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Del nido

Sotiris C Stamou, Cassandra Lopez, Courtney Novello, Marcos A Nores
BACKGROUND: Numerous studies have documented the safety of whole blood cardioplegia on clinical outcomes after cardiac surgery. However, there is a paucity of studies investigating the outcomes of whole blood microplegia after cardiac surgery. Our protocol of whole blood microplegia includes removal of the crystalloid portion and utilizing the Quest Myocardial Protection System, for delivery of del Nido cardioplegia additives in whole blood. This study sought to evaluate the effects of whole blood microplegia on clinical outcomes, following cardiac surgery, in high-risk cardiac surgery patients...
February 14, 2019: Journal of Cardiac Surgery
Mustafa Cagdas Cayir, Ahmet Yuksel
BACKGROUND: The del Nido (DN) cardioplegia solution has been widely used in paediatric open-heart surgery for years; however, its application in adult open-heart surgery has not yet gained sufficient popularity. We investigated the safety and efficiency of the DN cardioplegia solution versus the traditional crystalloid cardioplegia solution [St. Thomas' Hospital (STH) cardioplegia solution] in adult patients undergoing coronary artery bypass grafting (CABG). METHODS: A retrospective comparative analysis of 200 consecutive patients undergoing isolated on-pump CABG between April 2016 and September 2017 was performed...
January 18, 2019: Heart, Lung & Circulation
Deepak Prakash Borde, Shreedhar S Joshi, Murali Chakravarthy, Vishwas Malik, Ranjith B Karthekeyan, Antony George, Thomas Koshy, Uday Gandhe, Suresh G Nair
Context: Cardiac anesthesiologists play a key role during the conduct of cardiopulmonary bypass (CPB). There are variations in the practice of CPB among extracorporeal technologists in India. Aims: The aim of this survey is to gather information on variations during the conduct of CPB in India. Settings and Design: This was an online conducted survey by Indian College of Cardiac Anaesthesia, which is the research and academic wing of the Indian Association of Cardiovascular Thoracic Anaesthesiologists...
January 2019: Annals of Cardiac Anaesthesia
Wan Kee Kim, Joon Bum Kim
No abstract text is available yet for this article.
November 2018: Journal of Thoracic Disease
Patrick O Myers, Suyog A Mokashi, Edward Horgan, Michele Borisuk, John E Mayer, Pedro J Del Nido, Christopher W Baird
OBJECTIVES: There are little recent data on the outcomes of mechanical aortic valve replacement (AVR) in children and young adults with congenital aortic valve disease. We sought to review the survival and associated thromboembolic or bleeding complications after mechanical AVR at a single center. METHODS: Data were retrospectively collected for 121 patients undergoing prosthetic AVR from 2000 to 2014. Kaplan-Meier estimates and Cox proportional hazards were employed...
January 2019: Journal of Thoracic and Cardiovascular Surgery
Ignacio G Berra, Peter E Hammer, Sebastian Berra, Alfredo Oscar Irusta, Seok Chang Ryu, Douglas P Perrin, Nikolay V Vasilyev, Carlos Javier Cornelis, Pablo Garcia Delucis, Pedro J Del Nido
OBJECTIVE: Aortic valve repair is currently in transition from surgical improvisation to a reproducible operation and an option for many patients with aortic regurgitation. Our research efforts at improving reproducibility include development of methods for intraoperatively testing and visualizing the valve in its diastolic state. METHODS: We developed a device that can be intraoperatively secured in the transected aorta allowing the aortic root to be pressurized and the closed valve to be inspected endoscopically...
January 2019: Journal of Thoracic and Cardiovascular Surgery
Christian O'Donnell, Hanjay Wang, Phat Tran, Shari Miller, Paul Shuttleworth, Jack H Boyd
BACKGROUND: Studies assessing the safety and effectiveness of Del Nido cardioplegia for adult cardiac surgery remain limited. We investigated early outcomes after coronary artery bypass grafting (CABG) using single-dose Del Nido cardioplegia vs. conventional multi-dose blood cardioplegia. Methods and Results: The 81 consecutive patients underwent isolated CABG performed by a single surgeon. The initial 27 patients received anterograde blood cardioplegia, while the subsequent 54 patients received anterograde Del Nido cardioplegia...
December 7, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Ali Aycan Kavala, Saygin Turkyilmaz
OBJECTIVE: To compare del Nido cardioplegia (DNC) with blood cardioplegia (BC) in coronary artery bypass grafting (CABG) combined with mitral valve replacement. METHODS: A 3-year single-center retrospective cohort study was carried out. Subjects who underwent CABG (up to triple bypass) combined with mitral valve replacement were divided into DNC and BC groups. Each group had thirty subjects. RESULTS: Both groups demonstrated similar baseline characteristics, including age, gender, cardiac/non-cardiac comorbidity, and preoperative echocardiographic parameters...
September 2018: Brazilian Journal of Cardiovascular Surgery
Kamila Moskowitzova, Borami Shin, Kaifeng Liu, Giovanna Ramirez-Barbieri, Alvise Guariento, David Blitzer, Jerusha K Thedsanamoorthy, Rouan Yao, Erin R Snay, James A H Inkster, Arzoo Orfany, David Zurakowski, Douglas B Cowan, Alan B Packard, Gary A Visner, Pedro J Del Nido, James D McCully
BACKGROUND: Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial transplantation replaces damaged mitochondria and enhances myocardial function and tissue viability. Herein we investigated the efficacy of mitochondrial transplantation in enhancing graft function and viability after prolonged CIT. METHODS: Heterotopic heart transplantation was performed in C57BL/6J mice...
September 28, 2018: Journal of Heart and Lung Transplantation
Paolo Nardi, Calogera Pisano, Fabio Bertoldo, Giovanni Ruvolo
No abstract text is available yet for this article.
September 2018: Journal of Thoracic Disease
Michael Rosenbloom, Michael Hancock, Perry Weinstock, Allyson Paterek, Richard Highbloom, Frank Bowen, Kinjal Patel
A patient with known cold agglutinins requiring an aortic valve replacement was referred for surgery. Asanguinous, Del Nido cardioplegia was used for myocardial protection. Warm induction followed by cold infusion prevented any agglutination and eliminated the need for subsequent cardioplegia doses. Following the cross-clamp period, the heart returned to normal sinus rhythm without need for defibrillation. Postoperative ejection fraction and systolic function were normal.
September 2018: Journal of Extra-corporeal Technology
Laith Mukdad, William Toppen, Yas Sanaiha, Aditya Mantha, Stephanie Bland, Richard Shemin, Peyman Benharash
Cerebral microemboli have been associated with neurocognitive deficits after cardiac operations using cardiopulmonary bypass (CPB). Interventions by the perfusionist and alterations in blood flow account for a large proportion of previously unexplained microemboli. This study compared the incidence of microemboli during cardiac operations using conventional (multidose) and del Nido (single-dose) cardioplegia delivery. Transcranial Doppler ultrasonography was used to detect microemboli in bilateral middle cerebral arteries of 30 adult patients undergoing cardiac operations using CPB and aortic clamping...
September 2018: Journal of Extra-corporeal Technology
Han Yu, Pedro J Del Nido, Tal Geva, Chun Yang, Alexander Tang, Zheyang Wu, Rahul H Rathod, Xueying Huang, Kristen L Billiar, Dalin Tang
Patient-specific in vivo ventricle material parameter determination is important for cardiovascular investigations. A new cardiac magnetic image (CMR)-based modeling approach with different zero-load diastole and systole geometries was adopted to estimate right ventricle material parameter values for healthy and patients with Tetralogy of Fallot (TOF) and seeking potential clinical applications. CMR data were obtained from 6 healthy volunteers and 16 TOF patients with consent obtained. CMR-based RV/LV models were constructed using two zero-load geometries (diastole and systole, 2G model)...
September 10, 2018: International Journal of Cardiology
Joseph F Sabik, Sajjad Raza, Kenneth D Chavin
OBJECTIVE: To assess the safety and benefits of new techniques and technologies such as single-dose (del Nido) cardioplegia and suture fasteners (COR-KNOT) in patients undergoing mini-thoracotomy for degenerative mitral valve repair (MVR). METHODS: From 2009 to 2016, 252 patients underwent primary isolated degenerative MVR by mini-thoracotomy by a single surgeon. Del Nido cardioplegia was used in 153 patients (61%) and COR-KNOT in 168 (67%). Patient outcomes were compared using propensity-matching separately for del Nido versus Buckberg cardioplegia and COR-KNOT versus knot-pusher...
October 2018: Journal of Cardiac Surgery
Rinske Ijsselhof, Hua Liu, Frank Pigula, Kimberlee Gauvreau, John E Mayer, Pedro Del Nido, Meena Nathan
BACKGROUND: In the current era, coarctation repair is usually performed as soon as diagnosis is established. We sought to determine if neonatal isolated coarctation repair had a higher rate of interventions post-discharge when compared to older infants. METHODS: Retrospective review of neonates (≤30 days) and infants(1-6 months) undergoing isolated coarctation repair between 1/1/2000-3/31/2016. Preoperative/postoperative Z scores of arch, aortic valve and isthmus, rates of reintervention and length of stay were compared between groups...
September 1, 2018: Annals of Thoracic Surgery
K Z Rushel, A Hoque, M K Alamgir, M Z Islam, K A Hasan, M R Rahman, R Sarkar, M K Hasan, A B Adhikary
Pediatric myocardium is unique from mature myocardium; thus, the use of adult cardioplegia for pediatric cardiac operations may provide suboptimal myocardial protection. It is found that children undergoing heart surgery show evidence of less myocardial damage when del Nido cardioplegia is used instead of a standard cardioplegic solution. Del Nido cardioplegia solution provides a depolarized hyperkalaemic arrest lasting up to 60 minutes, reduces spontaneous and inducible activity during arrest, and prevents hyper contraction during early reperfusion...
July 2018: Mymensingh Medical Journal: MMJ
Nigel E Drury, Angela Horsburgh, Rehana Bi, Robert G Willetts, Timothy J Jones
INTRODUCTION: Many techniques are available for cardioplegic arrest in children, but there is a lack of late phase clinical trials to guide practice. We surveyed paediatric cardiac surgeons and perfusionists to establish current practice and willingness to change within a clinical trial. METHODS: An online survey was sent to all consultant paediatric cardiac surgeons and chief perfusionists in paediatric centres in the UK and Ireland. Information was sought on cardioplegia type, composition, temperature, topical cooling, dosing for induction and maintenance, interval between doses, whether practice changed with patient age or complexity and whether respondents would be willing and able to use different cardioplegia solutions within a randomised trial...
August 10, 2018: Perfusion
Haci Ali Ucak, Hasan Uncu
PURPOSE: In this study, we aim to investigate the efficacy and clinical results of using Del Nido solution (DNS) in coronary artery bypass grafting (CABG) surgery by comparing with intermittent warm blood cardioplegia (IWBC). METHODS: Between March 2017 and February 2018, 297 adult patients who underwent primary isolated CABG surgery with cardiopulmonary bypass (CPB) were included in the study. We used DNS in 112 patients and IWBC was used in 185 patients. We compared both the clinical and the laboratory results...
August 9, 2018: Annals of Thoracic and Cardiovascular Surgery
Helison Pereira do Carmo, Karla Reichert, Daniela Diógenes de Carvalho, Lindemberg da Mota Silveira-Filho, Karlos Vilarinho, Pedro Oliveira, Orlando Petrucci
OBJECTIVE: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents. Experiments were performed in isolated rat heart perfusion models. METHODS: Male rat heart perfusions, according to Langendorff technique, were induced to cause 3 hours of cardiac arrest with a single dose. The hearts were assigned to one of the following three groups: (I) control; (II) Custodiol-LP; and (III) del Nido-LP...
May 2018: Brazilian Journal of Cardiovascular Surgery
Sowmya Balasubramanian, David M Harrild, Basavaraj Kerur, Edward Marcus, Pedro Del Nido, Tal Geva, Andrew J Powell
BACKGROUND: In patients with repaired tetralogy of Fallot (TOF), a better understanding of the impact of surgical pulmonary valve replacement (PVR) on ventricular mechanics may lead to improved indications and outcomes. Therefore, we used cardiovascular magnetic resonance (CMR) feature tracking analysis to quantify ventricular strain and synchrony in repaired TOF patients before and after PVR. METHODS: Thirty-six repaired TOF patients (median age 22.4 years) prospectively underwent CMR a mean of 4...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
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