Steffen E Künzel, Inga-Marie Pompös, Leonie T M Flesch, Dominik P Frentzel, Vitus A Knecht, Silvia Winkler, Sergej Skosyrski, Anne Rübsam, Felix Dreher, Norbert Kociok, Moritz Schütte, Alexandre Dubrac, Bodo Lange, Marie-Laure Yaspo, Hans Lehrach, Olaf Strauß, Antonia M Joussen, Oliver Zeitz
PURPOSE: We aimed to determine the impact of artificial sweeteners (AS), especially saccharin, on the progression and treatment efficacy of patients with neovascular age-related macular degeneration (nAMD) under anti-vascular endothelial growth factor (anti-VEGF-A) treatment. METHODS: In a cross-sectional study involving 46 patients with nAMD undergoing intravitreal anti-VEGF therapy, 6 AS metabolites were detected in peripheral blood using liquid chromatography - tandem mass spectrometry (LC-MS/MS)...
April 1, 2024: Investigative Ophthalmology & Visual Science