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Gonçalo Silva Duarte, Afonso Nunes-Ferreira, Filipe Brogueira Rodrigues, Fausto J Pinto, Joaquim J Ferreira, Joao Costa, Daniel Caldeira
OBJECTIVE: Morphine is frequently used in acute coronary syndrome (ACS) due to its analgesic effect, it being recommended in the main cardiology guidelines in Europe and the USA. However, controversy exists regarding its routine use due to potential safety concerns. We conducted a systematic review of randomised-controlled trials (RCTs) and observational studies to synthesise the available evidence. DESIGN: Systematic review and meta-analysis. DATA SOURCES: CENTRAL, MEDLINE, EMBASE and trial registries...
March 15, 2019: BMJ Open
Ranjit Akolekar, Anca Ciobanu, Emilie Zingler, Argyro Syngelaki, Kypros H Nicolaides
BACKGROUND: Third trimester studies in selected high-risk pregnancies have reported that low cerebroplacental ratio (CPR), due to high pulsatility index (PI) in the umbilical artery (UA), and or decreased PI in the fetal middle cerebral artery (MCA), is associated with increased risk of adverse perinatal outcomes. OBJECTIVE: To investigate the predictive performance of screening for adverse perinatal outcome by the cerebroplacental ratio (CPR) measured routinely at 35 - 37 weeks' gestation...
March 13, 2019: American Journal of Obstetrics and Gynecology
Frederick A Zeiler, Ari Ercole, Manuel Cabeleira, Tommaso Zoerle, Nino Stocchetti N, David K Menon, Peter Smielewski, Marek Czosnyka
BACKGROUND: Monitoring cerebrovascular reactivity in adult traumatic brain injury (TBI) has been linked to global patient outcome. Three intra-cranial pressure (ICP)-derived indices have been described. It is unknown which index is superior for outcome association in TBI outside previous single-center evaluations. The goal of this study is to evaluate indices for 6- to 12-month outcome association using uniform data harvested in multiple centers. METHODS: Using the prospectively collected data from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study, the following indices of cerebrovascular reactivity were derived: PRx (correlation between ICP and mean arterial pressure (MAP)), PAx (correlation between pulse amplitude of ICP (AMP) and MAP), and RAC (correlation between AMP and cerebral perfusion pressure (CPP))...
March 15, 2019: Acta Neurochirurgica
Pär Wennberg, Rolf Norlin, Johan Herlitz, Elisabeth Kenne Sarenmalm, Margareta Möller
INTRODUCTION: Pain management in patients with hip fractures is a major challenge for emergency care. The objective of this study was to evaluate whether the supplementation of pre-operative analgesia with low-dose fascia iliaca compartment block (FICB) compared with placebo would improve pain relief in patients with hip fractures. METHODS: A double-blind, randomized, controlled trial was conducted on 127 patients. At hospital admission, a low-dose FICB was administered to patients with hip fractures as a supplement to regular pre-operative analgesia...
November 28, 2018: International Journal of Orthopaedic and Trauma Nursing
Anqi Jiao, Chuanhua Yu, Qianqian Xiang, Faxue Zhang, Dieyi Chen, Lan Zhang, Kejia Hu, Ling Zhang, Yunquan Zhang
BACKGROUND: Previous studies have widely assessed heat-mortality relationships across global regions, while the epidemiological evidence regarding the heat effect on years of life lost (YLL) is relatively sparse. Current investigations using daily mean data cannot take hourly temperature variation into consideration and may underestimate heat effects. We developed a novel indicator, daily excess hourly heat (DEHH), to precisely evaluate the potential heat effects on mortality and YLL...
February 1, 2019: Environmental Research
Francis Xavier Guyette, Christian Martin-Gill, Gabriela Galli, Neal McQuaid, Jonathan Elmer
INTRODUCTION: Hypotension in the prehospital environment is common and linked to dose-dependent mortality. Bolus dose epinephrine (BDE) may reverse hypotension. We tested if BDE use to treat profound hypotension is associated with 24-hour survival. METHODS: We performed a retrospective case-cohort study of critical care transport patients with systolic blood pressure (SBP) <70 mmHg from January 2011 to January 2017. To account for baseline differences between treated and untreated patients, we used nearest neighbor matching to estimate the average treatment effect of BDE on 24-hour survival...
March 15, 2019: Prehospital Emergency Care
Julien Lebleu, Christine Detrembleur, Camille Guebels, Pauline Hamblenne, Maxime Valet
RATIONALE, AIMS, AND OBJECTIVES: Consumer-based activity trackers aim at quantifying physical activity in a wide range of contexts. Nevertheless, they need to be validated before they are confidently used. This study assessed the concurrent validity of the Nokia Go against reference devices, according to different sensor locations, in two measurement conditions: during a walking task and during a 24-hour free-living condition. METHODS: We examined the agreement between devices and between locations in the number of steps and total sleep time by using intraclass correlation coefficient and Bland-Altman method...
March 15, 2019: Journal of Evaluation in Clinical Practice
Asli Buyukkurt, Clément Bourguignon, Christina Antinora, Elisabeth Farquhar, Xiaoya Gao, Eloise Passarella, Duncan Sibthorpe, Karine Gou, Sybille Saury, Serge Beaulieu, Kai-Florian Storch, Outi Linnaranta
OBJECTIVE: We present novel dimensional methods to describe the timing of eating in psychopathology. We focused on the relationship between current mood in bipolar disorder (BD) and the stability of the temporal pattern of daily eating events. METHODS: Consenting BD patients (n = 69) from an outpatient, tertiary care clinic completed hourly charts of mood and eating for two weeks. Mood was also evaluated with Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS)...
March 15, 2019: Nutritional Neuroscience
Darren Au, Andrew G Matthew, Shabbir Mh Alibhai, Jennifer M Jones, Neil E Fleshner, Antonio Finelli, Dean Elterman, Rajiv K Singal, Leah Jamnicky, Nelly Faghani, William J Hilton, Leslie E Auger, Paul Ritvo, John Trachtenberg, Daniel Santa Mina
BACKGROUND: Urinary incontinence (UI) is an important side effect of radical prostatectomy (RP). Co-activation of surrounding muscles via novel techniques for pelvic floor rehabilitation known as Pfilates and Hypopressives have not been compared to pelvic floor muscle exercises (PFMX) for UI. OBJECTIVE: To assess the feasibility and efficacy of isolated PFMX with and without the addition of Pfilates and Hypopressives on UI recovery following RP. DESIGN: Randomized controlled trial SETTING: Participants were recruited from a community and tertiary cancer centre in Toronto, Canada PARTICIPANTS: A total of 226 patients undergoing RP were assessed for eligibility...
March 14, 2019: PM & R: the Journal of Injury, Function, and Rehabilitation
Auréline Boitet, Stanislas Grassin-Delyle, Liliane Louedec, Sebastien Dupont, Elodie Lamy, Marc Coggia, Jean-Baptiste Michel, Raphaël Coscas
OBJECTIVE: Drug coated balloons (DCB) improve the patency of femoropopliteal angioplasty but their use in infrapopliteal lesions is debateable as paclitaxel (PTX) particle embolisation has been suspected in some trials. The aim of this study was to compare experimentally five DCBs in terms of distal embolism of PTX. METHODS: Twenty-five New Zealand rabbits were divided into five groups according to the DCB used: Lutonix (Bard), In.Pact (Medtronic), Passeo-18 Lux (Biotronik), Ranger (Boston Scientific), and Stellarex (Spectranetics) (n = 5 in each group)...
March 11, 2019: European Journal of Vascular and Endovascular Surgery
Hellen C G Nabuco, Crisieli M Tomeleri, Paulo Sugihara, Rodrigo R Fernandes, Edilaine F Cavalcante, Leandro Dos Santos, Analiza M Silva, Luís B Sardinha, Edilson S Cyrino
AIM: The purpose of study was to analyze the effects of a combined whey protein (WP) and RT intervention on cellular health in pre-conditioned older women. METHODS: The protocol is a randomized controlled clinical trial with a sample of seventy older women, divided into 3 groups: WP-placebo (WP-PLA, n = 24), placebo-WP (PLA-WP, n = 23), and placebo-placebo (PLA-PLA, n = 23). Each group drank 35 g of product (placebo or WP) pre- and post- training...
March 7, 2019: Archives of Gerontology and Geriatrics
Trijntje E Schat, Anne G J F van Zoonen, Michelle E van der Laan, Mirthe J Mebius, Arend F Bos, Christian V Hulzebos, H Marike Boezen, Jan B F Hulscher, Elisabeth M W Kooi
BACKGROUND AND AIM: Predicting necrotizing enterocolitis (NEC) might help in preventing its devastating consequences. We aimed to investigate whether early cerebral and intestinal tissue oxygen saturation (rSO2 ) and fractional tissue oxygen extraction (FTOE) predict the onset of NEC. STUDY DESIGN: Prospective observational case-control study. SUBJECTS: Infants with gestational age (GA) <32 weeks were included. For every NEC case we matched two controls based on GA, birth weight (BW), and a patent ductus arteriosus...
March 11, 2019: Early Human Development
Francis Sena Nuvey, Elijah Paa Edu-Quansah, George Khumalo Kuma, John Eleeza, Ernest Kenu, Samuel Sackey, Donne Ameme, Mahamat Fayiz Abakar, Katharina Kreppel, Richard Bongo Ngandolo, Edwin Afari, Bassirou Bonfoh
BACKGROUND: Influenza-like Illness (ILI) is a medical diagnosis of possible influenza or another respiratory illness with a common set of symptoms. The deaths of four schoolchildren, during a pandemic influenza outbreak in December 2017 in Ghana, raised doubts about the ILI surveillance system's performance. We evaluated the ILI surveillance system in the Greater Accra region, Ghana, to assess the system's attributes and its performance on set objectives. METHODS: CDC guidelines were used to evaluate the data of the ILI surveillance system between 2013 and 2017...
2019: PloS One
G E Orchard, K Wojcik, W Rickaby, B Martin, K Semkova, F Shams, C Stefanato
BACKGROUND: The use of immunohistochemical (IHC) methods employing a monoclonal antibody BRAF V600E which detects the main BRAF mutation in metastatic malignant melanoma is assessed in 71 malignant melanoma patients and compared to DNA probe screening, in a blind trial. MATERIAL AND METHODS: The respective paraffin blocks were cut with one Haematoxylin and Eosin staying technique (H&E) and one consecutive unstained slide. The unstained slide contained known positive micro array control material...
March 14, 2019: British Journal of Biomedical Science
Nina Liu, Jianlong Sheng, Tianrong Pan, Youmin Wang
BACKGROUND: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are inflammatory markers used for prediction of chronic complications of diabetes. Lower extremity arterial disease (LEAD) is one of chronic complications of type 2 diabetes mellitus (T2DM). The correlation between NLR, PLR, and lower extremity vascular lesions was investigated in subjects with T2DM to determine the best predictive marker for LEAD. METHODS: Three hundred thirty-five patients with T2DM (199 males and 136 females; age 54...
March 1, 2019: Clinical Laboratory
Ayşegül Aksan, Miriam Wohlrath, Tariq H Iqbal, Karima Farrag, Axel Dignass, Jürgen Stein
BACKGROUND: Hepcidin has been shown to be inversely associated with iron absorption and the expression of iron transport proteins in healthy females and patients with iron deficiency. Data describing the relationship between hepcidin expression and iron absorption in patients with inflammatory bowel disease (IBD) are lacking. The objective of this study was to assess the relationship between serum concentrations of hepcidin and iron absorption in patients with IBD and iron deficiency by means of an oral iron absorption test...
March 1, 2019: Clinical Laboratory
Stephen W Porges, Maria I Davila, Gregory F Lewis, Jacek Kolacz, Stephanie Okonmah-Obazee, Amie Ashley Hane, Katie Y Kwon, Robert J Ludwig, Michael M Myers, Martha G Welch
Preterm infants have maturational delays in several neurobehavioral systems. This study assesses the impact of the Family Nurture Intervention (FNI) in the neonatal intensive care unit (NICU) on the maturation of autonomic regulation of preterm infants. Preterm infants born at 26-34 weeks postmenstrual age (PMA) were assigned to groups receiving either standard care (SC) or SC plus FNI, using a randomized controlled trial design. At two collection time points, approximately 35 weeks and 41 weeks PMA, electrocardiograms (ECG) were monitored for approximately 1 hour during sleep...
March 13, 2019: Developmental Psychobiology
Anna Tokajuk, Agnieszka Zakrzeska, Ewa Chabielska, Halina Car
To study the influence of whey protein concentrate (WPC-80) on the development of thrombosis, rats were supplemented with two doses of WPC-80 (0.3 or 0.5 g/kg) for 7, 14 or 21 days. Then, one hour venous thrombosis model was performed in a half of the animals. Coagulation parameters, platelet count, and thrombus weight were assessed. Thrombus weight was decreased in rats obtaining WPC-80 and that was significant only for 14 and 21-day-supplementation. There were slight differences between groups in coagulation parameters and platelet count but without evident direction...
March 13, 2019: Applied Physiology Nutrition and Metabolism
Teck Guan Ong, Morris Gordon, Shel Sc Banks, Megan R Thomas, Anthony K Akobeng
BACKGROUND: Infantile colic is typically defined as full-force crying for at least three hours per day, on at least three days per week, for at least three weeks. Infantile colic affects a large number of infants and their families worldwide. Its symptoms are broad and general, and while not indicative of disease, may represent a serious underlying condition in a small percentage of infants who may need a medical assessment. Probiotics are live microorganisms that alter the microflora of the host and provide beneficial health effects...
March 13, 2019: Cochrane Database of Systematic Reviews
Marion Boulanger, Bertrand Lapergue, Francis Turjman, Emmanuel Touzé, René Anxionnat, Serge Bracard, Michel Piotin, Benjamin Gory
BACKGROUND: In acute ischemic stroke patients with large-artery occlusion, uncertainties remain about whether clinically important outcomes are comparable between first-line contact aspiration and stent-retriever thrombectomy, although two trials have investigated whether one strategy should be preferred over another. PURPOSE: The purpose of this article is to compare the efficacy and safety of first-line contact aspiration and stent-retriever thrombectomy in stroke patients with anterior circulation large-artery occlusion...
February 4, 2019: Interventional Neuroradiology
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