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Heart And ( Failure Or Infarction )

Mingmin Zhou, Yu Liu, Liang Xiong, Dajun Quan, Yan He, Yanhong Tang, He Huang, Congxin Huang
BACKGROUND Augmented cardiac sympathetic afferent reflex (CSAR) plays a role in enhanced sympathetic activity. Given that a strategy for abolishing augmented CSAR-induced sympathetic activation may be beneficial for protecting against ventricular arrhythmias (VAs) triggered by acute myocardial infarction (AMI), we investigated whether cardiac sympathetic afferent denervation (CSAD) could protect against VAs by modulating cardiac sympathetic nerve activity in an AMI dog model. MATERIAL AND METHODS Twenty-two anesthetized dogs were assigned to the CSAD group (n=9) and the sham group (n=13) randomly...
March 16, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Manabu Yamasaki, Kohei Abe, Rihito Horikoshi, Eri Hoshino, Hiromi Yanagisawa, Kunihiko Yoshino, Hiroyasu Misumi, Atsushi Mizuno, Nobuyuki Komiyama
BACKGROUND: We implemented our multidisciplinary heart team (MHT) approach since 2012 for patients with coronary artery disease (CAD) and assessed the effectiveness of it by comparing outcomes in patients treated before and after the introduction of the MHT approach. METHODS: Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for CAD were performed in 802 and 57 patients from 2009 to 2011 in Group NH, and were performed in 867 and 160 patients from 2012 to 2014 in Group H, respectively...
March 15, 2019: General Thoracic and Cardiovascular Surgery
Chien-Ju Lin, Yu-Chen Chang, Meng-Ting Tsou, Hsin-Lung Chan, Ying-Ju Chen, Lee-Ching Hwang
BACKGROUND: Pneumonia is a leading cause of hospitalization and death worldwide. However, studies focusing on risk factors of community-acquired pneumonia (CAP) in the home health care (HHC) population remain scarce. AIMS: This study aimed to evaluate risk factors associated with hospitalization for CAP among HHC patients in Taiwan. METHODS: This retrospective cross-sectional study extracted data from patients' electronic medical records between 1 January 2017 and 31 December 2017...
March 14, 2019: Aging Clinical and Experimental Research
Jing Chen, Qi Hu, Bo-Fang Zhang, Xiao-Pei Liu, Shuo Yang, Hong Jiang
BACKGROUND: Ischemia heart disease is one of the major causes of death worldwide which often associated with tissue infarction and limit the recovery of function. Multiple factors involved in the I/R-induced cardiomyocyte dysfunction which were consistent with a role of oxidative stress and altered endothelium-dependent responses. However, the pathogenic mechanisms in I/R injury remain unclear. MATERIALS AND METHODS: The H9C2 cells were in the ischaemia/reperfusion (I/R) condition...
March 15, 2019: Genes & Genomics
Na-Wei Liu, Xin Huang, Shuang Liu, Wen-Jian Liu, Hua Wang, Wei-da Wang, Yue Lu
Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes and often induced by chemotherapy. Recombinant human interleukin-11 (rhIL-11) is a cytokine that can stimulate thrombopoiesis and is commonly used to treat thrombocytopenia. We observed the side effects of rhIL-11 in 24 leukemia patients with chemotherapy-induced thrombocytopenia. To determine the cardiovascular effects of rhIL-11, we detected changes in the patients' serum brain natriuretic peptide (BNP), blood pressure fluctuations, weight change, and whether edema or heart failure occurred in leukemia patients after chemotherapy...
March 15, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Cheong-Whan Chae, Yoo-Wook Kwon
Currently, coronary artery disease accounts for a large proportion of deaths occurring worldwide. Damage to the heart muscle over a short period of time leads to myocardial infarction (MI). The biological mechanisms of atherosclerosis, one of the causes of MI, have been well studied. Resistin, a type of adipokine, is closely associated with intravascular level of low-density lipoprotein cholesterol and augmentation of the expression of adhesion molecules in endothelial cells. Therefore, resistin, which is highly associated with inflammation, can progress into coronary artery disease...
March 15, 2019: Archives of Pharmacal Research
Yi Zheng, Hui Wang, Qingqing Xu, Xin Yan, Yi Zhuang, Hanyi Jiang, Fanqing Meng, Yonglong Xiao, Hourong Cai, Jinghong Dai
OBJECTIVE: To evaluate the incidence and risk factors of relapse in pulmonary sarcoidosis treated with corticosteroids. METHODS: Medical records of patients with pulmonary sarcoidosis were retrospectively reviewed. Clinical features, chest radiographs, pulmonary function tests, and treatment information were collected. The starting point was the date of diagnosis. Clinical relapse was defined as chest high-resolution computed tomography (HRCT) showing radiographic progression in combination of worsening of clinical symptoms to warrant retreatment following a decrease in dose or discontinuation of corticosteroids, without alternative causes such as infections, heart failure, or pulmonary embolism...
March 15, 2019: Clinical Rheumatology
Giancarlo Di Giuseppe, Anna Chu, Jack V Tu, Shamila Shanmugasegaram, Peter Liu, Douglas S Lee
BACKGROUND: Several known traditional cardiovascular risk factors contribute to the development of heart failure (HF); however, whether ethnicity is also an important predictor is not well-established. We determined the incidence of hospitalization for HF among ethnic groups in Ontario, Canada and examined differences in risk factor prevalence that may contribute to disparities in HF hospitalization incidence between groups. METHODS AND RESULTS: We conducted a retrospective observational study from 2008 to 2012 using a linked cohort derived from population-based health administrative, clinical and survey datasets...
March 12, 2019: Journal of Cardiac Failure
Amanda R Vest, Michael Chan, Anita Deswal, Michael M Givertz, Carolyn Lekavich, Terry Lennie, Sheldon E Litwin, Lauren Parsly, Jo Ellen Rodgers, Michael W Rich, P Christian Schulze, Aaron Slader, Akshay Desai
Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited...
March 12, 2019: Journal of Cardiac Failure
Lidong Cai, Baozhen Qi, Xiaoyu Wu, Shi Peng, Genqing Zhou, Yong Wei, Juan Xu, Songwen Chen, Shaowen Liu
The apoptotic death of cardiomyocytes critically contributes to cardiac remodeling after myocardial infarction (MI). Circular RNAs (circRNAs) are important regulators for a variety of biological functions. Circ-Ttc3 represents one of the top highest expressed circRNAs in the heart; however, its role in MI remains unknown. Herein, we found that circ-Ttc3 was markedly upregulated in the ischemic myocardium and the cardiomyocytes subjected to hypoxic insult. Forced expression of circ-Ttc3 in cardiomyocytes counteracted hypoxia-induced ATP depletion and apoptotic death, in sharp contrast to circ-Ttc3 knockdown...
March 12, 2019: Journal of Molecular and Cellular Cardiology
Etsuko Tsuda, Osamu Yamada, Masataka Kitano
BACKGROUND: The treatment of heart failure has changed with the use of angiotensin-converting enzyme inhibitors (ACEIs) and beta-blockers since the middle of the 1990s. However, the outcome in infantile dilated cardiomyopathy (DCM) when treated with them remains poorly understood. METHODS: We reviewed the medical records of infants with DCM within 24 months old in our hospital between 1979 and 2012, and compared the outcome in the later group (1997-2012) with that in the early group (1979-1996)...
March 12, 2019: Journal of Cardiology
Hiromi Yamamoto, Toru Kawada, Shuji Shimizu, Yohsuke Hayama, Toshiaki Shishido, Yoshitaka Iwanaga, Kanji Fukuda, Shunichi Miyazaki, Masaru Sugimachi
AIMS: To compare the effects of metoprolol and carvedilol on baroreflex-mediated sympathetic circulatory regulation. METHODS: In anesthetized Wistar-Kyoto rats, carotid sinus baroreceptor regions were isolated. Changes in sympathetic nerve activity (SNA), arterial pressure (AP), heart rate (HR), and aortic flow (AoF) in response to a staircase-wise pressure input were examined before (control) and after intravenous injection of low-dose metoprolol (2 mg/kg), high-dose metoprolol (10 mg/kg), or carvedilol (0...
March 4, 2019: International Journal of Cardiology
Ravi B Patel, Muthiah Vaduganathan, G Michael Felker, Javed Butler, Margaret M Redfield, Sanjiv J Shah
Although atrial fibrillation/atrial flutter (AF/AFL) and heart failure with preserved ejection fraction (HFpEF) frequently coexist, the influence of AF/AFL on physical activity, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and quality of life in HFpEF is unclear and could have relevance to HFpEF trial design. We evaluated the association between AF/AFL and volitional physical activity, functional performance, NT-proBNP, and quality of life in patients with HFpEF in the Nitrate's Effect on Activity Tolerance (NEAT)-HFpEF trial...
February 23, 2019: American Journal of Cardiology
J A Rodríguez-Murillo, M Camafort
No abstract text is available yet for this article.
March 12, 2019: Revista Clínica Española
Yaxuan Ren, Yawen Liu, Tingyu Meng, Wenshu Liu, Yichun Qiao, Yulu Gu, Yong Li, Yunkai Liu, Yaqin Yu, Yi Cheng
BACKGROUND: Cold climates traditionally have conferred long sleep duration in the residents in northeast China; however, modern lifestyle reduces sleep duration. In this study, we investigated social-biological factors influencing sleep duration in the adult residents in northeast China. METHODS: This study was performed using data from the Investigation of Chronic Disease Morbidity Rate and Risk Factors of Adults in Jilin Province, China. Associations between sleep duration and indices of demographic characteristics, health-related behaviors, and disease history in adult residents were analyzed using univariate analysis and multivariate logistic regression analysis...
March 15, 2019: Health and Quality of Life Outcomes
Marile Santamarina, Curt J Carlson
BACKGROUND: Cardiovascular (CV) disease (CVD) is a well-recognized complication of type 2 diabetes mellitus (T2DM) and there is a clinical need for glucose-lowering therapies that do not further increase CV risk in this population. Although sulfonylureas (SUs) may be used as second-line therapy for patients requiring additional therapy after first-line metformin to improve glycemic control, their long-term effects on CV outcomes remain uncertain, and a wide range of alternative agents exist including dipeptidyl peptidase-4 (DPP-4) inhibitors...
March 15, 2019: BMC Cardiovascular Disorders
Byung-Kwan Lim, Jin Joo Park, Sung-Ji Park, You-Jung Lee, Jin-Sook Kwon, Eun-Ji Kim, Dong-Ju Choi
An angiotensin receptor blocker (ARB) mitigates cardiac remodeling after myocardial infarction (MI). Here, we investigated the effect of fimasartan, a new ARB, on cardiac remodeling after MI. Sprague⁻Dawley rats were assigned into 3 groups: surgery only (sham group, n = 7), MI without (MI-only group, n = 13), and MI with fimasartan treatment (MI + Fima group, n = 16). MI was induced by the permanent ligation of the left anterior descending artery. Treatment with fimasartan (10 mg/kg) was initiated 24 h after MI and continued for 7 weeks...
March 15, 2019: Journal of Clinical Medicine
Beatriz Paradela-Dobarro, Susana B Bravo, Adriana Rozados-Luís, Mercedes González-Peteiro, Alfonso Varela-Román, José Ramón González-Juanatey, Javier García-Seara, Ezequiel Alvarez
OBJECTIVES: Characterization of the type of glycation found in circulating proteins from cardiovascular patients in comparison with healthy control subjects and to explore the pathophysiological molecular effects of these glycomodified proteins on human umbilical vein endothelial cells (HUVEC) in culture. METHODS: Human serum albumin pools from 10 subjects each, of patients with heart failure (HF) presenting high or low glycation levels, and from healthy subjects were isolated and purified...
March 12, 2019: Biomedicine & Pharmacotherapy
Fumitoshi Tsurumi, Shiro Baba, Daisuke Yoshinaga, Katsutsugu Umeda, Takuya Hirata, Junko Takita, Toshio Heike
Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. The major symptoms of this condition are walking difficulties, dyspnea caused by progressive skeletal muscle weakness, and cardiomyopathy. Recent advances in ventilator support devices have dramatically decreased mortality caused by respiratory distress. Consequently, cardiomyopathy resulting in heart failure is currently the major cause of death among DMD patients. One mechanism by which skeletal muscle is damaged in DMD patients involves elevation of the intracellular Ca2+ concentration...
2019: PloS One
Tim Schutte, Shanti Ramawadhdoebe, Jeroen Schotten
BACKGROUND: Myocardial infarction can be categorized based on ECG-findings (presence or absence of ST-elevations on STEMI/NSTEMI) or on the results from coronary angiography (CAG) (presence or absence of obstructive atherosclerosis). Myocardial infarction without significant obstruction on CAG (Myocardial Infarction with Non-Obstructive Coronary Arteries/Atherosclerosis; MINOCA) occurs in up to a quarter of patients with myocardial infarcts. These patients have a higher risk of future heart diseases; up to a quarter of MINOCA patients suffer from heart diseases during a median follow-up of four years...
March 1, 2019: Nederlands Tijdschrift Voor Geneeskunde
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