Alves Bulzico, Fernanda Vaisman
INTRODUCTION: Cervical disease control might be challenging in advanced thyroid cancer (DTC). Indications for cervical external beam radiation therapy (EBRT) are controversial. PURPOSE: To identify clinical and molecular factors associated with control of cervical disease with EBRT. METHODS: Retrospective evaluation and molecular analysis of the primary tumor DTC patients who underwent cervical EBRT between 1995 and 2022 was performed. RESULTS: Eighty adults, median age of 61 years, were included...
March 6, 2024: Head & Neck
https://read.qxmd.com/read/38445350/prospective-evaluation-of-68ga-nodaga-rgd-pet-ct-in-patients-of-carcinoma-thyroid-with-thyroglobulin-elevated-negative-radioiodine-scintigraphy-tenis-with-a-head-to-head-comparison-with-fdg-pet-ct
#13
JOURNAL ARTICLE
Abhay Gondhane, Priyanka Verma, Ashok Chandak, Sandip Basu
BACKGROUND AND AIM: This study aimed to examine the expression of RGD binding integrins in patients of elevated serum thyroglobulin (Tg) level with negative radioiodine scintigraphy (TENIS) employing 68Ga-NODAGA-RGD PET-CT. MATERIAL AND METHODS: This was a prospective study involving 30 proven cases of TENIS with histopathological diagnosis of differentiated thyroid carcinoma post-surgery. In addition to observing the lesional concentration on 68Ga-NODAGA-RGD PET-CT, a 4-point visual grading system (grade I-IV), was undertaken to estimate the degree of radiotracer avidity, for potential of theranostics...
March 6, 2024: Nuclear Medicine Communications
https://read.qxmd.com/read/38440601/wide-composite-resection-of-sternal-metastasis-reconstruction-using-titanium-mesh-implant-and-myocutaneous-flap-in-differentiated-thyroid-carcinoma-case-report-of-two-cases
#14
JOURNAL ARTICLE
Mit Rojesara, Swati Sattavan, Mohit Sharma, Priyank Rathod, Ketul Puj, Shashank Pandya, Vivek Bande, Ajinkya Pawar, Nilanjan Ghosh, Sankhya Bhat S, Senthil Kumar M
Differentiated Thyroid carcinoma (DTC) with distant skeletal metastases is associated with a very poor prognosis and are unfortunately resistant to radioiodine therapy (RIT). Surgical removal of the metastases in such selected cases is a beneficial adjunct to RIT. We report two cases of DTC with sternal metastases whom we successfully managed with surgical resection of the sternal lesion with reconstruction of the chest wall defect using titanium mesh implant and myocutaneous flap.
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38432938/-chemical-design-of-radiohalogenated-agents-using-neopentyl-structure
#15
JOURNAL ARTICLE
Tomoya Uehara
Many useful radionuclides exist among the halogen elements. Fluorine-18 (18 F) is used for positron emission tomography (PET) diagnosis, iodine-123 and iodine-131 (131 I) for single photon emission computed tomography (SPECT) diagnosis, 131 I for nuclear medicine therapy, and iodine-125 (125 I) for research. Astatine-211 (211 At), which can be produced by a cyclotron and is attracting attention as a versatile α-ray emitting radionuclide, also belongs to the halogen family. Therefore, if a labeling agent that can stably hold radio-halogens can be developed, it would be useful for the development of radiotheranostic agents that can be expanded from nuclear medicine diagnosis using PET and SPECT to nuclear medicine therapy using β- -rays and even α-rays...
2024: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/38421515/nuclear-medicine-practice-in-japan-a-report-of-the-ninth-nationwide-survey-in-2022
#16
JOURNAL ARTICLE
Atsutaka Okizaki, Yoshihiro Nishiyama, Yoshitaka Inui, Hideki Otsuka, Kentaro Takanami, Masatoyo Nakajo, Koya Nakatani, Munenobu Nogami, Kenji Hirata, Yukito Maeda, Mana Yoshimura, Hiroshi Wakabayashi
Subcommittee on Survey of Nuclear Medicine Practice in Japan has performed a nationwide survey of nuclear medicine practice every 5 years since 1982 to survey contemporary nuclear medicine practice and its changes over the years. The subcommittee sent questionnaires, including the number and category of examinations as well as the kind of the radiopharmaceuticals during the 30 days of June 2022 to all nuclear medicine institutes in Japan. The total numbers of them for the year 2022 were estimated depends on the 1-month data...
February 29, 2024: Annals of Nuclear Medicine
https://read.qxmd.com/read/38390734/evaluation-of-the-relationship-between-mobile-phone-usage-and-mirna-574-5p-and-mirna-30c-5p-levels-in-thyroid-cancer-patients
#17
JOURNAL ARTICLE
Zekiye Hasbek, Ayça Taş, Seyit Ahmet Ertürk, Barış Sarıakçalı, Özge Ulaş Babacan, Gülhan Duman, Yavuz Siliğ
OBJECTIVES: This study aimed to evaluate the relationship between mobile phone usage and miRNA-574-5p and miRNA-30C-5p levels in patients diagnosed with differentiated thyroid cancer (DTC). METHODS: Fifty patients diagnosed with DTC and 50 healthy volunteers were included in the study. miRNA-574-5p and miRNA-30C-5p gene expression levels in the blood of all subjects were analyzed by real time-polymerase chain reaction, and a questionnaire including various questions was administered to both groups...
February 22, 2024: Molecular Imaging and Radionuclide Therapy
https://read.qxmd.com/read/38388076/second-radioiodine-treatment-in-patients-with-differentiated-thyroid-carcinoma-causes-and-effects
#18
JOURNAL ARTICLE
María de Las Nieves Sicilia Pozo, Francisco José Pena Pardo, Mariano Amo Salas, Marcos Cruz Montijano, Javier Torres Hernández, Amanda Padilla Bermejo, Cristina Montalbán Méndez, María Zhao Montero, Ángel Soriano Castrejón, Ana María García Vicente
INTRODUCTION: Patients with incomplete response to initial therapy of thyroid cancer can be managed with ongoing observation or potentially additional therapies. Our aim was to assess the effect of a second radioactive iodine treatment (RAIT) and its relationship with causes and clinical variables. MATERIAL AND METHODS: Patients undergoing a second RAIT for biochemical or structural incomplete response to initial therapy of DTC were retrospectively included (n=120)...
January 2024: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/38374795/acute-kidney-injury-after-thyroid-hormone-withdrawal-in-an-adolescent-with-papillary-thyroid-carcinoma
#19
JOURNAL ARTICLE
Yavuz Özer, Rüveyda Gülmez, Hande Turan, Gürkan Tarçın, Dilek Bingöl Aydın, Olcay Evliyaoğlu, Oya Ercan
OBJECTIVES: We report a patient with papillary thyroid carcinoma (PTC) who developed acute kidney injury (AKI) and elevated creatine kinase (CK) after thyroid hormone withdrawal (THW) prior to radioiodine therapy. CASE PRESENTATION: A 12-year-old female patient who had undergone total thyroidectomy for PTC one year ago presented with leg pain for the past 2 days. Following THW 3 weeks ago, the case had received 70 mCI radioiodine treatment 6 days ago. Serum creatinine (1...
February 20, 2024: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/38351437/tyrosine-kinase-inhibitors-for-radioiodine-refractory-differentiated-thyroid-cancer-a-systematic-review-and-meta-analysis
#20
REVIEW
Jiayi Yu, Zheran Liu, Yonglin Su, Xingchen Peng, Yuping Xie
BACKGROUND: The poor overall prognosis of radioiodine refractory thyroid cancer is an inevitable challenge in managing this disease. A series of trials have demonstrated the antitumor activity of tyrosine kinase inhibitors (TKIs) in radioiodine refractory differentiated thyroid cancer (RAIR-DTC). However, the available evidence cannot determine the optimal choice of TKI in RAIR-DTC. METHODS: This study searched PubMed, EMBASE, Cochrane databases, and the ClinicalTrials website...
February 13, 2024: Clinical Endocrinology
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