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Keywords diaphragmatic hernia and right...

diaphragmatic hernia and right ventricle

https://read.qxmd.com/read/38194948/abnormal-shape-and-size-of-the-cardiac-ventricles-is-associated-with-a-higher-risk-of-neonatal-death-in-fetuses-with-isolated-left-congenital-diaphragmatic-hernia
#1
JOURNAL ARTICLE
Erin S Huntley, Edgar Hernandez-Andrade, Ramesha Papanna, Eric Bergh, Jimmy Espinoza, Eleazar Soto, Suzanne Lopez, Matthew T Harting, Anthony Johnson
Objective To evaluate the association between fetal cardiac deformation analysis (CDA) and cardiac function with severe adverse perinatal outcomes in fetuses with isolated left congenital diaphragmatic hernia (CDH). Methods CDA in each ventricle (contractility, size, and shape), evaluated by speckle tracking and novel FetalHQ software, and markers of cardiac function (E/A ratios, pulmonary and aortic peak systolic velocities, and sigmoid annular valves diameters), were evaluated in fetuses with isolated left CDH...
January 9, 2024: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/37830982/slit3-fibroblast-signaling-as-a-potential-anti-fibrotic-target
#2
REVIEW
Lianghui Gong, Ming-Sing Si
The SLIT family (SLIT1-3) of highly conserved glycoproteins were originally identified as ligands for the Roundabout (ROBO) family of single-pass transmembrane receptors, serving to provide repulsive axon guidance cues in the nervous system. Intriguingly, studies involving SLIT3 mutant mice suggest that SLIT3 might have crucial biological functions outside the neural context. While these mutant mice display no noticeable neurological abnormalities, they present pronounced connective tissue defects, including congenital central diaphragmatic hernia, membranous ventricular septal defect, and osteopenia...
October 13, 2023: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/37744447/intact-cord-resuscitation-in-newborns-with-congenital-diaphragmatic-hernia-insights-from-a-lamb-model
#3
JOURNAL ARTICLE
Baptiste Teillet, Florian Manœuvrier, Céline Rougraff, Capucine Besengez, Laure Bernard, Anne Wojtanowski, Louise Ghesquieres, Laurent Storme, Sébastien Mur, Dyuti Sharma, Kévin Le Duc
INTRODUCTION: Congenital diaphragmatic hernia (CDH) is a rare condition characterized by pulmonary hypoplasia, vascular dystrophy, and pulmonary hypertension at birth. Validation of the lamb model as an accurate representation of human CDH is essential to translating research findings into clinical practice and understanding disease mechanisms. This article emphasizes the importance of validating the lamb model to study CDH pathogenesis and develop innovative therapeutics. MATERIAL AND METHODS: At 78 days of gestation, the fetal lamb's left forelimb was exposed through a midline laparotomy and hysterotomy, and a supra diaphragmatic thoracotomy was performed to allow the digestive organs to ascend into the thoracic cavity...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37644150/prenatal-mri-assessment-of-mediastinal-shift-angle-as-a-feasible-and-effective-risk-stratification-tool-in-isolated-right-sided-congenital-diaphragmatic-hernia
#4
JOURNAL ARTICLE
Wen Ding, Yuanyuan Gu, Haiyu Wang, Huiying Wu, Xiaochun Zhang, Rui Zhang, Hongying Wang, Li Huang, Junjian Lv, Bo Xia, Wei Zhong, Qiuming He, Longlong Hou
OBJECTIVES: To develop a mediastinal shift angle (MSA) measurement method applicable to right-sided congenital diaphragmatic hernia (RCDH) in fetal MRI and to validate the predictive value of MSA in RCDH. METHODS: Twenty-seven fetuses with isolated RCDH and 53 controls were included in our study. MSA was measured on MRI axial image at the level of four-chamber view of the fetal heart. The angle between the sagittal midline landmark line and the left boundary landmark line touching tangentially the lateral wall of the left ventricle was used to quantify MSA for RCDH...
August 30, 2023: European Radiology
https://read.qxmd.com/read/37434143/think-out-of-the-box-association-of-left-congenital-diaphragmatic-hernia-and-abnormal-origin-of-the-right-pulmonary-artery-a-train-can-hide-another
#5
JOURNAL ARTICLE
Arthur Gavotto, Pascal Amedro, Gilles Cambonie
BACKGROUND: We report the occurrence of a severe pulmonary hypertension (PH) in a neonate affected by a left congenital diaphragmatic hernia (CDH). PH in this patient was associated with an abnormal origin of the right pulmonary artery from the right brachiocephalic artery. This malformation, sometimes named hemitruncus arteriosus, has to the best of our knowledge never been reported in association with a CDH. CASE PRESENTATION: A male newborn was hospitalized from birth in the neonatal intensive care unit after prenatal diagnosis of a left CDH...
July 11, 2023: BMC Pediatrics
https://read.qxmd.com/read/37378468/pathological-findings-in-congenital-diaphragmatic-hernia-on-necropsy-studies-a-single-center-case-series
#6
JOURNAL ARTICLE
Chu-Yi Meng, Ji-Zhen Zou, Ying Wang, Yan-Dong Wei, Jing-Na Li, Chao Liu, Zhong Feng, Ling-Ling Cai, Ping Xiao, Li-Shang Ma
INTRODUCTION: Congenital diaphragmatic hernia (CDH) is associated with high mortality rates and significant pulmonary morbidities. The objective of this study was to delineate the histopathological features observed in necropsies of CDH patients and correlate these with their clinical manifestations. METHODS: We retrospectively reviewed the postmortem findings and corresponding clinical characteristics in eight CDH cases from 2017 to July 2022. RESULTS: The median survival time was 46 (8-624) hours...
September 2023: Pediatric Pulmonology
https://read.qxmd.com/read/37238337/persistent-tachypnoea-in-early-infancy-a-clinical-perspective
#7
JOURNAL ARTICLE
Samuel Menahem, Arvind Sehgal, Danielle F Wurzel
Tachypnoea in the newborn is common. It may arise from the many causes of the respiratory distress syndrome such as hyaline membrane disease, transient tachypnoea of the newborn, meconium aspiration etc. Congenital heart disease rarely presents with early tachypnoea on day one or two, in contrast to the early presentation of cyanosis, unless there is "pump" (ventricular) failure such as may occur in a cardiomyopathy/myocarditis, or as a result of severe obstruction to either ventricle. Space-occupying lesions within the chest, for example from a diaphragmatic hernia or a congenital cystic adenomatoid malformation, may present with early tachypnoea, as can a metabolic cause resulting in acidosis...
April 27, 2023: Children
https://read.qxmd.com/read/37194833/the-myocardial-capillary-network-is-altered-in-congenital-diaphragmatic-hernia-in-the-fetal-rabbit-model
#8
JOURNAL ARTICLE
A L A Nour, A T Fabro, S S Batah, M Oria, J L Peiro, L Sbragia
Congenital diaphragmatic hernia (CDH) is associated with thoracic compression of the lungs and heart caused by the herniated abdominal content, leading to cardiac modifications including pressure and vascular changes. Our aim was to investigate the experimental immunoexpression of the capillary proliferation, activation, and density of Ki-67, VEGFR2, and lectin in the myocardium after surgical creation of a diaphragmatic defect. Pregnant New Zealand rabbits were operated on the 25th gestational day in order to create left-sided CDH (LCDH, n=9), right-sided CDH (RCDH, n=9), and Control (n=9), for a total of 27 fetuses in 19 pregnant rabbits...
2023: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/37160691/brain-cortical-assessment-by-mri-in-fetuses-with-left-congenital-diaphragmatic-hernia
#9
JOURNAL ARTICLE
Isabella Fabietti, Giulia Grassini, Sara Savelli, Roberta Vicario, Anita Romiti, Milena Viggiano, Chiara Vassallo, Laura Valfrè, Paola Giliberti, Irma Capolupo, Marco Bonito, Pietro Bagolan, Francesco Morini, Leonardo Caforio
OBJECTIVE: To evaluate fetal brain development using MRI (magnetic resonance imaging) in CDH (congenital diaphragmatic hernia). METHODS: 52 isolated left CDH and 104 control fetuses were imaged using MRI. Brain morphometry (Biparietal diameter-BPD, brain fronto-occipital diameter-BFOD, third ventricle, posterior ventricles, transcerebellar diameter-TCD, anteroposterior and craniocaudal cerebellar vermis diameter-AP and CC) and cortical structures (bilateral cingulate fissure-CF, insular fissure-IF, insular depth - ID) were compared with controls using Mann-Whitney test...
July 2023: Prenatal Diagnosis
https://read.qxmd.com/read/36048922/prenatal-diagnosis-of-emanuel-syndrome-case-series-and-review-of-the-literature
#10
JOURNAL ARTICLE
Patrycja Piwowarczyk, Diana Massalska, Izabela Obodzińska, Sylwia Gawlik Zawiślak, Julia Bijok, Anna Kucińska-Chahwan, Tomasz Roszkowski
We present three new cases and review of the literature on the prenatal diagnosis of Emanuel syndrome (ES). Twenty-one foetuses have been analysed. In all three cases diagnosed in our department, posterior fossa abnormalities were seen and in one hypoplastic right ventricle was diagnosed at the first trimester scan. Defects of the posterior fossa (62% of foetuses; 13/21) and left diaphragmatic hernia (29% of foetuses; 6/21) are the most frequently reported prenatal findings in ES syndrome. No pattern of specific prenatal ultrasound markers of ES exists...
September 1, 2022: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/35995665/diagnosis-management-of-pulmonary-hypertension-in-congenital-diaphragmatic-hernia
#11
REVIEW
Shazia Bhombal, Neil Patel
Congenital diaphragmatic hernia (CDH) contributes to neonatal morbidity and mortality worldwide. Pulmonary hypertension (PH) is a key component of CDH pathophysiology and critical consideration for management and therapeutic options. PH associated with CDH has traditionally been attributed to pulmonary vascular maldevelopment and associated lung parenchymal hypoplasia, leading to pre-capillary increase in pulmonary vascular resistance (PVR). However, there is increasing recognition that left ventricular hypoplasia, dysfunction and elevated end diastolic pressure may contribute to post-capillary pulmonary hypertension in CDH patients...
August 2022: Seminars in Fetal & Neonatal Medicine
https://read.qxmd.com/read/35961833/resuscitation-from-cardiac-arrest-with-tension-gastrothorax-due-to-acquired-diaphragmatic-hernia
#12
Masaya Miyahara, Natsuki Kondo, Takuya Sugiyama, Yosuke Matsumura
Tension gastrothorax is a rare cause of obstructive shock induced by a distended stomach herniating into the thorax through a diaphragmatic defect. We report the process of diagnosis and emergency treatment for tension gastrothorax during cardiopulmonary resuscitation (CPR). A 71-year-old woman with multiple surgical histories had nausea and vomiting for two days. She was transferred to our hospital with circulatory failure and loss of consciousness. She presented pulseless electric activity and received CPR immediately after arrival...
October 2022: American Journal of Emergency Medicine
https://read.qxmd.com/read/35844758/use-of-prostaglandin-e1-in-the-management-of-congenital-diaphragmatic-hernia-a-review
#13
REVIEW
Srirupa Hari Gopal, Neil Patel, Caraciolo J Fernandes
Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly, whose presentation is complicated by pulmonary hypertension (PH), pulmonary hypoplasia, and myocardial dysfunction, each of which have significant impact on short-term clinical management and long-term outcomes. Despite many advances in therapy and surgical technique, optimal CDH management remains a topic of debate, due to the variable presentation, complex pathophysiology, and continued impact on morbidity and mortality. One of the more recent management strategies is the use of prostaglandin E1 (PGE1) infusion in the management of PH associated with CDH...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35040363/diaphragmatic-hernia-post-coronary-artery-bypass-with-gastroepiploic-artery
#14
JOURNAL ARTICLE
Hiroaki Hagiwara, Tomohiro Nakayama, Fumihiko Murakami
An 86-year-old man, with a medical history of coronary artery bypass grafting with the right gastroepiploic artery 20 years prior, was admitted to our hospital for right-sided heart failure. Computed tomography findings revealed an intrapericardial diaphragmatic hernia of the transverse colon compressing the right ventricle. The hernia was successfully repaired, and the patient recovered without any complications. Diaphragmatic hernia is rare but may be a lethal complication following coronary artery bypass grafting...
September 2022: Asian Cardiovascular & Thoracic Annals
https://read.qxmd.com/read/34970448/liver-herniation-into-the-pericardium-mimicking-a-pericardial-tumor-unusual-presentation-of-trisomy-13
#15
JOURNAL ARTICLE
Joanna Szymkiewicz-Dangel, Maria Magdalena Hussey
Aim of the study: Trisomy 13 is the third most common autosomal trisomy. The following case report shows an atypical case of trisomy 13, highlighting the usefulness of 3D volume storage and reconstruction, and the necessity of careful interpretation of the first trimester screening results. Case description: The results of the first trimester screening tests were interpreted as normal, and invasive tests were not recommended. At 21 weeks, a bright spot in the left ventricle was noted, and fetal echocardiography was performed at 33 weeks...
November 29, 2021: Journal of Ultrasonography
https://read.qxmd.com/read/32039782/prenatal-diagnosis-of-concomitant-distal-5q-duplication-and-terminal-10q-deletion-in-a-fetus-with-intrauterine-growth-restriction-congenital-diaphragmatic-hernia-and-congenital-heart-defects
#16
Chih-Ping Chen, Jian-Pei Huang, Shin-Wen Chen, Schu-Rern Chern, Peih-Shan Wu, Fang-Tzu Wu, Wen-Lin Chen, Li-Feng Chen, Wayseen Wang
OBJECTIVE: We present prenatal diagnosis of concomitant distal 5q duplication and terminal 10q deletion in a fetus with intrauterine growth restriction (IUGR), congenital diaphragmatic hernia (CDH) and congenital heart defects (CHD). CASE REPORT: A 34-year-old, gravida 4, para 2, woman was referred for amniocentesis at 21 weeks of gestation because of advanced maternal age and IUGR. There was no congenital malformation in the family. Amniocentesis revealed a derivative chromosome 10 with an additional maternal on the terminal region of 10q...
January 2020: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/31690278/use-of-sildenafil-in-an-infant-with-persistent-pulmonary-hypertension-secondary-to-lung-and-renal-hypoplasia-a-case-report
#17
JOURNAL ARTICLE
Karen Lavie-Nevo, Kevin C Harris, Joseph Y Ting
BACKGROUND: Premature preterm rupture of membranes (PPROM) is reported to be associated with high rates of neonatal mortality and morbidity. Sildenafil has been used in infants with persistent pulmonary hypertension of newborn (PPHN) due to congenital diaphragmatic hernia (CDH) and bronchopulmonary dysplasia (BPD). Recently, Sildenafil has been evaluated as an alternative or adjunctive pulmonary vasodilator. This case report illustrates the use of early sildenafil for PPHN and right ventricular dysfunction in an unusual setting of lung and renal hypoplasia...
November 6, 2019: BMC Pediatrics
https://read.qxmd.com/read/31420110/congenital-diaphragmatic-hernia-associated-cardiac-dysfunction
#18
REVIEW
Neil Patel, Anna Claudia Massolo, Florian Kipfmueller
There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair...
February 2020: Seminars in Perinatology
https://read.qxmd.com/read/30767157/evaluation-and-monitoring-of-pulmonary-hypertension-in-neonates-with-congenital-diaphragmatic-hernia
#19
REVIEW
Aura A Sanchez Mejia, Nathan J Rodgers
PURPOSE OF REVIEW: This review aims to describe the assessment of pulmonary hypertension and ventricular function in neonates with congenital diaphragmatic hernia and the long-term follow-up of their pulmonary vascular disease. RECENT FINDINGS: In 2015, the pediatric pulmonary hypertension guidelines from the American Heart Association and American Thoracic Society suggested class I level of evidence B guidelines for routine evaluation of patients with congenital diaphragmatic hernia, including longitudinal care in an interdisciplinary pulmonary hypertension program and following the recommendations offered for all children with pulmonary hypertension...
February 15, 2019: Current Treatment Options in Cardiovascular Medicine
https://read.qxmd.com/read/30442461/use-of-prostaglandin-e1-to-treat-pulmonary-hypertension-in-congenital-diaphragmatic-hernia
#20
JOURNAL ARTICLE
Kendall M Lawrence, Kelsey Berger, Lisa Herkert, Christine Franciscovich, Carol Lynn H O'Dea, Lindsay N Waqar, Emily Partridge, Brian D Hanna, William H Peranteau, Catherine M Avitabile, Rachel K Hopper, Natalie E Rintoul, Holly L Hedrick
BACKGROUND/PURPOSE: Prostaglandin E1 (PGE) has been used to maintain ductus arteriosus patency and unload the suprasystemic right ventricle (RV) in neonates with congenital diaphragmatic hernia (CDH) and severe pulmonary hypertension (PH). Here we evaluate the PH response in neonates with CDH and severe PH treated with PGE. METHODS: We performed a retrospective chart review of CDH infants treated at our center between 2011 and 2016. In a subset, PGE was initiated for echocardiographic evidence of severe PH, metabolic acidosis, or hypoxemia...
January 2019: Journal of Pediatric Surgery
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