keyword
https://read.qxmd.com/read/38531073/profiling-key-aroma-compounds-of-senecio-glaucus-l-and-their-antimicrobial-and-antioxidant-activities-multiplex-of-gc-ms-nmr-and-in-silico%C3%A2-studies
#1
JOURNAL ARTICLE
Mai M Elghonemy, Ahmed F Essa, Abeer F Osman, Doaa D Khalaf, Abd El-Nasser G El Gendy, Ahmed M Abd-ElGawad, Akemi Umeyama, Abdelsamed Elshamy
Senecio plants (Asteraceae) have been used to treat a wide range of ailments in traditional medicine. Current work has unveiled the identification of EO metabolites of collected S. glaucus from Egypt's Nile delta using GC-MS and GC-FID. Additionally, the antimicrobial activity has been investigated. Then, radical scavenging activity was evaluated using DPPH, ABTS, and metal chelating techniques. Also, the molecular docking studies were performed for the main compounds. Fifty components were identified within 98...
March 26, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38527573/anti-inflammatory-effects-and-related-mechanisms-in-vitro-and-in-vivo-of-hedychium-coccineum-rhizome-essential-oil
#2
JOURNAL ARTICLE
Minyi Tian, Dan Xie, Yi Hong, Furong Ding, Xia Wu, Dongxin Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Hedychium coccineum rhizome is an anti-inflammatory ethnomedicine used to remedy inflammation-related swelling and bronchial asthma. AIM OF THE STUDY: The study aimed to analyze the phytochemical constituents of H. coccineum rhizome essential oil (EO) and evaluate its in vitro and in vivo anti-inflammatory effects and underlying mechanisms. MATERIALS AND METHODS: Phytochemical constituents of H. coccineum rhizome EO were analyzed using GC-FID/MS...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38526597/detecting-microvascular-invasion-in-hepatocellular-carcinoma-using-the-impeded-diffusion-fraction-technique-to-sense-macromolecular-coordinated-water
#3
JOURNAL ARTICLE
Yunfei Zhang, Ruofan Sheng, Chun Yang, Yongming Dai, Mengsu Zeng
OBJECTIVES: Impeded diffusion fraction (IDF) is a novel and promising diffusion-weighted imaging (DWI) technique that allows for the detection of various diffusion compartments, including macromolecular coordinated water, free diffusion, perfusion, and cellular free water. This study aims to investigate the clinical potential of IDF-DWI in detecting microvascular invasion (MVI) in hepatocellular carcinoma (HCC). METHODS: 66 patients were prospectively included. Metrics derived from IDF-DWI and the apparent diffusion coefficient (ADC) were calculated...
March 25, 2024: Abdominal Radiology
https://read.qxmd.com/read/38525143/biofilm-containing-the-thymus-serpyllum-essential-oil-for-rice-and-cherry-tomato-conservation
#4
JOURNAL ARTICLE
Josefa Roselló, Juan Antonio Llorens-Molina, Silvina Larran, Francisca Sempere-Ferre, M Pilar Santamarina
INTRODUCTION: Fungal pathogens cause major yield losses in agriculture and reduce food quality and production worldwide. PURPOSE: To evaluate new safer alternatives to chemicals for disease management and preserve the shelf life of food, this research was conducted to: determine the chemical composition of the essential oils (EOs) of Thymus serpyllum and Thymus piperella chemotypes 1 and 2; investigate the antifungal potential of EOs in vitro against: Alternaria alternata , Bipolaris spicifera , Curvularia hawaiiensis , Fusarium oxysporum f...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38524698/rapid-quantification-of-50-fatty-acids-in-small-amounts-of-biological-samples-for-population-molecular-phenotyping
#5
JOURNAL ARTICLE
Pinghui Liu, Qinsheng Chen, Lianglong Zhang, Chengcheng Ren, Biru Shi, Jingxian Zhang, Shuaiyao Wang, Ziliang Chen, Qi Wang, Hui Xie, Qingxia Huang, Huiru Tang
Efficient quantification of fatty-acid (FA) composition (fatty-acidome) in biological samples is crucial for understanding physiology and pathophysiology in large population cohorts. Here, we report a rapid GC-FID/MS method for simultaneous quantification of all FAs in numerous biological matrices. Within eight minutes, this method enabled simultaneous quantification of 50 FAs as fatty-acid methyl esters (FAMEs) in femtomole levels following the efficient transformation of FAs in all lipids including FFAs, cholesterol-esters, glycerides, phospholipids and sphingolipids...
December 31, 2023: Biophysics Reports
https://read.qxmd.com/read/38521586/utility-of-intercalator-displacement-assays-for-screening-of-ligands-for-i-motif-dna-structures
#6
JOURNAL ARTICLE
Dilek Guneri, Zoë A E Waller
Cytosine rich sequences can form intercalated, i-motif DNA structures stabilized by hemi-protonated cytosine:cytosine base pairing. These sequences are often located in regulatory regions of genes such as promoters. Ligands targeting i-motif structures may provide potential leads for treatments for genetic disease. The focus on ligands interacting with i-motif DNA has been increasing in recent years. Here, we describe the fluorescent intercalator displacement (FID) assay using thiazole orange binding i-motif DNA and assess the binding affinity of a ligand to the i-motif DNA by displacing thiazole orange...
2024: Methods in Enzymology
https://read.qxmd.com/read/38515015/chromatin-accessibility-and-h3k9me3-landscapes-reveal-long-term-epigenetic-effects-of-fetal-neonatal-iron-deficiency-in-rat-hippocampus
#7
JOURNAL ARTICLE
Shirelle X Liu, Aarthi Ramakrishnan, Li Shen, Jonathan C Gewirtz, Michael K Georgieff, Phu V Tran
BACKGROUND: Iron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with pervasive hippocampal gene dysregulation. Prenatal choline supplementation partially normalizes these effects, suggesting an interaction between iron and choline in hippocampal transcriptome regulation. To understand the regulatory mechanisms, we investigated epigenetic marks of genes with altered chromatin accessibility (ATAC-seq) or poised to be repressed (H3K9me3 ChIP-seq) in iron-repleted adult rats having experienced fetal-neonatal ID exposure with or without prenatal choline supplementation...
March 21, 2024: BMC Genomics
https://read.qxmd.com/read/38507391/development-of-a-gc-fid-method-for-quantitative-characterisation-of-polyglycerols-in-polyglycerol-polyricinoleate-pgpr-present-in-a-lipid-matrix
#8
JOURNAL ARTICLE
Chunxia Su, Paul Van der Meeren, Bruno De Meulenaer
PGPR is an emulsifier (E476) widely used in the food industry. In this study, a gas chromatography-flame ionisation detection (GC-FID) method was developed for the quantitative characterisation of the polyglycerol composition of PGPR. The method was validated to analyse quantitatively the polyglycerol species in neat PGPR products and in PGPR samples present in a lipid matrix. This method consists of saponification, acidification and petroleum ether extraction to remove interfering fatty acids, neutralisation, silylation and finally GC-FID analysis...
March 20, 2024: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://read.qxmd.com/read/38506993/a-static-headspace-gas-chromatography-method-for-quantitation-of-residual-solvents-in-nanoformulations
#9
JOURNAL ARTICLE
Krishna Kattel, Jeffrey D Clogston
Various organic solvents are widely used in the manufacturing, processing, and purification of drug substances, drug products, formulations, excipients, etc. These solvents must be removed to the lowest amount permitted, as they do not possess any therapeutic advantages and may cause undesirable toxicities. Therefore, a rapid and sensitive analytical method for the quantitation of residual solvents is needed. The following chapter presents a static headspace gas chromatographic (HSGC) method for determining the concentration of common residual solvents in various nanoformulations...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38503039/from-inspection-to-analysis-a-combined-approach-to-identifying-counterfeit-whiskeys-using-hs-gc-fid-and-bottle-integrity
#10
JOURNAL ARTICLE
Vítor Luiz Caleffo Piva Bigão, Bruno Ruiz Brandão da Costa, Nayna Cândida Gomes, Wilson José Ramos Santos Júnior, Pablo Alves Marinho, Bruno Spinosa De Martinis
Counterfeiting of alcoholic beverages, particularly high-value spirits such as whiskey, presents significant challenges for regulators, manufacturers, and consumers. In this study, we introduce and validate a novel application of headspace extraction (HS) followed by gas chromatography with flame ionization detection (GC-FID) for the quantitative determination of ethanol content in 42 suspected counterfeit brazilian samples of whiskeys. This method, in conjunction with visual inspection of material inconsistencies, offers a combined approach to identify potential cases of fraud...
March 5, 2024: Forensic Science International
https://read.qxmd.com/read/38496932/biological-activities-and-chemical-compositions-of-prangos-platychlaena-boiss-essential-oil-and-fractions-multivariate-statistical-analyses
#11
JOURNAL ARTICLE
Damla Kırcı, Ceyda Sibel Kılıç, Hayri Duman, Betül Demirci
In this research, essential oil was obtained from the aerial parts of Prangos platychlaena Boiss. by hydrodistillation using a Clevenger-type apparatus, separated into fractions having different polarities by column chromatography. Both essential oil and the fractions were analyzed by GC-FID and GC/MS simultaneously. Nona-3,5-diyne-2-yl acetate (46%) and 3,5-nonadiyne (13.5%) were found to be the main constituents of the essential oil. While the main components of the n- hexane fraction were characterized as 3,5-nonadiyne (45...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38493600/dsg-gan-a-dual-stage-generator-based-gan-for-cross-modality-synthesis-from-pet-to-ct
#12
JOURNAL ARTICLE
Huabin Wang, Xiangdong Wang, Fei Liu, Grace Zhang, Gong Zhang, Qiang Zhang, Michael L Lang
PET/CT devices typically use CT images for PET attenuation correction, leading to additional radiation exposure. Alternatively, in a standalone PET imaging system, attenuation and scatter correction cannot be performed due to the absence of CT images. Therefore, it is necessary to explore methods for generating pseudo-CT images from PET images. However, traditional PET-to-CT synthesis models encounter conflicts in multi-objective optimization, leading to disparities between synthetic and real images in overall structure and texture...
March 16, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38485455/-31-p-mr-spectroscopy-in-the-pancreas-repeatability-comparison-with-liver-and-pilot-pancreatic-cancer-data
#13
JOURNAL ARTICLE
Leonard W F Seelen, Lieke van den Wildenberg, Ayhan Gursan, Martijn Froeling, Mark W J M Gosselink, Wybe J M van der Kemp, Nadia Haj Mohammad, I Quintus Molenaar, Hjalmar C van Santvoort, Dennis W J Klomp, Jeanine J Prompers
BACKGROUND: Non-invasive evaluation of phosphomonoesters (PMEs) and phosphodiesters (PDEs) by 31-phosphorus MR spectroscopy (31 P MRS) may have potential for early therapy (non-)response assessment in cancer. However, 31 P MRS has not yet been applied to investigate the human pancreas in vivo. PURPOSE: To assess the technical feasibility and repeatability of 31 P MR spectroscopic imaging (MRSI) of the pancreas, compare 31 P metabolite levels between pancreas and liver, and determine the feasibility of 31 P MRSI in pancreatic cancer...
March 14, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38474459/chemical-composition-of-piper-nigrum-l-cultivar-guajarina-essential-oils-and-their-biological-activity
#14
JOURNAL ARTICLE
Bruna de Souza Feitosa, Oberdan Oliveira Ferreira, Celeste de Jesus Pereira Franco, Himani Karakoti, Ravendra Kumar, Marcia Moraes Cascaes, Rahul D Jawarkar, Suraj N Mali, Jorddy Neves Cruz, Ilmarina Campos de Menezes, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade
The essential oils and aroma derived from the leaves (L), stems (St), and spikes (s) of Piper nigrum L. cv. Guajarina were extracted; the essential oils were extracted using hydrodistillation (HD), and steam distillation (SD), and the aroma was obtained by simultaneous distillation and extraction (SDE). Chemical constituents were identified and quantified using GC/MS and GC-FID. Preliminary biological activity was assessed by determining the toxicity against Artemia salina Leach larvae, calculating mortality rates, and determining lethal concentration values (LC50 )...
February 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38472917/nutritional-quality-and-safety-assessment-of-pork-meat-cuts-from-romania-fatty-acids-and-elemental-profile
#15
JOURNAL ARTICLE
Florina-Dorina Covaciu, Ioana Feher, Gabriela Cristea, Adriana Dehelean
In this study, the fatty acids and elemental profiles of 53 pork cut samples were determined. To offer insights into their potential health implications, we computed 18 key nutritional indices. These indices included parameters such as saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), unsaturated fatty acids (UFAs), the MUFAs/SFAs ratio, PUFAs/SFAs ratio, atherogenic index (AI), thrombogenic index (TI), the hypocholesterolemic to hypercholesterolemic ratio (h/H), health-promoting index (HPI), hypocholesterolemic index (HI), unsaturation index (UI), saturation index (SI), peroxidizability index (PI), nutritional value index (NVI), hypocholesterolemic index of fatty acids (DFAs), hypercholesterolemic index of fatty acids (OFAs), and the DFAs/OFAs ratio...
March 5, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38471968/kinematic-viscosity-prediction-of-jet-fuels-and-alternative-blending-components-via-comprehensive-two-dimensional-gas-chromatography-partial-least-squares-and-yeo-johnson-transformation
#16
JOURNAL ARTICLE
Louis Edwards Caceres-Martinez, Gozdem Kilaz
This work presents an accurate yet simplified partial least squares model to predict the kinematic viscosity of conventional and alternative jet fuels at -20°C using comprehensive two-dimensional gas chromatography coupled to a flame ionization detector (GC × GC/FID). Three different normalization methods (mean-centering, logarithmic, and Yeo-Johnson) were evaluated to identify their impact in the prediction of middle distillates' physical properties. Results using Yeo-Johnson transformation exhibited improved viscosity prediction capabilities over the validation set with a mean absolute percentage error of 5...
March 2024: Journal of Separation Science
https://read.qxmd.com/read/38466777/poly-ionic-liquid-coated-with-magnetic-nanoparticles-for-micro-solid-phase-extraction-of-polycyclic-aromatic-hydrocarbons-in-food-samples
#17
JOURNAL ARTICLE
Faizah Muhammad Yunus, Yatimah Alias, Noorfatimah Yahya, Nur Nadhirah Mohamad Zain, Muggundha Raoov
Poly(methyl methacrylate-vinyl imidazole bromide) (poly-MMA-IL)-grafted magnetic nanoparticles were successfully developed and applied in the micro-magnetic solid phase extraction (μ-MSPE) for 16 types of polycyclic aromatic hydrocarbons (PAHs) from tea, fried food, and grilled food samples via gas chromatography flame ionization detector (GC-FID). One variable at a time (OVAT) and response surface methodology (RSM) were used for efficient optimization. The validation method showed a good coefficient of determination ( R 2 ) ranging from 0...
March 11, 2024: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://read.qxmd.com/read/38463272/chemometric-analysis-combined-with-gc-%C3%A3-gc-fid-and-esi-hr-ms-to-evaluate-ultralow-sulfur-diesel-stability
#18
JOURNAL ARTICLE
Deborah V A de Aguiar, Jussara V Roque, Leomir A S de Lima, Iris M Junior, Helineia O Gomes, Emanoel N R de Sousa, Gláucia P L Piccoli, Boniek G Vaz
Diesel has been the most employed fuel in highway and nonhighway transportation systems. Many studies over the past years have attempted to classify diesel as a stable or unstable composition since this fuel can still degrade during storage or thermal oxidative processes. Products generated because of such degradation are the reason for the formation of soluble gums and insoluble organic particulates, which in turn cause a negative influence on engine performance. This work reports a detailed composition of nonpolar and polar compounds in many ultralow-sulfur diesel (ULSD) samples by comprehensive two-dimensional gas chromatography with a flame ionization detector (GC × GC-FID) and electrospray ionization high-resolution mass spectrometry (ESI HR-MS)...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38461280/evaluation-of-dispensaries-cannabis-flowers-for-accuracy-of-labeling-of-cannabinoids-content
#19
JOURNAL ARTICLE
Mona M Geweda, Chandrani G Majumdar, Malorie N Moore, Mostafa A Elhendawy, Mohamed M Radwan, Suman Chandra, Mahmoud A ElSohly
BACKGROUND: Cannabis policies have changed drastically over the last few years with many states enacting medical cannabis laws, and some authorizing recreational use; all against federal laws. As a result, cannabis products are marketed in dispensaries in different forms, most abundantly as flowers intended for smoking and sometimes vaping. All samples used in this study were obtained directly from law enforcement. The sample collection process was facilitated and funded by the National Marijuana Initiative (NMI), part of the High-Intensity Drug Trafficking Area (HIDTA) program...
March 9, 2024: Journal of cannabis research
https://read.qxmd.com/read/38460448/composition-and-nutritional-values-of-fatty-acids-in-marine-organisms-by-one-step-microwave-assisted-extraction-derivatization-and-comprehensive-two-dimensional-gas-chromatography-flame-ionization-detector
#20
JOURNAL ARTICLE
Donatella Ferrara, Mirco Cescon, Giulia Giacoppo, Valentina Costa, Giorgia Purcaro, Natasha Damiana Spadafora, Chiara Cordero, Luisa Pasti, Alberto Cavazzini, Marco Beccaria
This work reports the characterization of the lipidic fraction of seven species of marine organisms gathered along the shoreline of the Po Delta Park of Emilia-Romagna Region (Italy) and of the north Adriatic Sea. Two species of oysters (Crassostrea gigas and Ostrea edulis), two species of clams (Chamelea gallina and Ruditapes philippinarum), one species of mussel (Mytilus galloprovincialis), one species of macroalgae (Ulva rigida), and one species of spiny dogfish (Squalus acanthias) were analyzed to characterize their fatty acids profile and related nutritional value...
March 2, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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