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https://read.qxmd.com/read/30759016/hybrid-three-dimensional-lung-tissue-cultures-to-improve-ex-vivo-models-of-chronic-obstructive-pulmonary-disease
#1
Kolene E Bailey, Tyler J D'Ovidio, Nicole Manning, Melanie Koenigshoff, Chelsea M Magin
RATIONALE: Continued reliance on preclinical animal models and traditional human cell culture experiments conducted on supraphysiologically stiff surfaces in two dimensions often limits the translation of cellular and molecular mechanistic findings into effective therapies for patients suffering from chronic obstructive pulmonary disease (COPD). COPD ranks as the fourth highest cause of mortality in the United States, and thus it is imperative to improve ex vivo models of this devastating disease...
December 2018: Annals of the American Thoracic Society
https://read.qxmd.com/read/30691662/relationship-between-carotid-intima-media-thickness-and-carotid-artery-stiffness-assessed-by-ultrafast-ultrasound-imaging-in-patients-with-type-2-diabetes
#2
Fu-Shun Pan, Ming Xu, Liang Yu, Jia Luo, Man-Ying Li, Jin-Yu Liang, Yan-Ling Zheng, Xiao-Yan Xie
OBJECTIVES: To evaluate the relationship between carotid stiffness and carotid intima-media thickness (CIMT) in patients with type 2 diabetes (T2DM). MATERIALS AND METHODS: Carotid properties were evaluated in 317 consecutive subjects (98 volunteers for controls, 105 patients with normal CIMT for T2DM group 1, and 114 patients with thickened CIMT for T2DM group 2). The CIMT and carotid pulse wave velocity at the beginning (PWV-BS) and at the end of systole (PWV-ES) were measured...
February 2019: European Journal of Radiology
https://read.qxmd.com/read/30671807/correlation-of-serum-mac-2-binding-protein-glycosylation-isomer-m2bpgi-and-liver-stiffness-in-chronic-hepatitis-b-infection
#3
Lung-Yi Mak, Danny Ka-Ho Wong, Wai-Kay Seto, Qin Ning, Ka-Shing Cheung, James Fung, Ching-Lung Lai, Man-Fung Yuen
BACKGROUND AND AIM: Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel serum diagnostic marker for liver fibrosis in various liver diseases. We aimed to evaluate its role in assessment of liver fibrosis in chronic hepatitis B infection (CHB) with reference to liver stiffness measurement (LSM). METHODS: CHB patients with LSM by transient elastography technology and retrievable serum samples were recruited. Ten-year re-assessments of LSM and M2BPGi were repeated in a patient subgroup...
January 22, 2019: Hepatology International
https://read.qxmd.com/read/30650016/high-load-soft-grippers-based-on-bionic-winding-effect
#4
Haili Li, Jiantao Yao, Pan Zhou, Xinbo Chen, Yundou Xu, Yongsheng Zhao
The improvement of the load capacity of soft grippers has always been a challenge. To tackle this load capacity challenge, this work presents four novel types of high-load (HL) soft grippers that are bioinspired by bionic winding models. The winding models are found commonly in many animals and plants, where different winding patterns are used to grip different objects. Inspired by the winding models, we design four bionic winding structures that are driven by pneumatic artificial muscles (PAMs), and then four HL soft grippers are formed out of the winding structures...
January 16, 2019: Soft Robotics
https://read.qxmd.com/read/30615500/right-ventricular-fibrosis
#5
Stine Andersen, Jens Erik Nielsen-Kudsk, Anton Vonk Noordegraaf, Frances S de Man
The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject of ongoing discussion. Alterations of the collagen network of the extracellular matrix may help prevent ventricular dilatation in the pressure-overloaded RV. At the same time, fibrosis impairs cardiac function, and a growing body of experimental data suggests that fibrosis plays a crucial role in the development of RV failure. In idiopathic pulmonary arterial hypertension and chronic thromboembolic PH, the RV is exposed to a ≈5 times increased afterload, which makes these conditions excellent models for studying the impact of pressure overload on RV structure...
January 8, 2019: Circulation
https://read.qxmd.com/read/30594958/resection-of-lesions-in-the-ileum-of-patients-with-igg4-related-disease-may-ameliorate-disease-progression-without-steroid-administration
#6
Akihiro Watanabe, Takashi Goto, Hitomi Kamo, Ryuji Komine, Naomi Kuroki, Takanobu Sugase, Tsuyoshi Takaya, Rintaro Koga, Hiroshi Hojo, Shoji Taniguchi, Kazuhiko Ibusuki, Kazumi Koga
BACKGROUND: IgG4-related disease (IgG4-RD) is a pathological condition that is characterized by an infiltrate composed of IgG4-positive plasma cells and recently recognized as an immune-mediated condition. It causes tissue throughout the body to become stiff and thickened due to autoimmune reactions that cause fibrosis and scarring. Disease-related changes commonly occur in the salivary glands, bile duct, pancreas, and lungs, but are seldom seen in the small bowel. A diagnosis of IgG4-RD is suspected if a high level of IgG4 is found on a blood test...
December 29, 2018: Surgical Case Reports
https://read.qxmd.com/read/30567134/primary-synovial-osteochondromatosis-of-the-shoulder-a-rare-cause-of-shoulder-pain
#7
Emma Poyser, Rhys Morris, Hemang Mehta
Synovial osteochondromatosis is a benign neoplastic condition which manifests as multiple cartilaginous or osteocartilaginous nodules within a joint, bursa and tendon sheath. It typically results in pain and stiffness of the affected joint, and is thought to arise as a result of synovial membrane proliferation and metaplasia. 1 We report the diagnosis and management of a 36-year-old man who presented with a long history of shoulder pain, which had been managed conservatively prior to referral to orthopaedics...
November 28, 2018: BMJ Case Reports
https://read.qxmd.com/read/30563577/myocarditis-in-a-patient-treated-with-nivolumab-and-prostvac-a-case-report
#8
Cecilia Monge, Hoyoung Maeng, Alessandra Brofferio, Andrea B Apolo, Bharath Sathya, Andrew E Arai, James L Gulley, Marijo Bilusic
BACKGROUND: Immune checkpoint inhibitors have revolutionized treatment and improved survival in many cancers. However, since immune-related adverse events (irAEs) are potentially fatal, early recognition and prompt treatment are warranted. One of the rarest but most dramatic irAE is myocarditis, which has significant morbidity and mortality if not recognized and treated early. OBJECTIVE: To report the first case of myocarditis in a patient with metastatic castration-resistant prostate cancer (mCRPC) treated with a combination of nivolumab, an anti-programmed cell death protein 1 antibody, and PROSTVAC, a vector-based therapeutic prostate cancer vaccine...
December 18, 2018: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/30558576/guillain-barr%C3%A3-syndrome-following-bacterial-meningitis-a-case-report-and-literature-review
#9
Li Ding, Zhongjun Chen, Yan Sun, Haiping Bao, Xiao Wu, Lele Zhong, Pei Zhang, Yongzhong Lin, Ying Liu
BACKGROUND: We reported a case of an adult that presented Guillain-Barré syndrome (GBS) after bacterial meningitis which was secondary to chronic suppurative otitis media (CSOM). To our knowledge, this is the first case involving an adult presenting with GBS following bacterial meningitis. CASE PRESENTATION: A 46-year man with type 2 diabetes and otitis media (OM) suffered with fever, headache, and vomiting for 6 days. The patient's neck stiffness was obvious and the Kernig and Brudzinski signs were produced...
December 17, 2018: BMC Neurology
https://read.qxmd.com/read/30543737/-a-case-of-rheumatoid-arthritis-developed-during-treatment-with-nivolumab-for-renal-cell-carcinoma
#10
Mitsuru Tomizawa, Yasushi Nakai, Fumisato Maesaka, Takuya Owari, Ryota Hara, Makito Miyake, Takeshi Inoue, Satoshi Anai, Nobumichi Tanaka, Kiyohide Fujimoto
A 66-year-old man underwent nephrectomy for right renal cell carcinoma (cT3bNOMl (PUL)). Thereafter, he was treated with sunitinib for lung metastasis as the first-line therapy for 5 months and then axitinib as the second-line therapy for 2 months. Because lung metastasis progressed despite molecular targeted therapies, nivolumab was used as the third-line treatment. Three months later, he complained of painful stiffness in hands and wrist joints symmetrically. He was diagnosed as having rheumatoid arthritis...
October 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://read.qxmd.com/read/30526946/allograft-for-the-treatment-of-traumatic-severe-bone-loss-in-the-lateral-femoral-condyle-a-case-report
#11
Tomasz Nizegorodcew, Giuseppe Palmieri, Marco Peruzzi, Marco Galli
BACKGROUND: Open articular fractures are an important issue due to their increasing incidence, along with the rise in motorcycle accidents. Oncology experience with allograft in orthopedics may be extended to cases of traumatic bone loss. CLINICAL CASE: A 37-year-old man with an open fracture of the distal femur and proximal tibia presented a massive bone loss of the lateral femoral condyle after a motorcycle accident. Following Damage Control Surgery, a considerable lateral femoral condyle allograft was used to restore the joint anatomy...
December 2018: Injury
https://read.qxmd.com/read/30497413/identification-of-novel-compound-heterozygous-spg7-mutations-related-hereditary-spastic-paraplegia-in-a-chinese-family-a-case-report
#12
Xiaoqian Zhang, Lei Zhang, Yanqing Wu, Gang Li, Shengcai Chen, Yuanpeng Xia, Hongge Li
BACKGROUND: Autosomal recessive hereditary spastic paraplegias (ARHSPs) are a group of clinically and genetically heterogeneous neurodegenerative diseases with progressive spasticity and weakness in the lower limbs. Mutations in the Spastic Paraplegia gene 7 (SPG7) account for about 5-21% of ARHSP cases. However, in Asians, few reports about the mutations exist. In this study, we firstly report a novel finding from a Chinese family with compound heterozygous SPG7 mutations, in which three siblings were affected with a complicated form of ARHSP...
November 29, 2018: BMC Neurology
https://read.qxmd.com/read/30479837/multilevel-critical-stenosis-with-minimal-functional-deficits-a-case-of-cervical-spondylotic-myelopathy
#13
Anup K Gangavalli, Ajith Malige, Gbolabo Sokunbi
Introduction: We present a case of a previously asymptomatic and highly functional individual whose critical degenerative stenosis was exacerbated by recent trauma (motor vehicle accident), resulting in cervical spondylotic myelopathy. Case presentation: A 57-year-old African-American man with no significant past medical history presented to the Orthopaedic Surgery outpatient clinic with mild neck discomfort, stiffness, and bilateral hand numbness 4 days after being involved in a motor vehicle accident...
2018: Spinal Cord Series and Cases
https://read.qxmd.com/read/30415924/interleukin-17-drives-interstitial-entrapment-of-tissue-lipoproteins-in-experimental-psoriasis
#14
Li-Hao Huang, Bernd H Zinselmeyer, Chih-Hao Chang, Brian T Saunders, Andrew Elvington, Osamu Baba, Thomas J Broekelmann, Lina Qi, Joseph S Rueve, Melody A Swartz, Brian S Kim, Robert P Mecham, Helge Wiig, Michael J Thomas, Mary G Sorci-Thomas, Gwendalyn J Randolph
Lipoproteins trapped in arteries drive atherosclerosis. Extravascular low-density lipoprotein undergoes receptor uptake, whereas high-density lipoprotein (HDL) interacts with cells to acquire cholesterol and then recirculates to plasma. We developed photoactivatable apoA-I to understand how HDL passage through tissue is regulated. We focused on skin and arteries of healthy mice versus those with psoriasis, which carries cardiovascular risk in man. Our findings suggest that psoriasis-affected skin lesions program interleukin-17-producing T cells in draining lymph nodes to home to distal skin and later to arteries...
November 5, 2018: Cell Metabolism
https://read.qxmd.com/read/30407336/vertigo-caused-by-longus-colli-tendonitis-a-case-report-and-literature-review
#15
REVIEW
Yifeng Shen, Qiaoyin Zhou, Xinyue Zhu, Zuyun Qiu, Yan Jia, Zixiang Liu, Shiliang Li
RATIONALE: Tendinitis of the longus colli muscle is an aseptic inflammatory process leading to acute posterior neck pain, neck stiffness, and dysphagia or odynophagia. We present a patient exhibiting an infrequent symptom, vertigo. This is the first description of the occurrence of vertigo symptoms caused by longus colli tendinitis. PATIENT CONCERNS: A 38-year-old man was diagnosed with vertigo, presenting with a 1-month history of dizziness, palpitations, and numbness in the hands...
November 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30352484/quantitative-assessment-of-liver-stiffness-using-ultrasound-shear-wave-elastography-in-patients-with-chronic-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation-a-pilot-study
#16
Man Zhang, Mishal Mendiratta-Lala, Katherine E Maturen, Ashish P Wasnik, Sherry S Wang, Hadeel Assad, Jonathan M Rubin
OBJECTIVES: The purpose of this study was to compare hepatic stiffness on ultrasound (US) shear wave elastography (SWE) in patients with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation versus patients with no underlying liver disease. METHODS: We performed a retrospective analysis of 4901 patients who underwent abdominal US examinations with adjunctive liver SWE between August 2014 and December 2016. Each patient was scanned supine with gentle breath holding on LOGIQ E9 (GE Healthcare, Waukesha, WI) or Epiq (Philips Healthcare, Andover, MA) US machines (3-6 MHz)...
October 23, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/30342780/quantitative-elastography-of-rectal-lesions-the-value-ofshear-wave-elastography-in-identifying-benign-and-malignant-rectal-lesions
#17
Tingting Li, Man Lu, Yuan Li, Juan Li, Ziyue Hu, Xu Li, Xueqing Cheng, Jingzhen Jiang, Bo Tan
We evaluate the value of shear wave elastography (SWE) in diagnosing benign and malignant rectal lesions. A total of 96 lesions were reviewed in this study; endorectal ultrasound (ERUS) and SWE examinations were performed before surgery in all cases. Elasticity parameters including mean elastographic index (Emean ), maximum elastographic index (Emax ) and minimum elastographic index (Emin ) were analyzed. Correlations between elastographic parameters and histopathological results were studied. Inter-observer and intra-observer agreement was analyzed...
October 17, 2018: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/30305979/augmentation-of-a-locking-plate-system-using-bioactive-bone-cement-experiment-in-a-proximal-humeral-fracture-model
#18
Guan-Ming Kuang, Tak Man Wong, Jun Wu, Jun Ouyang, Haihua Guo, Yapeng Zhou, Christian Fang, Frankie K L Leung, William Lu
Introduction: The purpose of this study was to test whether local filling of a novel strontium-containing hydroxyapatite (Sr-HA) bone cement can augment the fixation of a locking plate system in a cadaveric proximal humeral facture model. Materials and Methods: Twelve pairs of formalin-treated cadaveric humeri were used. One side in each pair was for cemented group, while the other side was for the control group. The bone mineral density (BMD) of the samples was tested...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://read.qxmd.com/read/30284065/effect-of-an-egg-ovalbumin-derived-protein-hydrolysate-on-blood-pressure-and-cardiovascular-risk-in-adults-with-a-mildly-elevated-blood-pressure-a-randomized-placebo-controlled-crossover-trial
#19
Alice J Lucey, Clara Heneghan, Edmund Manning, Paul A Kroon, Máiréad E Kiely
PURPOSE: While animal and in vitro data demonstrate vasodilatory effects of egg white-derived peptides, human studies are lacking. We investigated for the first time the effects of an egg ovalbumin-derived protein hydrolysate on blood pressure (BP) and cardiovascular risk. METHODS: A double-blind, placebo-controlled randomized crossover trial was implemented in 75 adults aged 50-70 years with systolic BP (130-≤ 150 mmHg). Participants were randomized to an egg ovalbumin-derived protein hydrolysate (3 g/day) or placebo (3 g/day)...
October 3, 2018: European Journal of Nutrition
https://read.qxmd.com/read/30283322/effects-of-long-term-treatment-with-t-pemf-on-forearm-muscle-activation-and-motor-function-in-parkinson-s-disease
#20
Bente Rona Jensen, Anne Sofie Bøgh Malling, Bo Mohr Morberg, Ole Gredal, Per Bech, Lene Wermuth
Bipolar pulsed electromagnetic stimulation applied to the brain (T-PEMF) is a non-pharmacological treatment which has been shown to stimulate nerve growth, attenuate nerve abnormalities, and improve microcirculation. We report on a 62-year-old, medically well-treated man with idiopathic Parkinson's disease. He was treated with T-PEMF, 30 min per day for three 8-week periods separated by two 1-week breaks. The disease made his handwriting impossible to read mainly due to small letters and lack of fluency. Forearm EMG measured during standardized conditions showed an involuntary spiky EMG pattern with regular burst activity (on his left side) at baseline...
May 2018: Case Reports in Neurology
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