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Mohammad Mahdi Dehghan

Roghayeh Rastegar, Hamid Akbari Javar, Mehdi Khoobi, Poua Dehghan Kelishadi, Gholam Hossein Yousefi, Mahmoud Doosti, Mohammad Hossien Ghahremani, Ahmad Shariftabrizi, Fatemeh Imanparast, Elham Gholibeglu, Mahdi Gholami
Codelivery of chemo-sensitizers with chemotherapeutics using combo nanomedicine is a promising platform for overcoming chemoresistance in breast cancer. However, tumor accumulation of nano-carriers based on enhanced permeability and retention (EPR) effect is confounded by heterogeneity in tumor microenvironment. Adsorption of protein corona on surface of nanoparticle boost up clearance by reticulo-endothelial system. In this study, a surface functionalized magnetic nanocomposite (NC) for codelivery of doxorubicin (DOX) and curcumin (CUR) is developed...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Arman Dehghan, Mitra Amini, Mohammad Mahdi Sagheb, Seyed Mostafa Shidmoosavi, Parisa Nabeiei
INTRODUCTION: Teaching renal physiology for undergraduate medical students in an understandable way using methods which improve their deep learning has always been a problem. In this study, Early Clinical Exposure (ECE) was used in teaching renal physiology for the second year medical students in Shiraz Medical School. This article aims to introduce and develop this program and also measure the attitude of medical students toward ECE in learning renal physiology. METHODS: This is a mixed method study conducted on 120 second year undergraduate students...
October 2017: Journal of Advances in Medical Education & Professionalism
Mahdi Dehghan-Manshadi, Hossein Hadinedoushan, Mohammad Kazem Amirbaigy, Fateme Zare, Gilda Eslami, Seyyed Ali Mirghanizade-Bafghi, Mohsen Akhondi-Meybodi
BACKGROUND: Hepatitis C virus (HCV) is an important human pathogen affecting an estimated 120 - 170 million individuals in the world. Toll-Like receptors (TLRs) are pattern-recognition receptors that recognize pathogen-associated molecular patterns, and stimulate immune responses. OBJECTIVES: The aim of this study was to determine the mRNA expression level of TLR2 and TLR7 in HCV-infected patients in comparison with normal controls. PATIENTS AND METHODS: Nineteen consecutive patients with HCV infection and nineteen sex and age-matched healthy controls were studied in a case-controlled research...
November 2015: Hepatitis Monthly
Mohammad Zandi, Arash Dehghan, Khaled Ghadermazi, Hamid Malekzadeh, Mahdi Akbarzadeh
OBJECTIVE: To evaluate the effects of intravenous bisphosphonate discontinuation on incidence and severity of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: Seventy rats were randomly divided into 7 groups. In control and S0 groups, weekly injection of saline and 0.06 mg/kg zoledronate (respectively) for 4 weeks, tooth extraction, continuation of injections for 2 months and euthanasia were performed. In group S1, zolendronate injection for 4 weeks, tooth extraction, zolendronate discontinuation for 2 months, and euthanasia were done...
November 2015: Journal of Cranio-maxillo-facial Surgery
Mahdi Tabrizizadeh, Mojtaba Rasti, Fatemeh Ayatollahi, Mohammad Hossein Mossadegh, Hengameh Zandi, Farzad Dehghan, Zohreh Mousavi
INTRODUCTION: Calcium hydroxide (CH) is one of the most common intracanal medications. Corticosteroids (CS) are used in endodontics because of their anti-inflammatory activity. This study aimed to evaluate the antimicrobial effect of CH+betamethasone and CH+saline against Enterococcus faecalis (E. faecalis) using agar diffusion test and measuring the microbial zone of inhibition (ZOI). METHODS AND MATERIALS: Four plates containing Mueller-Hinton broth and E. faecalis culture media, were prepared...
2015: Iranian Endodontic Journal
Mirsaeed Attarchi, Faezeh Dehghan, Taraneh Yazdanparast, Saber Mohammadi, Mahdie Golchin, Zargham Sadeghi, Masoud Moafi, Seyed Mohammad Seyed Mehdi
BACKGROUND: During the past decade, incidence of asthma has increased, which might have been due to environmental exposures. OBJECTIVES: Considering the expansion of cable manufacturing industry in Iran, the present study was conducted to evaluate the prevalence of occupational asthma in a cable manufacturing company in Iran as well as its related factors. PATIENTS AND METHODS: This study was conducted on employees of a cable manufacturing company in Yazd, Iran, in 2012...
October 2014: Iranian Red Crescent Medical Journal
Sadeq Ali-Hasan-Al-Saegh, Seyed Jalil Mirhosseini, Oliver Liakopoulos, Anton Sabashnikov, Hamid Reza Dehghan, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Naser Ghaffari, Vahid Vahabzadeh, Mahdi Aghabagheri, Mohammad Reza Mozayan, Aron-Frederik Popov
This systematic review with meta-analysis sought to determine the impact of posterior pericardiotomy on incidences of atrial fibrillation and supraventricular arrhythmias, pericardial effusion, pleural effusion, tamponade, and the length of hospital stay after cardiac surgery. We searched for randomized controlled trials, using Medline, Embase, Elsevier and Sciences online databases as well as Google Scholar literature. The effect sizes measured were odds ratio for categorical variables and standard mean difference with 95% confidence interval for calculating differences between mean values of hospital stay in intervention and control groups...
March 2015: Asian Cardiovascular & Thoracic Annals
Ali Masoudi-Kazemabad, Khadijeh Jamialahmadi, Mohsen Moohebati, Majid Mojarrad, Raheleh Dehghan-Manshadi, Mohammad Mahdi Forghanifard, Saeed Akhlaghi, Gordon A Ferns, Majid Ghayour-Mobarhan
OBJECTIVE: Neuropeptide Y (NPY), a 36-amino acid peptide, is widely expressed in the central and peripheral nervous systems as well as in the heart. A relationship has been reported between NPY gene variants and coronary artery disease (CAD) in some populations. However, there are few data on the NPY gene polymorphism and CAD in the Persian population. In the current study we have investigated the relationship between the NPY Leu7Pro polymorphism and CAD within a population from Iran...
March 15, 2012: Gene
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