Allan Kengo, Firdaus Nabeemeeah, Paolo Denti, Ryan Sabet, Gifty Okyere-Manu, Pattamukkil Abraham, Lubbe Weisner, Modiehi Helen Mosala, Sibongile Tshabalala, Janine Scholefield, Juan Eduardo Resendiz-Galvan, Neil A Martinson, Ebrahim Variava
Clofazimine is included in drug regimens to treat rifampicin/drug-resistant tuberculosis (DR-TB), but there is little information about its interaction with other drugs in DR-TB regimens. We evaluated the pharmacokinetic interaction between clofazimine and isoniazid, linezolid, levofloxacin, and cycloserine, dosed as terizidone. Newly diagnosed adults with DR-TB at Klerksdorp/Tshepong Hospital, South Africa, were started on the then-standard treatment with clofazimine temporarily excluded for the initial 2 weeks...
April 10, 2024: Antimicrobial Agents and Chemotherapy