keyword
https://read.qxmd.com/read/38358471/therapeutic-effect-of-the-new-multilevel-brace-orthosis-on-cerebral-palsy-gait-a-case-report
#1
C Di Brina, G Rosellini, M Insogna, M Cerioli
BACKGROUND: Infantile spastic bilateral cerebral palsy (CP) is the most common form of CP. Diplegia (with ambulatory ability) is mostly a chronic condition that impairs the ability to walk. Standard orthotic management includes hip-knee-ankle-foot orthosis (HKAFO) as a pri-mary conservative treatment option to contrast spasticity and stabilise gait through partial immobilisation of the body structure. Multilevel brace orthosis (MLB) (Registered Trademark) is a specific type of light HKAFO designed to improve functional alignment and dynamic gait stability without limb immobilisation...
2024: La Clinica Terapeutica
https://read.qxmd.com/read/38354212/effects-of-a-full-body-electrostimulation-garment-application-in-a-cohort-of-subjects-with-cerebral-palsy-multiple-sclerosis-and-stroke-on-upper-motor-neuron-syndrome-symptoms
#2
JOURNAL ARTICLE
Andreas Hahn, Susan Moeller, Arne Schlausch, Matilda Ekmann, Gautier de Chelle, Marie Westerlund, Frank Braatz, Winfried Mayr
OBJECTIVES: Dysfunction of the central nervous system may inflict spastic movement disorder (SMD). Electrical stimuli were identified as promising therapeutic option. Electrical stimulation provided by a 58-electrode full body garment was investigated based on data from regular trial fittings. METHODS: Data from 72 testees were investigated. Age averages 36.6 (19.8) ys with 44 females. The cohort spans infantile cerebral paresis (CP) (n=29), multiple sclerosis (MS) (n=23) and stroke (n=20)...
February 26, 2024: Biomedizinische Technik. Biomedical Engineering
https://read.qxmd.com/read/38327671/differential-effects-of-growth-restriction-and-immaturity-on-predicted-psychomotor-development-at-4-years-of-age-in-preterms
#3
JOURNAL ARTICLE
Arne Jensen, Niels Rochow, Manfred Voigt, Gerhard Neuhäuser
BACKGROUND: Fetal growth restriction and immaturity are associated with poor neurocognitive development and child psychopathology affecting educational success at school and beyond. However, the differential effects of either obstetrical risk factor on predicted psychomotor development have not yet been deciphered. OBJECTIVE: This study aimed to separately study the impact of growth restriction and that of immaturity on predicted psychomotor development at the preschool age of 4...
February 2024: AJOG global reports
https://read.qxmd.com/read/38237316/purified-cannabidiol-as-add-on-therapy-in-children-with-treatment-resistant-infantile-epileptic-spasms-syndrome
#4
JOURNAL ARTICLE
Gabriela Reyes Valenzuela, Adolfo Gallo, Agustin Calvo, Santiago Chacón, Lorena Fasulo, Santiago Galicchio, Javier Adi, Pablo Sebastian Fortini, Roberto Caraballo
OBJECTIVE: The aim of this study was to assess efficacy, safety, and tolerability of highly purified cannabidiol oil (CBD) as add-on therapy for the treatment of a series of patients with infantile epileptic spasms syndrome (IESS) who were resistant to antiseizure medications and ketogenic dietary therapy. MATERIAL AND METHODS: We conducted a retrospective analysis of the medical records of 28 infants with treatment-resistant IESS aged 6 to 21 months who received highly purified CBD between July 2021 and June 2023...
February 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38156624/the-impact-of-operative-correction-of-equinus-in-cerebral-palsy-on-gait-patterns
#5
JOURNAL ARTICLE
Axel Horsch, Lara Petzinger, Julian Deisenhofer, Maher Ghandour, Matthias Klotz, Tobias Renkawitz, Cornelia Putz
BACKGROUND: This study aimed to evaluate gait outcomes and strength following the surgical correction of equinus in cerebral palsy (CP) based on different surgical procedures. We included the Baumann and Strayer procedures, as well as the Achilles tendon lengthening (ATL). METHODS: A retrospective analysis was performed in patients with infantile, bilateral CP who received instrumental 3D gait analysis before and after surgical correction (18.66 months postoperatively)...
December 29, 2023: Foot & Ankle International
https://read.qxmd.com/read/38146749/psychometric-measurement-properties-of-patient-reported-and-observer-reported-outcome-measures-for-spinal-mobilisations-and-manipulation-on-paediatric-subjects-with-diverse-medical-conditions-a-systematic-review
#6
REVIEW
Tricia Hayton, Anita Gross, Annalie Basson, Ken Olson, Oliver Ang, Nikki Milne, Jan Pool
INTRODUCTION: Reliable, valid, and responsive outcomes is foundational to address concerns about the risks and benefits of performing spinal manipulation and mobilization in pediatric populations. The aim of this systematic review was to synthesize evidence on measurement properties from cohort/case-control/cross-sectional/randomized studies on patient-reported (SQLI - Scoliosis Quality of Life Index; VAS-Visual Analog Scale; PAQLQ - Pediatric Asthma Quality of Life Questionnaire), observer-reported (Crying Diaries; ATEC - Autism Treatment Evaluation Checklist) and mixed (PedsQL - Pediatric Quality of Life Inventory) outcome measurements identified through a scoping review on manipulation and mobilization for pediatric populations with diverse medical conditions...
December 26, 2023: Journal of Manual & Manipulative Therapy
https://read.qxmd.com/read/38140949/pediatric-epilepsy-syndromes-with-associated-developmental-impairment
#7
REVIEW
Douglas R Nordli, John R Mclaren, Gabriel Araujo, Megan Gupta, Douglas R Nordli, Fernando Galan
In 2022, the International League Against Epilepsy revised their classification of epilepsy syndromes for clinicians to better understand the relationships between different epilepsy syndromes, their underlying causes, and their associated developmental and behavioral features. This review highlights portions of the current classification with an emphasis on epilepsy syndromes that readily present with developmental challenges and provides a unique framework, based on electroencephalography, to easily identify and understand these syndromes...
December 23, 2023: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38113603/distinct-manifestations-and-potential-mechanisms-of-seizures-due-to-cortical-versus-white-matter-injury-in-children
#8
JOURNAL ARTICLE
Monica S Cooper, Mark T Mackay, Daisy A Shepherd, Charuta Dagia, Michael C Fahey, Dinah Reddihough, Susan M Reid, A Simon Harvey
PURPOSE: To study seizure manifestations and outcomes in children with cortical versus white matter injury, differences potentially explaining variability of epilepsy in children with cerebral palsy. METHODS: In this population-based retrospective cohort study, MRIs of children with cerebral palsy due to ischemia or haemorrhage were classified according to presence or absence of cortical injury. MRI findings were then correlated with history of neonatal seizures, seizures during childhood, epilepsy syndromes, and seizure outcomes...
December 7, 2023: Epilepsy Research
https://read.qxmd.com/read/38068424/effects-of-vojta-therapy-on-the-motor-function-of-children-with-neuromotor-disorders-study-protocol-for-a-randomized-controlled-trial
#9
JOURNAL ARTICLE
Mónica Menéndez-Pardiñas, Miguel Alonso-Bidegaín, Fernando Santonja-Medina, Juan Luis Sánchez-González, Jose Manuel Sanz-Mengibar
BACKGROUND: Infantile cerebral palsy is a neurological pathology that causes great morbidity, mortality, and disability in people who suffer from it, mainly affecting motor development. There are a multitude of non-pharmacological methods or therapies for its treatment. One of the main methods is Vojta therapy. This methodology acts on ontogenetic postural function and automatic postural control. OBJECTIVE: This study aims to demonstrate that there are changes in the motor development of children with cerebral palsy with the application of Vojta therapy...
November 28, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38031151/infantile-outcome-at-3%C3%A2-years-of-age-among-monochorionic-twins-with-type-ii-or-iii-selective-fetal-growth-restriction-with-isolated-oligohydramnios-who-underwent-fetoscopic-laser-photocoagulation
#10
JOURNAL ARTICLE
R Yamamoto, K Ozawa, S Wada, H Sago, S Nagasaki, M Takano, M Nakata, M Nozaki, K Ishii
OBJECTIVE: This study aimed to examine infantile outcomes at 3 years of age with selective fetal growth restriction (sFGR) Types II and III with isolated oligohydramnios who underwent fetoscopic laser photocoagulation (FLP). METHODS: This multicenter prospective cohort study included monochorionic diamniotic twins who underwent FLP for sFGR between 16 and 25 weeks of gestation. The indication for performing FLP was in cases of sFGR Type II or III with oligohydramnios, where the maximal vertical pocket was ≤2 cm among twins with FGR...
November 29, 2023: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/37771170/cdkl5-deficiency-disorder-and-other-infantile-onset-genetic-epilepsies
#11
JOURNAL ARTICLE
Carolyn Daniels, Caitlin Greene, Lacey Smith, Elia Pestana-Knight, Scott Demarest, Bo Zhang, Timothy A Benke, Annapurna Poduri, Heather E Olson
AIM: To differentiate phenotypic features of individuals with CDKL5 deficiency disorder (CDD) from those of individuals with other infantile-onset epilepsies. METHOD: We performed a retrospective cohort study and ascertained individuals with CDD and comparison individuals with infantile-onset epilepsy who had epilepsy gene panel testing. We reviewed records, updated variant classifications, and compared phenotypic features. Wilcoxon rank-sum tests and χ2 or Fisher's exact tests were performed for between-cohort comparisons...
September 28, 2023: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/37757660/limitations-of-multigene-next-generation-sequencing-panel-for-cerebral-palsy-phenotype-and-other-complex-movement-disorders
#12
JOURNAL ARTICLE
Marina Eskandar, Laura Tochen, Mi Ran Shin, Bennett Lavenstein, Meira Meltzer, Andrea Gropman, Kuntal Sen
In the past couple of decades, literature in pediatric neurology and clinical genetics has identified hundreds of monogenic disorders that can masquerade as infantile cerebral palsy (CP). Accurate and prompt diagnosis in such cases may be challenging due to several reasons. There are commercial multigene CP panels, but their diagnostic yield is often limited compared with exome sequencing because of diverse etiologies that may mimic CP. We report one such case where a patient with spastic hemiplegia underwent a long diagnostic journey before genetic diagnosis was established with exome sequencing and appropriate management was started...
December 2023: Pediatric Neurology
https://read.qxmd.com/read/37750545/-a-series-of-22-cases-of-perinatal-arterial-ischaemic-stroke-risk-factors-clinical-management-and-neurological-sequelae
#13
JOURNAL ARTICLE
R P Arias-Llorente, S Lareu-Vidal, S González-Sánchez, R Blanco-Lago
INTRODUCTION: Perinatal arterial ischaemic stroke (PAIS) is almost as common as in adulthood and causes significant neurological sequelae. AIM: The aim is to describe the risk situations surrounding these neonates, the clinical manifestations, the management, the cost-effectiveness of diagnostic tests and the neurological sequelae. PATIENTS AND METHODS: We conducted an observational study of a cohort of patients consisting of neonates with a gestational age = 35 weeks diagnosed with PAIS in our hospital between 2010 and 2021...
October 1, 2023: Revista de Neurologia
https://read.qxmd.com/read/37741767/neuroprotective-effect-of-magnesium-sulfate-in-premature-infants-analysis-after-establishing-an-antenatal-administration-protocol-in-a-tertiary-care-hospital
#14
JOURNAL ARTICLE
Belén Fernández Monteagudo, Sonia Villar Castro, Paula Carrascosa García, Susana Zeballos Sarrato, Manuel Sánchez Luna
INTRODUCTION: In 2016, a protocol was developed in our hospital for the antenatal administration of magnesium sulfate in pregnant women at risk of imminent preterm birth as a method to reduce the risk of cerebral palsy (CP). MATERIAL AND METHODS: We conducted a retrospective observational study in a level IIIC hospital with the primary objective of comparing the incidence of CP before and after the implementation of this protocol. Among the secondary outcomes, we ought to highlight the incidence of cognitive deficits and necrotizing enterocolitis and the mortality in both groups...
October 2023: Anales de pediatría
https://read.qxmd.com/read/37719644/growth-variables-and-obstetrical-risk-factors-in-newborns-are-associated-with-psychomotor-development-at-preschool-age
#15
JOURNAL ARTICLE
Arne Jensen, Gerhard Neuhäuser
BACKGROUND: Low birthweight resulting from preterm birth or fetal growth restriction is associated with poor neurocognitive development and child psychopathology affecting school performance and educational success. Prediction of developmental performance may therefore serve as a basis for early intervention strategies to improve educational success and mental health of our children in a timely manner. OBJECTIVE: This study aimed to explore the predictive capacity of morphometric variables taken at birth and that of obstetrical risk factors to predict developmental performance at 4...
November 2023: AJOG global reports
https://read.qxmd.com/read/37691366/radiological-and-genetic-evaluation-in-hypotonic-infants
#16
JOURNAL ARTICLE
Selen Gur, Gurkan Gurbuz, Hilmi Tozkir
OBJECTIVE: To investigate the importance and diagnostic yield of genetic and radiological evaluations in children with hypotonia. STUDY DESIGN: Comparative observational study. Place and Duration of the Study: Department of Pediatrics Neurology, Namik Kemal University, Tekirdag, Turkey, between 2019 and 2022. METHODOLOGY: Patients' medical histories, laboratory results, radiological examinations, and genetic tests, if any, were obtained retrospectively from the patients' clinic files...
September 2023: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/37684631/long-term-outcomes-of-offspring-from-multiple-gestations-a-two-sample-mendelian-randomization-study-on-multi-system-diseases-using-uk-biobank-and-finngen-databases
#17
JOURNAL ARTICLE
Yi Jiang, Yuanyuan Du, Rui Su, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Chenyun Fang, Yuting Chen, Peng Gao, Liangnan Zhang, Shaoshuai Wang, Jun Yu, Mengzhou He, Wencheng Ding, Ling Feng
BACKGROUND: Assisted reproductive technologies (ART) have increased the incidence of multiple births, which can have a negative impact on maternal and offspring health. The study aimed to investigate the association between genetically predicted multiple birth and the risk of 42 common diseases of the nervous, psychiatric, cardiovascular, respiratory, digestive, and endocrine systems. METHODS: The study utilized two-sample Mendelian randomization (MR) analysis to explore the potential causal relationship between genetically predicted multiple birth and the genetically predicted risk of diseases...
September 8, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37566568/robust-deep-learning-based-gait-event-detection-across-various-pathologies
#18
JOURNAL ARTICLE
Bernhard Dumphart, Djordje Slijepcevic, Matthias Zeppelzauer, Andreas Kranzl, Fabian Unglaube, Arnold Baca, Brian Horsak
The correct estimation of gait events is essential for the interpretation and calculation of 3D gait analysis (3DGA) data. Depending on the severity of the underlying pathology and the availability of force plates, gait events can be set either manually by trained clinicians or detected by automated event detection algorithms. The downside of manually estimated events is the tedious and time-intensive work which leads to subjective assessments. For automated event detection algorithms, the drawback is, that there is no standardized method available...
2023: PloS One
https://read.qxmd.com/read/37427509/-the-content-analysis-of-normative-legal-regulation-of-medical-social-rehabilitation-of-children-with-infantile-cerebral-paralysis-in-the-russian-federation
#19
JOURNAL ARTICLE
O N Golovina, I V Vinyarskaya
The infantile cerebral paralysis is a significant medical social problem and economic burden for family, health care system and state economy in general since such children require organization of accessible environment and life-long rehabilitation maintenance. The purpose of the study is content-analysis of normative legal regulation of medical social rehabilitation of children with infantile cerebral paralysis in the Russian Federation. The analysis of main normative legal documents established that medical social rehabilitation is implemented in concordance with norms of international legislation and is regulated by provisions of Federal laws and other normative legal acts of the Russian Federation and its subjects...
May 2023: Problemy Sot︠s︡ialʹnoĭ Gigieny, Zdravookhranenii︠a︡ i Istorii Medit︠s︡iny
https://read.qxmd.com/read/37371788/juvenile-dermatomyositis-and-infantile-cerebral-palsy-aicardi-gouteres-syndrome-type-5-with-a-novel-mutation-in-samhd1-a-case-report
#20
Lubov S Sorokina, Rinat K Raupov, Mikhail M Kostik
INTRODUCTION: Aicardi-Gouteres syndrome (AGS) is a monogenic interferonopathy characterized by early onset, dysregulation of skin (chilblain lesions), brain, and immune systems (fever, hepatomegaly, glaucoma, arthritis, myositis, and autoimmune activity). The disease looks like TORCH (Toxoplasmosis, Others, Rubella, Cytomegalovirus, Herpes) infection with early-onset encephalopathy resulting in severe neuropsychological disability. CASE DESCRIPTION: A six-year-old girl has been suffering from generalized seizures, fever episodes, severe psychomotor development delay, and spastic tetraparesis since the first year of her life...
June 12, 2023: Biomedicines
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