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Amanda Mara Teles, Taynan Dulce da Silva Rosa, Adenilde Nascimento Mouchrek, Ana Lucia Abreu-Silva, Kátia da Silva Calabrese, Fernando Almeida-Souza
The resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of Cinnamomum zeylanicum , Origanum vulgare , and Curcuma longa essential oils. Chemical analysis was performed by gas chromatography-mass spectrometry...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Dulce Bento, Sandra Jesus, Filipa Lebre, Teresa Gonçalves, Olga Borges
Current vaccine research is mostly based on subunit antigens. Despite the better toxicity profile of these antigens they are often poorly immunogenic, so adjuvant association has been explored as a strategy to obtain a potent vaccine formulation. Recently, mast cell activators were recognized as a new class of vaccine adjuvants capable of potentiating mucosal and systemic immune responses. In this study, a co-adjuvanted delivery system was developed and characterized, combining the mast cell activator C48/80 with chitosan nanoparticles (Chi-C48/80 NPs), and the results were compared with plain chitosan nanoparticles...
February 9, 2019: Pharmaceutics
Ruqaiah Altassan, Romain Péanne, Jaak Jaeken, Rita Barone, Muad Bidet, Delphine Borgel, Sandra Brasil, David Cassiman, Anna Cechova, David Coman, Javier Corral, Joana Correia, María Eugenia de la Morena-Barrio, Pascale de Lonlay, Vanessa Dos Reis, Carlos R Ferreira, Agata Fiumara, Rita Francisco, Hudson Freeze, Simone Funke, Thatjana Gardeitchik, Matthijs Gert, Muriel Girad, Marisa Giros, Stephanie Grünewald, Trinidad Hernández-Caselles, Tomas Honzik, Marlen Hutter, Donna Krasnewich, Christina Lam, Joy Lee, Dirk Lefeber, Dorinda Marques-de-Silva, Antonio F Martinez, Hossein Moravej, Katrin Õunap, Carlota Pascoal, Tiffany Pascreau, Marc Patterson, Dulce Quelhas, Kimiyo Raymond, Peymaneh Sarkhail, Manuel Schiff, Małgorzata Seroczyńska, Mercedes Serrano, Nathalie Seta, Jolanta Sykut-Cegielska, Christian Thiel, Federic Tort, Mari-Anne Vals, Paula Videira, Peter Witters, Renate Zeevaert, Eva Morava
Phosphomannomutase 2 (PMM2-CDG) is the most common congenital disorder of N-glycosylation and is caused by a deficient PMM2 activity. The clinical presentation and the onset of PMM2-CDG vary among affected individuals ranging from a severe antenatal presentation with multisystem involvement to mild adulthood presentation limited to minor neurological involvement. Management of affected patients requires a multidisciplinary approach. In this article, a systematic review of the literature on PMM2-CDG was conducted by a group of international experts in different aspects of CDG...
January 2019: Journal of Inherited Metabolic Disease
Rosa Marques, Maria Isabel Prudêncio, Maria Manuela Abreu, Dulce Russo, José G Marques, Fernando Rocha
Climate and rich volcanic soils of Fogo Island (Cape Verde) are optimal conditions for grape agriculture. This study aims a first evaluation of the bioaccumulation of essential and non-essential elements in different parts of vines of the same variety (Vitis vinifera L.), grown on recent pyroclasts and lahar deposits. Chemical composition was obtained by instrumental neutron activation analysis. A general decrease of the chemical contents occurs in the following order: barks, leaves, and grapes. Lower chemical contents were found in the grapes cultivated on the lahar deposit, except for barium...
February 5, 2019: Environmental Monitoring and Assessment
Ana Isabel Vieira, Adriana Guerreiro, Maria Dulce Antunes, Maria da Graça Miguel, Maria Leonor Faleiro
Edible coatings supplemented with essential oil components have been investigated to control spoilage microorganisms. In this study, the survival of Listeria monocytogenes and Salmonella enterica serovar Typhimurium on apples treated with edible coatings based on sodium alginate (2%) (ECs) and supplemented with essential oil components, namely eugenol (Eug) at 0.2% or in combination with 0.1% (v/v) of Eug and citral (Cit) at 0.15% was determined. Both bacterial pathogens were exposed on apples treated with ECs supplemented with Eug or Eug + Cit and challenged with gastrointestinal fluids and their survival was examined...
February 4, 2019: Foods (Basel, Switzerland)
Luana Paula Pelinson, Charles Elias Assmann, Taís Vidal Palma, Ivana Beatrice Mânica da Cruz, Micheli Mainardi Pillat, Aline Mânica, Naiara Stefanello, Grazielle Castagna Cezimbra Weis, Audrei de Oliveira Alves, Cinthia Melazzo de Andrade, Henning Ulrich, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger, Margarete Dulce Bagatini
Cutaneous melanoma (CM) is an extremely aggressive cancer presenting low survival and high mortality. The vast majority of patients affected by this disease does not respond or show resistance to the chemotherapeutic drugs, which makes the treatment ineffective. In this sense, the necessity for the development of new agents to assist in CM therapy is extremely important. One of the sources of great interest in this search are compounds of natural origin. Among these compounds, caffeic acid has demonstrated a broad spectrum of pharmacological activities as well as antitumor effects in some types of cancer...
February 4, 2019: Molecular Biology Reports
Priscila Tomie Leme Ike, Willian Garcia Birolli, Danilo Martins Dos Santos, André Luiz Meleiro Porto, Dulce Helena Ferreira Souza
Laccases produced by Leucoagaricus gongylophorus act in lignocellulose degradation and detoxification processes. Therefore, the use of L. gongylophorus laccase (Lac1Lg) was proposed in this work for degradation of anthracene and others polycyclic aromatic hydrocarbons without the use of mediators. Degradation reactions were performed in buffer aqueous solution with 10 ppm of anthracene and other PAHs, Tween-20 in 0.25% v/v and a laccase preparation of 50 U. The optimum condition (pH 6.0 and 30 °C) was determined by response surface methodology with an excellent coefficient of determination (R2 ) of 0...
February 1, 2019: Environmental Science and Pollution Research International
Ana Belén Jiménez Muñoz, Belén Martínez Mondéjar, Antonio Muiño Miguez, Dulce Romero Ayuso, Gema Maria Saiz Ladera, Juan José Criado Álvarez
OBJECTIVE: Most studies of medication errors are focused only on finding global prevalence by patients, by phases or according to a certain group of medication. It's just a partial view of the problem. To analyze and compare the prevalence of errors in prescription, transcription and administration, and their clinical repercussions in different pharmacological groups in a third-level hospital. METHODS: Prospective inclusion study with direct observation disguised as medication administration and comparison with prescriptions and transcriptions at history clinical...
January 31, 2019: Revista Española de Salud Pública
Diogo A Fonseca, Mónica Ferreira, Maria Graça Campos, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim
Oxalis pes-caprae L. is a plant of the Oxalidaceae family, from which several compounds have been previously identified. Recently, we showed that an Oxalis pes-caprae L. extract inhibits the vasopressor effect of noradrenaline. In this work we aimed to explore the mechanisms involved in this effect. The results confirmed that the flavonoid fraction present in the extract inhibits noradrenaline-induced contractions and that this effect is concentration-dependent. Also, a parallel shift to the right in the noradrenaline concentration-response curve was observed, suggesting a decrease in efficacy and also in potency...
January 30, 2019: Natural Product Research
Donald Maciver, Marion Rutherford, Stella Arakelyan, Jessica M Kramer, Janet Richmond, Liliya Todorova, Dulce Romero-Ayuso, Hiromi Nakamura-Thomas, Marjon Ten Velden, Ian Finlayson, Anne O'Hare, Kirsty Forsyth
BACKGROUND: In order to make informed decisions about how best to support children and young people with disabilities, effective strategies that facilitate active and meaningful participation in school are required. Clinical factors, diagnosis or impairments somewhat helpful in determining what should be provided in interventions. However, clinical factors alone will not offer a clear view of how to support participation. It is helpful then to look at wider psychosocial and environmental factors...
2019: PloS One
Narayanan Narayanan, Getu Beyene, Raj Deepika Chauhan, Eliana Gaitán-Solís, Jackson Gehan, Paula Butts, Dimuth Siritunga, Ihuoma Okwuonu, Arthur Woll, Dulce M Jiménez-Aguilar, Erick Boy, Michael A Grusak, Paul Anderson, Nigel J Taylor
Less than 10% of the estimated average requirement (EAR) for iron and zinc is provided by consumption of storage roots of the staple crop cassava (Manihot esculenta Crantz) in West African human populations. We used genetic engineering to improve mineral micronutrient concentrations in cassava. Overexpression of the Arabidopsis thaliana vacuolar iron transporter VIT1 in cassava accumulated three- to seven-times-higher levels of iron in transgenic storage roots than nontransgenic controls in confined field trials in Puerto Rico...
January 28, 2019: Nature Biotechnology
Dulce Andrade-Pavón, Jossue Ortiz-Álvarez, Eugenia Sánchez-Sandoval, Joaquín Tamariz, César Hernández-Rodríguez, J Antonio Ibarra, Lourdes Villa-Tanaca
Due to increasing resistance of Candida species to antifungal drugs, especially azoles, new drugs are needed. The proposed compounds 3 and 4 are analogous to α-asarone (2), a naturally occurring potent inhibitor of HMGR with hypolipidemic and antifungal activity. We used the recombinant enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase of Candida glabrata (CgHMGR) as a model to test the effectiveness of the test compounds. Compounds 3 and 4 demonstrated inhibitory kinetics, having lower IC50 values (42...
January 25, 2019: Journal of Biotechnology
Gustavo Deza, Alvaro March-Rodríguez, Silvia Sánchez, Clara Ribas-Llauradó, Dulce Soto, Ramon M Pujol, Ramon Gimeno, Ana M Giménez-Arnau
BACKGROUND: The high-affinity IgE receptor (FcεRI) expression on effector cells has been poorly characterized in patients with chronic urticaria (CU) to date. OBJECTIVES: To investigate the FcεRI expression on blood basophils in a large cohort of CU patients and its potential relationship with relevant features of the disease. METHODS: Basophil FcεRI expression was measured by flow cytometry in 287 CU patients (192 with Chronic Spontaneous Urticaria and 95 with Chronic Inducible Urticaria) at their initial evaluation in our Department...
January 24, 2019: Journal of Allergy and Clinical Immunology in Practice
Diogo A Fonseca, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim
In this study, we aimed at performing a histomorphometric analysis of human left internal thoracic artery (ITA) samples as well as at correlating the histomorphometric findings with the clinical profile, including risk factors and medication. Distal segments of ITA were obtained from 54 patients undergoing coronary artery bypass grafting. Histological observation was performed in paraffin-embedded transverse sections of ITA through four staining protocols: hematoxylin-eosin, van Gieson, Masson's trichrome and von Kossa...
2019: PloS One
Cândida Fonseca, Dulce Brito, Jorge Ferreira, Fátima Franco, João Morais, José Silva Cardoso
Renin-angiotensin-aldosterone system (RAAS) inhibitors are a cornerstone in the treatment of heart failure with reduced ejection fraction (HFrEF). Sacubitril/valsartan modulates the neurohormonal axis by inhibiting both angiotensin receptors and neprilysin, and improves neurohormonal balance more than blocking the RAAS alone. The PARADIGM-HF trial validated this new treatment option for patients with HFrEF. Sacubitril/valsartan was also more effective than enalapril in slowing disease progression by decreasing the risk of worsening heart failure requiring hospitalization or emergency admission and the need for intensified therapy, heart failure devices or cardiac transplantation...
January 21, 2019: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
David N Perdigoto, Luís Tomé, Dulce Diogo, José Ferrão, Ricardo Martins, Pedro Oliveira, Guilherme Tralhão, Emanuel Furtado
Introduction: Acute liver failure is an uncommon condition associated with a high mortality. Most patients do not survive without liver transplantation. In the last decades, auxiliary liver transplantation has emerged as a therapeutic option. Clinical Case: The authors present two cases of acute liver failure that required liver transplantation. Given the patients' young age and the preserved macroscopic liver pattern evaluated in surgery, auxiliary liver transplantation was executed using different surgical approaches...
December 2018: GE Portuguese Journal of Gastroenterology
Ana Maria Ribeiro Dos Santos, Regina Dulce da Silva Nolêto, Rosalina Aparecida Partezani Rodrigues, Elaine Maria Leite Rangel Andrade, Elisiane Gomes Bonfim, Tatyanne Silva Rodrigues
OBJECTIVE: To analyze economic-financial and patrimonial cases of elder abuse, recorded in the specialized police station for security and protection of the elderly of a capital city in the northeast region of Brazil. METHOD: A cross-sectional study was carried out with data extracted from police reports and inquiries recorded in the abovementioned police station. Descriptive and inferential statistics were carried out by means of Pearson's chi-square test or Fisher's exact test, and multivariate logistic regression...
January 21, 2019: Revista da Escola de Enfermagem da U S P
Dana Goldner, Jennifer Vittorio, Dulce M Barrios, Jillian McGuire, Susan Brodlie, Jocelyn Brown, Steven Lobritto, Mercedes Martinez
Certain fractures in children are highly specific for child abuse. Metabolic bone disease frequently develops in patients with cholestatic liver disease (CLD); this can result in weakened bones and a predisposition to pathologic fractures. Fractures that occur in patients with rickets and osteopenia may mimic a bone response to inflicted injury, which in children raise the concern of child abuse. Here we report a series of 15 patients with CLD who developed pathologic fractures in the setting of metabolic bone disease...
January 21, 2019: Pediatric Emergency Care
Abril Jiménez-Cepeda, Giselle Dávila-Said, Arturo Orea-Tejeda, Dulce González-Islas, Marcela Elizondo-Montes, Guillermo Pérez-Cortes, Candace Keirns-Davies, Luis Felipe Castillo-Aguilar, Leslie Verdeja-Vendrell, Viridiana Peláez-Hernández, Rocío Nayelí Sánchez-Santillán
BACKGROUND & AIMS: The deterioration of pulmonary function has been associated with increased levels of systemic inflammation that can be stimulated by consumption of saturated fatty acids and trans fats. We hypothesized that fatty acids intake impact on pulmonary function. However, evidence about the impact of different types of fatty acids on pulmonary function in patients with chronic obstructive pulmonary disease (COPD) is limited and heterogeneous. The aim of this study was to evaluate the association between intake of fatty acids and pulmonary function in patients with COPD...
February 2019: Clinical Nutrition ESPEN
Diogo A Fonseca, Inês Amaral, Ana Catarina Pinto, Maria Dulce Cotrim
Biotechnology has provided powerful tools to assist in research and development (R&D) for rare diseases. However, orphan drug development presents several major challenges and obstacles, such as low disease prevalence, disease severity, small and heterogeneous patient populations, difficulties in patient recruitment, and limited knowledge of the natural history of disease, among others. Several strategies can be used to plan for and overcome these clinical and regulatory challenges, namely improved clinical trial design, improved patient recruitment, and closer collaboration with the regulatory authorities and with patient associations...
January 15, 2019: Drug Discovery Today
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