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https://read.qxmd.com/read/30770476/pharmacology-part-4-nuclear-cardiology
#1
Geoffrey M Currie
Pharmacology principles provide key understanding that underpins the clinical and research roles of nuclear medicine practitioners in nuclear cardiology. The scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. This article is the fifth in a series of articles that aims to enhance the understanding of pharmacological principles relevant to nuclear medicine...
February 15, 2019: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/30767166/a-randomised-investigator-initiated-clinical-trial-of-the-effects-of-fentanyl-on-p2y12-receptor-inhibition-in-patients-with-st-elevation-myocardial-infarction-who-are-pre-treated-with-crushed-ticagrelor-rationale-and-design-of-the-opioids-and-crushed-ticagrelor
#2
A H Tavenier, R S Hermanides, J P Ottervanger, S Rasoul, R J Slingerland, R Tolsma, S van Workum, E Kedhi, A W J van 't Hof
BACKGROUND: Fast and accurate platelet inhibition is an important therapeutic goal in the acute treatment of patients with ST-elevation myocardial infarction (STEMI). Platelet inhibitory effects induced by oral P2Y12-receptor antagonists are delayed in STEMI patients undergoing primary percutaneous coronary intervention (PCI) due to haemodynamic changes and delayed gastro-intestinal absorption. Concomitant use of opioids, although recommended in the American College of Cardiology/American Heart Association and European Society of Cardiology STEMI guidelines, further delays gastro-intestinal absorption...
February 14, 2019: Netherlands Heart Journal
https://read.qxmd.com/read/30765037/venoarterial-ecmo-for-adults-jacc-scientific-expert-panel
#3
REVIEW
Maya Guglin, Mark J Zucker, Vanessa M Bazan, Biykem Bozkurt, Aly El Banayosy, Jerry D Estep, John Gurley, Karl Nelson, Rajasekhar Malyala, Gurusher S Panjrath, Joseph B Zwischenberger, Sean P Pinney
Venoarterial extracorporeal membrane oxygenation (ECMO) is a rescue therapy that can stabilize patients with hemodynamic compromise, with or without respiratory failure, for days or weeks. In cardiology, the main indications for ECMO include cardiac arrest, cardiogenic shock, post-cardiotomy shock, refractory ventricular tachycardia, and acute management of complications of invasive procedures. The fundamental premise underlying ECMO is that it is a bridge-to recovery, to a more durable bridge, to definitive treatment, or to decision...
February 19, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30760415/2019-canadian-cardiovascular-society-canadian-association-of-interventional-cardiology-guidelines-on-the-acute-management-of-st-elevation-myocardial-infarction-focused-update-on-regionalization-and-reperfusion
#4
Graham C Wong, Michelle Welsford, Craig Ainsworth, Wael Abuzeid, Christopher B Fordyce, Jennifer Greene, Thao Huynh, Laurie Lambert, Michel Le May, Sohrab Lutchmedial, Shamir R Mehta, Madhu Natarajan, Colleen M Norris, Christopher B Overgaard, Michele Perry Arnesen, Ata Quraishi, Jean François Tanguay, Mouheiddin Traboulsi, Sean van Diepen, Robert Welsh, David A Wood, Warren J Cantor
Rapid reperfusion of the infarct-related artery is the cornerstone of therapy for the management of acute ST-elevation myocardial infarction (STEMI). Canada's geography presents unique challenges for timely delivery of reperfusion therapy for STEMI patients. The Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology STEMI guideline was developed to provide advice regarding the optimal acute management of STEMI patients irrespective of where they are initially identified: in the field, at a non-percutaneous coronary intervention-capable centre or at a percutaneous coronary intervention-capable centre...
February 2019: Canadian Journal of Cardiology
https://read.qxmd.com/read/30757908/efficacy-of-a-nurse-led-lipid-lowering-secondary-prevention-intervention-in-patients-hospitalized-for-ischemic-heart-disease-a-pilot-randomized-controlled-trial
#5
Sonia Ruiz-Bustillo, Consol Ivern, Neus Badosa, Nuria Farre, Esther Marco, Jordi Bruguera, Mercè Cladellas, Cristina Enjuanes, Miguel Cainzos-Achirica, Julio Marti-Almor, Josep Comin-Colet
BACKGROUND AND AIMS: Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an intensive lipid-lowering intervention, coordinated by nurses and implemented after hospital discharge, in patients hospitalized for an ischaemic heart disease event. METHODS: Randomized controlled trial, in which a nurse-led intervention including periodic follow-up, serial lipid level controls, and subsequent optimization of lipid-lowering therapy, if appropriate, was compared with standard of care alone in terms of serum lipid-level control at six months after discharge...
February 13, 2019: European Journal of Cardiovascular Nursing
https://read.qxmd.com/read/30746243/clinical-manifestations-diagnosis-and-treatment-of-ischemic-mitral-regurgitation-a-review
#6
REVIEW
Néstor Báez-Ferrer, María Manuela Izquierdo-Gómez, Belén Marí-López, Javier Montoto-López, Amelia Duque-Gómez, Javier García-Niebla, Julio Miranda-Bacallado, Alejandro de la Rosa Hernández, Ignacio Laynez-Cerdeña, Juan Lacalzada-Almeida
Ischemic mitral regurgitation (IMR) is a frequent complication after acute myocardial infarction (AMI) associated with a worse prognosis. The pathophysiological mechanisms of IMR are not fully understood, but it is known to be a complex process in which ventricular remodelling is the main causal factor. The various imaging techniques in cardiology and echocardiography fundamentally have contributed significantly to clarify the mechanisms that cause and progressively aggravate IMR. At present, different therapeutic options, the most important of which are cardio-surgical, address this problem...
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30744922/acc-aats-aha-ase-asnc-hrs-scai-scct-scmr-sts-2019-appropriate-use-criteria-for-multimodality-imaging-in-the-assessment-of-cardiac-structure-and-function-in-nonvalvular-heart-disease-a-report-of-the-american-college-of-cardiology-appropriate-use-criteria-task
#7
John U Doherty, Smadar Kort, Roxana Mehran, Paul Schoenhagen, Prem Soman, Gregory J Dehmer, John U Doherty, Paul Schoenhagen, Thomas M Bashore, Nicole M Bhave, Dennis A Calnon, Blase Carabello, John Conte, Timm Dickfeld, Daniel Edmundowicz, Victor A Ferrari, Michael E Hall, Brian Ghoshhajra, Praveen Mehrotra, Tasneem Z Naqvi, T Brett Reece, Randall C Starling, Molly Szerlip, Wendy S Tzou, John B Wong, John U Doherty, Gregory J Dehmer, Steven R Bailey, Nicole M Bhave, Alan S Brown, Stacie L Daugherty, Larry S Dean, Milind Y Desai, Claire S Duvernoy, Linda D Gillam, Robert C Hendel, Christopher M Kramer, Bruce D Lindsay, Warren J Manning, Manesh R Patel, Ritu Sachdeva, L Samuel Wann, David E Winchester, Michael J Wolk
This document is the second of 2 companion appropriate use criteria (AUC) documents developed by the American College of Cardiology, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. The first document1 addresses the evaluation and use of multimodality imaging in the diagnosis and management of valvular heart disease, whereas this document addresses this topic with regard to structural (nonvalvular) heart disease...
February 7, 2019: Journal of the American Society of Echocardiography
https://read.qxmd.com/read/30741039/amplatzer-patent-foramen-ovale-occluder-safety-and-efficacy
#8
Raouf Madhkour, Andreas Wahl, Fabien Praz, Bernhard Meier
The patent foramen ovale (PFO) is a common anatomical variant in humans (prevalence 25%). Most often asymptomatic, it may engender paradoxically embolic strokes, myocardial infarctions, or visceral or peripheral ischemia. It is causatively related to migraine, positional or exertional hypoxemia with dyspnea, diving incidents, high altitude edema, and sleep apnea. Percutaneous closure of atrial septal defects was first performed in the seventies. A dedicated PFO occluder (Amplatzer PFO Occluder) was first used on September 10, 1997 by Kurt Amplatz and Bernhard Meier...
February 9, 2019: Expert Review of Medical Devices
https://read.qxmd.com/read/30739508/lifestyle-and-impact-on-cardiovascular-risk-factor-control-in-coronary-patients-across-27-countries-results-from-the-european-society-of-cardiology-esc-eorp-euroaspire-v-registry
#9
Kornelia Kotseva, Guy De Backer, Dirk De Bacquer, Lars Rydén, Arno Hoes, Diederick Grobbee, Aldo Maggioni, Pedro Marques-Vidal, Catriona Jennings, Ana Abreu, Carlos Aguiar, Jolita Badariene, Jan Bruthans, Almudena Castro Conde, Renata Cifkova, Jim Crowley, Kairat Davletov, Jaap Deckers, Delphine De Smedt, Johan De Sutter, Mirza Dilic, Marina Dolzhenko, Vilnis Dzerve, Andrejs Erglis, Zlatko Fras, Dan Gaita, Nina Gotcheva, Peter Heuschmann, Hosam Hasan-Ali, Piotr Jankowski, Nebojsa Lalic, Seppo Lehto, Dragan Lovic, Silvia Mancas, Linda Mellbin, Davor Milicic, Erkin Mirrakhimov, Rafael Oganov, Nana Pogosova, Zeljko Reiner, Stefan Stöerk, Lâle Tokgözoğlu, Costas Tsioufis, Dusko Vulic, David Wood
AIMS: The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice. DESIGN: A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries. METHODS: Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later. RESULTS: A total of 8261 patients (females 26%) were interviewed...
February 10, 2019: European Journal of Preventive Cardiology
https://read.qxmd.com/read/30739219/neurological-complications-of-cardiological-interventions
#10
REVIEW
Amir Shaban, Enrique C Leira
PURPOSE OF REVIEW: Neurological complications are common during cardiac procedures. The type of procedure influences the profile of neurological complications and their management. In this article, we review the different neurological complications encountered following cardiac procedures, and treatment strategies for managing those complications. RECENT FINDINGS: Recent clinical trials have expanded the time window of eligibility for mechanical thrombectomy and intravenous thrombolysis...
February 9, 2019: Current Neurology and Neuroscience Reports
https://read.qxmd.com/read/30738714/women-in-cardiology-in-australia-are-we-making-any-progress
#11
REVIEW
Louise Segan, Anastasia Vlachadis Castles
Women remain largely under-represented in cardiology worldwide, despite gender parity among medical graduates. This is particularly notable in procedural subspecialties such as interventional cardiology and electrophysiology and is consistent at all levels of training. Cardiology continues to have the lowest proportion of females of all adult medicine specialties. This is a review of existing literature and statistics pertaining to women in cardiology and highlights the relative paucity of data or publications within Australia...
January 24, 2019: Heart, Lung & Circulation
https://read.qxmd.com/read/30732469/explanation-of-postprocedural-fractional-flow-reserve-below-0-85
#12
Laurens J C van Zandvoort, Kaneshka Masdjedi, Karen Witberg, Jurgen Ligthart, Maria Natalia Tovar Forero, Roberto Diletti, Miguel E Lemmert, Jeroen Wilschut, Peter P T de Jaegere, Eric Boersma, Felix Zijlstra, Nicolas M Van Mieghem, Joost Daemen
BACKGROUND: Fractional flow reserve (FFR) after percutaneous coronary intervention is a predictor of adverse cardiovascular events during follow-up. However, the rationale for low post procedural FFR values remains often elusive based on angiographic findings alone. METHODS AND RESULTS: FFR SEARCH (Stent Evaluated at Rotterdam Cardiology Hospital) is a prospective single-center registry in which post-percutaneous coronary intervention FFR was assessed in 1000 consecutive all-comer patients...
February 2019: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/30719977/the-evolution-of-device-technology-in-transcatheter-aortic-valve-implantation
#13
Christos V Bourantas, Rodrigo Modolo, Andreas Baumbach, Lars Søndergaard, Bernard D Prendergast, Muhidin Ozkor, Simon Kennon, Anthony Mathur, Michael J Mullen, Patrick W Serruys
Transcatheter aortic valve implantation (TAVI) has rapidly evolved and changed the landscape of structural interventional cardiology. Advances in transcatheter heart valve (THV) prostheses and TAVI enabling devices have simplified the procedure, reduced the risk of complications, improved short- and long-term outcomes and broadened the applications of TAVI not only in challenging patients and complex anatomies but also in intermediate-risk or even in low-risk patients, where surgical valve replacement constitutes an effective and well established therapy...
February 5, 2019: EuroIntervention
https://read.qxmd.com/read/30719828/in-vivo-validation-of-dosemap-software-use-in-interventional-cardiology-with-dosimetrics-indicators-and-peak-skin-dose-evaluation
#14
Romain Didier, David Bourhis, Chaker Oueslati, Bahaa Nasr, Florent Le Ven, Antoine Noël, Yannick Jobic, Pascal Damien, Dominique Pene-Baverez, Jacques Mansourati, Pierre Philippe Nicol, Martine Gilard
OBJECTIVES: The aim of this study was to determine the accuracy of DoseMap™ software as compared to gafchromic film in real clinical practices. BACKGROUND: The radiation exposure from cardiovascular procedures could expose patients to potential risk of cancer and/or skin injury. New tools like Dosemap software were developed to estimate the patient skin dose in the cardiac catheterization laboratory. However, little data are available to validate this estimation of patient radiation skin dose...
February 4, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30717959/evaluation-of-the-statewide-variability-in-the-current-role-of-different-specialties-in-lower-extremity-endovascular-revascularization-for-medicare-beneficiaries
#15
Bahman Roudsari, Mena Said, Catherine Vu, Rex Pillai
PURPOSE: To evaluate the statewide variability in the role of different specialties in lower extremity endovascular revascularization (LEER) and associated submitted charges of care and actual reimbursement for Medicare beneficiaries. METHODS: The 2015 "Medicare Provider Utilization and Payment Data: Physician and Other Supplier" data includes provider-specific information regarding the type of service, submitted average charges of care, and actual average Medicare reimbursements per Healthcare Common Procedure Coding System (HCPCS) code per provider...
February 2019: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/30716426/platelet-dysfunction-after-out-of-hospital-cardiac-arrest-results-from-pohcar-a-prospective-observational-cohort-study
#16
Agnieszka Skorko, Andrew Mumford, Matthew Thomas, Anthony E Pickering, Rosemary Greenwood, Elinor Griffiths, Thomas Johnson, Jonathan Benger
AIM: Coagulation and platelet function following out of hospital cardiac arrest (OHCA) at admission to a UK cardiology centre were investigated prospectively in this observational feasibility study, and compared to that of patients receiving percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI). METHOD: Blood samples taken immediately at emergency department admission from patients after OHCA of probable cardiac origin were analysed using near-patient thromboelastometry and a platelet function analyser...
February 1, 2019: Resuscitation
https://read.qxmd.com/read/30715608/what-s-new-in-the-esc-2018-guidelines-for-arterial-hypertension-the-ten-most-important-messages
#17
REVIEW
Jutta Bergler-Klein
The new guidelines on hypertension of the European Society of Cardiology (ESC) 2018 have refined the treatment cut-offs and therapy decisions in adults. This review highlights important recommendations of the guidelines and also on the situation of hypertension in Austria. The general treatment targets of blood pressure have been lowered to at least 130/80 mmHg for most patients. The definition of hypertension is specified as a repeated systolic blood pressure in the office of ≥140 and or diastolic BP ≥90 mmHg...
February 4, 2019: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/30703644/design-and-rationale-of-the-management-of-high-bleeding-risk-patients-post-bioresorbable-polymer-coated-stent-implantation-with-an-abbreviated-versus-standard-dapt-regimen-master-dapt-study
#18
Enrico Frigoli, Pieter Smits, Pascal Vranckx, Yokio Ozaki, Jan Tijssen, Peter Jüni, Marie-Claude Morice, Yoshinobu Onuma, Stephan Windecker, Andrè Frenk, Christian Spaulding, Bernard Chevalier, Emanuele Barbato, Pim Tonino, David Hildick-Smith, Marco Roffi, Ran Kornowski, Carl Schultz, Maciej Lesiak, Andrés Iñiguez, Antonio Colombo, Mirvat Alasnag, Ajit Mullasari, Stefan James, Goran Stankovic, Paul J L Ong, Alfredo E Rodriguez, Felix Mahfoud, Jozef Bartunek, Aris Moschovitis, Peep Laanmets, Sergio Leonardi, Dik Heg, Mikael Sunnåker, Marco Valgimigli
BACKGROUND: The optimal duration of antiplatelet therapy in high-bleeding risk (HBR) patients with coronary artery disease treated with newer-generation drug-eluting bioresorbable polymer-coated stents remains unclear. DESIGN: MASTER DAPT (clinicaltrial.govNCT03023020) is an investigator-initiated, open-label, multicenter, randomized controlled trial comparing an abbreviated versus a standard duration of antiplatelet therapy after bioresorbable polymer-coated Ultimaster (TANSEI) sirolimus-eluting stent implantation in approximately 4,300 HBR patients recruited from ≥100 interventional cardiology centers globally...
November 22, 2018: American Heart Journal
https://read.qxmd.com/read/30700519/international-comparison-of-acute-myocardial-infarction-care-and-outcomes-using-quality-indicators
#19
Oren Zusman, Owen Bebb, Marlous Hall, Tatendashe Bernadette Dondo, Adam Timmis, Francois Schiele, Keith Aa Fox, Ran Kornowski, Chris P Gale, Zaza Iakobishvili
OBJECTIVE: To compare temporal changes in European Society of Cardiology (ESC) acute myocardial infarction (AMI) quality indicator (QI) attainment in the UK and Israel. METHODS: Data cross-walking using information from the Myocardial Ischaemia National Audit Project and the Acute Coronary Syndrome in Israel Survey for matching 2-month periods in 2006, 2010 and 2013 was used to compare country-specific attainment of 14 ESC AMI QIs. RESULTS: Patients in the UK (n=17 068) compared with Israel (n=5647) were older, more likely to be women, and had less diabetes, dyslipidaemia and heart failure...
January 30, 2019: Heart: Official Journal of the British Cardiac Society
https://read.qxmd.com/read/30695882/-clinical-analysis-of-right-atrial-appendage-aneurysms-complicated-by-atrial-tachyarrhythmias-in-three-children
#20
Y Zhang, X M Li, H Jiang, F Q Zhang, Y Q Jin, H J Liu, H Y Ge
Objective: To investigate the clinical features and results of treatment for right atrial appendage aneurysms complicated by atrial tachyarrhythmias in children. Methods: This retrospective study included three children with right atrial appendage aneurysm complicated by atrial tachyarrhythmias (aged 1.0 to 5.3 years, weight 10 to 17.1 kg) who were hospitalized at the Pediatric Cardiology Department (Heart Center) of the First Hospital of Tsinghua University (Beijing Huaxin Hospital) during the period from January 2016 through April 2018...
February 2, 2019: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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