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JOURNAL ARTICLE
Juan Carlos Núñez-Enríquez, Rubí Romo-Rodríguez, Pedro Gaspar-Mendoza, Gabriela Zamora-Herrera, Lizeth Torres-Pineda, Jiovanni Amador-Cardoso, Jebea A López-Blanco, Laura Alfaro-Hernández, Lucero López-García, Arely Rosas-Cruz, Dulce Rosario Alberto-Aguilar, César Omar Trejo-Pichardo, Dalia Ramírez-Ramírez, Astin Cruz-Maza, Janet Flores-Lujano, Nuria Luna-Silva, Angélica Martínez-Martell, Karina Martínez-Jose, Anabel Ramírez-Ramírez, Juan Carlos Solis-Poblano, Patricia Zagoya-Martínez, Vanessa Terán-Cerqueda, Andrea Huerta-Moreno, Álvaro Montiel-Jarquín, Miguel Garrido-Hernández, Raquel Hernández-Ramos, Daniela Olvera-Caraza, Cynthia Shanat Cruz-Medina, Enoch Alvarez-Rodríguez, Lénica Anahí Chávez-Aguilar, Wilfrido Herrera-Olivares, Brianda García-Hidalgo, Lena Sarahí Cano-Cuapio, Claudia Guevara-Espejel, Gerardo Juárez-Avendaño, Juan Carlos Balandrán, Ma Del Rocío Baños-Lara, Mariana Cárdenas-González, Elena R Álvarez-Buylla, Sonia Mayra Pérez-Tapia, Diana Casique-Aguirre, Rosana Pelayo
The main objective of the National Project for Research and Incidence of Childhood Leukemias is to reduce early mortality rates for these neoplasms in the vulnerable regions of Mexico. This project was conducted in the states of Oaxaca, Puebla, and Tlaxcala. A key strategy of the project is the implementation of an effective roadmap to ensure that leukemia patients are the target of maximum benefit of interdisciplinary collaboration between researchers, clinicians, surveyors, and laboratories. This strategy guarantees the comprehensive management of diagnosis and follow-up samples of pediatric patients with leukemia, centralizing, managing, and analyzing the information collected...
2024: Frontiers in Oncology
#2
JOURNAL ARTICLE
Kathrine Jáuregui-Renaud, Dulce Maria García-Jacuinde, Simón Pedro Bárcenas-Olvera, Michael A Gresty, Aralia Gutiérrez-Márquez
In subjects with peripheral vestibular disease and controls, we assessed: 1. The relationship between spatial anxiety and perceived stress, and 2. The combined contribution of spatial anxiety, spatial perspective-taking, and individual cofactors to dizziness-related handicap. 309 adults participated in the study (153 with and 156 without peripheral vestibular disease), including patients with bilateral vestibular deficiency, unilateral deficiency (evolution <3 or ≥3 months), Meniere's disease, and Benign Paroxysmal Positional Vertigo...
2024: Frontiers in Neurology
#3
JOURNAL ARTICLE
Dulce C Guzmán-Ocampo, Rodrigo Aguayo-Ortiz, Laura Dominguez
Allosteric modulation plays a critical role in enzyme functionality and requires a deep understanding of the interactions between the active and allosteric sites. γ-Secretase (GS) is a key therapeutic target in the treatment of Alzheimer's disease (AD), through its role in the synthesis of amyloid β peptides that accumulate in AD patients. This study explores the structure and dynamic effects of GS modulation by E2012 binding, employing well-tempered metadynamics and conventional molecular dynamics simulations across three binding scenarios: (1) GS enzyme with and without L458 inhibitor, (2) the GS-substrate complex together with the modulator E2012 in two different binding modes, and (3) E2012 interacting with a C99 substrate fragment...
April 16, 2024: Journal of Chemical Information and Modeling
#4
JOURNAL ARTICLE
Osama Sawalha, Patrocinio Ariza-Vega, Fadwa Alhalaiqa, Sonia Pérez-Rodríguez, Dulce Romero-Ayuso
Background/Objetives : Cardiovascular disease (CVD) remains a significant contributor to global morbidity and mortality rates. Coronary artery bypass graft (CABG) surgery is a critical intervention for patients with coronary artery disease, yet it poses psychological challenges that can impact recovery. Methods : This prospective cohort study, conducted across six hospitals in the West Bank/Palestine, aimed to assess changes in depression, anxiety, and stress levels among CABG patients and identify associated factors...
March 30, 2024: Journal of Clinical Medicine
#5
JOURNAL ARTICLE
Lucas Cabrera Monteiro, Ludgero Cardoso Galli Vieira, José Vicente Elias Bernardi, Maria Cristina Nery do Nascimento Recktenvald, Adriely Ferreira da Costa Nery, Iara Oliveira Fernandes, Vinicius Lima de Miranda, Dulce Maria Sucena da Rocha, Ronaldo de Almeida, Wanderley Rodrigues Bastos
Litterfall is the main source of dry deposition of mercury (Hg) into the soil in forest ecosystems. The accumulation of Hg in soil and litter suggests the possibility of transfer to terrestrial vertebrates through environmental exposure or ingestion of plant tissues. We quantified total mercury (THg) concentrations in two soil layers (organic: 0 - 0.2 m; mineral: 0.8 - 1 m), litter, fresh leaves, and terrestrial invertebrates of the Araguaia River floodplain, aiming to evaluate the THg distribution among terrestrial compartments, bioaccumulation in invertebrates, and the factors influencing THg concentrations in soil and invertebrates...
April 10, 2024: Environmental Research
#6
JOURNAL ARTICLE
Laura Edith Martínez-Gómez, Carlos Martinez-Armenta, Teresa Tusie-Luna, Paola Vázquez-Cárdenas, Rosa P Vidal-Vázquez, Juan P Ramírez-Hinojosa, Diana Gómez-Martín, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, José Manuel Fragoso, Aurora de la Peña, José Manuel Rodríguez-Pérez, Mónica M Mata-Miranda, Gustavo J Vázquez-Zapién, Adriana Martínez-Cuazitl, Felipe de J Martínez-Ruiz, Dulce M Zayago-Angeles, Luis Ramos-Tavera, Alberto Méndez-Aguilera, María Del C Camacho-Rea, María L Ordoñez-Sánchez, Yayoi Segura-Kato, Carlos Suarez-Ahedo, Jessel Olea-Torres, Brígida Herrera-López, Carlos Pineda, Gabriela A Martínez-Nava, Alberto López-Reyes
INTRODUCTION: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 ( TMPRSS2 ) and serpine family E member 1 ( SERPINE1 ) could help to elucidate the contribution of variability to COVID-19 outcomes. METHODS: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled...
2024: Frontiers in Immunology
#7
JOURNAL ARTICLE
Joaquin A Nuñez, Sebastián Aguiar, Esteban G Jobbágy, Yohana G Jiménez, Pablo Baldassini
The demand for mountain water resources is increasing, and their availability is threatened by climate change, emphasizing the urgency for effective protection and management. The upper Sali-Dulce watershed holds vital significance as it contributes the majority of the Sali-Dulce water resources, supporting a densely populated dry region in Northwestern Argentina, covering an area of 24,217 km2 . However, the potential impact of climate change and land use/land cover change on water yield in this watershed remains uncertain...
April 8, 2024: Journal of Environmental Management
#8
JOURNAL ARTICLE
Ewelina Malanowska-Jarema, Andrzej Starczewski, Mariia Melnyk, Dulce Oliveira, Matteo Balzarro, Emanuel Rubillota
BACKGROUND: Laparoscopic sacrocolpopexy (LSC) is the gold standard for the treatment of apical prolapse, although dissection of the promontory may be challenging. Laparoscopic lateral suspension (LLS) with mesh is an alternative technique for apical repair with similar anatomical and functional outcomes, according to recent studies. The purpose of this study was to compare these operative techniques. METHODS: Women with uterine Pelvic Organ Prolapse Quantification (POP-Q) stage 2 were enrolled in this prospective study and were randomly allocated to the LLS or LSC group...
February 27, 2024: Journal of Clinical Medicine
#9
JOURNAL ARTICLE
Minerva Arce-Fonseca, Dulce Mata-Espinosa, Alberto Aranda-Fraustro, José Luis Rosales-Encina, Mario Alberto Flores-Valdez, Olivia Rodríguez-Morales
INTRODUCTION: There is currently no vaccine against Chagas disease (ChD), and the medications available confer multiple side effects. Mycobacterium bovis Bacillus Calmette-Guérin (BCG) produces balanced Th1, Th2, and Th17 modulatory immune responses and has improved efficacy in controlling chronic infections through nonspecific immunity. We aimed to improve the response to infection by inducing a stronger immune response and greater protection against the parasite by trained immunity...
2024: Frontiers in Immunology
#10
JOURNAL ARTICLE
Ailton S S Júnior, Felipe J Aidar, Luiz A S Silva, Thais de B Silva, Sara F M de Almeida, Daiane C S Teles, Waldecy de L Junior, Dulce M Schimieguel, Daniel A de Souza, Ana C S Nascimento, Enilton A Camargo, Jymmys L Dos Santos, Ana M de O E Silva, Rogéria de S Nunes, Lysandro P Borges, Ana A M Lira
(1) Background: Species of the genus Cymbopogon and its essential oil are known for their antioxidant and hypoglycemic effects. This study aimed to investigate the impact of the essential oil of Cymbopogon flexuosus (EOCF), and its major component, citral, on glycemic, lipid, antioxidant parameters, and oxidative stress in a type 1 diabetes (DM1) rat model. (2) Methods: Initially, EOCF was analyzed by Gas chromatography-mass spectrometry (GC-MS) and the antioxidant activity of EOCF and citral was evaluated...
March 4, 2024: Life
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JOURNAL ARTICLE
Dulce Concepción Domínguez-Cruz, Doireyner Daniel Velázquez-Ramírez, Zendy Evelyn Olivo-Vidal, José Antonio De Fuentes-Vicente, Héctor Ochoa-Díaz-López
BACKGROUND: Chagas disease, a zoonosis transmitted mainly by hematophagous insects of the subfamily Triatominae, is caused by Trypanosoma cruzi, classified into six discrete typing units (DTUs: TcI-TcVI and Tcbat). METHODS: Insect vectors were collected from 84 human dwellings in the municipality of Santo Domingo Tehuantepec, Oaxaca, Mexico; 4.76% were infested. DTUs were determined using conventional and nested PCR. RESULTS: The infection rate was 43...
2024: Revista da Sociedade Brasileira de Medicina Tropical
#12
JOURNAL ARTICLE
Dulce Jocelyn Bustamante-Valdez, Martin Alejandro Fuentes-Cano, Jesus Salvador Gonzalez-Ruano, Alonso Martinez-Canabal, Rene Cardenas-Vazquez, Pilar Duran
Maternal malnutrition plays a crucial role in functional development, resulting in behavioral, cognitive, and metabolic abnormalities and disturbances. "Cafeteria diet" has been linked to obesity, metabolic syndrome, diabetes, and other metabolic disruptions in the mammalian lifespan. However, there are very few reports about the effect of intrauterine and early postnatal malnutrition on the circadian rhythm programming of energy metabolites. In mammals, circadian rhythm central control is fundamental for correct interaction with the environment and physiological regulation...
2024: PloS One
#13
JOURNAL ARTICLE
Pedro A Pereira, Marta Tavares, Miguel Laires, Bárbara Mota, Maria Dulce Madeira, Manuel M Paula-Barbosa, Armando Cardoso
The basolateral amygdala (BLA) contains interneurons that express neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), both of which are involved in the regulation of functions and behaviors that undergo deterioration with aging. There is considerable evidence that, in some brain areas, the expression of NPY and VIP might be modulated by acetylcholine. Importantly, the BLA is one of the brain regions that has one of the densest cholinergic innervations, which arise mainly from the basal forebrain cholinergic neurons...
February 28, 2024: Biology
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JOURNAL ARTICLE
Leander van Eekelen, Joey Spronck, Monika Looijen-Salamon, Shoko Vos, Enrico Munari, Ilaria Girolami, Albino Eccher, Balazs Acs, Ceren Boyaci, Gabriel Silva de Souza, Muradije Demirel-Andishmand, Luca Dulce Meesters, Daan Zegers, Lieke van der Woude, Willemijn Theelen, Michel van den Heuvel, Katrien Grünberg, Bram van Ginneken, Jeroen van der Laak, Francesco Ciompi
Programmed death-ligand 1 (PD-L1) expression is currently used in the clinic to assess eligibility for immune-checkpoint inhibitors via the tumor proportion score (TPS), but its efficacy is limited by high interobserver variability. Multiple papers have presented systems for the automatic quantification of TPS, but none report on the task of determining cell-level PD-L1 expression and often reserve their evaluation to a single PD-L1 monoclonal antibody or clinical center. In this paper, we report on a deep learning algorithm for detecting PD-L1 negative and positive tumor cells at a cellular level and evaluate it on a cell-level reference standard established by six readers on a multi-centric, multi PD-L1 assay dataset...
March 26, 2024: Scientific Reports
#15
M Ángeles Sánchez Roldán, Héctor Duque, Bernat Masso, Dulce Moncho, Ramón Vilallonga, Manuel Armengol, Óscar González
The laryngeal adductor reflex (LAR) is a brainstem reflex that closes the vocal fold and constitutes a new method for continuously monitoring the vagus and laryngeal nerves during different surgeries. Previous reports concluded that topical lidocaine in spray inhibited LAR responses. However, topical anesthesia in the upper airway may be necessary in awake intubation. We present six patients who underwent neck endocrine surgery due to an intrathoracic goiter that compromised the airway. Before awake intubation, a nebulization of lidocaine 5% was applied for at least 10 min...
March 26, 2024: Laryngoscope
#16
JOURNAL ARTICLE
Felipe González-Alvarez, Bruno Estañol, Jesús Antonio González-Hermosillo, Francisco Javier Gómez-Pérez, Karla Maria Tamez-Torres, Eduardo Peña, Carlos Cantú, Erwin Chiquete, José Sifuentes-Osornio, Maria Del Carmen Alba-Lorenzo, Dulce Andrea Celestino-Montelongo, Guadalupe E Salazar-Calderón, Jose de Jesus Aceves Buendia
The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has emerged as a global public health concern and its sequels have barely started to outcrop. A good percentage of patients who suffered from COVID-19 are prone to develop long-COVID or post-COVID condition (PCC), a multisystemic, heterogeneous, chronic disorder. Patients with PCC may experience diverse manifestations, of which cardiovascular and neurological symptoms are among the most frequently reported...
March 11, 2024: Journal of Hypertension
#17
JOURNAL ARTICLE
Odilon Vieira Santos, Meiry Fernanda Pinto Okuno, Paula Hino, Mônica Taminato, Dulce Aparecida Barbosa, Hugo Fernandes
OBJECTIVES: to report an educational technology construction on nursing professionals' rights. METHODS: an experience report on educational technology construction during the crediting of university extension hours in an undergraduate nursing course at a Brazilian public university, between March and June 2023. The Deming cycle was used as a procedural method. RESULTS: four meetings were held between students and extension workers. Eight comic books were produced based on the Code of Ethics for Nurses, addressing professional autonomy, fair remuneration, risk-free work, denial of exposure in the media and others...
2024: Revista Brasileira de Enfermagem
#18
JOURNAL ARTICLE
Dulce Rodríguez-Morales, Armando Aguirre-Jaimes, José G García-Franco
Florivores consume floral structures with negative effects on plant fitness and pollinator attraction. Several studies have evaluated these consequences in hermaphroditic plants, but little is known about the effects on monoecious and dioecious species. We characterize the florivory and its effects on floral visitors and reproductive success in a monoecious population of Sagittaria lancifolia . Five categories of florivory were established according to the petal area consumed. Visits were recorded in male and female flowers within the different damage categories...
February 17, 2024: Plants (Basel, Switzerland)
#19
REVIEW
Geórgia de Carvalho Braga, João Victor Coiado, Vitória Capelli de Melo, Brenno Bianchoni Loureiro, Margarete Dulce Bagatini
Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effects. Due to this scenario emerges the need to analyze other possible treatments against this disease, such as the effect of phenolic compounds. These substances have proven antitumor effects, but still have not been fully explored as a form of therapy to combat melanoma. Also, the purinergic receptors, along with its system molecules, take part in the formation of tumors from many pathways, such as the actions of ectoenzymes and receptors activity, especially P2Rs family, and are formed by structures that can be modulated by the phenolic compounds...
March 18, 2024: Purinergic Signalling
#20
JOURNAL ARTICLE
Adriana Angelina Siller-Ceniceros, Dulce Carolina Almonte-Flores, M Esther Sánchez-Castro, Eduardo Martínez-Guerra, Javier Rodríguez-Varela, Nora Aleyda García Gómez, José Rubén Morones-Ramírez
As the global urgency for effective antimicrobial agents intensifies, this work harnesses the widely demonstrated antimicrobial activity of silver nanoparticles (Ag-NPs) and proposes alternative synthesis approaches to metal-organic hybrid systems with antimicrobial activity. In this study, the proposed synthesis route involves decorating metallic nanoparticles into organic substrates without previous doping. The synthesis simultaneously uses polyethylene glycol for three crucial purposes: (1) acting as a mild reducing agent to generate Ag-NPs with a spherical shape and diameters ranging from 10 to just over 20 nm, (2) functioning as a dispersing agent for flakes of commercial nanostructured carbon supports, including reduced graphene oxide (rGO, ID-nano), and commercial carbon nanoplatelets from Sigma-Aldrich (GNPs, Sigma-Aldrich), and (3) serving as a promoter for the homogeneous anchoring of Ag-NPs in the carbon lattice without altering the conformation of the carbon lattice...
March 12, 2024: ACS Omega
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