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Tumor AND imaging

Z J Liu, J M Yao, M L Wang, T T Geng, G Dong, M S Zeng
Objective: To investigate the MRI and diffusion weighted imaging (DWI) features of focal peliosis hepatis. Methods: The clinical data and MRI of 19 cases with focal peliosis hepatis confirmed by pathology from January 2012 to March 2018 in Zhongshan Hospital of Fudan University were retrospectively analyzed. The number, location, size, shape, signal intensity of plain scan of lesions, enhancement pattern of lesions, vessels within lesions, and perfusion disorders of hepatic parenchyma were analyzed. The apparent diffusion coefficient (ADC) values of the lesions and adjacent hepatic parenchyma were measured, then the differences between them were explored statistically...
February 19, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jonathan R Hughes, Balazs Szladovits, Randi Drees
Canine mast cell tumor staging is commonly performed using abdominal ultrasonography and fine-needle aspiration cytology of masses, lymph nodes, and hepatic and splenic parenchyma. Computed tomography is used for abdominal, thoracic, or whole body imaging in staging mast cell tumors in the authors' institution enabling evaluation of multiple body areas in one examination. The aim of this study was to compare the CT examinations acquired for staging of mast cell disease to their subsequent liver and spleen cytology findings...
February 20, 2019: Veterinary Radiology & Ultrasound
Elisabeth Pfaehler, Alex Zwanenburg, Johan R de Jong, Ronald Boellaard
PURPOSE: The widely known field 'Radiomics' aims to provide an extensive image based phenotyping of e.g. tumors using a wide variety of feature values extracted from medical images. Therefore, it is of utmost importance that feature values calculated by different institutes follow the same feature definitions. For this purpose, the imaging biomarker standardization initiative (IBSI) provides detailed mathematical feature descriptions, as well as (mathematical) test phantoms and corresponding reference feature values...
2019: PloS One
Ah-Young Kwon, Ha Young Park, Jiyeon Hyeon, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong-Han Yu, Se Kyung Lee, Soo Youn Cho, Eun Yoon Cho
The Ki-67 labeling index (LI) is an important prognostic factor in breast carcinoma. The Ki-67 LI is traditionally calculated via unaided microscopic estimation; however, inter-observer and intra-observer variability and low reproducibility are problems with this visual assessment (VA) method. For more accurate assessment and better reproducibility with Ki-67 LI, digital image analysis was introduced recently. We used both VA and automated digital image analysis (ADIA) (Ventana Virtuoso image management software) to estimate Ki-67 LI for 997 cases of breast carcinoma, and compared VA and ADIA results...
2019: PloS One
Natalia Buza
CONTEXT.—: Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Therefore, intraoperative frozen section evaluation is crucial for determining the required extent of surgery, that is, cystectomy for benign tumors, oophorectomy or limited surgical staging for borderline tumors in younger patients to preserve fertility, or extensive staging procedure for ovarian carcinomas...
January 2019: Archives of Pathology & Laboratory Medicine
Fu Rui Zhang, Jiao Yang Lu, Qing Feng Yao, Qiu Yan Zhu, Xin Xing Zhang, Wei Tao Huang, Li Qiu Xia, Xue Zhi Ding
Tumorigenesis, metastasis, and the recurrence of cancer, which may result from the abnormal presence or activation of cancer stem cells (CSCs), are involved in disorders of exchanged matter (biomarkers), energy and information in living organisms. Rapid and sensitive detection and imaging of CSC biomarkers (such as CD133) are helpful for early diagnosis and therapeutic evaluation of tumors. Recently, a preliminary exploration of a few affinity molecules (like peptide-based probes) has just begun for chemical measurements and imaging of CSC biomarker CD133...
February 20, 2019: Analyst
Pradeep Balineni, Rekha Arcot, Kannan Devygounder, Khalilur Rahaman, Bharath Narayansamy, Manoj Prabhu, Shantini Vaitheeswaran
INTRODUCTION: Nerve sheath tumors are tumors arising from nerve sheaths or which show nerve sheath differentiation. They are divided as benign and malignant. They are associated with Von Recklinghausen syndrome. Characterised by café-au-lait spots, lisch nodules, acoustic neuromas, pheochromocytomas. PRESENTATION OF CASE: A 62 year old gentleman came with complaints of Abdominal discomfort for 1month. He also had Left sided abdominal pain, Anorexia, Vomiting, No history of dyspepsia, fever, bowel disturbance...
February 13, 2019: International Journal of Surgery Case Reports
Benjamin L Viglianti, Daniel J Wale, Tianwen Ma, Timothy D Johnson, Nicolaas I Bohnen, Ka Kit Wong, Christy Ky, Kirk A Frey, Danyelle M Townsend, Domenico Rubello, Milton D Gross
PURPOSE: Hyperglycemia affects FDG uptake in the brain, potentially emulating Alzheimer's disease in normal individuals. This study investigates global and regional cerebral FDG uptake as a function of plasma glucose in a cohort of patients. METHODS: 120 consecutive male patients with FDG PET/CT for initial oncologic staging (July-Dec 2015) were reviewed. Patients with dementia, cerebrovascular accident, structural brain lesion, prior oncology treatment or high metabolic tumor burden (recently shown affecting brain FDG uptake) were excluded...
February 20, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nicole Wake, Andrew B Rosenkrantz, Richard Huang, Katalina U Park, James S Wysock, Samir S Taneja, William C Huang, Daniel K Sodickson, Hersh Chandarana
BACKGROUND: Patient-specific 3D models are being used increasingly in medicine for many applications including surgical planning, procedure rehearsal, trainee education, and patient education. To date, experiences on the use of 3D models to facilitate patient understanding of their disease and surgical plan are limited. The purpose of this study was to investigate in the context of renal and prostate cancer the impact of using 3D printed and augmented reality models for patient education...
February 19, 2019: 3D printing in medicine
Thibault Passeri, Pierre-Olivier Champagne, Anne-Laure Bernat, Shunya Hanakita, Henri Salle, Emmanuel Mandonnet, Sébastien Froelich
BACKGROUND: The relationship between increased meningioma incidence and growth and long-term hormonal therapy with cyproterone acetate (CPA) in women has been recently established in literature. Following the raise in awareness from hormonal treatment, we describe a potential relationship between the progesterone agonist nomegestrol acetate (NOMAC) and meningioma growth. METHODS: After implementation of a screening protocol to detect potential interactions between hormonal exposure and occurrence of meningioma, we identified patients taking NOMAC and newly diagnosed with a meningioma...
February 19, 2019: Acta Neurochirurgica
Nikos Fatsis-Kavalopoulos, Paul O'Callaghan, Beichen Xie, Rodrigo Hernández Vera, Olof Idevall-Hagren, Johan Kreuger
The function and behaviour of any given cell in a healthy tissue, or in a tumor, is affected by interactions with its neighboring cells. It is therefore important to create methods that allow for reconstruction of tissue niches in vitro for studies of cell-cell signaling and associated cell behaviour. To this end we created the cell assembly generator (CAGE), a microfluidic device which enables the organization of different cell types into precise cell clusters in a flow chamber compatible with high-resolution microscopy...
February 20, 2019: Lab on a Chip
Hiroyuki Yazawa, Kaoru Takiguchi, Asami Kato, Karin Imaizumi
We describe an extremely rare case of an unusually presented ovarian fibroma adherent to the sigmoid colon originating from an autoamputated ovary. A 64-year-old woman was referred to our hospital with an abnormal shadow that was approximately 4 cm in diameter in the pelvic cavity detected on abdominal X-ray imaging. Computed tomography demonstrated an irregularly shaped tumor with calcification in the pelvic cavity. Laparoscopy revealed that the tumor was adherent to the surface of the sigmoid colon with a discontinuous shell and empty cavity...
January 2019: Gynecology and minimally invasive therapy
Xiaoxiong Jia, Zhiyong Su, Junlin Hu, Hechun Xia, Hui Ma, Xiaodong Wang, Jiangshu Yan, Dede Ma
Background: An assessment of the degree of white matter tract injury is important in neurosurgical planning for patients with gliomas. The main objective of this study was to assess the injury grade of the corticospinal tract (CST) in rats with glioma using diffusion tensor imaging (DTI). Methods: A total 17 rats underwent 7.0T MRI on day 10 after tumor implantation. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were acquired in the tumor, peritumoral and contralateral areas, and the ADC ratio (ipsilateral ADC/contralateral ADC) and rFA (relative FA = ipsilateral FA/contralateral FA) in the peritumoral areas were measured...
2019: PeerJ
Juanette McKenzie, Curtis Oettel-Flaherty, Douglas Noel, Ruth H Walker, Andrew K Sobering
Background: Ataxia is diagnosed by typical features on examination suggestive of a cerebellar etiology and can invoke extensive diagnostic testing. Osteoid osteomas (OOs) are benign bone tumors of the lower limbs that occasionally present with focal neurological signs. Case Report: A 3-year-old male presented with apparent progressive gait ataxia and non-specific leg pain. Initial imaging was unremarkable. However, 12 months later, a lesion was identified in the distal right femur, which was found to be an OO...
2019: Tremor and Other Hyperkinetic Movements
Ronald S Weinstein, Michael J Holcomb, Elizabeth A Krupinski
This narrative-based paper provides a first-person account of the early history of telepathology (1985-2000) by the field's inventor, Ronald S. Weinstein, M. D. During the 1980s, Dr. Weinstein, a Massachusetts General Hospital-trained pathologist, was director of the Central Pathology Laboratory (CPL) for the National Cancer Institute-funded National Bladder Cancer Project, located at Rush Medical College in Chicago, IL. The CPL did post therapy revalidations of surgical pathology and cytopathology diagnoses before outcomes of the completed clinical trials were published...
2019: Journal of Pathology Informatics
Jian Li, Yolanda Wong Ying Yip, Jialin Ren, Wing Ki Hui, Jing Na He, Qiu Xiao Yu, Kai On Chu, Tsz Kin Ng, Sun On Chan, Chi Pui Pang, Wai Kit Chu
Autoimmune uveitis is a sight-threatening disease mainly caused by dysregulation of immunity. We investigated the therapeutic effects of green tea extract (GTE) and its major component, epigallocatechin-3-gallate (EGCG), on a murine model of experimental autoimmune uveoretinitis (EAU). Oral administration of GTE, EGCG, dexamethasone, or water, which started 5 days before the induction, was fed every two days to each group. On day 21 post induction, the eyes were examined by confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT), fundus fluorescein angiography (FFA) and electroretinography (ERG) prior to sacrificing the animals for histological assessments and gene expression studies...
February 19, 2019: Scientific Reports
Zoë Shancer, Xiu-Fen Liu, Satoshi Nagata, Qi Zhou, Tapan K Bera, Ira Pastan
Multiple myeloma (MM) is a B cell malignancy for which new treatments are urgently needed. The B cell maturation antigen (BCMA) is a lineage-restricted differentiation protein highly expressed on myeloma. Recombinant immunotoxins (RITs) are proteins composed of the Fv or Fab portion of an antibody fused to a bacterial toxin. We previously treated H929 myeloma s.c. tumors with anti-BCMA immunotoxins, very active on killing cultured cells, and observed tumor growth inhibition but not complete tumor responses...
February 19, 2019: Proceedings of the National Academy of Sciences of the United States of America
Wang-Sheng Chen, Lan Hong, Fei Wang, Jian-Jun Li
BACKGROUND: Glioma is one of the most epidemic and obstinate types of cancer in the central nervous system with poor survival rate. Dacomitinib inhibited cell viability and proliferation of  EGFR -amplified glioma. In the present study, the regional effects of Dacomitinib on tumor necrosis was investigated. METHODS: A C6 rat glioma model was evaluated using proton magnetic resonance spectroscopy (1H-MRS), diffusion weighted imaging (DWI), morphological T2-weighted imaging (T2W)...
February 19, 2019: Bioscience Reports
Chia-Cheng Yu, Yi-Wen Chen, Po-Ying Yeh, Yu-Sheng Hsiao, Wei-Ting Lin, Chiung-Wen Kuo, Di-Yen Chueh, Yun-Wen You, Jing-Jong Shyue, Ying-Chih Chang, Peilin Chen
BACKGROUND: Circulating tumor cells (CTCs) comprise the high metastatic potential population of cancer cells in the blood circulation of humans; they have become the established biomarkers for cancer diagnosis, individualized cancer therapy, and cancer development. Technologies for the isolation and recovery of CTCs can be powerful cancer diagnostic tools for liquid biopsies, allowing the identification of malignancies and guiding cancer treatments for precision medicine. METHODS: We have used an electrospinning process to prepare poly(lactic-co-glycolic acid) (PLGA) nanofibrous arrays in random or aligned orientations on glass slips...
February 19, 2019: Journal of Nanobiotechnology
Lingzhou Zhao, Yujie Li, Jingyi Zhu, Na Sun, Ningning Song, Yan Xing, He Huang, Jinhua Zhao
BACKGROUND: Malignant glioma is the most common and deadliest brain cancer due to the obstacle from indistinct tumor margins for surgical excision and blood brain barrier (BBB) for chemotherapy. Here, we designed and prepared multifunctional polyethylenimine-entrapped gold nanoparticles (Au PENPs) for targeted SPECT/CT imaging and radionuclide therapy of glioma. RESULTS: Polyethylenimine was selected as a template for sequential modification with polyethylene glycol (PEG), glioma-specific peptide (chlorotoxin, CTX) and 3-(4-hydroxyphenyl)propionic acid-OSu (HPAO), and were then used to entrap gold nanoparticles (Au NPs)...
February 19, 2019: Journal of Nanobiotechnology
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