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Tranexamic acid pigment

Amanda K Suggs, Selina S Hamill, Paul M Friedman
Melasma is a common, acquired, chronic cutaneous pigment disorder that is often difficult to treat and has a high recurrence rate. The goal of a melasma treatment regimen is to decrease pigment production and increase elimination. Topical tyrosinase inhibitors block melanin synthesis and thereby reduce pigment production. Peels and laserand light-based devices increase melanin elimination. A multimodality treatment approach targeting both pigment production and elimination is necessary to achieve equilibrium and disease remission...
December 2018: Seminars in Cutaneous Medicine and Surgery
Zhongyi Xu, Xiaoxue Xing, Chengfeng Zhang, Li Chen, Leihong Flora Xiang
BACKGROUND: Up till now, there is no standardized and satisfactory treatment strategy for Riehl's melanosis. OBJECTIVE: In this pilot study, we evaluated the efficacy and safety of a novel combination therapy with oral administration of tranexamic acid (TA) and Glycyrrhizin compound for recalcitrant Riehl's melanosis. METHODS: Ten patients with Riehl's melanosis were recruited in this study. After elimination of potential contraindication, all patients were treated with 500 mg TA together with 150 mg Glycyrrhizin compound per day orally for 3 months, followed by 500 mg TA per day orally alone for another 3 months...
October 19, 2018: Journal of Cosmetic Dermatology
Donthula Nagaraju, Rajsmita Bhattacharjee, Keshavamurthy Vinay, Uma Nahar Saikia, Davinder Parsad, Muthu Sendhil Kumaran
Tranexamic acid (TXA), a plasmin inhibitor, is an antifibrinolytic drug widely used to prevent and treat hemorrhage. We evaluated the effects of oral TXA clinically and immunohistopathologically in patients of refractory melasma. To evaluate the efficacy of oral TXA in patients with refractory melasma and correlate histopathological and immunohistochemical changes in pretreatment and post-treatment skin biopsies in patients willing to undergo biopsy. Thirty patients with refractory melasma were treated with oral TXA 500 mg twice daily along with a sunscreen and followed up...
September 2018: Dermatologic Therapy
Margit L W Juhasz, Melissa K Levin
BACKGROUND: Pigmentation of the skin occurs as a result of increased melanin production or deposition due to various reasons including age, hormonal imbalances, endocrine disease, inflammation, and/or exposure to damaging radiation, resulting in dermatologic conditions such as lentigines, melasma, or postinflammatory hyperpigmentation. Although numerous topical therapies exist for skin lightening, they are limited by efficacy and pigmentation recurrence after treatment cessation. New research into systemic therapies for hyperpigmentation has been promising...
December 2018: Journal of Cosmetic Dermatology
Sarah L Sheu
Tranexamic acid is a procoagulant agent that is approved by the US Food and Drug Administration for treatment of menorrhagia and to prevent hemorrhage in patients with hemophilia undergoing tooth extractions. Through its inhibitory effects on the plasminogen activation pathway, tranexamic acid also mitigates the UV radiation-induced pigmentation response. Systemic tranexamic acid has consistently been reported as an effective treatment of melasma, though its broad use may be limited by the risk for thromboembolism...
February 2018: Cutis; Cutaneous Medicine for the Practitioner
Yeong Hee Cho, Jung Eun Park, Do Sung Lim, Jung Sup Lee
BACKGROUND: As interest in skin beauty increases, the development of new skin whitening agents has attracted substantial attention; however, the action mechanism of the agents developed so far remains largely unknown. Tranexamic acid (TXA) is commonly being used to reduce melanin synthesis in patients with melasma and also used as a raw material for functional whitening cosmetics, although its action mechanism is poorly understood. Autophagy has been well known to be essential for tissue homeostasis, adaptation to starvation, and removal of dysfunctional organelles or pathogens...
October 2017: Journal of Dermatological Science
Je Byeong Chae, Seung Hye Yang, Sang Young Byun, Hye-Ryung Choi, Jung-Won Shin, Kyoung-Chan Park
BACKGROUND: Jet-M is a device for epidermal peeling and is used to deliver substances by spraying air and microdroplets. Previously, a case was treated with a mixed solution of copper-GHK, oligo-hyaluronic acid, Rhodiola extract, tranexamic acid, and β-glucan. The results showed significant improvement of aged skin. AIMS: This study was conducted to evaluate the effects of hydroporation on melasma with the formulation in a small group of volunteers. METHODS: Clinical effects were evaluated by both subjective and objective methods including melanin index (MI) and erythema index (EI) measurement...
December 2017: Journal of Cosmetic Dermatology
S J Kim, J-Y Park, T Shibata, R Fujiwara, H Y Kang
BACKGROUND: Tranexamic acid (TA) has been suggested as an effective treatment for melasma. AIM: To investigate the effects and mechanism of action of topical TA in the treatment of melasma. METHODS: In this study, 23 participants with melasma applied a 2% TA formulation to the whole face for 12 weeks. Clinical effects were evaluated using the modified Melasma Area and Severity Index (mMASI) and a chromameter. Skin biopsies were obtained from 10 participants to evaluate pigmentation, vascularity and the expression levels of possible paracrine factors contributing to the effect of TA...
July 2016: Clinical and Experimental Dermatology
Tanmay Padhi, Swetalina Pradhan
BACKGROUND: Melasma is a common acquired cause of facial hyperpigmentation with no definitive therapy. Tranexamic acid, a plasmin inhibitor, has demonstrated depigmenting properties and combining this oral drug with other modalities of treatment has shown promising results. OBJECTIVES: To compare the efficacy of a combination of oral tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients...
September 2015: Indian Journal of Dermatology
Jong Yoon Chung, Jong Hee Lee, Joo Heung Lee
BACKGROUND: Tranexamic acid (TNA) is a novel therapeutic agent for hyperpigmented skin disorders. The efficacy and safety of topical TNA in patients with melasma has not been heretofore studied. The main objective of this study is to evaluate the efficacy and safety of topical TNA combined with intense pulsed light (IPL) treatment in Asians with melasma. METHODS: A randomized, split-face (internally controlled) study was conducted in 15 women who received four monthly sessions of IPL to both sides of the face...
August 2016: Journal of Dermatological Treatment
Natsuko Matsumura, Yuka Hanami, Toshiyuki Yamamoto
A 33-year-old male showed multiple pigmented patches on his trunk and extremities after he took tranexamic acid for common cold. He stated that similar eruptions appeared when he was treated with tranexamic acid for influenza 10 months before. Patch test showed positive results at 48 h and 72 h by 1% and 10% tranexamic acid at the lesional skin only. To our knowledge, nine cases of fixed drug eruption induced by tranexamic acid have been reported in Japan. Tranexamic acid is a safe drug and frequently used because of its anti-fibrinolytic and anti-inflammatory effects, but caution of inducing fixed drug eruption should be necessary...
July 2015: Indian Journal of Dermatology
Mahnaz Banihashemi, Naghmeh Zabolinejad, Mahmoud Reza Jaafari, Maryam Salehi, Asma Jabari
BACKGROUND: Melasma is one of the most common cosmetic disorders with skin darkening. Although several treatment modalities are available, none is satisfactorily used in management of this condition. Tranexamic acid (TA), a plasmin inhibitor, is reported to improve melasma when injected locally or used as oral and topical forms. AIM: The aim of this study was to compare therapeutic effects of liposomal tranexamic acid and conventional hydroquinone on melasma. METHODS: Thirty women with bilateral melasma were enrolled in a split-face trial lasting 12 weeks...
September 2015: Journal of Cosmetic Dermatology
Do Hyun Lee, In Young Oh, Kyo Tan Koo, Jang Mi Suk, Sang Wook Jung, Jin Oh Park, Beom Joon Kim, Yoo Mi Choi
BACKGROUND: Facial hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin color. Thus, there is a need for the development of skin lightening agents, and niacinamide and tranexamic acid (TXA) are promising candidates. OBJECTIVE: To assess the effectiveness of a combination of niacinamide and TXA as a topical moisturizing formulation for treatment of irregular facial pigmentation. MATERIALS AND METHODS: A total of 42 Korean women (age range: 30-60 years) who were not pregnant, nursing, or undergoing any concurrent therapy were enrolled in this study for 8 weeks...
May 2014: Skin Research and Technology
Yassine El Hassani, Benoit Jenny, Brigitte Pittet-Cuenod, Armand Bottani, Paolo Scolozzi, Hulya Ozsahin Ayse, Benédict Rilliet
INTRODUCTION: Hypertrophy of the calvarium has different aetiologies, among them the rare Proteus syndrome. CASE REPORT: We report here the case of a young girl initially treated for relapsing right then left large chronic subdural haematoma, who progressively developed craniofacial hypertrophy consistent with the diagnosis of Proteus syndrome. Calvarium hypertrophy was shaved and remodelled combining midface advancement, essentially for cosmetic purposes. During the first calvarium remodelling, important bleeding of the bone required large volume of blood replacement...
October 2013: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Sailesh Konda, Aanand N Geria, Rebat M Halder
Pigmentary abnormalities are among the most common reasons why patients with skin of color visit a dermatologist. Hydroquinone has been a cornerstone for the treatment of hyperpigmentation; however, concerns regarding adverse effects have prompted a search for alternative agents. Some promising topical treatments include soy, licorice, rucinol, mulberry, niacinamide, ellagic acid, resveratrol, and dioic acid. Oral agents, primarily used for the prevention of postprocedural hyperpigmentation, include procyanidins, tranexamic acid, and Polypodium leucotomos...
June 2012: Seminars in Cutaneous Medicine and Surgery
Sufan Wu, Hangyan Shi, Hua Wu, Sheng Yan, Jincai Guo, Yi Sun, Lei Pan
BACKGROUND: Melasma is a common pigmentary disorder among Asian women. The available therapies such as bleaching agents, chemical peeling, laser, and intense pulsed light are not satisfactory or safe. In the search to find a new treatment therapy for melasma, oral administration of tranexamic acid (TA) was studied clinically in Chinese patients. METHODS: The study enrolled 74 patients. Tranexamic acid tablets were prescribed at a dosage of 250 mg twice daily for a therapeutic period of 6 months...
August 2012: Aesthetic Plastic Surgery
Pinyapat Kanechorn Na Ayuthaya, Nucha Niumphradit, Aranya Manosroi, Artit Nakakes
BACKGROUND: Topical tranexamic acid has been claimed to lighten melasma without serious adverse effects. However, controlled studies assessing the efficacy and safety of topical tranexamic acid (TA) for the treatment of melasma is limited. OBJECTIVE: To assess in a double blind, randomized, prospective study, the efficacy of topical 5% tranexamic acid versus vehicle for treatment of melasma. METHODS: Twenty-three women with bilateral epidermal melasma enrolled in a split-face trial lasting 12 weeks...
June 2012: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
J I Na, S Y Choi, S H Yang, H R Choi, H Y Kang, K-C Park
BACKGROUND: Melasma is associated with epidermal hyperpigmentation, weak basement membrane, vascular proliferation and increased numbers of mast cell. Tranexamic acid (TXA), a plasmin inhibitor, is reported to improve melasma when injected locally. However, the effects of oral and topical TXA on melasma have not been well studied and the underlying mechanism remains unclear. OBJECTIVES: To elucidate the effects of oral and topical TXA on melasma. METHODS: A clinical study was conducted with 25 women for 8 weeks from March to July 2010...
August 2013: Journal of the European Academy of Dermatology and Venereology: JEADV
Virendra N Sehgal, Prashant Verma, Govind Srivastava, Ashok K Aggarwal, Sangeeta Verma
Melasma, a hypermelanosis of the face, is a common skin problem of middle-aged women of all racial groups, especially with dark complexion. Its precise etio-pathogenesis is evasive, genetic influences, exposure to sunlight, pregnancy, oral contraceptives, estrogen-progesterone therapies, thyroid dysfunction, cosmetics, and drugs have been proposed. Centro-facial, malar, and mandibular are well-recognized. Epidermal pigmentation appears brown/black, while dermal is blue in color, and can be distinguished by Wood's lamp illumination...
December 2011: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Harunosuke Kato, Jun Araki, Hitomi Eto, Kentaro Doi, Rintaro Hirai, Shinichiro Kuno, Takuya Higashino, Kotaro Yoshimura
BACKGROUND: Postinflammatory hyperpigmentation (PIH) is the most common skin complication in Asians after invasive cosmetic treatments. OBJECTIVE: To determine whether oral tranexamic acid (TA) reduces the incidence of PIH after Q-switched ruby laser (QSRL) treatment. METHODS AND MATERIALS: Thirty-two Japanese women underwent QSRL treatment for senile lentigines on the face. They were randomly divided into two groups that did (n=15) and did not (n=17) receive oral TA treatment (750 mg/d) for the first 4 weeks after QSRL treatment...
May 2011: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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