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JOURNAL ARTICLE
Bálint Gergely Szabó, Eszter Czél, Imola Nagy, Dorina Korózs, Borisz Petrik, Bence Marosi, Zsófia Gáspár, Martin Rajmon, Márk Di Giovanni, István Vályi-Nagy, János Sinkó, Botond Lakatos, Ilona Bobek
BACKGROUND: Nearly 10% of COVID-19 cases will require admission to the intensive care unit (ICU). Our aim was to assess the clinical and microbiological outcomes of secondary infections among critically ill COVID-19 adult patients treated with/without immunomodulation. METHODS: A prospective observational cohort study was performed between 2020 and 2022 at a single ICU. The diagnosis and severity classification were established by the ECDC and WHO criteria, respectively...
July 17, 2023: Antibiotics
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JOURNAL ARTICLE
Tamás Resál, Péter Bacsur, Miklós Horváth, Kata Szántó, Mariann Rutka, Anita Bálint, Anna Fábián, Renáta Bor, Zoltán Szepes, János Fekete, Klaudia Farkas, Pál Miheller, Tamás Molnár
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has complicated the management of inflammatory bowel diseases (IBD). OBJECTIVES: This study aimed to assess the efficacy of different anti-SARS-CoV-2 vaccines under different treatments in IBD patients and identify predictive factors associated with lower serological response, including anti-tumor necrosis factor (anti-TNF) drug levels. DESIGN: A prospective, double-center study of IBD patients was conducted following messenger ribonucleotide acid (mRNA) and non-mRNA anti-SARS-CoV-2 vaccination...
2023: Therapeutic Advances in Gastroenterology
#23
REVIEW
Andrew Kertesz
Cerebral visual impairments have been of great interest to neurologists, ophthalmologists, and neuroscientists. Complicated or partial varieties related to cortical blindness are discussed in this review. They are a fascinating alphabet of eponymic clinical syndromes, bordering neurology, ophthalmology, and even psychiatry. Recent functional imaging and experimental studies have contributed further knowledge of cognitive visual organization in addition to the classical lesion evidence.
June 30, 2023: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
#24
Dóra Mátis, Péter Hegyi, Brigitta Teutsch, Tamás Tornai, Bálint Erőss, Gabriella Pár, Szilárd Váncsa
BACKGROUND: Based on cross-sectional studies, there is a link between body composition parameters and steatosis in non-alcoholic fatty liver disease (NAFLD). However, whether long-term changes in different body composition parameters will result in NAFLD resolution is unclear. Therefore, we aimed to summarize the literature on longitudinal studies evaluating the association between NAFLD resolution and body composition change. METHODS: Based on the recommendations of the Cochrane Handbook, we performed a systematic search on September 26th, 2021, in three databases: Embase, MEDLINE (via PubMed), and Cochrane Central Register of Controlled Trials (CENTRAL)...
2023: Frontiers in Medicine
#25
JOURNAL ARTICLE
Geza Balint, W Watson Buchanan, Colin A Kean, Walter Kean, K D Rainsford
Sjögren's syndrome (SS) is characterised as keratoconjunctivitis sicca (dry eyes), xerostomia (dry mouth) commonly associated with salivary gland enlargement, and is referred to as Primary Sjögren's syndrome. It is known as Secondary Sjögren's syndrome when it occurs in patients, with connective tissue disease, such as rheumatoid arthritis, systemic lupus erythematosus, polyarthritis nodosa, polymyositis, and systemic sclerosis. SS has also been associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation, human immunodeficiency syndrome (AIDS), hepatitis C infection (HCV), chronic biliary cirrhosis, neoplastic and myeloplastic syndromes, fibromyalgia, and chronic fatigue syndrome...
May 17, 2023: Inflammopharmacology
#26
JOURNAL ARTICLE
Eszter Sarolta Róka, Sára Bálint, László Tombor
The authors present the case of a young woman with mosaic karyotype Turner's syndrome who was admitted to a partial hospitalization program due to comorbid schizophrenia. Psychiatric history of the patient included the diagnosis of mild mental retardation and an outpatient appointment due to depressive symptoms. Medical history included hormone replacement therapy due to primary ovarian insufficiency and autoimmune thyroiditis as well as a single case of physical polytrauma due to a road traffic accident years before her admission...
May 14, 2023: Orvosi Hetilap
#27
JOURNAL ARTICLE
Patrick Malcolm Siegel, Bálint András Barta, Lukas Orlean, Ines Derya Steenbuck, Miguel Cosenza-Contreras, Tobias Wengenmayer, Georg Trummer, Dennis Wolf, Dirk Westermann, Oliver Schilling, Philipp Diehl
BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is applied in patients with refractory hemodynamic failure. Exposure of blood components to high shear stress and the large extracorporeal surfaces in the ECMO circuit trigger a complex inflammatory response syndrome and coagulopathy which are believed to worsen the already poor prognosis of these patients. Mass spectrometry-based proteomics allow a detailed characterization of the serum proteome as it provides the identity and concentration of large numbers of individual proteins at the same time...
May 12, 2023: Journal of Translational Medicine
#28
JOURNAL ARTICLE
Szilárd Váncsa, Zoltán Sipos, Alex Váradi, Rita Nagy, Klementina Ocskay, Félix Márk Juhász, Katalin Márta, Brigitta Teutsch, Alexandra Mikó, Péter Jenő Hegyi, Áron Vincze, Ferenc Izbéki, László Czakó, Mária Papp, József Hamvas, Márta Varga, Imola Török, Artautas Mickevicius, Bálint Erőss, Andrea Párniczky, Andrea Szentesi, Gabriella Pár, Péter Hegyi
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic-associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP. METHODS: We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in-hospital mortality and AP severity based on the revised Atlanta classification...
April 16, 2023: United European Gastroenterology Journal
#29
JOURNAL ARTICLE
György Hámori, Bálint File, Richárd Fiáth, Bea Pászthy, János M Réthelyi, István Ulbert, Nóra Bunford
We evaluated event-related potential (ERP) indices of reinforcement sensitivity as ADHD biomarkers by examining, in N=306 adolescents (Mage =15.78, SD=1.08), the extent to which ERP amplitude and latency variables measuring reward anticipation and response (1) differentiate, in age- and sex-matched subsamples, (i) youth with vs. without ADHD, (ii) youth at-risk for vs. not at-risk for ADHD, and, in the with ADHD subsample, (iii) youth with the inattentive vs. the hyperactive/impulsive (H/I) and combined presentations...
March 4, 2023: Psychiatry Research
#30
JOURNAL ARTICLE
Brittany Balint, Inés García Lascurain Bernstorff, Tanja Schwab, Hans-Joachim Schäfers
OBJECTIVES: Ascending aortic aneurysms are associated with pre-existing conditions, including connective tissue disorders (i.e., Marfan syndrome) and bicuspid aortic valves. The underlying mechanisms remain uncertain. Even less is known regarding ascending aortic aneurysms in individuals with normal (i.e., tricuspid) aortic valves (TAV), and without known aneurysm-associated disorders. Regardless of etiology, the risk of aortic complications increases with biological age. Phenotypic modulation of smooth muscle cells (SMCs) is a feature of ascending aortic aneurysms, whereby contractile SMCs are replaced with synthetic SMCs that are capable of degrading the aortic wall...
2023: Frontiers in Cardiovascular Medicine
#31
JOURNAL ARTICLE
Zsófia Gáspár, Bálint Gergely Szabó, Anita Ábrahám, Zsuzsanna Várnai, Noémi Kiss-Dala, János Szlávik, János Sinkó, István Vályi-Nagy, Botond Lakatos
Emerging evidence suggests that remdesivir might improve clinical outcome of high-risk outpatients with coronavirus disease 2019 (COVID-19). Our aim was to evaluate characteristics and outcomes of nonhospitalised adults diagnosed with COVID-19 and treated with early remdesivir therapy during the omicron wave. A single-centre prospective cohort study was performed among adult patients between February and June 2022, during the circulation of phylogenetic assignment of named global outbreak (PANGO) subvariants BA...
March 9, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
#32
JOURNAL ARTICLE
Bálint Vékony, Péter Igaz
One of the most frequent causes of secondary hypertension is primary aldosteronism. The disease is caused by the autonomous aldosterone production of the adrenal cortex leading to elevated aldosterone levels causing hypertension and often hypokalemia, and if untreated, could lead to a plethora of pathophysiological issues. The diagnosis and treatment of primary aldosteronism is of paramount significance, since depending on its subtype, surgical or pharmaceutical intervention can lead to the full recovery of the patient...
March 5, 2023: Orvosi Hetilap
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JOURNAL ARTICLE
Petra Aboulhosn, Andrew Ryu, Azadeh Shafieesabet, Anusha Lekshminarayanan, Sohni Husain, Kathryn O'Connor, Saarah D'Souza, Shannon O'Neill, Eric L Altschuler
A 66-year-old left-handed male was admitted to our acute inpatient rehabilitation (AIR) unit following a resection of the right occipito-parietal glioblastoma. He presented with symptoms of horizontal oculomotor apraxia, contralateral optic ataxia and left homonymous hemianopsia. We diagnosed this patient with partial Bálint's syndrome (BS)- oculomotor apraxia, optic ataxia but not simultanagnosia. BS is typically caused by bilateral posterior parietal lesions, but we here describe a unique case due toresection of a right intracranial tumor...
February 15, 2023: Neurocase
#34
JOURNAL ARTICLE
Hakan Erdem, Magdalena Baymakova, Sevil Alkan, Amel Letaief, Wissal Ben Yahia, Farouq Dayyab, Entela Kolovani, Svjetlana Grgic, Federica Cosentino, Imran Hasanoglu, Reham Khedr, Andrea Marino, Abdullah Umut Pekok, Fatma Eser, Jurica Arapovic, Hatice Rahmet Guner, Ionela-Larisa Miftode, Kostadin Poposki, Gamze Sanlidag, Alper Tahmaz, Oguz Resat Sipahi, Egidia Gabriela Miftode, Serkan Oncu, Meliha Cagla-Sonmezer, Syam Kumar Addepalli, Ilad Alavi Darazam, Hema Prakash Kumari, Meliha Meriç Koc, Meela Ranjith Kumar, Suresh Babu Sayana, Ahmed Ashraf Wegdan, Fatma Amer, Mehmet Resat Ceylan, Amani El-Kholy, Taylan Onder, Hamed Azhdari Tehrani, Atousa Hakamifard, Bircan Kayaaslan, Ghaydaa Shehata, Hulya Caskurlu, Nagwa Mostafa El-Sayed, Seyed Erfan Mortazavi, Mohammad Pourali, Umran Elbahr, Sholpan Kulzhanova, Tarkan Yetisyigit, Sahar Ahmed Saad, Yasemin Cag, Gulden Eser-Karlidag, Natalia Pshenichnaya, Maya Belitova, Nasim Akhtar, Fahad Al-Majid, Muge Ayhan, Mumtaz Ali Khan, Massimiliano Lanzafame, Mateja Jankovic Makek, Emmanuel Nsutebu, Antonio Cascio, Emine Kubra Dindar-Demiray, Emine Unal Evren, Rama Kalas, Ayşe Kaya Kalem, Rusmir Baljić, Aamer Ikram, Selcuk Kaya, Anna Liskova, Balint Gergely Szabo, Bilal Ahmad Rahimi, Esmeray Mutlu-Yilmaz, Alper Sener, Jordi Rello
Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected retrospectively and submitted from referral centers in 21 countries through ID-IRI clinical research platform. The countries were categorized into developing (low-income (LI) and lower middle-income (LMI) economies) and developed countries (upper middle-income (UMI) and high-income (HI) economies)...
April 2023: European Journal of Clinical Microbiology & Infectious Diseases
#35
JOURNAL ARTICLE
Ildikó Katalin Pribék, Bettina Kata Kádár, Lea Péter, Júlia Daróczy, András Bajsz, Csenge Sára Kovács, Ildikó Demeter, Zoltán Janka, Róbert Urbán, Zsolt Demetrovics, Bence András Lázár, Ildikó Kovács, János Kálmán, Bálint Andó
INTRODUCTION: Due to the high rate of mortality, recognizing the contributing factors of alcohol-related delirium tremens (DT), which is the most severe form of alcohol withdrawal state (AWS) is pivotal in clinical settings. Previous studies suggested relationship between seasonality and other types of delirium; however, to our knowledge, this is the first empirical study which examined the role of seasonality in DT in alcohol dependence syndrome (ADS). METHODS: A retrospective study was undertaken between 2008 and 2015; medical records of 1,591 patients were included, which yielded 2,900 hospital appearances...
January 23, 2023: European Addiction Research
#36
JOURNAL ARTICLE
Gábor Kökény, Tamás Bakos, Bálint András Barta, Georgina Viktória Nagy, Tamás Mészáros, Gergely T Kozma, András Szabó, János Szebeni, Béla Merkely, Tamás Radovits
Hemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of inflammatory cytokines into blood, is a bad prognostic indicator in severe COVID-19 and other diseases involving cytokine storm syndrome (CSS). The purpose of this study was to explore if zymosan, a known stimulator of the innate immune system, could reproduce these changes in pigs. Pigs were instrumented for hemodynamic analysis and, after i.v. administration of zymosan, serial blood samples were taken to measure blood cell changes, cytokine gene transcription in PBMC and blood levels of inflammatory cytokines, using qPCR and ELISA...
January 6, 2023: International Journal of Molecular Sciences
#37
Gréta Török, József Saláta, Emese Ábrám, Bálint Nemes, Péter Hermann, Noémi Rózsa, Barbara Kispélyi
AIM: Ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome is a rare genetic disorder that affects ectodermal derived structures, including teeth, nails, hair, and sweat glands. Prosthetic rehabilitation of patients with EEC syndrome is essential towards improving their overall quality of life. METHODS AND RESULTS: In the case shown, a telescopic retained overdenture was made on the lower jaw based on digital impression of a patient with EEC syndrome associated with cleft lip and cleft palate...
January 18, 2023: Special Care in Dentistry
#38
JOURNAL ARTICLE
Jason J S Barton
Cerebral visual disorders include a range of common and rare deficits. They can be divided into effects on low-, intermediate-, and high-level forms of visual processing. Low-level deficits are various forms of homonymous hemifield scotomata, which affect all types of vision within their borders. Intermediate-level deficits refer to impairments of colour or motion perception, which affect either one hemifield or the entire field when lesions are bilateral. High-level deficits are divided into those of the ventral (occipitotemporal) or dorsal (occipitoparietal) stream...
October 2022: Annals of Indian Academy of Neurology
#39
János Borbás, Máté Vámos, Lidia Hategan, Lilla Hanák, Nelli Farkas, Zsolt Szakács, Dezső Csupor, Bálint Tél, Péter Kupó, Beáta Csányi, Viktória Nagy, András Komócsi, Tamás Habon, Péter Hegyi, Róbert Sepp
BACKGROUND: Mutations in the CACNA1C gene-encoding for the major Ca2+ channel of the heart-may exhibit a variety of clinical manifestations. These include typical or atypical Timothy syndromes (TS) which are associated with multiple organ manifestations, and cardiac involvement in form of malignant arrhythmias, QTc prolongation, or AV block. "Cardiac only" Timothy syndrome (COTS) shows no extracardiac manifestation, whereas some CACNA1C gene mutations are associated with QTc prolongation alone (isolated long QT syndrome 8, LQT8)...
2022: Frontiers in Cardiovascular Medicine
#40
JOURNAL ARTICLE
Réka Garai, Péter Krivácsy, Vivien Herczeg, Fanni Kovács, Bálint Tél, Judit Kelemen, Anna Máthé, Eszter Zsáry, Johanna Takács, Dániel Sándor Veres, Attila J Szabó
BACKGROUND: There is a need for further understanding pediatric long COVID syndrome (LCS) to be able to create specific case definitions and guidelines for providing good clinical care. METHODS: Medical records of all LCS patients who presented at our designated LC clinic were collected. We carried out descriptive analyses summarizing the history, clinical presentation, and findings of children, while doing a diagnosis of exclusion with multi-disciplinary medical examinations (physical, laboratory, and radiological examinations, specialist consultations, etc...
May 2023: Pediatric Research
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