keyword
https://read.qxmd.com/read/36459665/childhood-neurologic-conditions-movement-disorders
#21
JOURNAL ARTICLE
Paul Youssef
Most movement disorders in children are hyperkinetic. The most common type is tic disorders, which can involve motor and phonic tics and are classified as simple or complex. Motor or phonic tics that persist for more than 1 year are defined as persistent (chronic) tic disorder. Tourette syndrome can be diagnosed if a child has multiple motor tics and at least one phonic tic for more than 1 year with onset before age 18 years. Children with Tourette syndrome may have symptoms of attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, depression, or behavioral disorders...
December 2022: FP Essentials
https://read.qxmd.com/read/36078300/psychopathological-impact-in-patients-with-history-of-rheumatic-fever-with-or-without-sydenham-s-chorea-a-multicenter-prospective-study
#22
MULTICENTER STUDY
Alessandro Orsini, Thomas Foiadelli, Attilio Sica, Andrea Santangelo, Niccolò Carli, Alice Bonuccelli, Rita Consolini, Sofia D'Elios, Nicolò Loddo, Alberto Verrotti, Giuseppe Di Cara, Chiara Marra, Maria Califano, Anna Fetta, Marianna Fabi, Stefania Bergamoni, Aglaia Vignoli, Roberta Battini, Marta Mosca, Chiara Baldini, Nadia Assanta, Pietro Marchese, Gabriele Simonini, Edoardo Marrani, Francesca Felicia Operto, Grazia Maria Giovanna Pastorino, Salvatore Savasta, Giuseppe Santangelo, Virginia Pedrinelli, Gabriele Massimetti, Liliana Dell'Osso, Diego Peroni, Duccio Maria Cordelli, Martina Corsi, Claudia Carmassi
Sydenham's chorea (SC) is a post-streptococcal autoimmune disorder of the central nervous system, and it is a major criterium for the diagnosis of acute rheumatic fever (ARF). SC typically improves in 12-15 weeks, but patients can be affected for years by persistence and recurrencies of both neurological and neuropsychiatric symptoms. We enrolled 48 patients with a previous diagnosis of ARF, with or without SC, in a national multicenter prospective study, to evaluate the presence of neuropsychiatric symptoms several years after SC's onset...
August 25, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/35792671/characterisation-of-an-experimental-model-to-determine-streptococcal-m-protein-induced-autoimmune-cardiac-and-neurobehavioral-abnormalities
#23
JOURNAL ARTICLE
Rukshan Am Rafeek, Adam S Hamlin, Nicholas M Andronicos, Craig S Lawlor, David J McMillan, Kadaba S Sriprakash, Natkunam Ketheesan
Group A streptococcal (GAS) infection is associated with spectrum of autoimmune diseases including Acute Rheumatic Fever/Rheumatic Heart Disease (ARF/RHD) and neurobehavioral abnormalities. Antibodies against GAS M proteins cross-react with host tissue proteins in the heart and brain leading to the symptomatology observed in ARF/RHD. Since throat carriage of Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been reported to be relatively high in some ARF/RHD endemic regions compared to GAS, and both SDSE and GAS express coiled coil surface protein called M protein, we hypothesised that streptococci other than GAS can also associated with ARF/RHD and neurobehavioral abnormalities...
July 6, 2022: Immunology and Cell Biology
https://read.qxmd.com/read/35441610/therapeutic-aspects-of-sydenham-s-chorea-an-update
#24
REVIEW
Greta Depietri, Niccolo Carli, Attilio Sica, Domenico Oliviero, Giorgio Costagliola, Pasquale Striano, Alice Bonuccelli, Flavia Frisone, Diego Peroni, Rita Consolini, Thomas Foiadelli, Alessandro Orsini
Sydenham's Chorea (SC) is a hyperkinetic movement disorder associated with neuropsychiatric manifestations. It is believed to be caused by the autoimmune response following a group A beta-hemolytic streptococcal (GABHS) pharyngitis, and it is one of the major diagnostic criteria for Acute Rheumatic Fever (ARF) diagnosis. Despite having been known and studied for centuries, there are still no standardized therapies or official guidelines for SC treatment, so that it is necessarily left to physicians' clinical experience...
March 21, 2022: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/35370928/autoimmune-and-paraneoplastic-chorea-a-review-of-the-literature
#25
REVIEW
Kevin Kyle, Yvette Bordelon, Nagagopal Venna, Jenny Linnoila
Autoimmune chorea syndromes represent a vast array of paraneoplastic, parainfectious and idiopathic disorders. It is increasingly apparent that familiarity with these disorders is critically important, as they may be treatable or may be part of a syndrome requiring further work-up and monitoring. These disorders are mediated by an aberrant immunologic attack with resultant neuronal dysfunction, manifesting as chorea. These conditions are typically accompanied by other neurologic or systemic manifestations. In this review we outline the clinical features, epidemiologic factors, and delineate the specific antibodies associated with each of these autoimmune mediated disorders...
2022: Frontiers in Neurology
https://read.qxmd.com/read/35136702/one-side-of-the-story-clues-to-etiology-in-patients-with-asymmetric-chorea
#26
REVIEW
Molly Cincotta, Ruth H Walker
BACKGROUND: Chorea can be due to a large number of etiologies. Unilateral chorea is classically related to a contralateral structural lesion, e.g. of the putamen or subthalamic nucleus, however, based upon personal impressions, we have observed that systemic disease, in particular metabolic or autoimmune conditions, can also lead to a unilateral or markedly asymmetric presentations. We sought to investigate this impression by reviewing the literature. METHODS: A PubMed search was conducted using the terms asymmetric" AND "chorea" OR "hemichorea" OR "unilateral" AND "chorea" OR "monochorea" OR "right greater than left" AND "chorea" OR "left greater than right" AND "chorea" OR "right more than left" AND "chorea" OR "left more than right" AND "chorea" as well as "hemiballismus" NOT "stroke" NOT "infarct" NOT "dyskinesia...
2022: Tremor and Other Hyperkinetic Movements
https://read.qxmd.com/read/35128332/sydenham-s-chorea-as-the-first-manifestation-of-rheumatic-fever-in-two-boys
#27
Jozélio Freire de Carvalho, Leonid P Churilov
Sydenham's chorea is a cardinal manifestation of rheumatic fever, but it is more common in girls. We describe two boys who developed Sydenham's chorea and were successfully treated. CASE 1: A 5-year-old boy started an involuntary movement of his hand, progressing to all the upper limbs, bilaterally. The family observed a deterioration in his handwriting skills. Heart auscultation did not reveal any murmur, and the oropharynx examination was normal. A brain magnetic resonance imaging, cerebrospinal fluid, and echocardiography were interpreted as normal...
December 2021: Mediterranean journal of rheumatology
https://read.qxmd.com/read/35110067/oxcarbazepine-may-be-useful-in-sydenham-chorea
#28
JOURNAL ARTICLE
Sedat Işıkay, Kutluhan Yılmaz
No abstract text is available yet for this article.
November 2021: Turkish archives of pediatrics
https://read.qxmd.com/read/34819453/sydenham-s-chorea-with-silent-cardiac-lesions-mimicking
#29
JOURNAL ARTICLE
K N Shakya, A Bhatta, A Yadav, U Gautam, S Basnet
Sydenham's chorea is an uncommon neurological manifestation of rheumatic fever and has many and varied differential diagnosis. It may mimic encephalitis when presents as an isolated feature even when silent cardiac lesions are present. Early diagnosis, treatment and penicillin prophylaxis prevents recurrence and progression of cardiac lesions. Prompt symptomatic relief and alleviation of distress is obtained with therapeutic intervention. A case of rheumatic chorea with silent cardiac valve lesions which mimicked herpes simplex encephalitis with choreoathetosis, in a 13 year old girl is presented along with review of literature...
April 2021: Kathmandu University Medical Journal (KUMJ)
https://read.qxmd.com/read/34768201/a-nationwide-study-on-sydenham-s-chorea-clinical-features-treatment-and-prognostic-factors
#30
JOURNAL ARTICLE
Alessandro Orsini, Thomas Foiadelli, Mariasole Magistrali, Niccolò Carli, Irene Bagnasco, Patrizia Dassi, Alberto Verrotti, Daniele Marcotulli, Carlotta Canavese, Francesco Nicita, Alessandro Capuano, Chiara Marra, Anna Fetta, Margherita Nosadini, Stefano Sartori, Amanda Papa, Maurizio Viri, Filippo Greco, Piero Pavone, Gabriele Simonini, Sara Matricardi, Sabrina Siquilini, Francesca Marchese, Elisa De Grandis, Bernadette Marrè Brunenghi, Clara Malattia, Francesco Bassanese, Patrizia Bergonzini, Alice Bonuccelli, Rita Consolini, Gian Luigi Marseglia, Diego Peroni, Pasquale Striano, Duccio Cordelli, Salvatore Savasta
OBJECTIVES: Sydenham's Chorea (SC) is a neuropsychiatric disorder and a major manifestation of acute rheumatic fever. The erroneous assumption that SC is a benign and self-limiting disease, has led to a lack of high-quality scientific evidence of the therapeutical and prognostic features of SC. STUDY DESIGN: We retrospectively analyzed the medical records of patients <18-years old with SC in 17 Italian pediatric centers. Recorded data included clinical, instrumental and laboratory parameters...
November 6, 2021: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/34674348/evaluation-of-executive-functions-in-children-with-rheumatic-heart-diseases
#31
JOURNAL ARTICLE
Nigar Aliyeva, Yilmaz Yozgat, Nijad Bakhshaliyev, Telli Zadehgan Afshord, Can Yilmaz Yozgat, Ali Guven Kilicoglu
BACKGROUND: Acute rheumatic fever (ARF) is a multisystemic inflammatory disease in children and young adults. The most notable complications of ARF are rheumatic heart disease (RHD) and sydenham's chorea (SC). There have been a lot of report about executive dysfunctions with children who have SC. Executive functions is an umbrella term that is used to describe higher-level cognitive functions. The aim of this study is to determine the executive functions of children with RHD. We evaluated executive functions in healthy children with the same sociodemographic characteristics as children with RHD...
October 21, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
https://read.qxmd.com/read/34469400/acute-movement-disorders-in-childhood-a-cohort-study-and-review-of-the-literature
#32
JOURNAL ARTICLE
Hanene Benrhouma, Amina Nasri, Hedia Klaa, Nedia Ben Achour, Aida Rouissi, Ichraf Kraoua, Ilhem Turki
OBJECTIVES: Acute movement disorders (AMD) are frequent in neurological and pediatric emergencies. Few studies analyzed AMD in children, none in Tunisia or other African country. The purpose of this study was to describe the peculiarities of AMD in a Tunisian pediatric population with a literature review. METHODS: We conducted a retrospective descriptive study over 8 years including 80 children (sex ratio, 1.05; mean age of onset, 4.8 years) with AMD, followed in tertiary referral Child Neurology Department in North Tunisia...
August 31, 2021: Pediatric Emergency Care
https://read.qxmd.com/read/34468807/an-unexpected-cause-of-chorea-in-an-adolescent-girl-systemic-lupus-erythematosus
#33
JOURNAL ARTICLE
Harun Terin, Meltem Akcaboy, Rukiye Demet, Mehmet Fatih Akif Özdemir, Mehmet Bülbül, Saliha Senel
Involuntary movement disorders are rare in childhood. Hyperkinetic movement disorders including chorea stand as the leading cause. Although Sydenham chorea is the major diagnosis in most children and adolescents, appropriate differential diagnosis is fundamental for a final decision. A detailed and careful history as well as physical examination is the principal proceeding for accurate diagnosis. Herein, we report on an adolescent girl who was admitted to our hospital with chorea and subsequently diagnosed with systemic lupus erythematosus (SLE)...
May 2022: Zeitschrift Für Rheumatologie
https://read.qxmd.com/read/34353207/sydenham-s-chorea-from-pathophysiology-to-therapeutics
#34
JOURNAL ARTICLE
Antonio L Teixeira, Luiz P Vasconcelos, Maria do Carmo Pereira Nunes, Harvey Singer
Sydenham's chorea is an autoimmune chorea emerging after a group A beta-hemolytic streptococcal (GABHS) infection, i.e. a rheumatic chorea with or without the presence of carditis or arthritis. The disorder, defined by the presence of chorea, is also associated with cognitive and behavioral symptoms, including emotional lability, anxiety, depressive and obsessive-compulsive symptoms. The authors review the pathophysiology, clinical characteristics, and available evidence on therapeutic strategies, the latter including the secondary prevention of GABHS infections, reduction of chorea, and immune modulation...
August 2021: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/34307738/cardiac-involvement-in-movement-disorders
#35
REVIEW
Malco Rossi, Nestor Wainsztein, Marcelo Merello
BACKGROUND: Several conditions represented mainly by movement disorders are associated with cardiac disease, which can be overlooked in clinical practice in the context of a prominent primary neurological disorder. OBJECTIVES: To review neurological conditions that combine movement disorders and primary cardiac involvement. METHODS: A comprehensive and structured literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria was conducted to identify disorders combining movement disorders and cardiac disease...
July 2021: Movement Disorders Clinical Practice
https://read.qxmd.com/read/34227703/incidence-and-clinical-characteristics-of-acute-rheumatic-fever-in-turkey-results-of-a-nationwide-multicentre-study
#36
JOURNAL ARTICLE
Dolunay Gürses, Gülendam Koçak, Ercan Tutar, Nazan Özbarlas
AIM: To evaluate the incidence and clinical features of acute rheumatic fever (ARF) in Turkey, following the revised Jones criteria in 2015. METHODS: This multicentre study was designed by the Acquired Heart Diseases Working Group of the Turkish Pediatric Cardiology and Pediatric Cardiac Surgery Association in 2016. The data during the first attack of 1103 ARF patients were collected from the paediatric cardiologists between 1 January 2016 and 31 December 2016. RESULTS: Turkey National Institute of Statistics records of 2016 were used for the determination of ARF incidence with regard to various cities and regions separately...
July 6, 2021: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/34223447/uncontrollable-movements-of-right-upper-and-lower-extremities-in-a-child-a-diagnostic-puzzle
#37
Rucha Patki, Raquelle Douglas, Natalia Rimareva, Noah Kondamudi
We describe a case of a 9-year-old child who presented with uncontrollable, involuntary movements associated with a recent streptococcal infection and echocardiographic evidence of valvulitis. These findings are consistent with the diagnosis of Sydenham's chorea, a rare but important movement disorder and one of the major "Jones criteria" for the diagnosis of acute rheumatic fever. Because of its rarity, patients with Sydenham's chorea often are misdiagnosed as having a behavioral or psychiatric illness. Early recognition and appropriate management can prevent the potential severe sequelae associated with acute rheumatic fever...
August 2021: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/34179722/group-a-streptococcal-antigen-exposed-rat-model-to-investigate-neurobehavioral-and-cardiac-complications-associated-with-post-streptococcal-autoimmune-sequelae
#38
JOURNAL ARTICLE
Rukshan A M Rafeek, Catherine M Lobbe, Ethan C Wilkinson, Adam S Hamlin, Nicholas M Andronicos, David J McMillan, Kadaba S Sriprakash, Natkunam Ketheesan
BACKGROUND: The neuropsychiatric disorders due to post-streptococcal autoimmune complications such as Sydenham's chorea (SC) are associated with acute rheumatic fever and rheumatic heart disease (ARF/RHD). An animal model that exhibits characteristics of both cardiac and neurobehavioral defects in ARF/RHD would be an important adjunct for future studies. Since age, gender, strain differences, and genotypes impact on the development of autoimmunity, we investigated the behavior of male and female Wistar and Lewis rat strains in two age cohorts (<6 weeks and >12 weeks) under normal husbandry conditions and following exposure to group A streptococcus (GAS)...
June 2021: Animal Models and Experimental Medicine
https://read.qxmd.com/read/34131535/sydenham-chorea-managed-with-immunoglobulin-in-acute-rheumatic-fever
#39
Asim Ali, Gibson O Anugwom, Usama Rehman, Muhammad Zain Khalid, Mohammad Omar Saeeduddin
Sydenham chorea (SC) is common in childhood with extensive differential diagnoses, including inherited disease, autoimmunity, endocrine disorders, and infections. SC due to acute rheumatic fever (ARF) is rare. Herein, we present a case of SC in an eight-year-old child who presented with choreiform movements of her face and limbs, including facial grimacing, difficulty walking, and slurred speech. She also had a runny nose and odynophagia. She had two episodes of sore throat in the last two months, and her physical examination was unremarkable except for hypertrophic tonsils and generalized hypotonia...
May 12, 2021: Curēus
https://read.qxmd.com/read/34026876/requirements-for-a-robust-animal-model-to-investigate-the-disease-mechanism-of-autoimmune-complications-associated-with-arf-rhd
#40
REVIEW
Rukshan A M Rafeek, Suchandan Sikder, Adam S Hamlin, Nicholas M Andronicos, David J McMillan, Kadaba S Sriprakash, Natkunam Ketheesan
The pathogenesis of Acute Rheumatic Fever/Rheumatic Heart Disease (ARF/RHD) and associated neurobehavioral complications including Sydenham's chorea (SC) is complex. Disease complications triggered by Group A streptococcal (GAS) infection are confined to human and determining the early events leading to pathology requires a robust animal model that reflects the hallmark features of the disease. However, modeling these conditions in a laboratory animal, of a uniquely human disease is challenging. Animal models including cattle, sheep, pig, dog, cat, guinea pigs rats and mice have been used extensively to dissect molecular mechanisms of the autoimmune inflammatory responses in ARF/RHD...
2021: Frontiers in Cardiovascular Medicine
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