Ilya Demchenko, Naaz Desai, Stephanie N Iwasa, Fatemeh Gholamali Nezhad, José Zariffa, Sidney H Kennedy, Nicholas O Rule, Jeffrey F Cohn, Milos R Popovic, Benoit H Mulsant, Venkat Bhat
BACKGROUND: Major Depressive Disorder (MDD) is associated with interoceptive deficits expressed throughout the body, particularly the facial musculature. According to the facial feedback hypothesis, afferent feedback from the facial muscles suffices to alter the emotional experience. Thus, manipulating the facial muscles could provide a new "mind-body" intervention for MDD. This article provides a conceptual overview of functional electrical stimulation (FES), a novel neuromodulation-based treatment modality that can be potentially used in the treatment of disorders of disrupted brain connectivity, such as MDD...
May 16, 2023: Journal of Neuroengineering and Rehabilitation