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Visceral adiposity index

Samira Behboudi-Gandevani, Fahimeh Ramezani Tehrani, Maryam Rahmati, Mina Amiri, Fereidoun Azizi
BACKGROUND: Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehran-Lipid and Glucose-Study (TLGS). METHODS: A total of 3395 eligible women aged (20-50 years), including 801 women with prior history of GDM and 2594 non-GDM controls were recruited from among Tehran-Lipid and Glucose-Study participants...
February 19, 2019: BMC Endocrine Disorders
Sulochana Wijetunge, R M C J Ratnayake, H M S R B Kotakadeniya, Shanthini Rosairo, Kembra Albracht-Schulte, Latha Ramalingam, Naima Moustaid-Moussa, Nishan Sudheera Kalupahana
BACKGROUND/OBJECTIVES: Mechanisms of obesity-associated insulin resistance and dysglycemia in South Asians remain relatively unknown. The objective of this study was to detect subcutaneous (SAT) vs. visceral (VAT) adipose tissue characteristics and adipocytokines associated with obesity, insulin resistance, and dysglycemia in South Asian women. SUBJECTS/METHODS: This was a hospital-based cross-sectional study conducted in Sri Lanka. Subjects comprised of 58 adult women who underwent routine abdominal surgeries...
February 18, 2019: Nutrition & Diabetes
Maciej Haberka, Michael Skilton, Małgorzata Biedroń, Karolina Szóstak-Janiak, Małgorzata Partyka, Monika Matla, Zbigniew Gąsior
Carotid artery atherosclerosis is a complex and multifactorial chronic disease. Our aim was to assess the associations between obesity, fat depots and carotid artery stenosis (CAS) in patients with high cardiovascular (CV) risk. METHODS: The study group included 391 patients (F/M: 136/255 pts.; age: 61.8 ± 8 years) scheduled for elective coronary angiography. A comprehensive clinical assessment included a carotid artery and abdominal ultrasound involving the following fat depots: (1) carotid extra-media thickness (EMT) indexed to the body mass index (perivascular adipose tissue [PVAT]), and (2) abdominal visceral and subcutaneous fat...
January 17, 2019: Journal of Diabetes and its Complications
Ravindra Shukla, M K Garg, Biplab Mandal, Praveen Devrabhai
We read with interest article by Crowley et al (1). The authors a found an apparent decrease in 11 β HSD- 1 expression in subcutaneous adipose tissue (SAT) of deteriorators as compared to improvers. They explained it as compensatory decrease of 11 β HSD- 1 activity as consequence of overall adverse metabolic phenotype. It remained speculative whether visceral adipose tissue (VAT) 11 β HSD1 was increased in deteriorators. While this is consistent with recently published study by us (2), in which we found liver/portal circulation 11 β HSD1 activity to be increased in diabetics as compared to controls...
February 15, 2019: Clinical Endocrinology
Hamid Ashraf, Bashir Ahmad Laway, Dil Afroze, Arshad Iqbal Wani
Background: Obesity is one of the most common yet neglected public health problems in both the developed and developing countries. Metabolic syndrome (MS) is a multiplex of risk factor for the development of type 2 diabetes (T2D) and cardiovascular disease (CVD) and it reflects the clustering of multiple risk factors resulting from obesity and insulin resistance. Despite its predominance in obese individuals, MS does occur in non-obese individuals. Many individuals characterised as normal weight as per their body mass index (BMI), have increased visceral adiposity thereby leading to an unfavourable inflammatory cytokine profile...
November 2018: Indian Journal of Endocrinology and Metabolism
Dominique Musselman, Neeta Shenvi, Amita Manatunga, Andrew H Miller, Edward Lin, Nana Gletsu-Miller
BACKGROUND: Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery. METHODS: The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administered before, and at 6-months after RYGB surgery in severely obese women (body mass index > 35 kg/m2 ; N = 19)...
February 11, 2019: Physiology & Behavior
Lucía De la Cruz-Color, Zamira Helena Hernández-Nazará, Montserrat Maldonado-González, Eliseo Navarro-Muñíz, José Alfredo Domínguez-Rosales, José Rodrigo Torres-Baranda, Elizabeth Del Carmen Ruelas-Cinco, Sandra Margarita Ramírez-Meza, Bertha Ruíz-Madrigal
The expansion of adipose tissue is regulated by insulin and leptin through SREBP-1c, up-regulating lipogenesis in tissues by SCD1 enzyme, while ATGL enzyme is key in lipolysis. THE RESEARCH OBJECTIVE WAS TO EVALUATE THE EXPRESSION OF SREBF1, SCD1, PNPLA2, AND LEP GENES IN HEPATIC-ADIPOSE TISSUE, AND RELATED THEM WITH THE INCREMENT AND DISTRIBUTION OF FAT DEPOTS OF INDIVIDUALS WITHOUT INSULIN RESISTANCE.: Thirty-eight subjects undergoing elective cholecystectomy with liver and adipose tissue biopsies (subcutaneous-omental) are included...
February 12, 2019: Experimental and Clinical Endocrinology & Diabetes
Nicolas Charette, Caroline Vandeputte, Lieveke Ameye, Camille Van Bogaert, Jonathan Krygier, Thomas Guiot, Amélie Deleporte, Thierry Delaunoit, Karen Geboes, Jean-Luc Van Laethem, Marc Peeters, Gauthier Demolin, Stéphane Holbrechts, Patrick Flamen, Marianne Paesmans, Alain Hendlisz
BACKGROUND: The prognostic value of body composition in cancer patients has been widely studied during the last decade. The main finding of these studies is that sarcopenia, or skeletal muscle depletion, assessed by CT imaging correlates with a reduced overall survival (OS). By contrast, the prognostic value of fat mass remains ill-defined. This study aims to analyze the influence of body composition including both muscle mass and adipose tissue on OS in a homogeneous population of advanced colorectal cancer (CRC) patients...
February 12, 2019: BMC Cancer
Mehmet Sipahi, Vehbi Yavuz Tokgöz, Özlem Keskin, Melahat Atasever, Ahmet Menteşe, Selim Demir
The aim of this study was to investigate the findings of ultrasound that could predict the metabolic syndrome (MetS) which may develop in polycystic ovary syndrome (PCOS) patients. A total of 96 consecutive PCOS patients, who were scheduled for any gynaecologic examination from January 2015 to January 2016 and who were eligible for the study, were prospectively enrolled in it. About 15.6% of PCOS patients were diagnosed with MetS. The mean age of the MetS patients and the non-MetS patients were 25.8 and 23...
February 11, 2019: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Aline Silva Santos Sena, Alex Sandro Rolland de Souza, Vivianne de Oliveira Barros, Maria do Carmo Pinto Lima, Adriana Suely Oliveira Melo, Melania Maria Ramos de Amorim
OBJECTIVE: To assess fetal visceral adiposity and associated factors during pregnancy. METHODS: Secondary analysis of prospective cohort data with 172 pairs (pregnant woman/fetus) treated at public health units. Anthropometric data, metabolic (glucose, glycated hemoglobin, insulin, insulin resistance, total cholesterol and fractions, triglycerides) measures, fetal biometry, and visceral and subcutaneous adiposity in the binomial (pregnant woman/fetus) were evaluated at the 16th, 28th and 36th gestational weeks by ultrasonography...
February 8, 2019: Jornal de Pediatria
Fábio da Silva Pimenta, Hadnan Tose, Élio Waichert Jr, Márcia Regina Holanda da Cunha, Fabiana Vasconcelos Campos, Elisardo Corral Vasquez, Hélder Mauad
BACKGROUND: Mobility of fat deposited in adipocytes among different fatty territories can play a crucial role in the pathogenesis of obesity-related diseases. Our goal was to investigate which of the remaining fat pads assume the role of accumulating lipids after surgical removal of parietal WAT (lipectomy; LIPEC) in rats of both sexes displaying MSG-induced obesity. METHODS: The animals entered the study straight after birth, being separated according to gender and randomly divided into CON (control, saline-treated) and MSG (monosodium glutamate-treated) groups...
February 9, 2019: Lipids in Health and Disease
M W Dzierlenga, M Yoon, F Wania, P L Ward, J M Armitage, S A Wood, H J Clewell, M P Longnecker
An association between serum concentrations of persistent organic pollutants (POPs), such as 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), and risk of type 2 diabetes mellitus (T2DM) has been reported. Conditional on body mass index (BMI) and waist circumference (WC), a higher serum PCB-153 concentration may be a marker of T2DM risk because it reflects other aspects of obesity that are related to T2DM risk and to PCB-153 clearance. To estimate the amount of residual confounding by other aspects of obesity, we performed a quantitative bias analysis on the results of a specific study...
February 4, 2019: Environment International
Turan Erdoğan, Murtaza Emre Durakoğlugil, Mustafa Çetin, Sinan Altan Kocaman, Hakan Duman, Yüksel Çiçek, Ömer Şatıroğlu
Background: Visceral obesity is strongly associated with atherosclerosis. Even though waist circumference (WC) is the most common assessment method of total visceral adipose tissue and cardiometabolic risk, this method lacks direct measurement of adipose tissue and has better correlation to subcutaneous fat rather than visceral fat. We intended to investigate whether epicardial adipose tissue (EAT) is clinically superior to body mass index (BMI) and WC in predicting Framingham risk score (FRS) and carotid intima-media thickness (CIMT)...
January 2019: Acta Cardiologica Sinica
Maria Pilar Aparisi Gómez, Federico Ponti, Daniele Mercatelli, Chiara Gasperini, Alessandro Napoli, Giuseppe Battista, Stefano Cariani, Giulio Marchesini, Alberto Bazzocchi
OBJECTIVE: The aim of this study was to review the existence and types of correlations between body composition densitometric parameters and laboratory values associated to cardiometabolic risk. METHODS: We retrospectively analyzed data from 316 individuals in the weight range from normality to super-obesity, submitted to total body dual-energy x-ray absorptiometry (DXA) scans and routine biochemistry at S.Orsola-Malpighi Hospital from June 2010 to March 2014. The study included 182 women, 45...
October 24, 2018: Nutrition
Hsin-Hsien Yu, Mao-Chih Hsieh, Szu-Yuan Wu, Edgar D Sy, Yan-Shen Shan
Background: Duodenal-jejunal bypass (DJB) is an important component of many types of current bariatric surgery including Roux-en-Y gastric bypass, mini-gastric bypass, biliopancreatic diversion, duodenal switch, and DJB plus sleeve gastrectomy. Surgery is often observed to ameliorate nonalcoholic steatohepatitis (NASH), but without a clearly delineated mechanism. In this study, we investigated the effects of DJB in diet-induced obese rats with NASH. Materials and methods: Male Wistar rats were divided into four groups and fed the following diets over 6 months: A) normal chow (NC group, n=6); B) methionine-choline-deficient (MCD)-high-fat (HF) diet (HF group, n=6); C) MCD-HF diet for 3 months followed by DJB and MCD-HF diet for subsequent 3 months (DJB group, n=6); and D) MCD-HF diet for 3 months followed by treatment with pioglitazone (PGZ) with MCD-HF diet for subsequent 3 months (PGZ group, n=6)...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Yesenia Covarrubias, Kathryn J Fowler, Adrija Mamidipalli, Gavin Hamilton, Tanya Wolfson, Olof Dahlqvist Leinhard, Garth Jacobsen, Santiago Horgan, Jeffrey B Schwimmer, Scott B Reeder, Claude B Sirlin
BACKGROUND: Quantitative-chemical-shift-encoded (CSE)-MRI methods have been applied to the liver. The feasibility and potential utility CSE-MRI in monitoring changes in pancreatic proton density fat fraction (PDFF) have not yet been demonstrated. PURPOSE: To use quantitative CSE-MRI to estimate pancreatic fat changes during a weight-loss program in adults with severe obesity and nonalcoholic fatty liver disease (NAFLD). To explore the relationship of reduction in pancreatic PDFF with reductions in anthropometric indices...
January 30, 2019: Journal of Magnetic Resonance Imaging: JMRI
Jahae Kim, Kang-Ho Choi, Sang-Geon Cho, Sae-Ryung Kang, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Ho-Chun Song
Increasing evidence indicates that sarcopenia and obesity can be risk factors for incident dementia. We investigated the association of body composition including muscle and visceral adipose tissue (VAT) with the probability of Alzheimer's disease (AD) in healthy middle-aged and elderly subjects using 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). This study included 110 healthy subjects with available whole-body FDG PET/CT scans and medical records. Muscle and VAT tissues were measured on the abdominal CT slice, and the PMOD Alzheimer's discrimination FDG PET analysis tool (PALZ) score was evaluated on the brain PET of the same subject using software PALZ...
January 30, 2019: Scientific Reports
Thejal Srikumar, Erin M Siegel, Yuhua Gu, Yoganand Balagurunathan, Alberto L Garcia, Y Ann Chen, Jun-Min Zhou, Xiuhua Zhao, Robert Gillies, Whalen Clark, Andrew Gamenthaler, Junsung Choi, David Shibata
BACKGROUND: The obesity epidemic has prompted the need to better understand the impact of adipose tissue on human pathophysiology. However, accurate, efficient, and replicable models of quantifying adiposity have yet to be developed and clinically implemented. We propose a novel semiautomated radiologic method of measuring the visceral fat area (VFA) using computed tomography scan analysis. MATERIALS AND METHODS: We obtained a cohort of 100 patients with rectal adenocarcinoma, with a median age of 60...
January 14, 2019: Journal of Surgical Research
Anthony Deldin, Jennifer L Kuk, SoJung Lee
BACKGROUND: We retrospectively examined the sex differences in the changes in (1) total fat, total and regional subcutaneous adipose tissue (SAT), visceral fat, and intermuscular fat and (2) total and regional skeletal muscle distribution in response to aerobic exercise (AE) or resistance exercise (RE) in adolescents with obesity. METHODS: Twenty-eight boys and 27 girls with obesity (BMI ≥95th percentile, 12-18 years) were randomly assigned to 3-month interventions (180 minutes per week) of AE or RE...
January 29, 2019: Childhood Obesity
Miriam Tan, Leanne J Brown, Kimberly I Mathews, Megan C Whatnall, Melinda J Hutchesson, Lesley K MacDonald-Wicks, Amanda J Patterson
OBJECTIVE: To describe and compare body composition and fat distribution of Australian women 18-44 years from an urban and rural location. DESIGN: Cross-sectional survey and collection of anthropometric and body composition measurements. SETTING: Newcastle and Tamworth in New South Wales. PARTICIPANTS: Convenience sample of women recruited through media and community. MAIN OUTCOME MEASURES: Weight, height, waist and hip girths, visceral fat area, body fat (kg and %) and skeletal muscle mass...
January 29, 2019: Australian Journal of Rural Health
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