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Clifford Akateh, Eliza W Beal, Jung-Lye Kim, Brenda F Reader, Katelyn Maynard, Jay L Zweier, Bryan A Whitson, Sylvester M Black
BACKGROUND: Ischemia/reperfusion injury (IRI) can occur during liver surgery. Endogenous catalase is important to cellular antioxidant defenses and is critical to IRI prevention. Pegylation of catalase (PEG-CAT) improves its therapeutic potential by extending plasma half-life, but systemic administration of exogenous PEG-CAT has been only mildly therapeutic for hepatic IRI. Here, we investigated the protective effects of direct intrahepatic delivery of PEG-CAT during IRI using a rat hilar clamp model...
February 13, 2019: Journal of Surgical Research
Minling Gao, Yujuan Yang, Zhengguo Song
Graphene oxide (GO) is extensively used in various fields because of its versatility. The presence of GO in the environment enhances the toxicity of toxicants or pollutants. Cadmium (Cd) and GO pollution is a problem in aquatic environment, which should be solved. We investigated the toxic effects of Cd on photosynthesis and oxidative stress in wheat seedlings in the presence of GO, by measuring seedling biomass, Cd content, photosynthesis, reactive oxygen species (ROS) level, antioxidant enzyme activities, and malondialdehyde (MDA) content...
February 13, 2019: Ecotoxicology and Environmental Safety
Shikha Raheja, Amit Girdhar, Anjoo Kamboj, Viney Lather, Deepti Pandita
AIMS: Aegle marmelos (L.) Correa (A. marmelos) has been used in Ayurvedic medicine as a brain tonic however its neuroprotective effect against streptozotocin (STZ) induced cognitive impairment and oxidative stress has not been reported yet in vivo. Therefore, the present study was attempted to investigate the neuroprotective potential of ethanolic extract of A. marmelos leaves (AME) on STZ induced memory impairment in male rats. MAIN METHODS: Albino Wistar rats were pre-treated orally with AME at the doses 200 and 400 mg/kg for two weeks, followed by intracerebroventricular (i...
February 13, 2019: Life Sciences
Kamelia Saremi, Sima Kianpour Rad, Faezeh Tayeby, Mahmood A Abdulla, Hamed Karimian, Nazia Abdul Majid
BACKGROUND: Basic function of bromine in body is to activate pepsin production in gastritis with low acidity. The present study encompasses a broad in vivo study to evaluate gastroprotective activity of a novel dibromo substituted Schiff base complex against Sprague Dawley (SD) rats. METHODS: 2, 2'-[1, 2-cyclohexanediylbis (nitriloethylidyne)]bis(4-bromophenol) (CNBP) is synthesized via a Schiff base reaction, using the related ketone and diamine as the starting materials...
February 15, 2019: BMC Pharmacology & Toxicology
Hasan Yousefi-Manesh, Samira Shirooie, Alireza Partoazar, Vahid Nikoui, Mohammad Reza Abdollahzadeh Estakhri, Azam Bakhtiarian
It has been proposed carbon tetrachloride (CCl4 ) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous studies. Therefore, this study was aimed to investigate the effects of PS liposomes treatment against the CCl4 -induced hepatotoxicity in a rat model. Male Wistar rats were treated with PS (10 mg/kg, oral) or phosphatidylcholine liposomes (PC) (10 mg/kg, oral) for 3 days before CCl4 (2 ml/kg; ip once on the third day) injection...
February 15, 2019: Journal of Cellular Biochemistry
Mohamed A El-Esawi, Aisha A Alayafi
Drought stress significantly restricts plant growth and crop productivity. Cotton is the most important textile fiber and oilseed crop worldwide, and its cultivation is affected by drought stress, particularly in dry regions. Improving cotton tolerance to drought stress using the advanced genetic engineering technologies is a promising strategy to maintain crop production and fiber quality and meet the increasing worldwide fiber and oil demand. Dehydration-responsive element binding (DREB) transcription factors play a main role in regulating stresses-tolerance pathways in plant...
February 14, 2019: Genes
Christian Kuete Fofie, Shankar Katekhaye, Swapnil Borse, Vipin Sharma, Manish Nivsarkar, Elvine Pami Nguelefack-Mbuyo, Albert Kamanyi, Vijai Singh, Telesphore Benoît Nguelefack
The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high-fat diet (HFD) and a single dose of streptozotocin (40 mg/kg, intraperitoneal) at the seventh day of experimentation. Diabetes was confirmed on day 10 by fasting blood glucose more than or equal to 200 mg/dL...
February 14, 2019: Journal of Cellular Biochemistry
Wan-Gen Liu, Li-Li Han, Rong Xiang
OBJECTIVE: To study the role and mechanism of microRNA 19b (miR-19b) in hypoxia/reoxygenation (H/R)-induced injury by targeting PTEN. METHODS: PC12 and BV2 cells induced by H/R were treated with miR-19b mimics/inhibitors or small interfering PTEN (si-PTEN), respectively. Lactate dehydrogenase (LDH) level, malondialdehyde (MDA), and superoxide dismutase (SOD) content was detected. Besides, cell viability and apoptosis were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Hoechst33342 staining, and flow cytometry, whereas mitochondrial membrane potential (MMP) tested by JC-1 assay, and reactive oxygen species (ROS) evaluated by the dichloro-dihydro-fluorescein diacetate assay...
February 14, 2019: Journal of Cellular Physiology
Rahmat Adetutu Adisa, Naimat Kolawole, Lateef A Sulaimon, Bathlomew Brai, Abraham Ijaola
Numerous ethnomedicinal uses have been attributed to different parts of Annona senegalensis (ASE), including its uses as food and food additives. The present study investigated toxicological and antioxidant effects of 28 days administration of ethanol extracts of ASE stem bark to Wistar strain albino rats. Acute toxicity test was done to determine lethal dose in Wistar rats while sub-acute toxicity test was conducted on rats divided into four groups (A - control, B - 50 mg/kg, C - 100 mg/kg, D - 150 mg/kg, respectively and treated for 28 days...
January 2019: Toxicological Research
Yafei Fan, Xiaochang Yin, Qing Xie, Youquan Xia, Zhenyu Wang, Jie Song, Yang Zhou, Xingyu Jiang
BACKGROUND: Na+ extrusion from cells is important for plant growth in high saline environments. SOS1 (salt overly sensitive 1), an Na+ /H+ antiporter located in the plasma membrane (PM), functions in toxic Na+ extrusion from cells using energy from an electrochemical proton gradient produced by a PM-localized H+ -ATPase (AHA). Therefore, SOS1 and AHA are involved in plant adaption to salt stress. RESULTS: In this study, the genes encoding SOS1 and AHA from the halophyte Sesuvium portulacastrum (SpSOS1 and SpAHA1, respectively) were introduced together or singly into Arabidopsis plants...
February 14, 2019: BMC Plant Biology
Vahid Reza Askari, Vafa Baradaran Rahimi, Amin Assaran, Mehrdad Iranshahi, Mohammad Hossein Boskabady
Inflammation is defined as a defensive response of the body against either the endogenous or exogenous triggers, while this process becomes chronic leading to various disorders such as asthma, cancers, and multiple sclerosis. Recently, pharmacological properties of different constituents of F. szowitsiana have been reported. In the present study, we aimed to evaluate the anti-oxidative and anti-inflammatory effects of the methanolic extract of F. szowitsiana root on human isolated lymphocytes. The effects of either F...
February 14, 2019: Drug and Chemical Toxicology
Mei-Fen Chen, Shorong-Shii Liou, Shung-Te Kao, I-Min Liu
Erianin is the major bibenzyl compound found in Dendrobium chrysotoxum Lindl. The current study was designed to investigate the protective effects of erianin on high glucose-induced injury in cultured renal tubular epithelial cells (NRK-52E cells) and determine the possible mechanisms for its effects. NRK-52E cells were pretreated with erianin (5, 10, 25 or 50 nmol/L) for 1 h followed by further exposure to high glucose (30 mmol/L, HG) for 48 h. Erianin concentration dependently enhanced cell viability followed by HG treatment in NRK-52E cells...
February 11, 2019: Food and Chemical Toxicology
Giuseppe Chichiriccò, Claudio Ferrante, Luigi Menghini, Lucia Recinella, Sheila Leone, Annalisa Chiavaroli, Luigi Brunetti, Simonetta Di Simone, Maurizio Ronci, Pierpaolo Piccone, Barbara Lanza, Stefania Cesa, Annamaria Poma, Giulia Vecchiotti, Giustino Orlando
Multiple studies revealed the potential application of high quality saffron byproducts as cheap sources of bioactive compounds endowed with antioxidant activity. In the present study, we analyzed the total fatty acids of the anthers, and explored the pharmacological and toxicological potential of anthers, by evaluating genotoxic and protective effects in multiple cell lines, brine shrimps and isolated rat tissues. The phytochemical analyses showed that anthers are rich in long chain fatty acids most of which are unsaturated (80...
February 11, 2019: Food and Chemical Toxicology
Jigang Chen, Wen Chen, Kaiwei Han, Enbo Qi, Rongbin Chen, Minkun Yu, Lijun Hou, Liquan Lv
Sympathetic hyperactivity occurs in a subgroup of patients after traumatic brain injury (TBI). The rostral ventrolateral medulla (RVLM) is a key region for the activity of sympathetic nervous system. Oxidative stress in the RVLM is proved to be responsible for the increased level of sympathetic activity in animal models of hypertension and heart failure. In this study, we investigated whether oxidative stress in the RVLM contributed to the development of sympathetic hyperactivity after TBI in rats. Model of diffuse axonal injury was induced using Sprague-Dawley rats, and level of mean arterial pressure (MAP) and plasma Norepinephrine (NE) was measured to evaluate the sympathetic activity...
February 14, 2019: European Journal of Neuroscience
Xiao-Jiao Jia, Lan-Xiang Liu, Yi-Ming Tian, Rui Wang, Qiang Lu
This study aims to investigate the correlation between oxidative stress and intra-abdominal fat (IAF) in obese young and middle-aged males.The present study included 136 male examinees in the Examination Center of the First Hospital of Qinhuangdao from October 10, 2015 to December 10, 2015. Then, clinical data, oxidative stress indices (8-iso-prostaglandin F2α [8-iso-PGF2α], malondialdehyde [MDA], and superoxide dismutase [SOD]), and IAF area were recorded. All subjects were assigned into 3 groups according to body mass index (BMI): obese group (BMI ≥ 28 kg/m, 43 subjects), overweight group (24 ≤ BMI < 28 kg/m, 46 subjects), and control group (BMI < 24 kg/m, 47 subjects)...
February 2019: Medicine (Baltimore)
Ashti Morovati, Bahram Pourghassem Gargari, Parvin Sarbakhsh, Hushyar Azari, Lida Lotfi-Dizaji
Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60 years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8 weeks...
February 14, 2019: Phytotherapy Research: PTR
Noha I Hussien, Hend S El-Wakeel, Safwa M Souror, Inas A Ahmed
Chronic stress is associated with oxidative stress and mitochondrial dysfunction. These mechanisms promote adverse cardiovascular events. Though many experimental studies have reported a protective effect of vitamin D (VitD) on cardiovascular system, its effect on cardiovascular system in case of chronic stress is not studied yet. The present study aimed to detect the effects of VitD treatment against chronic immobilization stress (CIS)-induced cardiac dysfunction, focusing mainly on mitochondrial function and oxidative stress in rats...
January 2019: General Physiology and Biophysics
S Rashid, M Irshadullah
The present study aimed to assess the antioxidant and oxidant status of goats naturally infected with Haemonchus contortus. Based upon the parasite burden, infection in goats was categorized as heavy (&gt; 500 worms), mild (100-500 worms) or low (&lt; 100 worms). Abomasal tissues from non-infected and infected goats were used for the determination of catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), aspartate (AST) and alanine (ALT) aminotransferases, acid (ACP) and alkaline (ALP) phosphatases, superoxide content (O2-), protein carbonyl (PC), malondialdehyde (MDA) and reduced glutathione (GSH)...
February 14, 2019: Journal of Helminthology
Mian Zhang, Man-Man Fu, Cheng-Wei Qiu, Fangbin Cao, Zhong-Hua Chen, Guoping Zhang, Feibo Wu
Tibetan wild barley has been identified to show large genetic variation and stress tolerance. A genome-wide association (GWA) analysis was performed to detect quantitative trait loci (QTLs) for drought tolerance using 777 Diversity Array Technology (DArT) markers and morphological and physiological traits of 166 Tibetan wild barley accessions in both hydroponic and pot experiments. Large genotypic variation for these traits was found; and population structure and kinship analysis identified three subpopulations among these barley genotypes...
February 12, 2019: International Journal of Molecular Sciences
Carmen Vida, Hikaru Kobayashi, Antonio Garrido, Irene Martínez de Toda, Eva Carro, José Antonio Molina, Mónica De la Fuente
In Parkinson's Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in healthy elderly and adult controls...
February 12, 2019: International Journal of Molecular Sciences
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