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JOURNAL ARTICLE
Felix Beuschlein, Tobias Else, Irina Bancos, Stefanie Hahner, Oksana Hamidi, Leonie van Hulsteijn, Eystein S Husebye, Niki Karavitaki, Alessandro Prete, Anand Vaidya, Christine Yedinak, Olaf M Dekkers
Glucocorticoids are widely prescribed as anti-inflammatory and immunosuppressive agents. This results in at least 1% of the population using chronic glucocorticoid therapy, being at risk for glucocorticoid-induced adrenal insufficiency. This risk is dependent on the dose, duration and potency of the glucocorticoid, route of administration, and individual susceptibility. Once glucocorticoid-induced adrenal insufficiency develops or is suspected, it necessitates careful education and management of affected patients...
May 10, 2024: Journal of Clinical Endocrinology and Metabolism
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JOURNAL ARTICLE
Júlio Otávio Jardim Barcellos, Daniele Zago, Helena Xavier Fagundes, Gabriel Ribas Pereira, Everton Dezordi Sartori
The aim of this study was to evaluate the effects of pregnant ewe nutrition on the performance of offspring in terms of meat, wool production, and reproduction. Foetal programming in sheep has focused on several aspects related to foetal growth, postnatal production, behaviour, and immunological performance. Currently, significant efforts are being made to understand the endocrine, metabolic, and epigenetic mechanisms involved in offspring development. Current studies have not only evaluated the foetal period, despite the pre-conception parental nutrition has demonstrated an effect on the foetal, embryonic, and pre-implantation periods and can generate permanent effects in the foetal and postnatal phases...
May 7, 2024: Animal Reproduction Science
#23
JOURNAL ARTICLE
Tianfang Peng, Xiaolian Yi, Yan Lin, Xianhui Dong, Pengwei Zhang, Zhihui Qiao, Li Li
OBJECTIVES: Controlled attenuation parameter (CAP) is a noninvasive and quantitative method to evaluate hepatic steatosis, which is not well evaluated in children. The aim of this study was to examine the diagnostic value of CAP for hepatic steatosis in children with obesity based on MR proton density fat fraction (PDFF). METHODS: About 108 pediatric patients with nonalcoholic fatty liver disease (NAFLD) who were assessed for PDFF, CAP, and other laboratory results were enrolled...
May 10, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
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JOURNAL ARTICLE
David M Williams, Barbara-Alex Alberts, Asem Sharaf, Giselle Sharaf, Stephen C Bain, Atul Kalhan, Thinzar Min
INTRODUCTION: Oral semaglutide improves cardiovascular risk factors in people with type 2 diabetes (T2D) in clinical trials, though real-world evidence is limited. We aimed to determine the real-world impact of oral semaglutide on routinely collected clinical data in our practice. METHODS: People with T2D initiated on oral semaglutide in secondary care diabetes clinics at two hospital sites in Wales (United Kingdom) were included. Data were collected on reasons for oral semaglutide initiation and changes in bodyweight, blood pressure, glycemic control, and lipid profiles over follow-up at 3-6 months, and at 6-12 months...
May 9, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
#25
JOURNAL ARTICLE
Jieun Oh, Boah Kim, Gyutaek Oh, Yul Hwangbo, Jong Chul Ye
BACKGROUND: Osteoporosis is the most common metabolic bone disease and can cause fragility fractures. Despite this, screening utilization rates for osteoporosis remain low among populations at risk. Automated bone mineral density (BMD) estimation using computed tomography (CT) can help bridge this gap and serve as an alternative screening method to dual-energy X-ray absorptiometry (DXA). METHODS: The feasibility of an opportunistic and population agnostic screening method for osteoporosis using abdominal CT scans without bone densitometry phantom-based calibration was investigated in this retrospective study...
May 9, 2024: Endocrinology and Metabolism
#26
JOURNAL ARTICLE
Hyun Jin Ryu, Da Eun Leem, Ji Hyun Yoo, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
BACKGROUND: Malignant struma ovarii (MSO) is a very rare disease in which thyroid cancer originates from the ovary. Because it is rare for endocrinologists to encounter patients with MSO, endocrinologists may have a limited understanding of the disease. Therefore, we analyzed and introduced its incidence and clinical course in a tertiary hospital in Korea. METHODS: We retrospectively investigated the clinical data of 170 patients who underwent surgery for struma ovarii at the Department of Obstetrics and Gynecology of Samsung Medical Center from 1994 to May 2023...
May 9, 2024: Endocrinology and Metabolism
#27
JOURNAL ARTICLE
Jooyoung Cho, Ho-Chan Cho, Ohk-Hyun Ryu, Hyo-Jeong Kim, Chang Geun Kim, Young Ran Yun, Choon Hee Chung
BACKGROUND: The Korean Endocrine Hormone Reference Standard Data Center (KEHRS DC) has created reference standards (RSs) for endocrine hormones since 2020. This study is the first of its kind, wherein the KEHRS DC established RSs for serum Cpeptide levels in a healthy Korean population. METHODS: Healthy Korean adults were recruited from May 2021 to September 2023. After excluding participants according to our criteria, serum samples were collected; each participant could then choose between fasting glucose only or fasting glucose plus an oral glucose tolerance test (OGTT)...
May 9, 2024: Endocrinology and Metabolism
#28
REVIEW
Masaji Sakaguchi
Adipose tissues, such as white, brown, and beige tissues, play pivotal roles in maintaining energy balance and metabolic health. Whereas white adipocytes store energy, brown and beige adipocytes exhibit high energy expenditure owing to their distinct mitochondrial density and UCP1 expression. Dysfunction in these tissues contributes to metabolic disorders such as type 2 diabetes and cardiovascular diseases. Adipose tissue expansion through cell enlargement or increased cell numbers caused by excess energy storage in white adipocytes substantially influences metabolic health...
April 15, 2024: JMA journal
#29
REVIEW
Daniel M Marko, Meghan O Conn, Jonathan D Schertzer
Intermittent fasting (IF) modifies cell- and tissue-specific immunometabolic responses that dictate metabolic flexibility and inflammation during obesity and type 2 diabetes (T2D). Fasting forces periods of metabolic flexibility and necessitates increased use of different substrates. IF can lower metabolic inflammation and improve glucose metabolism without lowering obesity and can influence time-dependent, compartmentalized changes in immunity. Liver, adipose tissue, skeletal muscle, and immune cells communicate to relay metabolic and immune signals during fasting...
May 7, 2024: Trends in Endocrinology and Metabolism: TEM
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JOURNAL ARTICLE
Yuan Wang, Rui Jiang
INTRODUCTION: Androgens play important roles in regulating the growth and development of the male reproductive system and maintaining libido and erectile function. The specific mechanisms by which androgen deficiency leads to erectile dysfunction (ED) are not yet fully understood. OBJECTIVES: To understand the mechanisms and treatment of androgen deficiency-related ED. METHODS: A literature search in the past 10 years was conducted in PubMed and Google Scholar to determine the effects of androgen deficiency on erectile function and the treatment of androgen deficiency...
May 8, 2024: Sexual Medicine Reviews
#31
JOURNAL ARTICLE
Liam Mahoney Clifford, Flavian Joseph
A gentleman in his 90s presented with a slowly enlarging goitre over 18 months, causing manifestations of superior vena cava obstruction, dysphagia and hoarseness of voice. Investigations were suggestive of a fibrosing thyroid pathology. Surgical management was avoided due to high surgical risk. Treatment included prednisolone and tamoxifen with palliative management in the event of further medical deterioration. This article illustrates the difficulties in diagnosing and managing fibrosing thyroid diseases...
May 8, 2024: BMJ Case Reports
#32
JOURNAL ARTICLE
Meng Ye, Yameng Liu, Feng Wang, Xiyuchen Yang, Xiaobing Yang, Xiangdong Gao, Wei Liu, Juping Yu
Diabetic encephalopathy (DE), characterized by cognitive impairment, currently lacks targeted treatment. Previous studies have shown that Sarcandra glabra extracted residue polysaccharide (SERP) exhibited hypoglycemic effects either in vitro or in streptozotocin-induced diabetes mice. However, the therapeutic effect of SERP on DE was not elucidated. This study investigated the therapeutic effect of SERP on DE and its underlying mechanism. Our results revealed that SERP regulates glucose and lipid metabolism, improves cognitive function, and exhibits diminished activity post-antibiotic intervention...
May 6, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Qingwen Qian, Mark Li, Zeyuan Zhang, Shannon W Davis, Kamal Rahmouni, Andrew W Norris, Huojun Cao, Wen-Xing Ding, Gökhan S Hotamisligil, Ling Yang
Obesity alters levels of pituitary hormones that govern hepatic immune-metabolic homeostasis, dysregulation of which leads to nonalcoholic fatty liver disease (NAFLD). However, the impact of obesity on intra-pituitary homeostasis is largely unknown. Here, we uncovered a blunted unfolded protein response (UPR) but elevated inflammatory signatures in pituitary glands of obese mice and humans. Furthermore, we found that obesity inflames the pituitary gland, leading to impaired pituitary inositol-requiring enzyme 1α (IRE1α)-X-box-binding protein 1 (XBP1) UPR branch, which is essential for protecting against pituitary endocrine defects and NAFLD progression...
May 3, 2024: Cell Metabolism
#34
JOURNAL ARTICLE
Mone Zaidi, Samir Zaidi, Tony Yuen
Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress.
May 7, 2024: Cell Metabolism
#35
JOURNAL ARTICLE
Christian Posern, Benjamin Dreyer, Sarah L Maier, Florian Eichler, Michael H Gelb, René Santer, Annette Bley, Simona Murko
BACKGROUND: Canavan disease is a devastating neurometabolic disorder caused by accumulation of N acetylaspartate in brain and body fluids due to genetic defects in the aspartoacylase gene (ASPA). New gene therapies are on the horizon but will require early presymptomatic diagnosis to be fully effective. METHODS: We therefore developed a fast and highly sensitive liquid chromatography mass spectrometry (LC-MS/MS)-based method for quantification of N-acetylaspartate in dried blood spots and established reference ranges for neonates and older controls...
May 3, 2024: Molecular Genetics and Metabolism
#36
JOURNAL ARTICLE
Kiavash Mokhtarpour, Amirhossein Yadegar, Fatemeh Mohammadi, Seyedeh Nazanin Aghayan, Seyed Arsalan Seyedi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani
INTRODUCTION: This study aimed to assess and compare the prevalence of diabetes complications between men and women with Type 2 diabetes (T2D), as well as how gender relates to these complications. METHODS: In this cross-sectional study, complications of diabetes, including coronary artery disease (CAD), retinopathy, neuropathy and diabetic kidney disease (DKD), were evaluated in 1867 participants with T2D. Additionally, baseline characteristics of the individuals, including anthropometric measurements, metabolic parameters and the use of dyslipidaemia drugs and antihyperglycaemic agents, were assessed...
May 2024: Endocrinology, Diabetes & Metabolism
#37
JOURNAL ARTICLE
Akira Mima, Yasuhiro Horii
OBJECTIVE: Tirzepatide is an injectable peptide approved by the US Food and Drug Administration for the treatment of Type 2 diabetes (T2DM). Its weight-loss effect primarily targets fat reduction; however, such effect on patients with chronic kidney disease (CKD) undergoing haemodialysis (HD) has not been reported. METHODS: Nine patients with CKD undergoing HD received weekly tirzepatide doses (2.5-7.5 mg) once a week. Evaluations encompassed tirzepatide's impact on dry weight (DW) and body composition assessed at baseline and study conclusion using bioelectrical impedance analysis...
May 2024: Endocrinology, Diabetes & Metabolism
#38
JOURNAL ARTICLE
Julian Martinez-Mayer, Sebastian Vishnopolska, Catalina Perticarari, Lucia Iglesias Garcia, Martina Hackbartt, Marcela Martinez, Jonathan Zaiat, Andrea Jacome-Alvarado, Debora Braslavsky, Ana Keselman, Ignacio Bergadá, Roxana Marino, Pablo Ramírez, Natalia Pérez Garrido, Marta Ciaccio, Maria Isabel Di Palma, Alicia Belgorosky, Maria Veronica Forclaz, Gabriela Benzrihen, Silvia D'Amato, Maria Lujan Cirigliano, Mirta Miras, Alejandra Paez Nuñez, Laura Castro, Maria Susana Mallea-Gil, Carolina Ballarino, Laura Latorre-Villacorta, Ana Clara Casiello, Claudia Hernandez, Veronica Figueroa, Guillermo Alonso, Analia Morin, Zelmira Guntsche, Hane Lee, Eugene Lee, Yongjun Song, Marcelo Adrian Marti, Maria Ines Perez-Millan
CONTEXT: The pituitary gland is key for childhood growth, puberty, and metabolism. Pituitary dysfunction is associated with a spectrum of phenotypes, from mild to severe. Congenital Hypopituitarism (CH) is the most commonly reported pediatric endocrine dysfunction with an incidence of 1:4000, yet low rates of genetic diagnosis have been reported. OBJECTIVE: We aimed to unveil the genetic etiology of CH in a large cohort of patients from Argentina. METHODS: We performed whole exome sequencing of 137 unrelated cases of CH, the largest cohort examined with this method to date...
May 8, 2024: Journal of Clinical Endocrinology and Metabolism
#39
JOURNAL ARTICLE
Qingyang Liu, Shams Tabrez, Patrick Niekamp, Chang H Kim
Innate lymphoid cells (ILCs), strategically positioned throughout the body, undergo population declines over time. A solution to counteract this problem is timely mobilization of multipotential progenitors from the bone marrow. It remains unknown what triggers the mobilization of bone marrow ILC progenitors (ILCPs). We report that ILCPs are regulated by the circadian clock to emigrate and generate mature ILCs in the periphery. We found that circadian-clock-defective ILCPs fail to normally emigrate and generate ILCs...
May 7, 2024: Cell Reports
#40
JOURNAL ARTICLE
Steven A Krauklis, Jamal Hussain, Katherine M Murphy, Evan L Dray, Carey G Ousley, Katarzyna Justyna, Mark D Distefano, Andrew J Steelman, Daniel B McKim
Statins are used to treat hypercholesterolemia and function by inhibiting the production of the rate-limiting metabolite mevalonate. As such, statin treatment not only inhibits de novo synthesis of cholesterol but also isoprenoids that are involved in prenylation, the post-translational lipid modification of proteins. The immunomodulatory effects of statins are broad and often conflicting. Previous work demonstrated that statins increased survival and inhibited myeloid cell trafficking in a murine model of sepsis, but the exact mechanisms underlying this phenomenon were unclear...
May 8, 2024: American Journal of Physiology. Endocrinology and Metabolism
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