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https://read.qxmd.com/read/30753398/from-patient-specific-induced-pluripotent-stem-cells-to-clinical-translation-in-long-qt-syndrome-type-2
#1
Peter J Schwartz, Massimiliano Gnecchi, Federica Dagradi, Silvia Castelletti, Gianfranco Parati, Carla Spazzolini, Luca Sala, Lia Crotti
Aims: Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two LQT2 patients, we tested whether the commercial association Lumacaftor + Ivacaftor (LUM + IVA) could shorten the QTc in the same two patients. Methods and results: After hospital admission and 1 day of baseline recordings, half dose LUM + IVA was administered on Day 1, followed by full dose (LUM 800 mg + IVA 500 mg) for 7 days...
February 6, 2019: European Heart Journal
https://read.qxmd.com/read/30745493/dietary-inflammatory-index-positively-associated-with-high-sensitivity-c-reactive-protein-level-in-japanese-from-nippon-data2010
#2
Yunqing Yang, Atsushi Hozawa, Mana Kogure, Akira Narita, Takumi Hirata, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Toshiharu Ninomiya, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
BACKGROUND: It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, the Dietary Inflammatory Index (DII® ) was developed to assess the inflammatory potential of the overall diet. The DII has been reported as relevant to various diseases but has not been validated in Japanese. Thus in the present study, we analyzed the relationship between DII scores and high-sensitivity C-reactive protein (hs-CRP) levels in a Japanese population...
February 9, 2019: Journal of Epidemiology
https://read.qxmd.com/read/30739424/-vascular-endothelial-growth-factor-polylactide-polyethyleneglycol-polylactic-acid-copolymer-basic-fibroblast-growth-factor-mixed-microcapsules-in-promoting-angiogenic-differentiation-of-rat-bone-marrow-mesenchymal-stem-cells-in-vitro
#3
Shengli Zhao, Jie Yin, Qinghe Yu, Guowei Zhang, Shaoxiong Min
Objective: To observe the effect of vascular endothelial growth factor/polylactide-polyethyleneglycol-polylactic acid copolymer/basic fibroblast growth factor (VEGF/PELA/bFGF) mixed microcapsules in promoting the angiogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) in vitro . Methods: The BMSCs were isolated by the method of whole bone marrow adherent, and sub-cultured. The passage 3 BMSCs were identified by Wright-Giemsa staining and flow cytometry, and used for subsequent experiments...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/30738643/cycloxygenase-2-inhibition-potentiates-trans-differentiation-of-wharton-s-jelly-mesenchymal-stromal-cells-into-endothelial-cells-transplantation-enhances-neovascularization-mediated-wound-repair
#4
Komal Kaushik, Amitava Das
BACKGROUND: Neo-vascularization, an indispensible phenomenon for tissue regeneration, facilitates repair and remodeling of wound tissues. This process is impaired in chronic wounds due to reduced number and recruitment of endothelial cells (ECs), thereby necessitating development of newer strategies to enhance the EC repertoire as a therapeutic approach. METHODS: We explored the 'plasticity' of Wharton's jelly derived-mesenchymal stromal cells (WJ-MSCs) using an anti-inflammatory drug-mediated enhanced trans-differentiation into ECs, based on our observation of temporal decrease in COX-2 expression during trans-differentiation of MSCs into ECs at day 7 and 14 along with mature ECs...
February 6, 2019: Cytotherapy
https://read.qxmd.com/read/30737049/the-inflammatory-potential-of-diet-is-related-to-incident-frailty-and-slow-walking-in-older-adults
#5
Martin Laclaustra, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon, Jose R Banegas, Auxiliadora Graciani, Esther Garcia-Esquinas, Esther Lopez-Garcia
BACKGROUND: Certain foods and dietary patterns have been associated with both inflammation and frailty. As chronic inflammation may play a role in frailty and disability, we examined the association of the inflammatory potential of diet with these outcomes. METHODS: Data were taken from 1948 community-dwelling individuals ≥60 years old from the Seniors-ENRICA cohort, who were recruited in 2008-2010 and followed-up through 2012. Baseline diet data, obtained with a validated diet history, was used to calculate Shivappa's Dietary Inflammatory Index (DII), an "a priori" pattern score which is based on known associations of foods and nutrients with inflammation, and Tabung's Empirical Dietary Inflammatory Index (EDII), an "a posteriori" pattern score which was statistically derived from an epidemiological study...
January 24, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30735283/a-lambda-shaped-retractor-lentis-muscle-in-the-yellowfin-goby-acanthogobius-flavimanus
#6
Taeko Miyazaki, Akari Kato, Takanori Ikenaga, Hanako Hagio, Naoyuki Yamamoto
We identified a morphologically uncommon piscine retractor lentis muscle in the yellowfin goby Acanthogobius flavimanus. This lentis muscle has a shape similar to the Greek small letter lambda (λ). The two legs of the muscle are attached to the retinal periphery at the ventral eyecup, while the tip is connected to the lens surface by a ligament. Scanning electron microscopy showed that the fibers of the lentis muscle run along the length of both the anterior and posterior legs. Immunolabeling with antiacetylated tubulin antibody and neuronal tracing with DiI of the whole lentis muscle revealed that the anterior leg is innervated by one or more nerves...
February 8, 2019: Journal of Morphology
https://read.qxmd.com/read/30733149/a-selectivity-filter-gate-controls-voltage-gated-calcium-channel-calcium-dependent-inactivation
#7
Fayal Abderemane-Ali, Felix Findeisen, Nathan D Rossen, Daniel L Minor
Calcium-dependent inactivation (CDI) is a fundamental autoregulatory mechanism in CaV 1 and CaV 2 voltage-gated calcium channels. Although CDI initiates with the cytoplasmic calcium sensor, how this event causes CDI has been elusive. Here, we show that a conserved selectivity filter (SF) domain II (DII) aspartate is essential for CDI. Mutation of this residue essentially eliminates CDI and leaves key channel biophysical characteristics untouched. DII mutants regain CDI by placing an aspartate at the analogous SF site in DIII or DIV, but not DI, indicating that CaV SF asymmetry is key to CDI...
January 28, 2019: Neuron
https://read.qxmd.com/read/30723387/an-assay-to-assess-gap-junction-communication-in-cell-lines
#8
Ujjwala M Warawdekar
This protocol was developed to assess communication in tumor cells and to provide a dependable and standardized assay for the in vitro determination of gap junction function. The method is noninvasive; in this method, the cell population under study is divided such that 1 fraction is loaded with a lipophilic cell plasma membrane permeable dye, calcein acetoxymethyl ester, that is hydrolyzed upon cellular uptake by cytoplasmic esterases to yield calcein, a fluorescent and membrane-impermeable molecule. The other fraction is loaded with 1,1'-dioctadecyl-3,3,3',3' tetramethylindodicarbocyanine perchlorate (DiD)/1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate [Dil; DilC18 (3)], which is a lipophilic membrane dye that diffuses laterally to stain the entire cell membrane, is impermeable, and attains an orange-red fluorescence upon incorporation into membranes...
January 30, 2019: Journal of Biomolecular Techniques: JBT
https://read.qxmd.com/read/30699847/inflammation-as-a-unique-marker-of-suicide-ideation-distinct-from-depression-syndrome-among-u-s-adults
#9
Rachel S Bergmans, Kristen M Kelly, Briana Mezuk
BACKGROUND: Recent evidence suggests that pro-inflammatory states may be independently associated with the risk of suicidality, above and beyond depression. This study assesses whether four indicators of inflammation, circulating levels of C-reactive protein (CRP), white blood cell (WBC) count and immunoglobulin E (IgE), and dietary inflammatory potential, measured using the Dietary Inflammatory Index® (DII), distinguish suicidal ideation (SI) from major depression (MD). METHODS: Data come from multiple cycles of the US National Health and Nutrition Examination Survey (NCRP&WBC   = 13,912; NDII   = 17,076; NIgE   = 4,060)...
February 15, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30688269/postnatal-calpeptin-treatment-causes-hippocampal-neurodevelopmental-defects-in-neonatal-rats
#10
Zhu-Jin Song, San-Juan Yang, Lan Han, Bin Wang, Guoqi Zhu
Our previous studies showed that the early use of calpain inhibitors reduces calpain activity in multiple brain regions, and that postnatal treatment with calpeptin may lead to cerebellar motor dysfunction. However, it remains unclear whether postnatal calpeptin application affects hippocampus-related behaviors. In this study, Sprague-Dawley rats were purchased from the Animal Center of Anhui Medical University of China. For the experiments in the adult stage, rats were intraperitoneally injected with calpeptin, 2 mg/kg, once a day, on postnatal days 7-14...
May 2019: Neural Regeneration Research
https://read.qxmd.com/read/30684849/dietary-inflammatory-index-and-parameters-of-diet-quality-in-normal-weight-and-obese-patients-undergoing-hemodialysis
#11
Elham Alipoor, Razieh Karimbeiki, Nitin Shivappa, Mehdi Yaseri, James R Hebert, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVE: Better nutritional reserves are proposed as a mechanism for the protective role of obesity in hemodialysis. Little is known about the quality of diet as a major contributor to nutritional status, specifically body mass index and obesity. The aim of this study was to assess dietary inflammatory index (DII®) score and other parameters of diet in normal-weight and obese patients undergoing hemodialysis to understand whether there is a benefit for obese patients. METHODS: This cross-sectional study included 85 hemodialysis patients (44 obese and 41 normal-weight)...
October 19, 2018: Nutrition
https://read.qxmd.com/read/30684590/regenerative-failure-following-rat-neonatal-chorda-tympani-transection-is-associated-with-geniculate-ganglion-cell-loss-and-terminal-field-plasticity-in-the-nucleus-of-the-solitary-tract
#12
Louis J Martin, Amy H Lane, Kaeli K Samson, Suzanne I Sollars
Neural insult during development results in recovery outcomes that vary dependent upon the system under investigation. Nerve regeneration does not occur if the rat gustatory chorda tympani nerve is sectioned (CTX) during neonatal (≤ P10) development. It is unclear how chorda tympani soma and terminal fields are affected after neonatal CTX. The current study determined the impact of neonatal CTX on chorda tympani neurons and brainstem gustatory terminal fields. To assess terminal field volume in the nucleus of the solitary tract (NTS), rats received CTX at P5 or P10 followed by chorda tympani label, or glossopharyngeal (GL) and greater superficial petrosal (GSP) label as adults...
January 23, 2019: Neuroscience
https://read.qxmd.com/read/30683311/hyperhomocysteinemia-induced-endothelial-progenitor-cells-dysfunction-through-hyper-methylation-of-cbs-promoter
#13
Jyotirmaya Behera, Suresh C Tyagi, Neetu Tyagi
Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are the key players in angiogenesis and vascular function. Cystathionine-β-synthase (CBS), an H2 S-generating enzyme in methionine metabolism, regulates the function of these EPCs. This study aims to examine whether CBS hyper-methylation contributes to the bone marrow endothelial progenitor cell (BM-EPCs) function and subsequent bone blood flow in mice fed with a high methionine diet (HMD). Bone marrow (BM) cells were collected from HMD and control mice, differentiated into BM-EPCs, and were characterized by acLDL-DiI labeling...
January 22, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30668438/indole-alkaloid-from-nauclea-latifolia-promotes-ldl-uptake-in-hepg2-cells-by-inhibiting-pcsk9
#14
Mike Okweesi Aggrey, Hui-Hui Li, Wen-Qiong Wang, Yiping Wang, Li-Jiang Xuan
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been found to play a major role in atherosclerotic cardiovascular disease (ASCVD) by promoting hyperlipidemia. Its inhibition has therefore emerged as a viable drug target for improving the outcome of ASCVD. However, current monoclonal antibody PCSK9 inhibitors are considered cost ineffective and there is the need to discover new effective and cheaper small molecule alternatives. PURPOSE: The methanolic and ethanolic crude extracts of Nauclea latifolia have been shown to possess anti-hyperlipidemic activity, but the chemical component(s) responsible for this activity and the mechanism of action have remained unknown...
August 19, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30667357/quantitative-analysis-of-auxin-sensing-in-leaf-primordia-argues-against-proposed-role-in-regulating-leaf-dorsoventrality
#15
Neha Bhatia, Henrik Åhl, Henrik Jönsson, Marcus G Heisler
Dorsoventrality in leaves has been shown to depend on the pre-patterned expression of KANADI and HD-ZIPIII genes within the plant shoot apical meristem (SAM). However, it has also been proposed that asymmetric auxin levels within initiating leaves help establish leaf polarity, based in part on observations of the DII auxin sensor. By analyzing and quantifying the expression of the R2D2 auxin sensor, we find that there is no obvious asymmetry in auxin levels during Arabidopsis leaf development. We further show that the mDII control sensor also exhibits an asymmetry in expression in developing leaf primordia early on, while it becomes more symmetric at a later developmental stage as reported previously...
January 22, 2019: ELife
https://read.qxmd.com/read/30661693/dietary-inflammatory-index-and-its-association-with-renal-function-and-progression-of-chronic-kidney-disease
#16
Mohammad Hossein Rouhani, Mojgan Mortazavi Najafabadi, Pamela J Surkan, Ahmad Esmaillzadeh, Awat Feizi, Leila Azadbakht
BACKGROUND: While evidence exists for an association between the dietary inflammatory index (DII) and cardiovascular diseases, the relation between DII and chronic kidney disease (CKD) is not known. OBJECTIVE: To examine the association between DII, renal function and progression of CKD. METHODS: In this cross-sectional study, dietary data from 221 subjects with diagnosed CKD were collected using a validated food frequency questionnaire. DII was calculated based on overall inflammatory effect scores...
February 2019: Clinical Nutrition ESPEN
https://read.qxmd.com/read/30651193/dietary-inflammatory-index-and-all-cause-mortality-in-large-cohorts-the-sun-and-predimed-studies
#17
Ana Garcia-Arellano, Miguel A Martínez-González, Raul Ramallal, Jordi Salas-Salvadó, James R Hébert, Dolores Corella, Nitin Shivappa, Luis Forga, Helmut Schröder, Carlos Muñoz-Bravo, Ramón Estruch, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Emilio Ros, Javier Rekondo, Estefanía Toledo, Cristina Razquin, Miguel Ruiz-Canela
BACKGROUND: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII® ) was developed to appraise the inflammatory potential of the diet. OBJECTIVE: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts...
May 24, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30643221/healthy-diets-and-telomere-length-and-attrition-during-a-10-year-follow-up
#18
Jelena Meinilä, Mia-Maria Perälä, Hannu Kautiainen, Satu Männistö, Noora Kanerva, Nitin Shivappa, James R Hébert, Patricia Iozzo, Maria Angela Guzzardi, Johan G Eriksson
BACKGROUND: Telomeres are repeats of DNA that contain the sequence TTAGGG at the ends of each chromosome, and their function is to protect DNA from damage. Little evidence exists regarding the relationship between dietary patterns and telomere length, especially derived applying longitudinal design. The aim was to study if overall dietary pattern is associated with leukocyte telomere length (LTL) or faster telomere attrition or both. METHODS: The setting was longitudinal and observational...
January 14, 2019: European Journal of Clinical Nutrition
https://read.qxmd.com/read/30641979/dietary-inflammatory-index-score-and-its-association-with-body-weight-blood-pressure-lipid-profile-and-leptin-in-indonesian-adults
#19
Harry Freitag Luglio Muhammad, Marleen A van Baak, Edwin C Mariman, Dian Caturini Sulistyoningrum, Emy Huriyati, Yi Yi Lee, Wan Abdul Manan Wan Muda
It was previously reported that dietary intake is an important trigger for systemic inflammation and one of the lifestyle factors for the development of cardiovascular diseases. The aim of this study was to evaluate the association between Dietary Inflammatory Index (DII) score and body weight, blood pressure, lipid profile and leptin in an Indonesian population. This was a cross-sectional study conducted in 503 Indonesian adults. The DII score was calculated based on data of 30 nutrients and food components...
January 11, 2019: Nutrients
https://read.qxmd.com/read/30626470/-the-%C3%AE-2gpi-a%C3%AE-2gpi-inhibits-phagocytosis-of-oxidized-low-density-lipoprotein-in-thp-1-macrophages-via-activating-tlr4
#20
Chao He, Hong Zhou, Guiting Zhang, Yudan Chen, Peng Zhang, Ren Wang, Qianqian Wu, Yuye Yao, Ming Kuang
Objective To investigate the effects of β2 glycoprotein I/anti-β2 glycoprotein I antibody complex (β2GPI/aβ2GPI) on lipid phagocytosis and class B scavenger receptor CD36 expression of macrophages, and the role of Toll-like receptor 4 (TLR4) during the process. Methods THP-1 macrophages were induced from THP-1 cells treated by 100 ng/mL phorbol ester (PMA), and then identified by morphological observation and DiI-oxLDL uptake assay. THP-1 macrophages were treated with RPMI1640 medium, β2GPI, aβ2GPI or β2GPI/aβ2GPI...
December 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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