Kai Wang, Fu-Hai Li, Lu-Yu Zhou, Xue-Mei Zhao, Xiang-Qian Gao, Cui-Yun Liu, Xin-Min Li, Xin-Zhe Chen, Yan Zhao, Xue-Li Cheng, Rui-Quan Wang, Rui-Feng Li, Yu-Hui Zhang, Fei Gao, Jin-Wei Tian, Kun Wang
PIWI-interacting RNAs (piRNAs) are highly expressed in various cardiovascular diseases. However, their role in cardiomyocyte death caused by ischemia/reperfusion (I/R) injury, especially necroptosis, remains elusive. In this study, a heart necroptosis-associated piRNA (HNEAP) is found that regulates cardiomyocyte necroptosis by targeting DNA methyltransferase 1 (DNMT1)-mediated 5-methylcytosine (m5 C) methylation of the activating transcription factor 7 (Atf7) mRNA transcript. HNEAP expression level is significantly elevated in hypoxia/reoxygenation (H/R)-exposed cardiomyocytes and I/R-injured mouse hearts...
October 23, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)