Wang-Da Liu, Jann-Tay Wang, Ming-Chieh Shih, Kai-Hsiang Chen, Szu-Ting Huang, Chun-Fu Huang, Tien-Hao Chang, Ming-Jui Tsai, Po-Hsien Kuo, Yi-Chen Yeh, Wan-Chen Tsai, Mei-Yan Pan, Guei-Chi Li, Yi-Jie Chen, Kuan-Yin Lin, Yu-Shan Huang, Aristine Cheng, Pao-Yu Chen, Sung-Ching Pan, Hsin-Yun Sun, Shih-Chi Ku, Sui-Yuan Chang, Wang-Huei Sheng, Chi-Tai Fang, Chien-Ching Hung, Yee-Chun Chen, Yi-Lwun Ho, Ming-Shiang Wu, Shan-Chwen Chang
BACKGROUND: The RECOVERY trial demonstrated that the use of dexamethasone is associated with a 36% lower 28-day mortality in hospitalized patients with COVID-19 on invasive mechanical ventilation. Nevertheless, the optimal timing to start dexamethasone remains uncertain. METHODS: We conducted a quasi-experimental study at National Taiwan University Hospital (Taipei, Taiwan) using propensity score matching to simulate a randomized controlled trial to receive or not to receive early dexamethasone (6 mg/day) during the first 7 days following the onset of symptoms...
February 17, 2024: Journal of Microbiology Immunology and Infection