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Particulate Matter Cancer

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https://read.qxmd.com/read/30756357/inhalation-cancer-risk-estimation-of-source-specific-personal-exposure-for-particulate-matter-bound-polycyclic-aromatic-hydrocarbons-based-on-positive-matrix-factorization
#1
Bin Han, Yan You, Yating Liu, Jia Xu, Jian Zhou, Jiefeng Zhang, Can Niu, Nan Zhang, Fei He, Xiao Ding, Zhipeng Bai
In previous studies, inhalation cancer risk was estimated using conventional risk assessment method, which was normally based on compound-specific analysis, and cannot provide substantial data for source-specific particulate matter concentrations and pollution control. In the present study, we applied an integrated risk analysis method, which was a synthetic combination of source apportionment receptor model and risk assessment method, to estimate cancer risks associated to individual PAHs coming from specific sources...
February 13, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30698894/vitamin-d-protects-against-particles-caused-lung-injury-through-induction-of-autophagy-in-an-nrf2-dependent-manner
#2
Shasha Tao, Hong Zhang, Lian Xue, Xiaoyan Jiang, Hongyan Wang, Bingyan Li, Hailin Tian, Zengli Zhang
Fine particulate matter is a well-known air pollutant threatening public health. Studies have confirmed long-term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as increase the incidence and mortality of lung cancer. A clinical study has explored that the prevalence and risks of vitamin D (VD) deficiency in various chronic disease and toxins induced tissue damage. Our current study aimed to explore the mechanism and further therapeutic potential of VD administration to ameliorate fine particles exposure induced pulmonary damage in vivo and in vitro...
January 30, 2019: Environmental Toxicology
https://read.qxmd.com/read/30694199/data-analysis-and-visualization-of-newspaper-articles-on-thirdhand-smoke-a-topic-modeling-approach
#3
Qian Liu, Qiuyi Chen, Jiayi Shen, Huailiang Wu, Yimeng Sun, Wai-Kit Ming
BACKGROUND: Thirdhand smoke has been a growing topic for years in China. Thirdhand smoke (THS) consists of residual tobacco smoke pollutants that remain on surfaces and in dust. These pollutants are re-emitted as a gas or react with oxidants and other compounds in the environment to yield secondary pollutants. OBJECTIVE: Collecting media reports on THS from major media outlets and analyzing this subject using topic modeling can facilitate a better understanding of the role that the media plays in communicating this health issue to the public...
January 29, 2019: JMIR Medical Informatics
https://read.qxmd.com/read/30691464/a-global-perspective-on-coal-fired-power-plants-and-burden-of-lung-cancer
#4
Cheng-Kuan Lin, Ro-Ting Lin, Tom Chen, Corwin Zigler, Yaguang Wei, David C Christiani
BACKGROUND: Exposure to ambient particulate matter generated from coal-fired power plants induces long-term health consequences. However, epidemiologic studies have not yet focused on attributing these health burdens specifically to energy consumption, impeding targeted intervention policies. We hypothesize that the generating capacity of coal-fired power plants may be associated with lung cancer incidence at the national level. METHODS: Age- and sex-adjusted lung cancer incidence from every country with electrical plants using coal as primary energy supply were followed from 2000 to 2016...
January 28, 2019: Environmental Health: a Global Access Science Source
https://read.qxmd.com/read/30671885/spatial-patterns-and-effects-of-air-pollution-and-meteorological-factors-on-hospitalization-for-chronic-lung-diseases-in-beijing-china
#5
Lin Tian, Chuan Yang, Zijun Zhou, Ziting Wu, Xiaochuan Pan, Archie C A Clements
Chronic obstructive pulmonary disease (COPD), lung cancer (LC) and tuberculosis (TB) are common chronic lung diseases that generate a large disease burden and significant health care resource use in China. The aim of this study was to quantify spatial patterns and effects of air pollution and meteorological factors on hospitalization of COPD, LC and TB in Beijing. Daily counts of hospitalization for 2010 were obtained from the Beijing Urban Employees Basic Medical Insurance (UEBMI) system. Bayesian hierarchical Poisson regression models were applied to identify spatial patterns of hospitalization for COPD, LC and TB at the district level and explore associations with inhalable particulate matter (aerodynamic diameter <10 μm, PM10 ), sulfur dioxide (SO2 ), nitrogen dioxide (NO2 ), mean temperature and relative humidity...
January 21, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30664991/the-relationship-between-air-pollution-and-lung-cancer-in-non-smokers-in-taiwan
#6
Chien-Hua Tseng, Ben-Jei Tsuang, Chun-Ju Chiang, Kai-Chen Ku, Jeng-Sen Tseng, Tsung-Ying Yang, Kuo-Hsuan Hsu, Kun-Chieh Chen, Sung-Liang Yu, Wen-Chung Lee, Tsang-Wu Liu, Chang-Chuan Chan, Gee-Chen Chang
INTRODUCTION: For never-smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5 ) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between northern Taiwan (NT) and southern Taiwan (ST). METHODS: We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non-AdLC...
January 18, 2019: Journal of Thoracic Oncology
https://read.qxmd.com/read/30656582/levels-and-health-risk-assessments-of-particulate-matters-pm-2-5-and-pm-10-in-indoor-outdoor-air-of-waterpipe-caf%C3%A3-s-in-tehran-iran
#7
Gholamreza Heydari, Farhad Taghizdeh, Mehdi Fazlzadeh, Ahmad Jonidi Jafari, Zahra Asadgol, Ehsan Abouee Mehrizi, Masoud Moradi, Hossein Arfaeinia
To determine the concentration of particulate matters (PM2.5 and PM10 ), 36 samples were collected from indoor/outdoor air of hookah cafés (HS), cigarette cafés (CS), both hookah and cigarette (HCS), and no-smoking building (NS) in Tehran City from December 2017 to March 2018. The mean ± SD of PM10 concentration in the indoor air of the cafés in terms of HS, CS, HCS, and NS sites has been 702.35, 220.20, 1156.60, and 60.12 μg/m3 , while for PM2.5 , the values have been 271.92, 111.80, 619.10, and 22.25 μg/m3 , respectively...
January 17, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30653254/ambient-air-pollution-and-incident-bladder-cancer-risk-updated-analysis-of-the-spanish-bladder-cancer-study
#8
Michelle C Turner, Esther Gracia-Lavedan, Marta Cirac, Gemma Castaño-Vinyals, Núria Malats, Adonina Tardon, Reina Garcia-Closas, Consol Serra, Alfredo Carrato, Rena R Jones, Nathaniel Rothman, Debra T Silverman, Manolis Kogevinas
Although outdoor air pollution and particulate matter in outdoor air have been consistently linked with increased lung cancer risk, the evidence for associations at other cancer sites is limited. Bladder cancer shares several risk factors with lung cancer and some positive associations of ambient air pollution and bladder cancer risk have been observed. This study examined associations of ambient air pollution and bladder cancer risk in the large-scale Spanish Bladder Cancer Study. Estimates of ambient fine particulate matter (PM2...
January 17, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30652275/spatial-clusters-of-breast-cancer-mortality-and-incidence-in-the-contiguous-usa-2000-2014
#9
Raid W Amin, Bridget A Fritsch, John E Retzloff
BACKGROUND: Clusters of breast cancer with varied incidence or mortality are known to exist. No national scale of analysis of geographical variation in breast cancer incidence has been published before for the contiguous USA. METHODS: This was a spatial cluster analysis of incidence and mortality data on breast cancer in the contiguous USA at the county resolution. Data for the years 2000-2014 were downloaded and analyzed with the software SaTScan with the goal to identify significant spatial clusters of breast cancer...
January 16, 2019: Journal of General Internal Medicine
https://read.qxmd.com/read/30649585/bituminous-coal-combustion-and-xuan-wei-lung-cancer-a-review-of-the-epidemiology-intervention-carcinogens-and-carcinogenesis
#10
REVIEW
Jinhui Li, Jinjun Ran, Lung-Chi Chen, Max Costa, Yunchao Huang, Xiao Chen, Linwei Tian
Indoor air pollution from bituminous coal combustion has been linked to the extremely high lung cancer rates of nonsmoking women in Xuan Wei County, Yunnan Province, China. Venting the smoke outdoors by installing chimneys was found to be effective at reducing the lung cancer risk in a cohort study of 21,232 farmers in central Xuan Wei. However, the lung cancer mortality rates in all 1.2 million residents of Xuan Wei have been increasing dramatically over the last four decades. It was higher than that in Yunnan Province and China overall, with significant heterogeneities in the geographic patterns of Xuan Wei...
January 16, 2019: Archives of Toxicology
https://read.qxmd.com/read/30647065/particulate-matter-and-traffic-related-exposures-in-relation-to-breast-cancer-survival
#11
Natalie C DuPre, Jaime E Hart, Michelle D Holmes, Elizabeth M Poole, Peter James, Peter Kraft, Francine Laden, Rulla M Tamimi
BACKGROUND: While particulate matter (PM) has not been consistently associated with breast cancer risk, two studies have reported harmful associations for breast cancer survival. We examined PM exposures and breast cancer survival in two US-based prospective cohort studies. METHODS: The Nurses' Health Study (NHS) and NHSII are cohorts with detailed data on medical history, lifestyle factors, and causes of death. Women with Stage I-III breast cancer (n=8,936) were followed through June 2014...
January 15, 2019: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/30628315/-source-apportionment-and-heath-risk-quantification-of-heavy-metals-in-pm-2-5-in-yangzhou-china
#12
Shi-Hao Dong, Yang Xie, Yan-Qi Huangfu, Xu-Rong Shi, Rui Yi, Guo-Liang Shi, Yin-Chang Feng
Recently, a new method combining positive matrix factorization (PMF) and heavy metal health risk (HMHR) assessment was proposed to apportion sources of heavy metals in ambient particulate matter and the associated heavy metal cancer health risk (HMCR), which has been applied to data collected in Yangzhou, China. The annual average concentrations of six measured heavy metals were Pb (64.4 ng·m-3 ), followed by Cr (25.24 ng·m-3 ), As (6.36 ng·m-3 ), Ni (5.36 ng·m-3 ), Cd (3.34 ng·m-3 ), and Co (1.21 ng·m-3 )...
February 8, 2019: Huan Jing Ke Xue= Huanjing Kexue
https://read.qxmd.com/read/30612014/cytotoxic-and-genotoxic-effects-in-mechanics-occupationally-exposed-to-diesel-engine-exhaust
#13
Grethel León-Mejía, Ibeth Luna-Rodríguez, Cristiano Trindade, Ludis Oliveros-Ortíz, Marco Anaya-Romero, Jaime Luna-Carrascal, Nebis Navarro-Ojeda, Martha Ruiz-Benitez, Karen Franco-Valencia, Juliana Da Silva, João Antônio Pêgas Henriques, Amner Muñoz-Acevedo, M Quintana-Sosa
Diesel engine exhaust (DEE), which is the product of diesel combustion, is considered carcinogenic in humans. It comprises toxic gases, polycyclic aromatic hydrocarbons (PAHs) and particulate matter which can reach the pulmonary parenchyma and trigger various diseases, including cancer. The aim of the present study was to evaluate the potential cytotoxic and genotoxic effects of DEE exposure on peripheral blood and buccal epithelial cells in mechanics occupationally exposed to DEE. We recruited 120 exposed mechanics and 100 non-exposed control individuals...
January 3, 2019: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30602677/tmt-based-quantitative-proteomics-analysis-reveals-airborne-pm-2-5-induced-pulmonary-fibrosis
#14
Shan Liu, Wei Zhang, Fang Zhang, Peter Roepstorff, Fuquan Yang, Zhongbing Lu, Wenjun Ding
Epidemiological and experimental studies have documented that long-term exposure to fine particulate matter (PM2.5 ) increases the risk of respiratory diseases. However, the details of the underlying mechanism remain unclear. In this study, male C57BL/6 mice were exposed to ambient PM2.5 (mean daily concentration ~64 µg/m³) for 12 weeks through a "real-world" airborne PM2.5 exposure system. We found that PM2.5 caused severe lung injury in mice as evidenced by histopathological examination. Then, tandem mass tag (TMT) labeling quantitative proteomic technology was performed to analyze protein expression profiling in the lungs from control and PM2...
December 31, 2018: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30596563/fine-particulate-matter-pm%C3%A2-5-promoted-the-invasion-of-lung-cancer-cells-via-an-arnt2-pp2a-stat3-mmp2-pathway
#15
Zhongqi Chen, Ningfei Ji, Zhengxia Wang, Chaojie Wu, Zhixiao Sun, Yan Li, Fan Hu, Zibin Wang, Mao Huang, Mingshun Zhang
No abstract text is available yet for this article.
February 1, 2019: Journal of Biomedical Nanotechnology
https://read.qxmd.com/read/30594197/air-pollution-and-female-fertility-a-systematic-review-of-literature
#16
REVIEW
Alessandro Conforti, Marika Mascia, Giuseppina Cioffi, Cristina De Angelis, Giuseppe Coppola, Pasquale De Rosa, Rosario Pivonello, Carlo Alviggi, Giuseppe De Placido
Air pollution is a cause of concern for human health. For instance, it is associated with an increased risk for cancer, cardiovascular and respiratory disorders. In vitro and in vivo studies suggested that air pollutants could act as endocrine disruptors, promote oxidative stress and exert genotoxic effect. Whether air pollution affects female infertility is under debate. The aim of the present study was to conduct a systematic review of studies that evaluated the impact of air pollution on female infertility...
December 30, 2018: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/30594114/health-benefit-assessment-of-pm-2-5-reduction-in-pearl-river-delta-region-of-china-using-a-model-monitor-data-fusion-approach
#17
Jiabin Li, Yun Zhu, James T Kelly, Carey J Jang, Shuxiao Wang, Adel Hanna, Jia Xing, Che-Jen Lin, Shicheng Long, Lian Yu
The Pearl River Delta (PRD), one of the most polluted and populous regions of China, experienced a 28% reduction in fine particulate matter (PM2.5 ) concentration between 2013 (47 μg/m3 ) and 2015 (34 μg/m3 ) under a stringent national policy known as the Air Pollution Prevention and Control Action Plan (hereafter Action Plan). In this study, the health and economic benefits associated with PM2.5 reductions in PRD during 2013-2015 were estimated using the Environmental Benefits Mapping and Analysis Program-Community Edition (BenMAP-CE) software...
December 26, 2018: Journal of Environmental Management
https://read.qxmd.com/read/30579988/meteorological-correlates-and-airq-health-risk-assessment-of-ambient-fine-particulate-matter-in-tehran-iran
#18
Mohsen Ansari, Mohammad Hassan Ehrampoush
There are few studies in the world that have been evaluated the mortality due to exposure to particulate matter smaller than 2.5 µm by AirQ+ software. Therefore, the study aimed to correlate between fine particulate matter (PM2.5) and meteorological variables and estimate all-cause annual mortality and mortality from cerebrovascular disease (stroke), ischemic heart disease (IHD), acute lower respiratory infection (ALRI), lung cancer (LC), chronic obstructive pulmonary disease (COPD) attributed to long-term exposure to ambient PM2...
December 1, 2018: Environmental Research
https://read.qxmd.com/read/30579164/transgenerational-effects-of-diesel-particulate-matter-on-caenorhabditis-elegans-through-maternal-and-multigenerational-exposure
#19
Mudi Wang, Yaguang Nie, Ying Liu, Hui Dai, Jingjing Wang, Bo Si, Zhen Yang, Lei Cheng, Yun Liu, Shaopeng Chen, An Xu
Diesel particulate matter (DPM) is a dominant contaminant in fine particulate matters (PM2.5 ) and has been proved to induce serious harmful effects to human beings, including lung cancer, allergic, and chronic bronchitis. However, little attention has been paid to understand the transgenerational effects of DPM. In the present study, we focused on the transgenerational effects of DPM in the model organism Caenorhabditis elegans (C. elegans) exposed in either maternal generation (F0) or consecutive generations (F0-F5)...
December 19, 2018: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30573075/pm-2-5-bound-polycyclic-aromatic-hydrocarbons-pahs-in-beijing-seasonal-variations-sources-and-risk-assessment
#20
Baihuan Feng, Lijuan Li, Hongbing Xu, Tong Wang, Rongshan Wu, Jie Chen, Yi Zhang, Shuo Liu, Steven Sai Hang Ho, Junji Cao, Wei Huang
Polycyclic aromatic hydrocarbons (PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk (ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5μm (PM2.5 ) in metropolitan Beijing, China. We collected 24-hour integrated PM2.5 samples on daily basis between November 2014 and June 2015 across both central heating (cold months) and non-heating (warm months) seasons, and further analyzed the PAH components in these daily PM2...
March 2019: Journal of Environmental Sciences (China)
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