Daria V Babushok, Amy E DeZern, Carlos de Castro, Zora R Rogers, David Beenhouwer, Michael S Broder, Suzanne Fanning, Sarah N Gibbs, Rabi Hanna, Jaroslaw P Maciejewski, Bart L Scott, Srinivas K Tantravahi, Marcin W Wlodarski, Irina Yermilov, Bhumika J Patel
Severe aplastic anemia (SAA) is a rare hematologic condition for which there is no clear management algorithm. A panel of 11 adult and pediatric experts on aplastic anemia was assembled and, using the RAND/UCLA modified Delphi panel method, evaluated >600 varying patient care scenarios to develop clinical recommendations for the initial and subsequent management of patients of all ages with SAA. Here we present the panel's recommendations to rule out inherited bone marrow failure (IBMF) syndromes, on supportive care prior to and during first-line therapy, and on first-line (initial management) and second-line (subsequent management) therapy of acquired SAA, focusing on when transplant versus medical therapy is most appropriate...
April 26, 2024: Blood Advances