Markus Grube, Sabine Ameling, Michel Noutsias, Kathleen Köck, Ivonne Triebel, Karina Bonitz, Konrad Meissner, Gabriele Jedlitschky, Lars R Herda, Markus Reinthaler, Maria Rohde, Wolfgang Hoffmann, Uwe Kühl, Heinz-Peter Schultheiss, Uwe Völker, Stephan B Felix, Karin Klingel, Reinhard Kandolf, Heyo K Kroemer
Organic cation transporters (OCT1-3 and OCTN1/2) facilitate cardiac uptake of endogenous compounds and numerous drugs. Genetic variants of OCTN2, for example, reduce uptake of carnitine, leading to heart failure. Whether expression and function of OCTs and OCTNs are altered by disease has not been explored in detail. We therefore studied cardiac expression, heart failure-dependent regulation, and affinity to cardiovascular drugs of these transporters. Cardiac transporter mRNA levels were OCTN2>OCT3>OCTN1>OCT1 (OCT2 was not detected)...
June 2011: American Journal of Pathology