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https://read.qxmd.com/read/30772702/good-outcome-of-living-donor-liver-transplantation-for-severe-alcoholic-hepatitis-not-responding-to-medical-management-a-single-center-experience-of-39-patients
#1
Narendra S Choudhary, Sanjiv Saigal, Dheeraj Gautam, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Srinivasan Thiagrajan, Sanjay K Yadav, Saurabh Mehrotra, Vipul Rastogi, Arvinder S Soin
INTRODUCTION: There are limited data on outcomes of living donor liver transplantation (LDLT) for patients with severe alcoholic hepatitis. METHODS: The study included LDLT recipients for severe alcoholic hepatitis (n = 39) who did not improve with medical treatment and compared their outcomes with patients who underwent LDLT for alcoholic liver disease (n = 461). The diagnosis of severe alcoholic hepatitis was based on both clinical and explants data. No patients had psychiatric contraindications for liver transplant and all had good family support...
July 24, 2018: Alcohol
https://read.qxmd.com/read/30772606/pyranocarbazole-derivatives-as-potent-anti-cancer-agents-triggering-tubulin-polymerization-stabilization-induced-activation-of-caspase-dependent-apoptosis-and-downregulation-of-akt-mtor-in-breast-cancer-cells
#2
Om P S Patel, Ashutosh Arun, Pankaj K Singh, Deepika Saini, Sharanbasappa Shrimant Karade, Manish K Chourasia, Rituraj Konwar, Prem P Yadav
A series of new pyranocarbazole derivatives were synthesized via semi-synthetic modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya koenigii. Among all, compound 3bg displayed significant anti-cancer activity against MDA-MB-231, DU145 and PC3 cell lines with the IC50 values of 3.8, 7.6 and 5.8 μM, respectively. It was also observed that the halogenated-benzyl substitution at N-9 position, C-3 Methyl and C-7 methoxy group on carbazole motif are favoured for anti-cancer activity...
February 7, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30772208/blumgart-s-technique-of-pancreaticojejunostomy-analysis-of-safety-and-outcomes
#3
Vishal Gupta, Saket Kumar, Vivek Gupta, Pradeep Joshi, Rahul Rahul, Rakesh Kumar Yadav, Amit Dangi, Abhijit Chandra
BACKGROUND: Blumgart's pancreaticojejunostomy (PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. METHODS: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula (CR-POPF) and analysis of its risk factors...
January 31, 2019: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/30771145/community-pharmacists-role-in-preventing-opioid-substitution-therapy-related-deaths-a-qualitative-investigation-into-current-uk-practice
#4
Ramesh Yadav, Denise Taylor, Gordon Taylor, Jenny Scott
Background Opioid substitution therapy involves prescribing of medical substitutes like methadone and buprenorphine to patients who are addicted to opioids. The majority of opioid substitution therapy dispensing in the UK is done by community pharmacists and they often see the patients on daily basis. It is unknown to what extent community pharmacists implement the policy to prevent overdose in patients receiving such treatment. Objective To explore what UK community pharmacists think about their role in preventing opium substitution-related deaths, their understanding of the risks associated with this substitution therapy and their views on what else community pharmacists could do to reduce such deaths...
February 15, 2019: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/30769240/design-and-synthesis-of-aminothiazolyl-norfloxacin-analogues-as-potential-antimicrobial-agents-and-their-biological-evaluation
#5
Liang-Liang Wang, Narsaiah Battini, Rammohan R Yadav Bheemanaboina, Shao-Lin Zhang, Cheng-He Zhou
A series of aminothiazolyl norfloxacin analogues as a new type of potential antimicrobial agents were synthesized and screened for their antimicrobial activities. Most of the prepared compounds exhibited excellent inhibitory efficiencies. Especially, norfloxacin analogue II-c displayed superior antimicrobial activities against K. pneumoniae and C. albicans with MIC values of 0.005 and 0.010 mM to reference drugs, respectively. This compound not only showed broad antimicrobial spectrum, rapid bactericidal efficacy and strong enzymes inhibitory potency including DNA gyrase and chitin synthase (CHS), low toxicity against mammalian cells and no obvious propensity to trigger the development of bacterial resistance, but also exerted efficient membrane permeability, and could effectively intercalate into K...
February 4, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30766814/efficacy-and-safety-of-90-000-iu-versus-300-000-iu-single-dose-oral-vitamin-d-in-nutritional-rickets-a-randomized-controlled-trial
#6
Medha Mittal, Vineeta Yadav, Rajesh Khadgawat, Manish Kumar, Poonam Sherwani
Aim: To compare efficacy and safety of 90,000 IU versus 300,000 IU oral single dose vitamin D for treatment of nutritional rickets. Study Design: Randomized controlled trial. Setting: Tertiary care hospital. Participants: One hundred ten children (6 months to 5 years, median age 10.5 months) with rickets. Exclusion criteria were disease affecting absorption, intake of calcium/vitamin D preparation in last 6 months, abnormal renal function, and rickets other than nutritional...
November 2018: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30766743/tuberculosis-among-children-adolescents-and-young-adults-in-the-philippines-a-surveillance-report
#7
K Snow, R Yadav, J Denholm, S Sawyer, S Graham
The Philippines, a country with a young population, is currently experiencing an intense and persistent tuberculosis epidemic. We analysed patient-based national surveillance data to investigate the epidemiology of reported tuberculosis among children (aged 0-9 years), adolescents (aged 10-19 years) and young adults (aged 20-24 years) to better understand the burden of disease and treatment outcomes in these age groups. Descriptive analyses were performed to assess age-related patterns in notifications and treatment outcomes...
October 2018: Western Pacific Surveillance and Response Journal: WPSAR
https://read.qxmd.com/read/30765968/is-crush-cytology-of-central-nervous-system-lesions-relevant-in-surgical-practice-today
#8
Krishan Kumar Yadav, Rashmi Bhatti, Nikhil Moorchung, Deepti Mutreja, Ajay S Carvalho
Background: Intraoperative crush cytology is a useful tool for diagnosing the lesions of the central nervous system (CNS). However, because of the development of newer and better imaging techniques, it is important to evaluate if crush cytology is still relevant in neurosurgical practice. Aims: We evaluated the crush cytology smears in a series of cases where neurosurgical intervention was performed. We studied the role of crush cytology in the intraoperative diagnosis...
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30765934/controlled-attenuation-parameter-for-assessment-of-hepatic-steatosis-in-indian-patients
#9
Gyanranjan Rout, Saurabh Kedia, Baibaswata Nayak, Rajni Yadav, Prasenjit Das, Subrat K Acharya, Deepak Gunjan, Vishwajeet Singh, Mousumi Mahanta, Swatantra Gupta, Sandeep Aggarwal, Shalimar
Background/Aims: The gold standard method for measurement of hepatic steatosis is liver histology. Controlled Attenuation Parameter (CAP) can measure hepatic steatosis non-invasively. We aimed to assess the accuracy of CAP for detection of hepatic steatosis. Methods: A total of 462 patients (May 2012-January 2017)-89 non-alcoholic fatty liver disease, 182 chronic hepatitis B, 88 chronic hepatitis C and 103 patients with other etiologies who underwent simultaneous liver biopsy and CAP estimation using Transient Elastography (TE) were included...
January 2019: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/30765600/cytochrome-c-deficiency-confers-apoptosome-and-mitochondrial-dysfunction-in-african-american-men-with-prostate-cancer
#10
Rahul Kumar, Tariq A Bhat, Elise M Walsh, Ajay K Chaudhary, Jordan O'Malley, Johng S Rhim, Jianmin Wang, Carl D Morrison, Kristopher Attwood, Wiam Bshara, James L Mohler, Neelu Yadav, Dhyan Chandra
Although African-American (AA) prostate cancer (PCa) patients tend to develop greater therapeutic resistance and faster PCa recurrence compared to Caucasian-American men, the molecular mechanisms of this racial PCa disparity remain undefined. In this study, we provide the first comprehensive evidence that cytochrome c (CC) deficiency in AA primary tumors and cancer cells abrogates apoptosome-mediated caspase activation and contributes to mitochondrial dysfunction, thereby promoting therapeutic resistance and PCa aggressiveness in AA men...
February 14, 2019: Cancer Research
https://read.qxmd.com/read/30765001/controlled-growth-of-highly-aligned-cu-nanowires-by-pulse-electrodeposition-in-nanoporous-alumina
#11
Arti Yadav, M S Bobji, Steve J Bull
Metallic nanowire networks are emerging as potential replacements for transparent conducting oxide coatings because of their high conductivity, flexibility and relative transparency. However, a cheap, reliable and controlled manufacturing process is required to exploit this and the surface of the copper nanowire needs to be protected if high conductivity is to be retained. In this study a fabrication method for highly aligned and densely packed copper nanowires with controlled length using pulse-electrodeposition and a nanoporous alumina template has been developed...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30761251/plasmodium-palmitoylation-machinery-engineered-in-e-coli-for-high-throughput-screening-of-palmitoyl-acyl-transferase-inhibitors
#12
Preeti Yadav, R Ayana, Swati Garg, Ravi Jain, Raj Sah, Nishant Joshi, Soumya Pati, Shailja Singh
Lipid-based palmitoylation is a post-translation modification (PTM) which acts as a biological rheostat in life cycle progression of a deadly human malaria parasite, Plasmodium falciparum . P. falciparum palmitoylation is catalyzed by 12 putative palmitoyl acyl-transferase enzymes containing the conserved DHHC-CRD (DHHC motif within a cysteine-rich domain) which can serve as a druggable target. However, the paucity of high-throughput assays has impeded the design of drugs targeting palmitoylation. We have developed a novel strategy which involves engineering of Escherichia coli , a PTM-null system, to enforce ectopic expression of palmitoyl acyl-transferase in order to study Plasmodium -specific palmitoylation and screening of inhibitors...
February 2019: FEBS Open Bio
https://read.qxmd.com/read/30755093/development-validation-of-quechers-based-method-for-simultaneous-determination-of-multiclass-pesticide-residue-in-milk-and-evaluation-of-the-matrix-effect
#13
Vandana Tripathy, Krishan Kumar Sharma, Rajbir Yadav, Suneeta Devi, Amol Tayade, Khushbu Sharma, Priya Pandey, Gitansh Singh, Amar Nath Patel, Rahul Gautam, Ruchi Gupta, Shobhita Kalra, Poonam Shukla, Suresh Walia, Najam Akhtar Shakil
Extraction and quantification of pesticide residue from the milk matrix at or below the established maximum residue limit (MRL) is a challenging task for both analytical chemists and the regulatory institutions to take corrective actions for the human health and safety. The main aim of the study is to develop a simple rapid and less expensive QuEChERS extraction and cleanup method for simultaneous analysis of 41 multiclass pesticide residue in milk by gas chromatography-electron capture detector (GC-ECD), followed by confirmation of the residues with gas chromatography-mass spectrometer (GC-MS)...
February 12, 2019: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://read.qxmd.com/read/30753955/supplementing-multi-functional-groups-to-polysulfone-membranes-using-azadirachta-indica-leaves-powder-for-effective-and-highly-selective-acid-recovery
#14
Sudesh Yadav, Khantong Soontarapa, Jyothi M S, Mahesh Padaki, R Geetha Balakrishna, Juin-Yih Lai
Moderate and eco-pleasing ion-exchange trade membranes are in need to recover acid from industrial waste. Present study is focused on incorporation of plant waste (Azadirachta indica, neem leaves powder (NP)) of different composition as filler to polysulfone (PSf) membrane matrix to achieve acid recovery. Membranes were characterized, their chemical, mechanical and thermal stabilities and effectiveness in acid recovery via diffusion has been inspected. Multi-functional groups (-COOH, -NH2 , -OH, -OAc, -C = O) present in different components of NP contributes in their own means in H+ ion transportation through membrane in acid recovery...
February 6, 2019: Journal of Hazardous Materials
https://read.qxmd.com/read/30753543/ki-67-labeling-index-as-a-predictor-of-response-to-neoadjuvant-chemotherapy-in-breast-cancer
#15
Parveen Jain, Dinesh Chandra Doval, Ullas Batra, Pankaj Goyal, Sneha Jatan Bothra, Chaturbhuj Agarwal, Dutta Kumardeep Choudhary, Abhishek Yadav, Venkata Pradeep Babu Koyalla, Mansi Sharma, Prashanta Dash, Vineet Talwar
Aims: To investigate Ki-67 index with regard to its ability to predict achievement of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer patient. Material and methods: It was a prospective observational study, conducted in Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Center (RGCIRC), New Delhi from February 2014 to March 2016. A total of 134 patients with Stage II/III breast cancer who underwent NACT followed by surgery at our center were enrolled and analyzed...
February 12, 2019: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/30745918/a-comparative-study-of-the-clinical-efficiency-of-chemomechanical-caries-removal-using-carie-care-gel-for-permanent-teeth-of-children-of-age-group-of-12-15-years-with-that-of-conventional-drilling-method-a-randomized-controlled-trial
#16
Priyanka Sontakke, Prateek Jain, Aniket Dhote Patil, Gautam Biswas, Pramod Yadav, Diljot Kaur Makkar, Vikas Jeph, Banu Pyari Sakina
Background: Dental caries is considered as one of the most serious dental diseases that results in localized dissolution and destruction of the calcified tooth tissues. As possible alternatives to conventional techniques of caries removal, chemomechanical caries removal systems have emerged. This study aims to clinically observe the advantages of chemomechanical method of caries removal over conventional technique. Materials and Methods: Inthis randomized controlled trial a total of 60 children with Class 1 open carious lesions were selected for the study...
January 2019: Dental Research Journal
https://read.qxmd.com/read/30745664/eyelid-petechiae-as-a-window-to-relapse-in-a-case-of-purging-type-anorexia-nervosa
#17
Mahima Agrawal, Pravesh Yadav, Roopam Kumari, Ram Chander
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745659/new-initiatives-a-psychiatric-inpatient-facility-for-older-adolescents-in-india
#18
Arun Singh Yadav, Rajendra Kiragasur Madegowda, Eesha Sharma, Preeti Jacob, Kommu John Vijaysagar, Satish Chandra Girimaji, Shekhar P Seshadri, Shoba Srinath
Context: Almost 1/5th of the adolescent population suffers from mental morbidity. In older adolescents, clinical challenges are accompanied by unique psychosocial and developmental needs. Recent legislations in India - the Mental Health Care Act, 2017 and the Juvenile Justice Act, 2015 - mandate specific arrangements and provisions for evaluation and treatment of children and adolescents. A separate inpatient Adolescent Psychiatry Center (APC) was started at National Institute of Mental Health and Neurosciences, Bangalore, in 2016...
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745607/comparison-between-macintosh-miller-and-mccoy-laryngoscope-blade-size-2-in-paediatric-patients-a-randomised-controlled-trial
#19
Pratishtha Yadav, Sudeshna Bhar Kundu, Dhurjoti P Bhattacharjee
Background and Aims: Paediatric airway needs special consideration as it is not a miniature replica of adult airway, rather it has different anatomy with different proportion and angulations. This study was conducted with the aim to find a laryngoscope blade that provides best laryngoscopic and intubation conditions in paediatric patients of age 2-6 years. Methods: This trial was conducted in a total of 75 children age 2-6 years, either gender, with American Society of Anesthesiologists grade I or II scheduled for elective surgery under general anaesthesia...
January 2019: Indian Journal of Anaesthesia
https://read.qxmd.com/read/30743086/clinical-neuroimaging-and-therapeutic-response-in-aqp4-positive-nmo-patients-from-india
#20
M Netravathi, B Hari Krishna, B Maya, V H Ganaraja, P Shwetha, M Anita, L K Nitish, A Nalini, R Yadav, P K Pal, P Satishchandra
BACKGROUND: Neuromyelitis Optica (NMO) is an autoimmune astrocytopathic disorder due to AQP4 antibodies. OBJECTIVES: To analyse clinical, neuroimaging features in NMO patients and assess the efficacy of various therapeutics. METHODS: AQP4+ve NMO patients were diagnosed based on consensus diagnostic criteria. RESULTS: 101 AQP4+ve NMO patients were seen with female (90) predominance. Adult population (71.3%) formed the larger group followed by pediatric (19...
February 4, 2019: Multiple Sclerosis and related Disorders
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