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hydroxybenzoic acid

Noppawat Pengkumsri, Kanittha Kaewdoo, Wilaipan Leeprechanon, Bhagavathi Sundaram Sivamaruthi
BACKGROUND AND OBJECTIVE: Several plants have been commonly used in Thailand for health improvement, but the phytochemical content and its bio-activities are not yet elucidated completely. The aim of this research was to study the influence of extraction method on total phenolic content (TPC) and antioxidant activity of representative plants such as Punica granatum, Hibiscus sabdariffa, leistocalyx operculatus (Roxb.) Merr., litoria ternatea Linn., Mulberry and Oryza sativa L. indica...
January 2019: Pakistan Journal of Biological Sciences: PJBS
Bruno de Souza Basso, Fernanda Cristina de Mesquita, Henrique Bregolin Dias, Gabriele Catyana Krause, Matheus Scherer, Eliane Romanato Santarém, Jarbas Rodrigues de Oliveira
The therapeutic potential of Baccharis anomala DC. extracts was evaluated through its cytotoxic and antiproliferative effect and their phenotypic reversion property in activated hepatic stellate cells (HSCs). Baccharis anomala is distributed in Brazil (southeastern and south regions) and used for diuretic effect in folk medicine. Four fractions were obtained from the fractionation of the methanolic extract. Fractions III and IV decreased cell proliferation without increasing cell necrosis markers levels and induced cell cycle arrest in G1 phase...
2019: EXCLI Journal
Daniel Bury, Peter Griem, Tanja Wildemann, Thomas Brüning, Holger M Koch
The UV filter 2-ethylhexyl salicylate (EHS) is used in sunscreens and other personal care products worldwide and has been found in a variety of environmental media. We aimed to provide human toxicokinetic data on EHS as a tool for risk assessment. For that purpose, we investigated metabolism and urinary metabolite excretion after a single oral EHS dose (57.4-75.5 µg/(kg body weight)) in three male volunteers. In a suspect screening, we tentatively identified seven EHS metabolites. Three EHS specific metabolites were quantitatively investigated: 2-ethyl-5-hydroxyhexyl 2-hydroxybenzoate (5OH-EHS), 2-ethyl-5-oxohexyl 2-hydroxybenzoate (5oxo-EHS), and 5-(((2-hydroxybenzoyl)oxy)methyl)heptanoic acid (5cx-EPS)...
April 3, 2019: Toxicology Letters
Lucía Michel, Álvaro Peña, Claudio Pastenes, Pablo Berríos, Adamo Domenico Rombolà, José Ignacio Covarrubias
The aim of this investigation was to study the effect of sustainable strategies to correct iron deficiency in blueberries, based on Fe-heme applications or intercropping with graminaceous species, on yield, and berry quality variables. The experiment was conducted in a blueberry orchard established in a sub-alkaline soil. The association with grasses increased the crop load and yield (only Festuca rubra ), and decreased the skin/flesh ratio. In addition, these treatments increased anthocyanins as well as some hydroxybenzoic acids, hydroxycinnamic acids, flavanols, and flavonol concentrations in skins with a similar effectiveness as Fe-EDDHA, whereas the Fe-heme applications did not influence such parameters...
2019: Frontiers in Plant Science
Haíssa de Castro Abrantes, Marc Briquet, Céline Schmuziger, Leonardo Restivo, Julien Puyal, Nadia Rosenberg, Anne-Bérengère Rocher, Stefan Offermanns, Jean-Yves Chatton
The discovery of a G protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional non-metabolic effects of lactate for regulating neuronal network activity. In this study, we characterized the intracellular pathways engaged by HCAR1 activation, using mouse primary cortical neurons from wild-type (WT) and HCAR1 knock-out (KO) mice from both sexes. Using whole-cell patch-clamp, we found that activation of HCAR1 with 3-chloro-5-hydroxybenzoic acid (3Cl-HBA) decreased miniature excitatory postsynaptic current frequency, increased paired-pulse ratio, decreased firing frequency, and modulated membrane intrinsic properties...
March 29, 2019: Journal of Neuroscience
Yaqiong Zhang, Ming Li, Hang Gao, Bo Wang, Xu Tongcheng, Boyan Gao, Liangli Lucy Yu
In this study, a new red sorghum variety (Ji Liang No. 1) was investigated for its triacylglycerol (TAG) and fatty acid profiles, carotenoid and tocopherol compositions, total phenolic, total flavonoid and phenolic acid contents, and antioxidant and anti-inflammatory properties. A total of 17 TAGs were identified in the red sorghum oil. Linoleic and oleic acids were the primary fatty acids, contributing more than 80% of the total fatty acids. β-Carotene was the primary carotenoid at a level of 26.14 μg/g...
March 2019: Food Science & Nutrition
Gokhan Zengin, Claudio Ferrante, Ismail Senkardes, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova, Luigi Menghini, Giustino Orlando, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Luigi Brunetti, Carene Marie Nancy Picot-Allain, Kannan Rr Rengasamy, Mohamad Fawzi Mahomoodally
In the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ellagitannins, flavonoids, and triterpenoid saponins were determined using UHPLC-ESI/HRMS technique. The ethyl acetate and methanol extracts of the studied Rubus species effectively inhibited acetyl and butyryl cholinesterase...
March 23, 2019: Food and Chemical Toxicology
Marion Thomas, Lucille Stuani, Ekaterina Darii, Christophe Lechaplais, Emilie Pateau, Jean-Claude Tabet, Marcel Salanoubat, Pierre-Loïc Saaidi, Alain Perret
INTRODUCTION: Metabolite identification remains a major bottleneck in the understanding of metabolism. Many metabolomics studies end up with unknown compounds, leaving a landscape of metabolites and metabolic pathways to be unraveled. Therefore, identifying novel compounds within a metabolome is an entry point into the 'dark side' of metabolism. OBJECTIVES: This work aimed at elucidating the structure of a novel metabolite that was first detected in the soil bacterium Acinetobacter baylyi ADP1 (ADP1)...
March 14, 2019: Metabolomics: Official Journal of the Metabolomic Society
Ramesh K Jha, Niju Narayanan, Naresh Pandey, Jeremy Bingen, Theresa L Kern, Christopher W Johnson, Charlie E M Strauss, Gregg T Beckham, Scott P Hennelly, Taraka Dale
Product inhibition is often a common bottleneck in industrial enzymes, and testing mutations to alleviate product inhibition via traditional methods remains challenging as many variants need to be tested against multiple substrate and product concentrations. Further, traditional screening methods are conducted in vitro, and resulting enzyme variants may perform differently in vivo in the context of whole cell metabolism and regulation. In this study, we address these two problems by establishing a high throughput screening method to alleviate product inhibition in an industrially relevant enzyme, chorismate pyruvate-lyase (UbiC)...
March 12, 2019: ACS Synthetic Biology
Ciao-Wei Siao, Wen-Lian William Lee, Yong-Ming Dai, Wen-Hsin Chung, Jiun-Ting Hung, Peng-Hao Huang, Wan-Yu Lin, Chiing-Chang Chen
Herein, the preparation of numerous bismuth oxychloride/bismuth oxybromide/bismuth oxyiodide/graphene oxide (BiOx Cly /BiOm Brn /BiOp Iq /GO) composites is reported. A facile hydrothermal method was employed to synthesize these photocatalysts, which had various GO contents. A total of 10 bismuth-oxyhalide composites were isolated and characterized using FE-SEM, XRD, FE-TEM, UV-Vis-DRS, FT-IR, EPR, HR-XPS, PL, and BET. The photocatalytic efficiencies of these 10 bismuth-oxyhalide composites were measured under visible-light irradiation by estimating the concentration of 2-hydroxybenzoic acid (HBA) degradation...
February 21, 2019: Journal of Colloid and Interface Science
Kevin Chi-Chung Chou, Hsiang-Lin Wu, Pei-Yin Lin, Shang-Han Yang, Tsu-Liang Chang, Fuu Sheu, Kai-Hsien Chen, Been-Huang Chiang
Antrodia cinnamomea, an endemic fungus species of Taiwan, has long been used as a luxurious dietary supplement to enhance liver functions and as a remedy for various cancers. Antroquinonol (AQ), identified from the mycelium of A. cinnamomea, is currently in phase II clinical trials in the USA and Taiwan for the treatment of non-small-cell lung cancer. In the previous studies, we have demonstrated that AQ and 4-acetylantroquinonol B (4-AAQB) utilize orsellinic acid, via polyketide pathway, as the ring precursor, and their biosynthetic sequences are similar to those of coenzyme Q...
February 26, 2019: Phytochemistry
Kent D Nakamoto, Scott W Perkins, Ryan G Campbell, Matthew R Bauerle, Tyler John Gerwig, Selim Gerislioglu, Chrys Wesdemiotis, Mark A Anderson, Katherine A Hicks, Mark J Snider
6-Hydroxynicotinate 3-monooxygenase (NicC) is a Group A FAD-dependent monooxygenase that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH in nicotinic acid degradation by aerobic bacteria. Two mechanisms for the decarboxylative hydroxylation half-reaction have been proposed [Hicks, K. et al. (2016) Biochemistry 55, 3432 - 3446]. Results with the Bordetella bronchiseptica RB50 NicC here show that a homocyclic analogue of 6-HNA, 4-hydroxybenzoic acid (4-HBA), is decarboxylated and hydroxylated by NicC with a 420-fold lower catalytic efficiency than is 6-HNA...
February 27, 2019: Biochemistry
Daniel Bury, Thomas Brüning, Holger M Koch
The UV filter 2‑ethylhexyl salicylate (EHS) is widely used in sunscreens and other personal care products (PCP). EHS has been detected in a variety of environmental matrices. However, data on the internal EHS exposure in humans is not available, due to the lack of exposure biomarkers and analytical methods for their determination. Here, we report a method for the determination of three oxidative EHS metabolites in human urine: 2‑ethyl‑5‑hydroxyhexyl 2‑hydroxybenzoate (5OH-EHS), 2‑ethyl‑5‑oxohexyl 2‑hydroxybenzoate (5oxo-EHS), and 5‑(((2‑hydroxybenzoyl)oxy)methyl)heptanoic acid (5cx-EPS)...
February 14, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Jinglan Feng, Jiahui Zhao, Nannan Xi, Wei Guo, Jianhui Sun
In this study, six alkyl esters of p-hydroxybenzoic acids (parabens) and their metabolite, 4-hydroxybenzoic acid (p-HB) were simultaneously determined in surface water and sediment from the Yellow River and the Huai River in Henan Province, China. Concentrations of ∑parabens in surface water were 3.31-55.2 ng/L in the Yellow River and 15.0-164 ng/L in the Huai River, while in the sediment, concentrations of ∑parabens were 13.3-37.2 ng/g and 16.1-31.6 ng/g, respectively. Compared with other studies, levels of parabens in the studied area were relatively high in the sediments but middle in the surface water...
February 6, 2019: Ecotoxicology and Environmental Safety
Takuya Hasegawa, Yusuke Kato, Atsushi Okabe, Chie Itoi, Atsushi Ooshiro, Hiroshi Kawaide, Masahiro Natsume
The chemotactic activity of the pathogen of bacterial wilt disease, Ralstonia solanacearum, was tested against 30 aromatic acids and plant hormones infused on filter discs in bioassays on agar plates. 4-Hydroxycinnamic acid ( p-coumaric acid) and 4-hydroxybenzoic acid were strong chemoattractants, 3,4-dihydroxybenzoic acid (protocatechuic acid) and jasmonic acid were weak attractants, and 2-hydroxybenzoic acid (salicylic acid) showed both attracting and repelling activity depending on dose. Examination of the dose dependency revealed that the ED50 for 4-hydroxycinnamic acid and 4-hydroxybenzoic acid was 0...
February 8, 2019: Journal of Agricultural and Food Chemistry
Chembi Solomon Lekala, Khalil Saber H Madani, Anh Dao Thi Phan, Martin Makgose Maboko, Helene Fotouo, Puffy Soundy, Yasmina Sultanbawa, Dharini Sivakumar
Antioxidant constituents such as carotenoids (capsanthin, phytoene, lutein, β-cryptoxanthin), polyphenols content (p-coumaric, ferulic, p-hydroxybenzoic, caffeic acid, sinapic acid, and quercetin-3-glucoside) and marketable yield were investigated in 11 sweet pepper cultivars grown under controlled temperature plastic tunnel and white shade net. Marketable yield was not affected by either of the environments, while the interaction between cultivar and growing environment significantly affected the accumulation of antioxidant constituents...
March 1, 2019: Food Chemistry
Kelly Cristina Massarolo, Cláudia Fetter Jorge Ferreira, Verônica Simões de Borba, Larine Kupski, Eliana Badiale Furlong
The influence of particle size and chemical composition of three different cornmeals on the resistant starch (RS) content formed during the hydrothermal treatment was studied. The changes in reducing sugars and phenolic acids in different fractions caused by the hydrothermal treatment were correlated with RS content. The cornmeal with smaller particle size had higher RS content (202 mg/g). The hydrothermal treatment promoted a reduction in the total reducing sugars (46.7-84.5%), availability of free phenolic acids (256...
June 15, 2019: Food Chemistry
Naglaa S Ashmawy, Haidy A Gad, Nawal Al-Musayeib, Sherweit H El-Ahmady, Mohamed L Ashour, Abdel Nasser B Singab
Phytochemical investigation of Polyscias guilfoylei leaves extract (PGE) led to the isolation of nine compounds, that is, ent-labda-8(17),13-diene-15,18-diol (1), stigmasterol (2), spinasterol (3), N-(1,3-dihydroxyoctadecan-2-yl) palmitamide (4), panaxydiol (5), 3-O-β-d-glucopyranosylstigmasta-5,22-diene-3-β-ol (6), (8Z)-2-(2 hydroxypentacosanoylamino) octadeca-8-ene-1,3,4-triol (7), 4-hydroxybenzoic acid (8), and tamarixetin 3,7-di-O-α-L-rhamnopyranoside (9). Compound 4 is reported in this study for the first time in nature whereas compound 9 is reported for the second time...
February 6, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Gabriele Rocchetti, Sudarshana Reddy Bhumireddy, Gianluca Giuberti, Rupasri Mandal, Luigi Lucini, David S Wishart
The fate of polyphenols from edible tree nuts was investigated using a simulated in vitro intestinal fermentation system. The digested food matrix was fermented for 48 h and the changes in the phenolic profiles were evaluated by both untargeted UHPLC-QTOF and targeted UHPLC-Orbitrap mass spectrometry. The untargeted metabolomics approach allowed us to monitor the comprehensive changes in phenolic profiles from 0 up to 48 h of in vitro fermentation. Multivariate statistics (i.e., orthogonal projection to latent structures discriminant analysis) applied to this untargeted data allowed us to identify the most discriminating phenolic metabolites and to further understand the colonic transformation pathways involved...
February 2019: Food Research International
Fábio Jesus, Ana C Gonçalves, Gilberto Alves, Luís R Silva
The aim of the present work was to evaluate the phenolic profile of leaves, stems and flowers of P. avium and their biological potential. For this purpose, two extracts of each matrix (hydroethanolic and infusion) were prepared. A total of twenty-six phenolics were identified by LC-DAD, including 1 hydroxybenzoic acid, 9 hydroxycinnamic acids, 7 flavonols, 3 isoflavones, 3 flavanones and 3 flavan-3-ols, being the hydroethanolic leaves extract the richest one. 5-O-caffeoylquinic acid, hydroxycinnamic derivative 1 and sakuranetin derivative were the major compounds found in leaves, flowers and stems, respectively...
February 2019: Food Research International
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