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https://read.qxmd.com/read/30776747/dna-methylation-profiling-implicates-exposure-to-pcbs-in-the-pathogenesis-of-b-cell-chronic-lymphocytic-leukemia
#1
Panagiotis Georgiadis, Marios Gavriil, Panu Rantakokko, Efthymios Ladoukakis, Maria Botsivali, Rachel S Kelly, Ingvar A Bergdahl, Hannu Kiviranta, Roel C H Vermeulen, Florentin Spaeth, Dennie G A J Hebbels, Jos C S Kleinjans, Theo M C M de Kok, Domenico Palli, Paolo Vineis, Soterios A Kyrtopoulos
OBJECTIVES: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. METHODS: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene. RESULTS: We identified 650 CpG sites whose methylation correlates strongly (FDR < 0...
February 15, 2019: Environment International
https://read.qxmd.com/read/30776734/liver-function-biomarkers-disorder-is-associated-with-exposure-to-perfluoroalkyl-acids-in-adults-isomers-of-c8-health-project-in-china
#2
Min Nian, Qing-Qing Li, Michael Bloom, Zhengmin Min Qian, Kevin M Syberg, Michael G Vaughn, Si-Quan Wang, Qi Wei, Mohammed Zeeshan, Namratha Gurram, Chu Chu, Jia Wang, Yan-Peng Tian, Li-Wen Hu, Kang-Kang Liu, Bo-Yi Yang, Ru-Qing Liu, Dan Feng, Xiao-Wen Zeng, Guang-Hui Dong
Exposure to chemicals may affect liver enzyme to increase the risk of liver diseases. Perfluoroalkyl acids (PFAAs) are one kind of persistent organic pollutants with hepatotoxic effect in organism. However, data is scarce to characterize the hepatotoxic effects of specific structural PFAA isomers in general population. To address this data gap, we evaluated the association between serum PFAAs concentration and liver function biomarkers in the Isomers of C8 Health Project in China. High performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to measure 18 serum PFAAs, except for linear and branched isomers of PFOA/PFOS, nine perfluorinated carboxylic acids (PFCAs) and two perfluorinated sulfonic acids (PFSAs) were also included, in 1605 adult residents of Shenyang, China...
February 11, 2019: Environmental Research
https://read.qxmd.com/read/30776574/maternal-high-fat-diet-impairs-leptin-signaling-and-up-regulates-type-1-cannabinoid-receptor-with-sex-specific-epigenetic-changes-in-the-hypothalamus-of-newborn-rats
#3
Mariana M Almeida, Camilla P Dias-Rocha, Clara F Reis-Gomes, Haimei Wang, Georgia C Atella, Aline Cordeiro, Carmen C Pazos-Moura, Lisa Joss-Moore, Isis H Trevenzoli
Maternal nutritional imbalances trigger developmental adaptations involving early epigenetic mechanisms associated with adult chronic disease. Maternal high-fat (HF) diet promotes obesity and hypothalamic leptin resistance in male rat offspring at weaning and adulthood. Leptin resistance is associated with over activation of the endocannabinoid system (ECS). The ECS mainly consists of endocannabinoids derived from n-6 fatty acids and cannabinoid receptors (CB1 coded by Cnr1 and CB2 coded by Cnr2). The CB1 activation in hypothalamus stimulates feeding and appetite for fat while CB2 activation seems to play an immunomodulatory role...
February 8, 2019: Psychoneuroendocrinology
https://read.qxmd.com/read/30776470/exploring-on-the-bioactive-markers-of-codonopsis-radix-by-correlation-analysis-between-chemical-constituents-and-pharmacological-effects
#4
Shiman Gao, Jiushi Liu, Min Wang, Yunbao Liu, Xiangbao Meng, Tao Zhang, Yaodong Qi, Bengang Zhang, Haitao Liu, Xiaobo Sun, Peigen Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: Codonopsis Radix is a commonly used traditional Chinese medicine, and has the effect of strengthening spleen and tonifying lung, nourishing blood and engendering liquid. In addition, it is also used as important food materials. AIM OF THE STUDY: The aim of the study was to explain the underlying correlations between chemical constituents and pharmacological effects and explore the bioactive markers of Codonopsis Radix. MATERIALS AND METHODS: Codonopsis Radix samples from Min county, Gansu province processed with different methods were taken as the materials, UPLC-ESI-Q-TOF-MS/MS analysis was conducted to identify the compounds and establish UPLC fingerprint...
February 15, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30776446/spontaneous-and-iatrogenic-hypoglycaemia-related-to-mortality-in-the-icu
#5
Simon Lebech Cichosz, Finn Redke, Ole K Hejlesen
AIM: - Our study investigated the relationship between both spontaneous and iatrogenic hypoglycaemia and mortality. METHODS: - A total of 200,859 patients from the eICU Collaborative Research Database were grouped by whether they had registered episodes of hypoglycaemia or not. Patients with hypoglycaemia were then further divided into subgroups according to type of hypoglycaemia-whether spontaneous or iatrogenic. Spontaneous hypoglycaemia during an ICU stay was defined as one or more registered blood glucose measurements < 70 mg/dL (3...
February 15, 2019: Diabetes & Metabolism
https://read.qxmd.com/read/30776444/analysis-of-hematopoietic-stem-cells-using-a-composite-approach
#6
Rohit P Nagare, S Sneha, S Ramesh, Trivadi S Ganesan
Stem cells or Cancer stem cells (CSCs) have now been identified in different type of tissues by using surface markers. Functional assays such as ALDEFLUOR and side population which are marker independent have been additional approaches. However, whether all these approaches identify the same population of cells remain uncertain. To address this issue we have used hematopoietic stem cells as a model. Peripheral blood stem cells enumerated by CD34 are used routinely in bone marrow transplantation which supports the recovery of bone marrow after ablative chemotherapy or radiation...
February 15, 2019: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/30776253/short-term-exercise-training-reduces-glycaemic-variability-and-lowers-circulating-endothelial-microparticles-in-overweight-and-obese-women-at-elevated-risk-of-type-2-diabetes
#7
Hossein Rafiei, Emily Robinson, Julianne Barry, Mary Elizabeth Jung, Jonathan Peter Little
Exercise is recognized as a frontline therapy for the prevention and treatment of type 2 diabetes (T2D) but the optimal type of exercise is not yet determined. We compared the effects of high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) for improvement of continuous glucose monitoring (CGM)-derived markers of glycaemic variability, and biomarkers of endothelial cell damage (CD31+ and CD62+ endothelial microparticles (EMPs)) within a population at elevated risk of developing T2D...
February 18, 2019: European Journal of Sport Science
https://read.qxmd.com/read/30776229/design-and-synthesis-of-1-2-bis-hydroxymethyl-pyrrolo-2-1-a-phthalazine-hybrids-as-potent-anticancer-agents-that-inhibit-angiogenesis-and-induce-dna-interstrand-crosslinks
#8
Sue-Ming Chang, Vicky Jain, Tai-Lin Chen, Anilkumar Patel, Hima Bindu Pidugu, Yi-Wen Lin, Ming-Hsi Wu, Jiao-Ren Huang, Han-Chung Wu, Anamik K Shah, Tsann-Long Su, Te-Chang Lee
Hybrid molecules are composed of two pharmacophores with different biological activities. Here, we conjugated phthalazine moieties (anti-angiogenetic pharmacophore) and bis(hydroxymethyl)pyrrole moieties (DNA crosslinking agent) to form a series of bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine hybrids. These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, arresting cell cycle progression at the G2/M phase, triggering apoptosis and inhibiting vascular endothelial growth factor receptor 2 (VEGFR-2) in endothelial cells...
February 18, 2019: Journal of Medicinal Chemistry
https://read.qxmd.com/read/30776063/heritability-of-cerebral-blood-flow-and-the-correlation-to-schizophrenia-spectrum-disorders-a-pseudo-continuous-arterial-spin-labeling-twin-study
#9
Christian S Legind, Brian V Broberg, Rachel Brouwer, René C W Mandl, Bjørn H Ebdrup, Simon J Anhøj, Maria H Jensen, Rikke Hilker, Birgitte Fagerlund, Hilleke E Hulshoff Pol, Birte Y Glenthøj, Egill Rostrup
Whether aberrant cerebral blood flow (CBF) in schizophrenia is affected by genetic influences, and consequently a potential marker for genetic susceptibility, is unknown. Our aims were to determine the heritability of CBF in thalamic, frontal, and striatal areas, and to ascertain if associations with disease were under genetic influence. Monozygotic (MZ) twin pairs concordant (n = 2) or discordant (n = 20) for schizophrenia spectrum disorders (ICD-10 F2x.x), matched on sex and age with dizygotic (DZ; n = 20) and healthy control pairs (MZ: n = 27; DZ: n = 18; total: n = 181 individuals), were recruited via the National Danish Twin Register...
February 18, 2019: Schizophrenia Bulletin
https://read.qxmd.com/read/30776004/resistance-exercise-induced-responses-in-physiological-factors-linked-with-cognitive-health
#10
Kieran J Marston, Belinda M Brown, Stephanie R Rainey-Smith, Jeremiah J Peiffer
The global population is aging at an unprecedented rate giving rise to a greater prevalence of age-related illnesses such as dementia and vascular disease. Dementia affects approximately 47 million individuals globally with projections of 130 million by the year 2050. Late-onset Alzheimer's disease is the most common form of dementia, accounting for approximately 75% of all cases and is characterized by a progressive decline in cognitive function, memory, and cerebral volume. The pathogenesis of Alzheimer's disease is poorly understood; however, aging, genetics, and an individual's diet and lifestyle over several decades appear to be key determinants...
February 13, 2019: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/30775977/the-alz-tau-biomarker-for-alzheimer-s-disease-study-in-a-caucasian-population
#11
Leonardo Guzmán-Martínez, José Pablo Tapia, Gonzalo A Farías, Andrea González, Matías Estrella, Ricardo B Maccioni
The establishment of a molecular biomarker for early detection of Alzheimer's disease (AD) is critical for diagnosis and follow up of patients, and as a quantitative parameter in the evaluation of potential new drugs to control AD. A list of blood biomarkers has been reported but none has been validated for the Alzheimer's clinic. The changes in hyperphosphorylated tau and amyloid peptide in the cerebrospinal fluid is currently used as a tool in the clinics and for research purposes, but this method is highly invasive...
February 11, 2019: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/30775892/the-association-of-d-dimer-and-spontaneous-hemorrhagic-ascites-with-outcomes-in-cirrhosis-a-retrospective-study
#12
He-Bin Fan, Xiao-Ling Tong, Xin-Yu Qian, Zhi Li
BACKGROUND: Cirrhotic patients with hemorrhagic ascites have significant morbidity and mortality. This study aims to determine the relationship between D-dimer values and hemorrhagic ascites in cirrhotic patients and analyze its predictive value. METHODS: This retrospective study screened 572 consecutive cirrhotic patients with ascites and hemorrhagic ascites (defined as red blood cells (RBC) in ascitic fluid ≥ 10,000/µL) during a 72-month period. The overall patient survival rate was measured by Kaplan-Meier analysis method...
January 1, 2019: Clinical Laboratory
https://read.qxmd.com/read/30775885/peripheral-blood-lymphocyte-to-monocyte-ratio-predicts-mortality-in-patients-with-hbv-related-decompensated-cirrhosis
#13
XiaoTing Qi
BACKGROUND: Recent reports suggest that the lymphocyte-to-monocyte ratio (LMR) is a potential biomarker for predicting clinical outcomes. In the present study, LMR in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi) was investigated to evaluate whether LMR may have utility as a new predictive marker for mortality in HBV-DeCi patients. METHODS: This was a retrospective cohort study that included 135 patients with HBV-DeCi. Logistic regression analysis and receiver operating characteristic curve were employed to assess the independent predictors for 1-month mortality rate of patients with HBV-DeCi...
January 1, 2019: Clinical Laboratory
https://read.qxmd.com/read/30775813/occult-hepatitis-c-virus-infection-in-patients-with-beta-thalassemia-major-is-it-a-neglected-and-unexplained-phenomenon
#14
Ahmad Ayadi, Amir Hossein Nafari, Shiva Irani, Elham Mohebbi, Fahimeh Mohebbi, Fatemeh Sakhaee, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh
Occult hepatitis C virus (HCV) infection (OCI) is described as the presence of viral genome in both hepatocytes and peripheral blood mononuclear cells (PBMCs) despite constant negative results on serum HCV RNA tests. Beta-thalassemia major (BTM) describes a group of inherited blood diseases. Patients with BTM require repeated blood transfusions, increasing the risk of exposure to infectious agents. We aimed to assess the prevalence of OCI in Iranian BTM patients and to identify the role of host factors in OCI positivity...
February 18, 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30775623/left-ventricular-structure-in-patients-with-mild-to-moderate-ckd-a-magnetic-resonance-imaging-study
#15
Markus P Schneider, Johannes B Scheppach, Ulrike Raff, Sebastian Toncar, Christian Ritter, Thorsten Klink, Stefan Störk, Christoph Wanner, Georg Schlieper, Turgay Saritas, Sebastian D Reinartz, Jürgen Floege, Nele Friedrich, Rolf Janka, Michael Uder, Roland E Schmieder, Kai-Uwe Eckardt
Introduction: The high burden of left ventricular (LV) abnormalities in patients with advanced chronic kidney disease (CKD) is well established. However, less is known about the prevalence, patterns, and determinants of LV abnormalities in patients with early CKD. Methods: We examined LV structure in 290 patients with a median estimated glomerular filtration rate (eGFR) of 51 ml/min per 1.73 m2 by magnetic resonance imaging (MRI). We explored associations with clinical and hemodynamic parameters, hydration (bioimpedance), endothelial function, inflammation (including C-reactive protein and tumor necrosis factor-α and its soluble receptors) and mineral bone disease (MBD) markers (including vitamin D, parathyroid hormone, α-klotho and fibroblast growth factor-23)...
February 2019: KI Reports
https://read.qxmd.com/read/30775184/the-detailed-distribution-of-t-cell-subpopulations-in-immune-stable-renal-allograft-recipients-a-single-center-study
#16
Quan Zhuang, Bo Peng, Wei Wei, Hang Gong, Meng Yu, Min Yang, Lian Liu, Yingzi Ming
Background: Most renal allograft recipients reach a stable immune state (neither rejection nor infection) after transplantation. However, the detailed distribution of overall T lymphocyte subsets in the peripheral blood of these immune-stable renal transplant recipients remains unclear. We aim to identify differences between this stable immune state and a healthy immune state. Methods: In total, 103 recipients underwent renal transplantation from 2012 to 2016 and received regular follow-up in our clinic...
2019: PeerJ
https://read.qxmd.com/read/30774841/effects-of-intermittent-fasting-during-ramadan-on-insulin-like-growth-factor-1-interleukin-2-and-lipid-profile-in-healthy-muslims
#17
Ali R Rahbar, Eisa Safavi, Maryam Rooholamini, Fateme Jaafari, Sadegh Darvishi, Amin Rahbar
Background: Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before-after study was to investigate the effects of fasting in Ramadan on IGF-1 and IL-2 levels in individuals. Methods: In all, 34 men age 16-64 years were selected out of the overall number of individuals who were ready for fasting entirely throughout Ramadan...
2019: International Journal of Preventive Medicine
https://read.qxmd.com/read/30774833/the-relationship-between-fatigue-and-cytokine-levels-in-patients-with-acute-myeloid-leukemia
#18
Malihe Khosravi, Hamidreza Taghvaye Masoumi, Kheirollah Gholami, Mohammad Vaezi, Molouk Hadjibabaei, Ardeshir Ghavamzadeh
Background: Cancer-related fatigue (CRF) is a very prominent complaint and disabling symptom in cancer patients probably influenced by endogenous cytokines. But, the published data on this subject are limited. We explored the relationship of cytokines such as tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) with fatigue in patients with AML. Materials and Methods: This study was performed on 45 patients (25 men, 20 women) with newly diagnosed AML. We examined fatigue in these patients with validated questionnaire...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774600/strength-training-improves-metabolic-health-markers-in-older-individual-regardless-of-training-frequency
#19
Johanna K Ihalainen, Alistair Inglis, Tuomas Mäkinen, Robert U Newton, Heikki Kainulainen, Heikki Kyröläinen, Simon Walker
The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65-75 year). Ninety-two healthy participants were randomly assigned to one of four groups; performing strength training one- (EX1), two- (EX2), or three- (EX3) times-per-week and a non-training control (CON) group. Whole-body strength training was performed using 2-5 sets and 4-12 repetitions per exercise and 7-9 exercises per session...
2019: Frontiers in Physiology
https://read.qxmd.com/read/30774493/residual-risk-of-hiv-hcv-and-hbv-transmission-by-blood-transfusion-between-2015-and-2017-at-the-regional-blood-transfusion-center-of-ouagadougou-burkina-faso
#20
REVIEW
Arzouma Paul Yooda, Salam Sawadogo, Serge Théophile Soubeiga, Dorcas Obiri-Yeboah, Koumpingnin Nebie, Abdoul Karim Ouattara, Birama Diarra, Abibou Simpore, Yetema Dieudonné Yonli, Abdoul-Guaniyi Sawadogo, Bia Emile Drabo, Seimbou Zalla, Anita Pierrette Siritié, Rodrigue Sosthène Nana, Honorine Dahourou, Jacques Simpore
Introduction: In sub-Saharan Africa, the high endemicity of blood-borne infections is a serious threat to transfusion safety. In order to improve transfusion safety, Burkina Faso has undertaken in recent years a reorganization of its blood-transfusion system through the creation of a National Blood Transfusion Center, which is the only blood operator in the whole country. This study aimed to estimate the residual risk of transmission of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) by blood transfusion at the Regional Blood Transfusion Center (RBTC) of Ouagadougou...
2019: Journal of Blood Medicine
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