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Mofs therapy

Haipeng Zhang, Qin Zhang, Chunshui Liu, Bing Han
Janus nanoparticles (JNPs) have emerged in recent years as new compartmentalized colloids with two sides of different components, chemical properties or morphologies that have opened up a wide range of unique applications in biomedicine. Here, we explored a unique lactobionic acid (LA) modified metallic one-dimensional nanorod/metal organic framework (1D NR/MOF) JNP, the LA-gold NR/zeolitic imidazolate framework-8 (LA-AuNR/ZIF-8) JNP, for computed X-ray tomography (CT) image-guided liver cancer targeted synergistic chemo-photothermal theranostics...
February 12, 2019: Biomaterials Science
N L Kozlovskaya, Yu V Korotchaeva, E M Shifman, L A Bobrova
AIM: Analysis of clinical manifestations, course and outcomes of obstetric aHUS. MATERIALS AND METHODS: 45 patients with aHUS development during pregnancy or immediately after childbirth were observed between 2011 and 2017, age from 16 to 42 years. RESULTS: All patients had AKI (serum creatinine 521,5±388,0 µmol/l, oliguria or anuria that required initiation of hemodialysis). 93.3% pts had extrarenal manifestations of TMA with the development of multiple organ failure (MOF)...
June 20, 2018: Terapevticheskiĭ Arkhiv
Bahareh Khezri, Martin Pumera
Synthetic nano/micro/millimeter-sized machines that harvest energy from the surrounding environment and then convert it to motion have had a significant impact on many research areas such as biology (sensing, imaging, and therapy) and environmental applications. Autonomous motion is a key element of these devices. A high surface area is preferable as it leads to increased propellant or cargo-loading capability. Integrating highly ordered and porous metal-organic frameworks (MOFs) with self-propelled machines is demonstrated to have a significant impact on the field of nano/micro/millimeter-sized devices for a wide range of applications...
January 30, 2019: Advanced Materials
Xueyan Zhao, Zhixiang Zhang, Xuechao Cai, Binbin Ding, Chunqiang Sun, Guofeng Liu, Chunling Hu, Shuai Shao, Maolin Pang
Attributed to the large pore size and excellent stability, the metal organic framework (MOF) NU-1000, which is formed by the coordination of Zr cluster and 1,3,6,8-tetrakis(p-benzoicacid)pyrene (H4TBAPy) ligand, has been widely studied in the catalysis research field, however, only a few reports about the biomedical application of NU-1000 could be found in the open literature. In this study, a functional ligand, tetrakis(4-carboxyphenyl)porphyrin (TCPP) was introduced into NU-1000 via post-synthetic ligand exchange method, and the resultant mixed ligand MOF possesses excellent photodynamic effect...
January 30, 2019: ACS Applied Materials & Interfaces
Dorina F Sava Gallis, Kimberly S Butler, Jacob Ongudi Agola, Charles Pearce, Amber McBride
Long-term antimicrobial therapies are necessary to treat infections caused by virulent intracellular pathogens, including biothreat agents. Current treatment plans include injectable therapeutics given multiple times daily over a period for up to 8 weeks. Here we present a metal-organic framework (MOF), zeolitic imidazolate framework-8 (ZIF-8), as a robust platform to support the sustained release of ceftazidime, an important antimicrobial agent for many critical bacterial infections. Detailed materials characterization confirms the successful encapsulation of ceftazidime within the ZIF-8 matrix, indicating sustained drug release for up to a week...
January 25, 2019: ACS Applied Materials & Interfaces
Masayuki Iki, Yuki Fujita, Katsuyasu Kouda, Akiko Yura, Takahiro Tachiki, Junko Tamaki, Yuho Sato, Jong-Seong Moon, Masami Hamada, Etsuko Kajita, Nozomi Okamoto, Norio Kurumatani
PURPOSE: Patients with type 2 diabetes mellitus have an increased fracture risk. However, population-based studies on the association between glycemic status and fracture risk are scarce, and none have targeted a Japanese population. In addition, patients in the lowest category of hemoglobin A1c (HbA1c) do not always show the lowest risk. This study aimed to clarify the association between glycemic status and fracture risk in community-dwelling elderly Japanese men. METHODS: A total of 1992 men aged ≥65 years completed baseline measurements including fasting plasma glucose (FPG), HbA1c, bone density, and an interview regarding past disease history...
January 5, 2019: Bone
Sandip Mondal, Jianqiao Xu, Guosheng Chen, Siming Huang, Chuyu Huang, Li Yin, Gangfeng Ouyang
Antibiotics are a group of antibacterial drugs used in the treatment and prevention of bacterial diseases in humans, veterinary animals, and farmed fish. Inappropriate and excessive use of antibiotic therapy leads to antibiotic fragment in the water bodies thus affect the aquatic organisms. In this study, an amino group modified high surface area metal-organic framework (MOF) MIL-101(Cr)-NH2 was used to prepare solid-phase microextraction (SPME) fiber to detect four different classes (total 6 ABs) of antibiotics for the first time from living tilapia fish (Oreochromis mossambicus) by coupling SPME with high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
January 24, 2019: Analytica Chimica Acta
Jan Hynek, Sebastian Jurík, Martina Koncošová, Jaroslav Zelenka, Ivana Křížová, Tomáš Ruml, Kaplan Kirakci, Ivo Jakubec, František Kovanda, Kamil Lang, Jan Demel
Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin...
2018: Beilstein Journal of Nanotechnology
Yingchao Su, Irsalan Cockerill, Yadong Wang, Yi-Xian Qin, Lingqian Chang, Yufeng Zheng, Donghui Zhu
Zinc has been described as the 'calcium of the twenty-first century'. Zinc-based degradable biomaterials have recently emerged thanks to their intrinsic physiological relevance, biocompatibility, biodegradability, and pro-regeneration properties. Zinc-based biomaterials mainly include: metallic zinc alloys, zinc ceramic nanomaterials, and zinc metal-organic frameworks (MOFs). Metallic zinc implants degrade at a desirable rate, matching the healing pace of local tissues, and stimulating remodeling and formation of new tissues...
November 20, 2018: Trends in Biotechnology
Monika Miklaszewska, Przemysław Korohoda, Katarzyna Zachwieja, Alina Sobczak, Krzysztof Kobylarz, Constantinos J Stefanidis, Jolanta Goździk, Dorota Drożdż
BACKGROUND: Acute kidney injury (AKI) occurs in up to 30% of pediatric intensive care unit (PICU) patients and is associated with a high mortality rate. OBJECTIVES: The objective of the study was to evaluate factors associated with the outcome and to identify the prognostic factors in children receiving continuous renal replacement therapy (CRRT). MATERIAL AND METHODS: This was a retrospective, single-center study, including 46 patients. RESULTS: Logistic regression analysis demonstrated significant effects on patient survival exerted by the percentage of fluid overload (FO%) (odds ratio (OR): 1...
November 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Xun Liu, Fan Wu, Yong Ji, Lichen Yin
Protein/peptide drugs possess unique advantages, such as high pharmacological potency, molecular specificity, multifunctionality, and low toxicity, and thus hold great potential for use in cancer therapy. In the past decades, great achievements have been made in protein delivery systems, which can protect cargo proteins against detrimental physiological environments and efficiently deliver proteins into tumor sites and cells. In this Review, we first summarize the existing protein/peptide drugs used for cancer treatment, illustrate their anti-tumor mechanisms, and point out the potential challenges/barriers against their medical utility...
November 26, 2018: Bioconjugate Chemistry
Ying Zhang, Lei Wang, Liang Liu, Lin Lin, Feng Liu, Zhigang Xie, Huayu Tian, Xuesi Chen
Imaging-guided therapy has considerable potential in tumor treatment. Different treatments have been integrated to realize combinational tumor therapy with improved therapeutic efficiency. Herein, the conventional metal-organic framework (MOF) MIL-100 is utilized to load curcumin with excellent encapsulation capacity. Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs). The HA-PDA coating not only improves the dispersibility and stability of NPs but also introduces a tumor-targeting ability to this nanosystem...
November 26, 2018: ACS Applied Materials & Interfaces
Xuechao Cai, Bei Liu, Maolin Pang, Jun Lin
Recently, fabrication of nanoscale MOFs (NMOFs) has attracted great attention for biomedical applications. NMOFs not only maintain the structural diversity and physicochemical properties of bulk MOFs, but also possess suitable dimensions, making them potential nanocarriers for imaging agents and drug molecules. In this work, highly monodispersed Fe-soc-MOF nanoparticles (about 100 nm) were fabricated through the liquid-solid-solution (LSS) method. Indocyanine green (ICG) was conjugated to the surface-modified Fe-soc-MOF to construct a multifunctional theranostic platform...
November 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
C Freystätter, C Radtke, G Ihra, F Thalhammer, A Fochtmann-Frana
Septic complications are a major problem in burn care. Infections caused by multidrug-resistant (MDR) Klebsiella pneumoniae strains represent a growing threat. In particular, Romania has seen rapidly increasing rates of MDR Klebsiella pneumoniae isolates in recent years. The PubMed database was searched with the terms 'Klebsiella pneumoniae', 'multiple drug resistant', 'enterobacteria', 'infection', 'sepsis or septicaemia or blood stream infection', 'surveillance', 'diagnose', 'burn', 'intensive care unit' and 'Romania or Europe'...
June 30, 2018: Annals of Burns and Fire Disasters
Luyun Zhang, Chuang Liu, Yang Gao, Zihou Li, Jie Xing, Wenzhi Ren, Lili Zhang, Aiguo Li, Guangming Lu, Aiguo Wu, Leyong Zeng
Compared with other subtypes of breast cancer, triple-negative breast cancer (TNBC) is seriously threatening to human life. Therefore, it is a matter of urgency to develop multifunctional nanoprobes for visualized theranostics of TNBC, achieving specific targeting toward only TNBC, but not other subtypes. Nanoscale metal-organic frameworks (MOFs) show important potential in visualized theranostics of tumors, but it is critical to synthesize well-defined core-shell MOF-based nanocomposites by encapsulating a single nanoparticle within MOF...
October 29, 2018: Advanced Healthcare Materials
Ze Yuan, Lu Zhang, Shaozhou Li, Weina Zhang, Min Lu, Yue Pan, Xiaoji Xie, Ling Huang, Wei Huang
The combination of metal-organic frameworks (MOFs) and luminescent nanomaterials with upconversion characteristics could enable the development of new nanomaterials and applications in information security, optical sensing, and theranostics. However, currently available methods are not ideally suitable for fabricating composites of MOF and upconversion nanomaterial, and incorporating upconversion nanomaterials with MOFs in a controllable manner remains challenging. Here, we demonstrate an in situ self-assembly route to the nanocomposites in which MOFs are homogeneously paved with upconversion nanoparticles...
November 2, 2018: Journal of the American Chemical Society
Jiani Huang, Ning Li, Chunmei Zhang, Zhaowei Meng
Metal-organic frameworks (MOFs) have been applied in chemotherapeutic drug loading for cancer treatment, but challenging for cases with large and malignant lesions. To overcome these difficulties, combinational therapies of chemotherapy and photothermal therapy (PTT) with potentially high selectivity and slight aggressiveness have drawn tremendous attention to treat various tumors. However, current MOF-based nanohybrids with photothermal agents involve tedious synthesis processes and heterogeneous structures...
October 30, 2018: ACS Applied Materials & Interfaces
M Wallander, K F Axelsson, D Lundh, M Lorentzon
Osteoporosis is a common complication of androgen deprivation therapy (ADT). In this large Swedish cohort study consisting of a total of nearly 180,000 older men, we found that those with prostate cancer and ADT have a significantly increased risk of future osteoporotic fractures. INTRODUCTION: Androgen deprivation therapy (ADT) in patients with prostate cancer is associated to increased risk of fractures. In this study, we investigated the relationship between ADT in patients with prostate cancer and the risk of incident fractures and non-skeletal fall injuries both compared to those without ADT and compared to patients without prostate cancer...
October 15, 2018: Osteoporosis International
Yuan Liu, Weijia Hou, Lian Xia, Cheng Cui, Shuo Wan, Ying Jiang, Yu Yang, Qiong Wu, Liping Qiu, Weihong Tan
Porphyrinic metal-organic framework (MOF) nanoparticles for photodynamic therapy solve the photosensitizer problems of poor solubility, self-quenching and aggregation. However, their low selectivity towards malignant tissues is an obstacle for bioimaging and a bottle-neck to cellular uptake for highly efficient photodynamic therapy of cancer. Here, ZrMOF nanoparticles as quenchers to conjugate DNA aptamers were developed for target-induced bioimaging and photodynamic therapy. A phosphate-terminal aptamer prepared by solid-phase DNA synthesis was anchored on the surface of ZrMOF nanoparticles through strong coordination between phosphate and zirconium...
October 14, 2018: Chemical Science
Xin Hua, Guosheng Gao, Shengdong Pan
In this paper, a high-affinity graphene oxide-encapsulated magnetic Zr-MOF (GO-Mag@Zr-MOF) was synthesized and characterized by SEM, TEM, and XPS for its morphology, structure, and components. Subsequently, the as-prepared GO-Mag@Zr-MOF was, for the first time, employed as magnetic solid-phase extraction (MSPE) adsorbent for pretreatment and determination of photodynamic therapy (PDT) with the photosensitizers hematoporphyrin (Hp) and hematoporphyrin monomethyl ether (HMME) in human urine samples coupled with ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS)...
October 2, 2018: Analytical and Bioanalytical Chemistry
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