keyword
https://read.qxmd.com/read/38314835/roller-microneedle-combined-with-tranexamic-acid-solution-in-treating-melasma
#1
JOURNAL ARTICLE
Wenhao Zheng, Sutao Liu, Liming Tian, Dan Ke
Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes of melasma remain elusive, and the current therapeutic approaches predominantly encompass pharmaceutical and laser interventions, with limited efficacy. Transdermal administration stands as a prevalent treatment method for melasma, often facilitated by the application of microneedles. Among these, tranexamic acid emerges as a frequently employed therapeutic agent...
January 19, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38256889/comparative-studies-on-the-photoreactivity-efficacy-and-safety-of-depigmenting-agents
#2
JOURNAL ARTICLE
Sandra Mota, Gonçalo P Rosa, Maria Carmo Barreto, Jorge Garrido, Emília Sousa, Maria T Cruz, Isabel F Almeida, Clara Quintas
Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents-4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid-for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase inhibition was compared, and cell viability was assessed in B-16V melanocytes to evaluate safety...
December 28, 2023: Pharmaceuticals
https://read.qxmd.com/read/38151661/the-role-of-755-nm-alexandrite-picosecond-laser-in-melasma-management
#3
REVIEW
Anika Pulumati, Dana Jaalouk, Yanci A Algarin, Keyvan Nouri
Melasma is a skin dyspigmentation condition that disproportionately affects women, particularly those of Latino, Black, and Asian ethnicities, significantly impacting their quality of life. Efforts to identify effective treatment options have led to the exploration of picosecond laser technology which utilizes brief pulse durations to break down pigment while minimizing thermal damage to surrounding tissue. The 755-nm alexandrite picosecond laser, currently FDA approved for benign pigmented lesion removal, including melasma, is a promising solution...
December 27, 2023: Archives of Dermatological Research
https://read.qxmd.com/read/37867785/evaluation-of-the-effectiveness-of-microneedling-with-tranexamic-acid-in-comparison-with-microneedling-with-vitamin-c-in-the-treatment-of-melasma-a-prospective-and-single-blind-clinical-trial
#4
JOURNAL ARTICLE
Nader Pazyar, Maryam Raeispour, Reza Yaghoobi, Maryam Seyedtabib
BACKGROUND AND AIMS: Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin. Therefore, this study aimed to compare the effectiveness of microneedling with TXA with microneedling and vitamin C in treating melasma. METHODS: In patients with melasma, microneedling was performed at 2-3 mm depth. During that, TXA and vitamin C were poured on the skin of each side of the face, and then each ampoule was soaked for 15 min...
October 2023: Health Science Reports
https://read.qxmd.com/read/37653821/efficacy-of-photorejuvenation-combined-with-tranexamic-acid-and-hydroquinone-cream-in-the-treatment-of-complex-facial-pigmentation
#5
JOURNAL ARTICLE
Caihui Lin, Xuehua Zhu
The aim of this study was to assess the effectiveness of photo rejuvenation combined with tranexamic acid and hydroquinone cream in the treatment of complex facial pigmentation. A total of 108 patients with complex facial pigmentation between October 2019 and October 2021 were included in this retrospective study and divided into 2 groups according to the treatment that they received, with 54 cases in each group. The control group received treatment with tranexamic acid and hydroquinone cream. On the basis of the control group, the observation group was treated with photo rejuvenation combined with tranexamic acid and hydroquinone cream...
August 25, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37571190/clinical-development-and-evaluation-of-a-multi-component-dissolving-microneedle-patch-for-skin-pigmentation-disorders
#6
JOURNAL ARTICLE
Chenxin Yan, Mengzhen Xing, Suohui Zhang, Yunhua Gao
Excessive melanin deposition in the skin leads to various skin pigmentation diseases, such as chloasma and age spots. The deposition is induced by several factors, including tyrosinase activities and ultraviolet-induced oxidative stress. Herein, we propose a multi-component, multi-pathway drug combination, with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid employed as, respectively, a tyrosinase inhibitor, an antioxidant, and a melanin transmission inhibitor. Considering the poor skin permeability associated with topical application, dissolving microneedles (MNs) prepared with hyaluronic acid/poly(vinyl alcohol)/poly(vinylpyrrolidone) were developed to load the drug combination...
August 4, 2023: Polymers
https://read.qxmd.com/read/37479524/amber-photobiomodulation-versus-tranexamic-acid-for-the-treatment-of-melasma-protocol-for-a-double-blind-randomised-controlled-trial
#7
JOURNAL ARTICLE
Thais Rodrigues Galache, Marcelo Galache, Michelle Mota Sena, Christiane Pavani
INTRODUCTION: Photobiomodulation (PBM) has been suggested as an alternative treatment for melasma. In vitro studies have shown PBM with amber light inhibits the tyrosinase enzyme, induces autophagy and reduces the melanin content, but randomised controlled clinical trials are still needed. This study aims to evaluate the efficacy of amber PBM (590 nm) in the treatment of melasma compared with liposomal tranexamic acid. METHODS AND ANALYSIS: This study is a controlled, randomised, double-blind, non-inferiority trial...
July 21, 2023: BMJ Open
https://read.qxmd.com/read/37401632/unveiling-the-mystery-of-riehl-s-melanosis-an-update-from-pathogenesis-diagnosis-to-treatment
#8
REVIEW
Yuecen Ding, Zhongyi Xu, Leihong Flora Xiang, Chengfeng Zhang
Riehl's melanosis is a hyperpigmentation disorder that has a significant psychological and social impact on individuals. In the past 10 years, new categories have been developed, raising questions about how to classify Riehl's melanosis. The mechanism of this disease remains unclear, although the type IV hypersensitivity response caused by allergic sensitization, as well as genetic, ultraviolet radiation, and autoimmune factors, is to blame. Clinical manifestation, dermoscopy, reflectance confocal microscopy, patch/photopatch testing, histopathology, and a novel multimodality skin imaging system have been used for the diagnosis...
July 4, 2023: Pigment Cell & Melanoma Research
https://read.qxmd.com/read/37102219/the-clinical-benefit-of-a-multimodal-topical-approach-to-treating-skin-dyspigmentation
#9
JOURNAL ARTICLE
Zoe Diana Draelos, Isabel Diaz
BACKGROUND: The recent removal of hydroquinone from the over-the-counter market has created a need for modern skin lightening formulations. An effective pigment lightening formulation must be non-irritating to prevent skin darkening from post-inflammatory hyperpigmentation, penetration enhanced to reach the epidermal/dermal junction, contain anti-inflammatory ingredients, and address multiple mechanisms of pigment production. OBJECTIVE: The objective of this research was to demonstrate the efficacy of a topical multimodal pigment lightening preparation containing tranexamic acid, niacinamide, and licorice...
April 26, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/36987386/evaluation-of-effectiveness-of-tranexamic-acid-as-mesotherapy-in-improvement-of-periorbital-wrinkling-in-a-trial-study
#10
JOURNAL ARTICLE
Afsaneh Sadeghzadeh Bazargan, Mahsa Shemshadi, Elham Ziaeifar, Amirmasoud Taheri, Masoumeh Roohaninasab, Azadeh Goodarzi, Mahta Mirhashemi
BACKGROUND: Tranexamic acid is used to treat pigmented disorder in dermatology for a long time however there are limited data for effectiveness of tranexamic acid for rejuvenation and improvement of wrinkle. Here we want to find the effectiveness of tranexamic acid as mesotherapy in improvement of periorbital wrinkle in a clinical trial study. METHODS: Patients with melasma who were treated with 4 session of tranexamic acid mesotherapy at intervals on 1 week were evaluated with Visioface device before starting and 1 month after last course of treatment...
September 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/36779738/the-clinical-effect-of-topical-application-of-tranexamic-acid-in-arthroscopic-synovectomy-of-pigmented-villonodular-synovitis-of-the-knee
#11
JOURNAL ARTICLE
Weihao Sun, Yunhe Mao, Yan Xiong, Jian Li
This study investigated the clinical effect of topical application of tranexamic acid (TXA) in arthroscopic synovectomy of pigmented villonodular synovitis (PVNS) of the knee. Eighty patients who were diagnosed with unilateral knee PVNS underwent arthroscopic synovectomies from January 2017 to January 2021 and were retrospectively investigated in this study. Patients were divided into two groups: group A was the control group, whereas patients in group B received an intra-articular injection of 50 mL of TXA (1 g:100 mL) immediately after the synovectomies...
February 10, 2023: Orthopedics
https://read.qxmd.com/read/36542040/licorice-zinc-suppresses-melanogenesis-via-inhibiting-the-activation-of-p38mapk-and-jnk-signaling-pathway-in-c57bl-6j-mice-skin
#12
JOURNAL ARTICLE
Jing-Yan Wang, Xing-Yu Xie, Ying Deng, Hong-Qiu Yang, Xiao-Shuang Du, Ping Liu, Yu Du
PURPOSE: The active melanocytes in the skin were affected by hormones and ultraviolet (UV) irradiation. Licorice zinc has a whitening effect, which may have a prominent potential in the treatment of pigmented skin disease. METHODS: Modeling chloasma C57BL/6J mice by daily progesterone injection (15 mg/kg) and ultraviolet B (UVB) irradiation (λ = 312 nm, 2 h/day) for 30 days. Then, mice were given 0.65, 1.3, and 2.6 (g/kg) of licorice zinc and tranexamic acid 250 mg daily by oral administration for 14 days, respectively...
2022: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/36181344/design-and-development-of-tranexamic-acid-loaded-film-forming-gel-to-alleviate-melasma
#13
JOURNAL ARTICLE
Naga Thirumalesh Chevala, Jenica Alwin Dsouza, Hitesh Saini, Lalit Kumar
BACKGROUND: Melasma is a skin condition that causes increased epidermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymph histiocytic infiltrates. OBJECTIVE: To develop the film-forming gel to alleviate melasma. Tranexamic acid was used as a model drug to evaluate the suitability of formulation to prevent symmetric hyperpigmentation. METHODS: FFG is a hydrophilic polymeric cross-linked system loaded with an active moiety...
December 2022: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/35897958/timeline-of-the-development-of-skin-lightening-active-ingredients-in-japan
#14
REVIEW
Kazuhisa Maeda
Japanese pharmaceutical cosmetics, often referred to as quasi-drugs, contain skin-lightening active ingredients formulated to prevent sun-induced pigment spots and freckles. Their mechanisms of action include suppressing melanin production in melanocytes and promoting epidermal growth to eliminate melanin more rapidly. For example, arbutin and rucinol are representative skin-lightening active ingredients that inhibit melanin production, and disodium adenosine monophosphate and dexpanthenol are skin-lightening active ingredients that inhibit melanin accumulation in the epidermis...
July 26, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/35347552/comparison-of-fractional-erbium-yag-laser-assisted-tranexamic-acid-delivery-alone-and-in-combination-with-oral-tranexamic-acid-in-melasma
#15
JOURNAL ARTICLE
Aysenur Botsali, Pelin Esme, Hakan Erbil, Ercan Caliskan
Tranexamic acid (TA) emerged as a promising agent for melasma. However, due to its hydrophilic structure, topical TA should be combined with a penetration-enhancing strategy to augment efficacy. To evaluate the efficacy of fractional erbium:YAG laser-assisted delivery (LAD) of topical TA 5% either with or without oral TA treatment in recalcitrant melasma patients. The authors retrospectively assessed the treatment outcomes of melasma patients treated by fractional erbium:YAG LAD of topical TA 5%. Patients receiving a standard protocol including four biweekly laser sessions were eligible...
September 2022: Lasers in Medical Science
https://read.qxmd.com/read/35340120/oral-tranexamic-acid-with-a-triple-combination-cream-versus-oral-tranexamic-acid-monotherapy-in-the-treatment-of-severe-melasma
#16
RANDOMIZED CONTROLLED TRIAL
Jessica Carolina Martinez-Rico, Sonia Chavez-Alvarez, Maira Elizabeth Herz-Ruelas, Sergio Axel Sosa-Colunga, Jorge Ocampo-Candiani, Yeudiel Suro-Santos, Osvaldo Vazquez Martinez
BACKGROUND: Melasma is an acquired pigmentation disorder with a complex multifactorial etiopathogenesis. Oral tranexamic acid (TA) is a promising drug for its treatment and may enhance outcomes when used in combination. OBJECTIVE: To provide evidence of the efficacy and safety of oral TA as a monotherapy, and in combination with a triple combination cream, for treating melasma in the Hispanic population. METHODS: Forty-four female Hispanic patients with melasma were randomly assigned to receive 325 mg of oral TA every 12 h plus f-TCC (fluocinolone-based triple combination cream) every 24 h (group A) or 325 mg of oral TA every 12 h (group B) for 8 weeks, after which both groups were crossed-over, and treated for an additional 8 weeks...
August 2022: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/35333207/tranexamic-acid-microinjection-alone-versus-its-combination-with-fractional-carbon-dioxide-laser-in-melasma-treatment-a-dermoscopic-evaluation
#17
JOURNAL ARTICLE
Shereen O Tawfic, Rania M Abdel Hay, Dina I Abouelazm, Eman R Said
BACKGROUND: Melasma is a challenging pigmentation disorder. OBJECTIVE: To assess and compare the efficacy of tranexamic acid (TXA) intradermal microinjection alone versus its combination with low-power, low-density fractional CO2 laser in a sequential pattern in melasma. PATIENTS AND METHODS: This study included 29 patients with melasma. Half of the face was randomly assigned to fractional CO2 laser; the other half to TXA. This split-face session was repeated every 6 weeks for 3 sessions...
May 1, 2022: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/35060229/a-split-face-comparative-study-using-a-novel-triple-combination-therapy-for-the-treatment-of-persistent-post-acne-erythema
#18
JOURNAL ARTICLE
Naglaa Agamia, Sara El-Nagdy, Aly El-Ariny
Persistent post acne erythema (PAE) is common cosmetically unacceptable and challenging sequelae of acne lesions. Tranexamic acid (TXA) is an antifibrinolytic agent that shows a positive effect on wound healing in several studies, and it showed benefits in treating skin diseases like melasma, rosacea erythema and ultraviolet induced pigmentations. Oxymetazoline (OXZ) is a synthetic, highly selective agonist for alpha 1A-adrenoceptor. It is a potent vasoconstrictor. OXZ hydrochloride 1% cream was approved by the FDA in January 2017 as a topical treatment for persistent facial erythema in rosacea patients...
April 2022: Dermatologic Therapy
https://read.qxmd.com/read/34988730/split-face-comparative-study-between-intradermal-tranexamic-acid-injection-alone-versus-intradermal-tranexamic-acid-injection-combined-with-q-switched-nd-yag-laser-in-melasma-treatment-dermoscopic-and-clinical-evaluation
#19
JOURNAL ARTICLE
Soha Abdalla Hawwam, Mayada Ismail, Yasmina Ahmed El-Attar
Melasma is a chronic, dark brown-pigmented patches and macules commonly on the face. Many treatment modalities for melasma have been used as hydroquinone, laser treatment, and recently tranexamic acid. Dermoscopy is used to diagnose and follow up the treatment of melasma and to detect underlying invisible vessels and their change with treatment. Melasma treatment evaluation by using combined Q-switched Nd:YAG laser with intradermal tranexamic acid injection versus tranexamic acid intradermal injection alone...
June 2022: Lasers in Medical Science
https://read.qxmd.com/read/34840657/therapeutic-effect-of-microneedling-with-platelet-rich-plasma-versus-microneedling-with-tranexamic-acid-for-melasma
#20
JOURNAL ARTICLE
Khaled Gharib, Fawzia Farag Mostafa, Soheir Ghonemy
Background: Melasma is a chronic acquired focal pigment disorder showing symmetrical hyperpigmentation or hypermelanosis of photoexposed areas on the face. Tranexamic acid (TXA) is a treatment for melasma. The regression of melasma after platelet-rich-plasma (PRP) treatment is an interesting finding. Objective: We investigated the effect of microneedling followed by PRP versus microneedling followed by tranexamic acid in the treatment of patients with melasma. Methods: The study included 26 patients with melasma divided into two groups of 13 patients each...
August 2021: Journal of Clinical and Aesthetic Dermatology
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