Aigul Sharip, Saule Rakhimova, Askhat Molkenov, Ainur Ashenova, Ulan Kozhamkulov, Ilyas Akhmetollayev, Andrei Zinovyev, Yuri Zhukov, Marat Omarov, Mukhtar Tuleutaev, Venera Rakhmetova, Joseph D Terwilliger, Joseph H Lee, Zhaxybay Zhumadilov, Ainur Akilzhanova, Ulykbek Kairov
Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer in Central Asia, often diagnosed at advanced stages. Understanding population-specific patterns of ESCC is crucial for tailored treatments. This study aimed to unravel ESCC's genetic basis in Kazakhstani patients and identify potential biomarkers for early diagnosis and targeted therapies. ESCC patients from Kazakhstan were studied. We analyzed histological subtypes and conducted in-depth transcriptome sequencing. Differential gene expression analysis was performed, and significantly dysregulated pathways were identified using KEGG pathway analysis ( p -value < 0...
2024: Frontiers in Genetics