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Immunosuppresion

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https://read.qxmd.com/read/30889977/topical-application-of-polymeric-nanomicelles-in-ophthalmology-a-review-on-research-efforts-for-the-non-invasive-delivery-of-ocular-therapeutics
#1
Maria Aurora Grimaudo, Silvia Pescina, Cristina Padula, Patrizia Santi, Angel Concheiro, Carmen Alvarez-Lorenzo, Sara Nicoli
Polymeric micelles represent nowadays an interesting formulative approach for ocular drug delivery, as they act as solubility enhancers of poorly soluble drugs and promote drug transport across cornea and sclera. In particular, in the last 5 years polymeric nanomicelles have been increasingly investigated to overcome some of the important challenges of the topical treatment of ocular diseases. Areas covered: The aim of this review was to gather up-to-date information on the different roles that polymeric micelles (commonly in the nano-size scale) can play in ocular delivery...
March 20, 2019: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/30770088/open-surgical-repair-of-abdominal-aortic-aneurysms-in-beh%C3%A3-et-s-disease
#2
A Bouarhroum, H Naouli, H Jiber
BACKGROUND: Behçet's disease (BD) is a multisystem chronic autoimmune inflammatory disorder that involves multiple organs. Arterial involvement in BD is rare. Aortic involvement is one of the most severe manifestations and is associated with a much higher mortality. In this article, we will present our experience in open surgical repair of abdominal aortic aneurysm combined with immunosuppressive therapy. METHODS: Between January 2010 and December 2017, 7 patients were treated for abdominal aortic aneurysms (5 infra-renal and 2 supra-renal, in 1 woman and 6 men)...
February 2019: Journal de Médecine Vasculaire
https://read.qxmd.com/read/30698041/evaluation-of-ovarian-reserve-in-women-with-psoriasis
#3
Begum Aydogan Mathyk, Berna Aslan Cetin, Sule Bilici, Julia Fasse, Pinar Avci
The aim of this study is to evaluate ovarian reserve in women with psoriasis. Thirty-six women with psoriasis and 36 healthy women were enrolled in this prospective study. On day 3 of the menstrual cycle, blood samples for AMH and other hormones were collected. On the same day, antral follicle count (AFC), and ovarian volumes were measured. A multiple regression analysis was carried out to examine the contribution of factors to the serum AMH levels in patients with psoriasis. The serum AMH levels and ovarian volumes were lower in the psoriasis group than in the control group (1...
January 30, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/30649812/cerebral-amyloid-angiopathy-related-%C3%A4-nflammation-presenting-as-steroid-responsive-brain-mass
#4
Hakan Silek, Bahar Erbas
Cerebral amyloid angiopathy (CAA) is a common but often asymptomatic disease, characterized by the deposition of amyloid proteins within brain parenchyma and leptomeningeal-cortical vessels. It can occur as a sporadic disorder or accompany Alzheimer disease (AD). The usual presantation of CAA is spontenous lobar hemorrage, Unlike CAA, cerebral amyloid angiopathy-related inflammation (CAA-ri),a subtype of CAA, can show different presentations and responds to steroid (or immunsupressive) treatment. We report a patient with mixed dementia who showed subacute progression in cognitive impairment and had a mass lesion on the brain (MRI) magnetic resonance imaging...
September 11, 2018: Turkish Neurosurgery
https://read.qxmd.com/read/30337196/complementary-medicine-use-symptom-burden-and-non-adherence-in-kidney-transplant-recipients
#5
Mariana S Markell, Sima Terebelo
BACKGROUND: Complementary Medicine (CAM) is often used by patients with chronic illness and may not be disclosed to health care providers without prompting. In other populations, patients who use CAM were more likely to alter medications without discussing it with their provider. This study examined the relationship between self-reported use of CAM, attitudes toward care, and adherence to medical therapy in a population of inner-City kidney transplant recipients. METHODS: Cross-sectional observational analysis in a random convenience sample from the outpatient transplant clinic...
September 12, 2018: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/30072754/effect-of-imidacloprid-ingestion-on-immune-responses-to-porcine-reproductive-and-respiratory-syndrome-virus
#6
J Hernandez, A Volland, B J Leyshon, M Juda, J M Ridlon, R W Johnson, A J Steelman
Nicotine and acetylcholine cause immunosuppresion by signaling to the α7 nicotinic acetylcholine receptor (α7 nAChR) on immune cells. Neonicotinoids are nAChR agonists and widly used insecticides. We aimed to define the immunosuppressive potential of dietary exposure to the neonicotinoid imidacloprid (IMI) on the generation of innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus (PRRSV). Piglets were randomized into groups based on diet and infection. Behavioral signs of illness were recorded...
August 2, 2018: Scientific Reports
https://read.qxmd.com/read/30024415/facilitating-cells-role-in-inducing-transplantation-tolerance
#7
Anita Yogendra Chhabra, Suzanne T Ildstad
PURPOSE OF REVIEW: This review discusses the role and mechanisms by which facilitating cells promote stem cell engraftment and induce tolerance in HLA-disparate kidney transplant recipients. RECENT FINDING: Facilitating cells in both mice and human are heterogeneous, consisting of several subpopulations. They have been shown to enhance stem cell engraftment in allogeneic recipients. They also increase hematopoietic stem cells (HSC) clonogenicity, enhance migration and homing of stem cells via secretion of cytokines/chemokines/growth factors, prevent apoptosis of stem cells and induce regulatory cells...
October 2018: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/29726735/therapeutic-strategies-for-pigmented-purpuric-dermatoses-a-systematic-literature-review
#8
Kerasia-Maria Plachouri, Vaia Florou, Sophia Georgiou
BACKGROUND: Pigmented purpuric dermatoses (PPDs) is a group of diseases with distinguishing clinical characteristics, characterized mainly by purpuric skin lesions. The course of PPDs is chronic and recurrences are common. Although PPDs are considered to be benign, the associated symptoms, such as pruritus, and their cosmetic effect can be extremely distressing to patients. So far no evidence-based treatment has been found to be drastically effective in a large scale of patients. MATERIALS AND METHODS: This paper is a systematic overview of all the reported successful treatments described in the literature...
May 18, 2018: Journal of Dermatological Treatment
https://read.qxmd.com/read/29724319/-clinicopathological-features-and-treatment-of-renal-impair-in-primary-sj%C3%A3-gren-syndrome
#9
Jing Wang, Li Meng Chen
Primary Sjögren syndrome,characterized by autoimmune epithelitis,is a prevalent systemic autoimmune disease involving multiple organs,among which kidney is a major target organ.Tubulointerstitial lesion is the most frequent form,involving proximal tubule,distal tubule,or collecting duct.The disease has an occult onset and may progressively develop into renal function impairment and end-stage renal disease,which can be accompanied with low-molecular-weight proteinuria,renal tubule acidosis and electrolyte disturbance...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://read.qxmd.com/read/29626527/in-vitro-photodynamic-inactivation-effects-of-benzylidene-cyclopentanone-photosensitizers-on-clinical-fluconazole-resistant-candida-albicans
#10
Shaona Zhou, Zhiyuan Sun, Zulin Ye, Ying Wang, Leili Wang, Limei Xing, Haixia Qiu, Naiyan Huang, Yanping Luo, Yuxia Zhao, Ying Gu
BACKGROUND: The incidence of Candida infections has increased for various reasons, including, the more frequent use of immunosuppresants or broad-spectrum antibiotics. Photodynamic inactivation (PDI) is a promising approach for treating localized Candida infections. METHODS: The PDI efficacies of three benzylidene cyclopentanone-based (BCB) photosensitizers (PSs: P1, P2 and Y1) against three fluconazole-resistant C. albicans (cal-1, cal-2, and cal-3) and one control C...
June 2018: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/29601561/-cardiac-sarcoidosis-diagnostics-treatment-and-follow-up
#11
REVIEW
Maria Dudziak, Hanna Jankowska, Karolina Dorniak
Sarcoidosis is a generalised granulomatous disorder of unknown aetiology. Cardiac involvement may affect conduction system, myocardium, valvular apparatus and pericardium. Clinical spectrum ranges from asymptomatic involvement to sudden cardiac death. Patients with biopsy-proven extracardiac sarcoidosis should be screened for cardiac involvement (standard ECG, 24-hour Holter ECG, echocardiography) and in case of any abnormalities found on these tests, more advanced diagnostic methods should be used. Steroid treatment is still the mainstay of therapy in cardiac sarcoidosis...
March 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/29453958/age-dependent-effects-of-dimethyl-fumarate-on-cognitive-and-neuropathological-features-in-the-streptozotocin-induced-rat-model-of-alzheimer-s-disease
#12
Irena Majkutewicz, Ewelina Kurowska, Magdalena Podlacha, Dorota Myślińska, Beata Grembecka, Jan Ruciński, Karolina Pierzynowska, Danuta Wrona
We previously demonstrated that dimethyl fumarate (DMF), an anti-oxidative and immunosuppresive compound, prevents intracerebroventricular (ICV) streptozotocin-induced disruption of spatial memory and neurodegeneration in 4-month-old rats. The present study evaluated the influence of age on DMF's therapeutic effect. Aged rats (22-months-old, n = 40) were provided rodent chow containing DMF (0.4%) and given ICV injections of streptozotocin (STZ) or vehicle (Sham) on days 2 and 4. Spatial memory was evaluated using the Morris water maze (MWM) on days 14-21...
May 1, 2018: Brain Research
https://read.qxmd.com/read/29405487/history-of-psychosis-and-mania-and-outcomes-after-kidney-transplantation-a-retrospective-study
#13
Miklos Z Molnar, James D Eason, Abduzhappar Gaipov, Manish Talwar, Praveen K Potukuchi, Kiran Joglekar, Adam Remport, Zoltan Mathe, Istvan Mucsi, Marta Novak, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score-matched cohort (n = 442). Associations between pretransplantation psychosis/mania and death with functioning graft, all-cause death, graft loss, and rejection were examined in survival models and logistic regression models...
May 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://read.qxmd.com/read/29306022/t-regulatory-cells-mediate-immunosuppresion-by-adenosine-in-peripheral-blood-sentinel-lymph-node-and-tils-from-melanoma-patients
#14
P Di Gennaro, G Gerlini, R Caporale, S Sestini, P Brandani, C Urso, N Pimpinelli, L Borgognoni
T regulatory cells (Tregs), involved in tumour tolerance, can generate Adenosine by CD39/CD73 surface enzymes, which identify four Tregs subsets: CD39+ CD73- nTregs, CD39+ CD73+ iTregs, CD39- CD73+ oTregs and CD39- CD73- xTregs. In melanoma patients, increased Tregs levels are detected in peripheral blood (PB), sentinel lymph node (SLN) and tumour infiltrating lymphocytes (TILs), but Adenosine role was not investigated yet. We examined total Tregs and Adenosine subsets in PB, SLN and TILs from melanoma patients (n = 32) and PB from healthy donors (HD; n = 10) by flow cytometry...
March 28, 2018: Cancer Letters
https://read.qxmd.com/read/29291200/human-herpesvirus-8-positive-iatrogenic-kaposi-s-sarcoma-in-the-setting-of-refractory-ulcerative-colitis
#15
Erica Duh, Sean Fine
Although Kaposi sarcoma (KS) has been more traditionally considered an AIDS-defining illness, it may also be seen in individuals on immunosuppresive therapy. We report a case of a patient who presented to the hospital in the setting of increasingly refractory ulcerative colitis. Computed tomography scan of the abdomen was consistent with sigmoid diverticulititis and blood cultures were positive for Klebsiella. After a course of antibiotics with resolution of infection, a colonoscopy was performed to evaluate his diverticulitis and incidentally revealed a new rectal tumor...
December 16, 2017: World Journal of Clinical Cases
https://read.qxmd.com/read/29082050/a-case-of-rituximab-induced-necrotizing-fasciitis-and-a-review-of-the-literature
#16
Abdullateef Abdulkareem, Ryan S D'Souza, Oluwaseun Shogbesan, Anthony Donato
Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation...
2017: Case Reports in Hematology
https://read.qxmd.com/read/28978142/glioblastoma-progression-is-assisted-by-induction-of-immunosuppressive-function-of-pericytes-through-interaction-with-tumor-cells
#17
Rut Valdor, David García-Bernal, Carlos Bueno, Mónica Ródenas, José M Moraleda, Fernando Macian, Salvador Martínez
The establishment of immune tolerance during Glioblastoma Multiforme (GBM) progression, is characterized by high levels expression of anti-inflammatory cytokines, which suppress the function of tumor assocciated myeloid cells, and the activation and expansion of tumor antigen specific T cells. However, the mechanisms underlying the failed anti-tumor immune response around the blood vessels during GBM, are poorly understood. The consequences of possible interactions between cancer cells and the perivascular compartment might affect the tumor growth...
September 15, 2017: Oncotarget
https://read.qxmd.com/read/28948913/natural-mismatch-repair-mutations-mediate-phenotypic-diversity-and-drug-resistance-in-cryptococcus-deuterogattii
#18
R Blake Billmyre, Shelly Applen Clancey, Joseph Heitman
Pathogenic microbes confront an evolutionary conflict between the pressure to maintain genome stability and the need to adapt to mounting external stresses. Bacteria often respond with elevated mutation rates, but little evidence exists of stable eukaryotic hypermutators in nature. Whole genome resequencing of the human fungal pathogen Cryptococcus deuterogattii identified an outbreak lineage characterized by a nonsense mutation in the mismatch repair component MSH2. This defect results in a moderate mutation rate increase in typical genes, and a larger increase in genes containing homopolymer runs...
September 26, 2017: ELife
https://read.qxmd.com/read/28786066/regulatory-t-cell-activity-in-immunosuppresive-mice-model-of-pseudomonas-aeruginosa-pneumonia
#19
Jun-Lu Li, Ting-Sang Chen, Cong-Cong Yuan, Guo-Qiang Zhao, Min Xu, Xiao-Yan Li, Jie Cao, Li-Hua Xing
Pseudomonas aeruginosa (PA) pneumonia is a refractory, even lethal complication in immunosuppressive individuals and immune disturbances may promote the pathological process. We aimed to investigate the regulatory T (Treg) cell activity in an immunosuppressive mice model of PA pneumonia by estimating levels of main transcription factor and the main effector of Treg cells, i.e., Forkhead box protein 3 (FOXP3) and interleukine-10 (IL-10). Seventy-two BALB/c mice were divided into four groups randomly: control (A), PA pneumonia (B), immunosuppression (C) and immunosuppression with PA pneumonia (D)...
August 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://read.qxmd.com/read/28710997/dynamics-of-torque-teno-virus-plasma-dnaemia-in-allogeneic-stem-cell-transplant-recipients
#20
Eliseo Albert, Carlos Solano, Tania Pascual, Ignacio Torres, Lisa Macera, Daniele Focosi, Fabrizio Maggi, Estela Giménez, Paula Amat, David Navarro
BACKGROUND: Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). OBJECTIVES: We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. STUDY DESIGN: Retrospective single-center observational study including 72 allo-HSCT patients...
September 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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