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Evidenced based

Sara M A Pinto, Mário J F Calvete, Mariana E Ghica, Sérgio Soler, Iluminada Gallardo, Agnès Pallier, Mariana B Laranjo, Ana M S Cardoso, M Margarida C A Castro, Christopher M A Brett, Mariette M Pereira, Éva Tóth, Carlos F G C Geraldes
For the development of redox responsive MRI probes based on the MnIII/MnII couple, stable complexation of both reduced and oxidized forms of the metal ion and appropriate tuning of the redox potential in the biologically relevant range are key elements. The water soluble fluorinated Mn-porphyrin derivative Mn-3 satisfies both requirements. In aqueous solutions, it can reversibly switch between MnIII/MnII oxidation states. In the presence of ascorbic acid or β-mercaptoethanol, the MnIII form undergoes reduction, which is slowly but fully reversed in the presence of air oxygen...
February 18, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Reddymasu Sreenivasulu, Kotthireddy Thirumal Reddy, Pombala Sujitha, C Ganesh Kumar, Rudraraju Ramesh Raju
In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth inhibition and apoptosis induction characteristics are being strongly screened for their cancer chemo-preventive potential. In the present study, N-methyl and N,N-dimethyl bis(indolyl)hydrazide-hydrazone analog derivatives were designed, synthesized and allowed to evaluate for their anti-proliferative and apoptosis induction potential against cervical (HeLa), breast (MCF-7 and MDA-MB-231) and lung (A549) cancer cell lines relative to normal HEK293 cells...
February 4, 2019: Bioorganic & Medicinal Chemistry
Chayenne Van Meel, Annelies Baeck, Céline R Gillebert, Johan Wagemans, Hans P Op de Beeck
Several computational models explain how symmetry might be detected and represented in the human brain. However, while there is an abundance of psychophysical studies on symmetry detection and several neural studies showing where and when symmetry is detected in the brain, important questions remain about how this detection happens and how symmetric patterns are represented. We studied the representation of (vertical) symmetry in regions of the ventral visual stream, using multi-voxel pattern analyses (MVPA) and functional connectivity analyses...
February 13, 2019: NeuroImage
Laura A Rice, Joseph Peters, JongHun Sung, Wendy D Bartlo, Jacob J Sosnoff
OBJECTIVE: To examine the circumstances surrounding the worst fall experienced by full time manual wheelchair users in the past 12 months, the recovery process, and influence on community participation. DESIGN: Mixed-methods. Semi-structured interviews were conducted to understand the circumstances of the worst fall experienced and the recovery process. A quantitative fear of falling assessment and the Community Participation Indicators (CPI) were used to further evaluate the influence of the fall...
February 13, 2019: American Journal of Physical Medicine & Rehabilitation
Marine Perrier, Louise Castain, Leslie Regad, Eve Todesco, Roland Landman, Benoit Visseaux, Yazdan Yazdanpanah, Christophe Rodriguez, Véronique Joly, Vincent Calvez, Anne-Geneviève Marcelin, Diane Descamps, Charlotte Charpentier
OBJECTIVES: To assess, at ART initiation, the impact of baseline substitutions in protease, Gag and gp41 regions on the virological response to a first-line PI-based regimen. PATIENTS AND METHODS: One hundred and fifty-four HIV-infected ART-naive patients initiating a PI-based regimen including darunavir (n = 129) or atazanavir (n = 25) were assessed, including 36 experiencing virological failure (VF). Whole pol, gag and gp41 genes were sequenced at ART baseline by ultra-deep sequencing (UDS) using Illumina® technology...
February 14, 2019: Journal of Antimicrobial Chemotherapy
Yue-Peng Cao, Jing-Ya Sun, Mei-Qian Li, Yu Dong, Yuan-Heng Zhang, Jun Yan, Rui-Min Huang, Xiang Yan
Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone modifiers are often dysregulated in cancer development, thus they can serve as an excellent drug targets for cancer therapy. Here, we investigated whether G9a, one of the histone H3 methyltransferases, was associated with UBC development. We first analyzed clinical data from public databases and found that G9a was significantly overexpressed in UBC patients...
February 14, 2019: Acta Pharmacologica Sinica
Dana Toloman, Ovidiu Pana, Maria Stefan, Adriana Popa, Cristian Leostean, Sergiu Macavei, Dan Silipas, Ioana Perhaita, Mihaela Diana Lazar, Lucian Barbu-Tudoran
Interface modified SnO2 -TiO2 composite nanoparticles were produced in two stages: first SnO2 nanoparticles were prepared by chemical precipitation in the presence of polyvinylpyrrolidone (PVP) and thermally treated at 500 °C then TiO2 was deposited on top of modified SnO2 and followed by a final annealing. As a consequence SnO2 -TiO2 composite nanoparticles get crystallized while PVP is decomposed into monomer units and other attached smaller molecular fragments. TGA coupled with FT-IR spectroscopy confirmed the presence of monomers and other moieties as a result of PVP thermal fragmentation...
February 7, 2019: Journal of Colloid and Interface Science
Clare E Holley, Carolynne Mason
PURPOSE OF REVIEW: To synthesise the research which has sought to evaluate interventions aiming to tackle children's food insecurity and the contribution of this research to evidencing the effectiveness of such interventions. RECENT FINDINGS: The majority of studies in this review were quantitative, non-randomised studies, including cohort studies. Issues with non-complete outcome data, measurement of duration of participation in interventions, and accounting for confounds are common in these evaluation studies...
February 14, 2019: Current Nutrition Reports
Muzaffer A Bhat, Jai B Sharma, Kallol K Roy, Jayasree Sengupta, Debabrata Ghosh
BACKGROUND: Previous studies, which were primarily based on the fluorescent in-situ hybridisation (FISH) technique, revealed conflicting evidence regarding male foetal microchimerism in endometriosis. FISH is a relatively less sensitive technique, as it is performed on a small portion of the sample. Additionally, the probes used in the previous studies specifically detected centromeric and telomeric regions of Y chromosome, which are gene-sparse heterochromatised regions. In the present study, a panel of molecular biology tools such as qPCR, expression microarray, RNA-seq and qRT-PCR were employed to examine the Y chromosome microchimerism in the endometrium using secretory phase samples from fertile and infertile patients with severe (stage IV) ovarian endometriosis (OE) and without endometriosis...
February 13, 2019: Reproductive Biology and Endocrinology: RB&E
Roberta Senger, Michelle Dornelles Santarem, Sílvia Goldmeier
OBJECTIVES: To create and implement a computerized clinical registry to verify in the short-, medium- and long-term the mortality and the incidence of significant surgical outcomes in adult patients submitted to cardiovascular surgeries. METHODS: This is a prospective, observational registry-based study aimed at documenting the characteristics of patients undergoing cardiovascular surgery. RESULTS: Variables were standardized according to international references from the Society of Thoracic Surgeons (STS), American College of Cardiology (ACC), Michigan Society of Thoracic and Cardiovascular Surgeons (MSTCVS) and the Department of Informatics of SUS (DATASUS)...
January 2019: Revista da Associação Médica Brasileira
Miina Ojansivu, Ahmad Rashad, Astrid Elisabet Ahlinder, Jonathan Massera, Ayush Mishra, Kristin Syverud, Anna Finne-Wistrand, Susanna Miettinen, Kamal Mustafa
A challenge in the extrusion-based bioprinting is to find a bioink with optimal biological and physicochemical properties. The aim of this study was to evaluate the influence of wood-based cellulose nanofibrils (CNF) and bioactive glass on the rheological properties of gelatin-alginate bioinks and the initial responses of bone cells embedded in these inks. CNF modulated the flow behavior of the hydrogels, thus improving their printability. Chemical characterization by SEM-EDX and ion release analysis confirmed the reactivity of the BaG in the hydrogels...
February 12, 2019: Biofabrication
C E Rupprecht, H Bannazadeh Baghi, V J Del Rio Vilas, A D Gibson, F Lohr, F X Meslin, J F R Seetahal, K Shervell, L Gamble
Rabies is one of the oldest recorded pathogens, with the broadest distribution of any known viral zoonosis. Antarctica is believed to be free of all lyssaviruses, but no laboratory-based surveillance has taken place to support this supposition. Re-introduction of the disease is possible in Pacific Oceania, as evidenced by a historical outbreak in Guam and the translocation of rabid bats to Hawaii. Australia is the only inhabited continent with enzootic rabies, without the presence of rabies virus. Europe and North America have broken the cycle of dog-mediated rabies, with a few remaining focal points in Latin America and the Caribbean, but wildlife rabies predominates...
August 2018: Revue Scientifique et Technique
Imène Reghioua, Mattia Fanetti, Sylvain Girard, Diego Di Francesca, Simonpietro Agnello, Layla Martin-Samos, Marco Cannas, Matjaz Valant, Melanie Raine, Marc Gaillardin, Nicolas Richard, Philippe Paillet, Aziz Boukenter, Youcef Ouerdane, Antonino Alessi
We report an experimental study demonstrating the feasibility to produce both pure and Ge-doped silica nanoparticles (size ranging from tens up to hundreds of nanometers) using nanosecond pulsed KrF laser ablation of bulk glass. In particular, pure silica nanoparticles were produced using a laser pulse energy of 400 mJ on pure silica, whereas Ge-doped nanoparticles were obtained using 33 and 165 mJ per pulse on germanosilicate glass. The difference in the required energy is attributed to the Ge doping, which modifies the optical properties of the silica by facilitating energy absorption processes such as multiphoton absorption or by introducing absorbing point defects...
2019: Beilstein Journal of Nanotechnology
Matthew Buckthorpe, Giovanni La Rosa, Francesco Della Villa
One of the main priorities of rehabilitation after anterior cruciate ligament reconstruction (ACLR) surgery is the restoration of knee extensor muscle strength. Residual deficits in knee extensor muscle size and strength after injury are linked to poor biomechanics, reduced knee function, increased knee osteoarthritis risk, as well as heightened risk of re-injury upon return to sport. Most studies indicate that knee extensor muscle strength is typically not resolved prior to return to sport. This clinical commentary discusses strategies to optimize and accelerate the recovery of knee extensor strength post-surgery, with the purpose to support the clinician with evidence-based strategies to implement into clinical practice...
February 2019: International Journal of Sports Physical Therapy
Davide Pacifico, Paolo Margaria, Luciana Galetto, Mauro Legovich, Simona Abbà, Flavio Veratti, Cristina Marzachì, Sabrina Palmano
The biological bases of recovery of two grapevine cultivars, Nebbiolo and Barbera, showing different susceptibility and recovery ability to "flavescence dorée" (FD) phytoplasma infection were investigated. The expression over one vegetative season, in FD-recovered and healthy grapevines, of 18 genes involved in defence, hydrogen peroxide and hormone production was verified at two time points. Difference (Δ) between the relative expressions of August and July were calculated for each target gene of both cultivars...
March 2019: Microbiological Research
Washim Hossain, Chandana Sen, Chittaranjan Sinha, Uttam K Sarkar
Raman and SER spectra of 1-H-2 (tolylazo) imidazole (Tai H) are reported for the first time. Monomolecular layer of TaiH is formed on silver nano particles (SNPs) at a concentration of 4.93×10-6 M in Ag-sol. TaiH molecules are adsorbed on to SNPs the through the imidazole N atom and undergo trans -to- cis dark isomerization as evidenced by the appearance of signature cis -peaks and the UV-Vis absorption spectra. Stable non-aggregated SNPs are resulted by the interaction of TaiH and the particle size is significantly reduced...
June 1, 2019: Journal of Nanoscience and Nanotechnology
Janet E Squires, Ian D Graham, Doris Grinspun, John Lavis, France Légaré, Robert Bell, Stephen Bornstein, Susan E Brien, Mark Dobrow, Megan Greenough, Carole A Estabrooks, Michael Hillmer, Tanya Horsley, Alan Katz, Christina Krause, Wendy Levinson, Adrian Levy, Michelina Mancuso, Alies Maybee, Steve Morgan, Letitia Nadalin Penno, Andrew Neuner, Tamara Rader, Janet Roberts, Gary Teare, Joshua Tepper, Amanda Vandyk, Denise Widmeyer, Michael Wilson, Jeremy M Grimshaw
BACKGROUND: There is increasing recognition in Canada and globally that a substantial proportion of health care delivered is inappropriate as evidenced by (1) harmful and/or ineffective practices being overused, (2) effective clinical practices being underused, and (3) other clinical practices being misused. Inappropriate health care leads to negative patient experiences, poor health outcomes, and inefficient use of scarce health care resources. The purpose of this study is to conduct a systematic review of inappropriate health care in Canada...
February 11, 2019: Systematic Reviews
Ece Bayram, Brent Bluett, Xiaowei Zhuang, Dietmar Cordes, Denise R LaBelle, Sarah J Banks
OBJECTIVE: Cognitive decline is common in Parkinson's disease (PD), but changes can occur in a variety of cognitive domains. The lack of a single cognitive phenotype complicates diagnosis and tracking. In an earlier study we used a data-driven approach to identify distinct cognitive phenotypes of early PD. Here we identify the morphometric brain differences between those different phenotypes compared with cognitively normal PD participants. METHODS: Six different cognitive classes were included (Weak, Typical, Weak-Visuospatial/Strong-Memory, Weak-Visuospatial, Amnestic, Strong)...
February 7, 2019: Journal of the Neurological Sciences
Marco Mariotti, Gustavo Salinas, Toni Gabaldón, Vadim N Gladyshev
Selenoproteins are a diverse group of proteins containing selenocysteine (Sec)-the twenty-first amino acid-incorporated during translation via a unique recoding mechanism1,2 . Selenoproteins fulfil essential roles in many organisms1 , yet are not ubiquitous across the tree of life3-7 . In particular, fungi were deemed devoid of selenoproteins4,5,8 . However, we show here that Sec is utilized by nine species belonging to diverse early-branching fungal phyla, as evidenced by the genomic presence of both Sec machinery and selenoproteins...
February 11, 2019: Nature Microbiology
Diana S Vargas-Bermudez, Fabricio S Campos, Laura Bonil, Darío Mogollon, Jairo Jaime
Porcine circovirus 3 (PCV3) was recently discovered and is a new species of the genus circovirus. Clinically, it is associated with absence of symptoms or with different clinical syndromes. It has been reported in different countries of America, Europe and Asia. Last year, in Colombia, some farms have reported symptoms similar to those caused by PCV2. Samples were taken from two farms located in the centre of the country, and the presence of PCV3 was determined by PCR in two samples, one from a pool of sera and another from mesenteric lymph node...
February 11, 2019: Veterinary Medicine and Science
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