keyword
https://read.qxmd.com/read/38497062/navigated-peel-away-sheath-assisted-placement-of-fully-pre-assembled-ommaya-reservoir-systems-technical-note
#1
JOURNAL ARTICLE
Connor A Wathen, Maria Punchak, Peter Madsen, Kerry Vaughan, Vivek Buch, Paul J Marcotte
No abstract text is available yet for this article.
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38464207/feasibility-of-safe-outpatient-treatment-in-pediatric-patients-following-intraventricular-radioimmunotherapy-with-131i-omburtamab-for-leptomeningeal-disease
#2
Kavya Prasad, Brian E Serencsits, Bae P Chu, Lawrence T Dauer, Maria Donzelli, Ellen Basu, Kim Kramer, Neeta Pandit-Taskar
Background Radiolabeled antibody 131 I-omburtamab was administered intraventricularly in patients with leptomeningeal disease under an institutionally approved study (# NCT03275402 ). Radiation safety precautions were tailored for individual patients, enabling outpatient treatment based on in-depth, evidence-based recommendations for such precautions. The imperative advancement of streamlined therapeutic administration procedures, eliminating the necessity for inpatient isolation and resource-intensive measures, holds pivotal significance...
February 28, 2024: Research Square
https://read.qxmd.com/read/38416167/ommaya-reservoir-use-in-pediatric-all-and-nhl-a-review-at-st-jude-children-s-research-hospital
#3
JOURNAL ARTICLE
Alyssa Gaietto, John C Panetta, Jennifer L Pauley, Mary V Relling, Raul Ribeiro, Matthew J Ehrhardt, Ching-Hon Pui, Hiroto Inaba, Hope D Swanson
PURPOSE: The intraventricular route of chemotherapy administration, via an Ommaya Reservoir (OmR) improves drug distribution in the central nervous system (CNS) compared to the more commonly used intrathecal administration. We retrospectively reviewed our experience with intraventricular chemotherapy, focused on methotrexate, in patients with Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin Lymphoma (NHL). METHODS: Twenty-four patients (aged 7 days - 22.2 years) with 26 OmR placements were identified for a total of 25,009 OmR days between 1990 and 2019...
February 28, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38388726/sequencing-of-cerebrospinal-fluid-cell-free-dna-facilitated-early-differential-diagnosis-of-intramedullary-spinal-cord-tumors
#4
JOURNAL ARTICLE
Ruichao Chai, Songyuan An, Han Lin, Bo Pang, Hao Yan, Yun Liu, Yilin Wu, Long Wang, Xing Liu, Huiyuan Chen, Xueyu Yang, Qing Chang, Wenqing Jia, Yongzhi Wang
Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) for differential diagnosis of these tumors. Prospectively enrolling 45 patients with intramedullary spinal cord lesions, including diffuse midline glioma (DMG), H3K27-altered (14/45), glioblastoma (1/45), H3-wildtype-astrocytoma (10/45), ependymoma (11/45), and other lesions (9/45), CSF samples were collected via lumbar puncture (41/45), intraoperative extraction (3/45), and Ommaya reservoir (1/45)...
February 22, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38371146/augmented-reality-assisted-placement-of-ommaya-reservoir-for-cyst-aspiration-a-case-report
#5
Joshua Olexa, Annie Trang, Kevin Kim, Maureen Rakovec, Jordan Saadon, Whitney Parker
Image guidance technologies can significantly improve the accuracy and safety of intracranial catheter insertions. Augmented reality (AR) allows surgeons to visualize 3D information overlaid onto a patient's head. As such, AR has emerged as a novel image guidance technology that offers unique advantages when navigating intracranial targets. A 71-year-old woman with a history of brain metastasis from breast cancer and prior resection surgery and chemotherapy presented with altered mental status and generalized weakness worse on her left side...
January 2024: Curēus
https://read.qxmd.com/read/38325716/locoregional-drug-delivery-for-cancer-therapy-preclinical-progress-and-clinical-translation
#6
REVIEW
Suyog Shaha, Danika Rodrigues, Samir Mitragotri
Systemic drug delivery is the current clinically preferred route for cancer therapy. However, challenges associated with tumor localization and off-tumor toxic effects limit the clinical effectiveness of this route. Locoregional drug delivery is an emerging viable alternative to systemic therapies. With the improvement in real-time imaging technologies and tools for direct access to tumor lesions, the clinical applicability of locoregional drug delivery is becoming more prominent. Theoretically, locoregional treatments can bypass challenges faced by systemic drug delivery...
February 14, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38222058/ventriculoperitoneal-shunting-with-an-on-off-valve-for-patients-with-leptomeningeal-metastases-and-intracranial-hypertension
#7
JOURNAL ARTICLE
Kristin M Huntoon, Jaime Gasco, Isabella C Glitza Oliva, Sherise D Ferguson, Nazarin K Majd, Ian E McCutcheon
BACKGROUND: We report our experience with using a ventriculoperitoneal shunt (VPS) with an on-off valve and in-line Ommaya reservoir for the treatment of hydrocephalus or intracranial hypertension in patients with leptomeningeal disease (LMD). Our goal was to determine whether control of intracranial pressure elevation combined with intrathecal (IT) chemotherapy would extend patient survival. METHODS: In this IRB-approved retrospective study, we reviewed 58 cases of adult patients with LMD from solid cancers who received a VPS with a reservoir and an on-off valve at M D Anderson Cancer Center from November 1996 through December 2021...
February 2024: Neuro-oncology Practice
https://read.qxmd.com/read/38192377/combination-of-conventional-evd-and-ommaya-drainage-for-intraventricular-hemorrhage-ivh
#8
JOURNAL ARTICLE
Tongming Zhu, Junyan Fu, Di Zang, Zhe Wang, Xiangru Ye, Xuehai Wu, Jin Hu
BACKGROUND: The effect of Ommaya reservoirs on the clinical outcomes of patients with intraventricular hemorrhage (IVH) remains unclear. OBJECTIVE: We aimed to determine the effect of combining the Ommaya reservoir and external ventricular drainage (EVD) therapy on IVH and explore better clinical indicators for Ommaya implantation. METHODS: A retrospective analysis was conducted on patients diagnosed with IVH who received EVD-Ommaya drainage between January 2013 and March 2021...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38165414/ommaya-reservoir-placement-using-ultrasound-guidance-via-anterior-fontanelle-combined-with-frameless-electromagnetic-neuronavigation-in-patients-with-mucopolysaccharidosis-type-2-case-reports-and-review-of-the-literature
#9
JOURNAL ARTICLE
Makoto Mizushima, Masahito Kawabori, Kazuyoshi Yamazaki, Kiyoshi Egawa, Miki Fujimura
Mucopolysaccharidosis type II (MPS II) results from the genetic deficiency of a lysosomal enzyme and is associated with central nervous system (CNS) dysfunction. In Japan, in addition to intravenous enzyme administration, intracerebroventricular enzyme delivery through the Ommaya reservoir has recently gained approval. Nevertheless, the ideal approach for safely implanting the reservoir into the narrow ventricles of infantile MPS II patients remains uncertain. In this report, we present two cases of successful reservoir placement in infantile MPS II patients using ultrasound guidance via the anterior fontanelle, coupled with flameless electromagnetic neuronavigation...
January 2, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38149027/chimeric-antigen-receptor-t-cell-therapy-for-acute-leukemia
#10
JOURNAL ARTICLE
Jing Pan
The worldwide use of CD19 chimeric antigen receptor (CAR)-T cells has increased the response rate in patients with refractory or relapsed B-cell acute lymphoblastic leukemia. Clinical practice has become much safer with the help of immunotherapy-related toxicity management guidelines, such as the ASTCT consensus grading system. Tocilizumab and steroids are the major interventions for controlling cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). New drugs and interventions for uncontrolled CRS and ICANS, including JAK1/2 inhibitors, have also been investigated...
November 25, 2023: Blood Cell Ther
https://read.qxmd.com/read/38061763/clinical-safety-and-efficiency-of-the-h-port-for-treatment-of-leptomeningeal-metastasis
#11
JOURNAL ARTICLE
Sung Min Jang, Ho-Shin Gwak, Ji-Woong Kwon, Sang Hoon Shin, Heon Yoo
OBJECTIVE: To evaluate the usefulness of a cranial implantable chemoport, the H-port, as an alternative to the Ommaya reservoir for intraventricular chemotherapy/cerebrospinal fluid (CSF) access in patients with leptomeningeal metastasis (LM). METHODS: One hundred fifty-two consecutive patients with a diagnosis of LM and who underwent H-port installation between 2015 and 2021 were evaluated. Adverse events associated with installation and intraventricular chemotherapy, and the rate of increased intracranial pressure (ICP) control via the port were evaluated for safety and efficacy...
December 8, 2023: Journal of Korean Neurosurgical Society
https://read.qxmd.com/read/37920238/awake-intracerebroventricular-delivery-and-safety-assessment-of-oligonucleotides-in-a-large-animal-model
#12
JOURNAL ARTICLE
Hector Ribeiro Benatti, Rachel D Prestigiacomo, Toloo Taghian, Rachael Miller, Robert King, Matthew J Gounis, Ugur Celik, Stephanie Bertrand, Susan Tuominen, Lindsey Bierfeldt, Elizabeth Parsley, Jillian Gallagher, Erin F Hall, Abigail W McElroy, Miguel Sena-Esteves, Anastasia Khvorova, Neil Aronin, Heather L Gray-Edwards
Oligonucleotide therapeutics offer great promise in the treatment of previously untreatable neurodegenerative disorders; however, there are some challenges to overcome in pre-clinical studies. (1) They carry a well-established dose-related acute neurotoxicity at the time of administration. (2) Repeated administration into the cerebrospinal fluid may be required for long-term therapeutic effect. Modifying oligonucleotide formulation has been postulated to prevent acute toxicity, but a sensitive and quantitative way to track seizure activity in pre-clinical studies is lacking...
December 14, 2023: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/37899660/dual-responsive-nanorobot-based-marsupial-robotic-system-for-intracranial-cross-scale-targeting-drug-delivery
#13
JOURNAL ARTICLE
Junfeng Wu, Niandong Jiao, Daojing Lin, Na Li, Tianyang Ma, Steve Tung, Wen Cheng, Anhua Wu, Lianqing Liu
Nanorobots capable of active movement are an exciting technology for targeted therapeutic intervention. However, the extensive motion range and hindrance of the blood-brain barrier impeded their clinical translation in glioblastoma therapy. Here, we report a marsupial robotic system constructed by integrating chemical/magnetic hybrid nanorobots (child robots) with a miniature magnetic continuum robot (mother robot) for intracranial cross-scale targeting drug delivery. For primary targeting on macro-scale, the continuum robot enters the cranial cavity through a minimally invasive channel (e...
October 29, 2023: Advanced Materials
https://read.qxmd.com/read/37819074/continuous-intrathecal-medication-delivery-with-the-irraflow-catheter-pearls-and-early-experience
#14
JOURNAL ARTICLE
Jeffrey Garavaglia, Trevor Hardigan, Ryan Turner, Gracie Monachello, Muhammad Babar Khan, Johnie O Hodge, Nicholas J Brandmeir
BACKGROUND AND OBJECTIVES: Intrathecal (IT) medications are routinely introduced through catheterization of the intraventricular space or subarachnoid space. There has been sporadic use of IT medications delivered directly to the ventricle either by intermittent injection through an external ventricular drain (EVD) or by an Ommaya reservoir with a ventricular catheter. IT medication delivery through EVD has many drawbacks, including the necessary opening of a sterile system, delivery of medication in a bolus form, and requirements to clamp the EVD after medication delivery...
October 11, 2023: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/37755386/neurosurgical-application-of-pineal-region-tumor-resection-with-3d-4k-exoscopy-via-infratentorial-approach-a-retrospective-cohort-study
#15
JOURNAL ARTICLE
Wei Hua, Xin Zhang, Qijun Wang, Tianming Qiu, Zixiao Yang, Xiaowen Wang, Hao Xu, Jinsen Zhang, Guo Yu, Minjie Fu, Liang Chen, Wei Zhu, Ying Mao
BACKGROUND: The pineal region tumors are challenging for neurosurgeons and can lead to secondary hydrocephalus. The advent of the exoscope has provided clinical interventions with high image quality and an ergonomic system for pineal region tumor operations. In this study, we describe the exoscopic approach used to facilitate the surgical resection of pineal region tumors and relieve hydrocephalus. MATERIALS AND METHODS: In this retrospective cohort study, we consecutively reviewed clinical and radiological data of 25 patients with pineal region lesions who underwent three-dimensional exoscopic tumor resection at a single center...
September 27, 2023: International Journal of Surgery
https://read.qxmd.com/read/37725052/radionuclide-shuntography-for-cerebrospinal-fluid-shunt-flow-evaluation-in-adults
#16
JOURNAL ARTICLE
Khizar R Nandoliya, Jon P Klein, Amr Alwakeal, Logan Linscheid, Ryan J Avery, Matthew B Potts
OBJECTIVE: Radionuclide shuntography (RS) performed using 99mTc-DTPA injected into the reservoir of CSF shunts enables evaluation of CSF flow for suspected shunt malfunctions. The goal of this study was to report the authors' institutional experience with RS and evaluate its utility and associated complications. METHODS: The authors retrospectively reviewed all RS studies performed between November 2003 and June 2022. Patients with shunted hydrocephalus who were ≥ 18 years of age were included...
September 8, 2023: Journal of Neurosurgery
https://read.qxmd.com/read/37722807/dr-ayub-khan-ommaya-1930-2008-the-eventful-life-of-a-revolutionary-neurosurgeon
#17
JOURNAL ARTICLE
Salim Usman, Sakshi Roy, Arjun Ahluwalia, Muhammad Hamza Shah
Dr Ayub Khan Ommaya (1930-2008) was a pioneering figure in the field of neurosurgery, with a particular focus on traumatic brain injury. As history books have held, he was a man of great intellect and vision, possessing a rare combination of scientific rigour and compassionate empathy. One of Dr Ommaya's most notable contributions was his development of the Ommaya reservoir, a device used to deliver drugs directly into the brain. This groundbreaking technology transformed the treatment of brain tumours and other neurological disorders, enabling clinicians to administer medications with unprecedented precision and efficacy...
September 18, 2023: Journal of Medical Biography
https://read.qxmd.com/read/37682134/free-flap-reconstruction-of-scalp-in-a-case-of-advanced-lung-cancer-with-brain-metastasis-a-case-report
#18
JOURNAL ARTICLE
Dong Yun Lee, SooA Lim, SuRak Eo, Jung Soo Yoon
RATIONALE: Reconstruction of wound complications in patients with advanced cancer with distant metastases is challenging for plastic surgeons. This may be due to the cancer patients' hypercoagulability and potential intolerance to general anesthesia. This article aimed to discuss the risk of free-flap reconstruction in such cases. PATIENT CONCERNS: The patient was a 58-year-old female with advanced non-small cell lung cancer and brain metastasis. The patient underwent brain radiotherapy and chemotherapy through the Ommaya Reservoir...
September 8, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37675543/-clinical-characteristics-and-their-influences-on-the-survival-of-leptomeningeal-metastasis-derived-from-lung-adenocarcinoma-harboring-epithelial-growth-factor-receptor-mutation
#19
JOURNAL ARTICLE
A F Jiang, S S Zhou, Q Zhou, J Zhao, X P Li, R R Zhou, B Li
Objective: To analyze the clinical characteristics of leptomeningeal metastasis (LM) patients from epithelial growth factor receptor (EGFR)-mutated lung adenocarcinoma, and their impacts on the survival of the patients. Methods: From July 2018 to July 2022, the clinicopathological data of 81 patients diagnosed as EGFR-mutated lung adenocarcinoma LM by cytopathology who admitted to the Department of Oncology of Xiangya Hospital of Central South University were retrospectively analyzed, including 33 males and 48 females...
September 12, 2023: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/37410604/supraorbital-minicraniotomy-for-open-ommaya-reservoir-placement-in-pediatric-craniopharyngiomas-a-case-series-and-technical-report
#20
JOURNAL ARTICLE
Ladina Greuter, Oliver L Richards, Noor Malik, Sara Breitbart, Johanna N Riesel, Ute Bartels, George M Ibrahim, Abhaya V Kulkarni
OBJECTIVE: Craniopharyngiomas with a predominant cystic component are often seen in children and can be treated with an Ommaya reservoir for aspiration and/or intracystic therapy. In some cases, cannulation of the cyst can be challenging via a stereotactic or transventricular endoscopic approach due to its size and proximity to critical structures. In such cases, a novel placement technique for Ommaya reservoirs via a lateral supraorbital incision and supraorbital minicraniotomy has been used...
June 30, 2023: Journal of Neurosurgery. Pediatrics
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