keyword
https://read.qxmd.com/read/38525133/short-term-inhalation-exposure-to-cigarette-smoke-induces-oxidative-stress-and-inflammation-in-lungs-without-systemic-oxidative-stress-in-mice
#1
JOURNAL ARTICLE
Yoon-Seok Seo, Kwang-Hoon Park, Jung-Min Park, Hyuneui Jeong, Bumseok Kim, Jang Su Jeon, Jieun Yu, Sang Kyum Kim, Kyuhong Lee, Moo-Yeol Lee
Smoking is a well-established risk factor for various pathologies, including pulmonary diseases, cardiovascular disorders, and cancers. The toxic effects of cigarette smoke (CS) are mediated through multiple pathways and diverse mechanisms. A key pathogenic factor is oxidative stress, primarily induced by excessive formation of reactive oxygen species. However, it remains unclear whether smoking directly induces systemic oxidative stress or if such stress is a secondary consequence. This study aimed to determine whether short-term inhalation exposure to CS induces oxidative stress in extrapulmonary organs in addition to the lung in a murine model...
April 2024: Toxicological Research
https://read.qxmd.com/read/38521275/high-spatial-resolved-source-specific-exposure-and-risk-in-the-city-scale-influence-of-spatial-interrelationship-between-pm-2-5-sources-and-population-on-exposure
#2
JOURNAL ARTICLE
Xinyao Feng, Yingze Tian, Tengfei Zhang, Qianqian Xue, Danlin Song, Fengxia Huang, Yinchang Feng
Research on High Spatial-Resolved Source-Specific Exposure and Risk (HSRSSER) was conducted based on multiple-year, multiple-site synchronous measurement of PM2.5 -bound (particulate matter with aerodynamic diameter<2.5 μm) toxic components in a Chinese megacity. The developed HSRSSER model combined the Positive Matrix Factorization (PMF) and Land Use Regression (LUR) to predict high spatial-resolved source contributions, and estimated the source-specific exposure and risk by personal activity time- and population-weighting...
March 21, 2024: Science of the Total Environment
https://read.qxmd.com/read/38518972/elucidating-the-changing-particulate-matter-pollution-and-associated-health-effects-in-rural-india-during-2000-2019
#3
JOURNAL ARTICLE
Mansi Pathak, Jayanarayanan Kuttippurath
Atmospheric pollution is a great problem in many countries, including India, and it is generally considered as an urban issue. To fill the knowledge gap about particulate pollution and its adverse health effects in rural India for well-informed region-specific policy interventions, we present new insights on the rural pollution of India in terms of PM2.5 . Here, we analyse PM2.5 pollution and its associated health burden in rural India using satellite and reanalyses data for the period 2000-2019. We observe a gradual and consistent rise of atmospheric pollution in rural areas of India...
March 20, 2024: Environmental Pollution
https://read.qxmd.com/read/38518612/dysfunction-of-nrf2-regulated-cellular-defence-system-and-jnk-activation-induced-by-high-dose-of-fly-ash-particles-are-associated-with-pulmonary-injury-in-mouse-lungs
#4
JOURNAL ARTICLE
Jingwen Zhang, Kaihua Liu, Xiuwen Tang, Xiu Jun Wang
The mechanisms of the exposure to fine particulate matter (PM) as a risk factor for pulmonary injury are not fully understood. The transcription factor, NF-E2-related factor 2 (Nrf2), plays a key role in protection lung against PM insult and cancer chemoprevention. In this study, F3-S fly ash particles from a municipal waste incinerator were evaluated as a PM model. We found that F3-S triggered hierarchical oxidative stress responses involving the prolonged activation of the cytoprotective Nrf2 transcriptional program via Keap1 Cys151 modification, and c-Jun NH2-terminal kinase (JNK) phosphorylation at higher doses...
March 21, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38513187/assessing-the-global-impact-of-ambient-air-pollution-on-cancer-incidence-and-mortality-a-comprehensive-meta-analysis
#5
REVIEW
Thilagavathi Ramamoorthy, Anita Nath, Shubhra Singh, Stany Mathew, Apourv Pant, Samvedana Sheela, Gurpreet Kaur, Krishnan Sathishkumar, Prashant Mathur
PURPOSE: This study aims to examine the association between exposure to major ambient air pollutants and the incidence and mortality of lung cancer and some nonlung cancers. METHODS: This meta-analysis used PubMed and EMBASE databases to access published studies that met the eligibility criteria. Primary analysis investigated the association between exposure to air pollutants and cancer incidence and mortality. Study quality was assessed using the Newcastle Ottawa Scale...
March 2024: JCO global oncology
https://read.qxmd.com/read/38497801/fine-particulate-matter-noise-pollution-and-greenspace-and-prostate-cancer-risk-in-the-prostate-lung-colorectal-and-ovarian-plco-cancer-screening-trial-cohort
#6
JOURNAL ARTICLE
Aleah L Thomas, Jongeun Rhee, Jared A Fisher, Marie-Josèphe Horner, Rena R Jones
BACKGROUND: Greenspace is hypothesized as being protective against cancer, whereas noise pollution and fine particulate matter (<2.5 µm in diameter, PM2.5) are both potential risk factors. Findings from recent studies of greenspace and PM2.5 with prostate cancer are not conclusive and the association between noise exposure and cancer has not been evaluated in a U.S. METHODS: We assessed PM2.5, noise, and greenspace exposure using spatiotemporal models and satellite-based estimates at enrollment addresses for N=43,184 male participants of the prospective Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial cohort (enrolled 1994-2001)...
March 18, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38482782/stima-dei-decessi-attribuibili-all-inquinamento-da-no2-pm10-e-pm2-5-nella-citt%C3%A3-di-milano-nel-2019
#7
JOURNAL ARTICLE
Sara Tunesi, Walter Bergamaschi, Antonio Giampiero Russo
BACKGROUND: there is growing evidence that exposure to environmental pollutants affects health, including mortality, chronic diseases, and acute diseases. The World Health Organisation has recently revised downwards the safety thresholds for exposure to environmental pollutants. The City of Milan (CoM) has particularly high levels of pollution; this is due both to the presence of various emission sources and to climatic and orographic conditions. OBJECTIVES: to describe the health effects of exposure to pollutants, measured by deaths due to environmental exposure to NO2, PM10, and PM2...
2024: Epidemiologia e Prevenzione
https://read.qxmd.com/read/38462082/comparing-the-risks-of-environmental-carcinogenic-chemicals-in-japan-using-the-loss-of-happy-life-expectancy-indicator
#8
JOURNAL ARTICLE
Michio Murakami, Kyoko Ono, Yoshitake Takebayashi, Masaharu Tsubokura, Shuhei Nomura
In this study, we aimed to use the loss of happy life expectancy (LHpLE), an indicator that enables risk assessment considering wellbeing, to compare the risks of environmental carcinogenic chemicals in Japan. First, we surveyed Japanese people to determine their emotional happiness by age and sex and evaluated whether cancer incidence reduced emotional happiness. Questionnaires were administered to a general population panel and a panel of patients with cancer in 2022, recruiting a predetermined number of responses of 5000 and 850, respectively...
March 8, 2024: Environmental Research
https://read.qxmd.com/read/38450584/particulate-matters-2-5-induce-tumor-progression-in-lung-cancer-by-increasing-the-activity-of-hnrnpa2b1-resulting-in-retarding-mrna-decay-of-oxidative-phosphorylation
#9
JOURNAL ARTICLE
Wen Bian, Haifeng Yu, Xiaofei Zhang, Yuxuan Wang, Bin Ni
Particulate matter 2.5 (PM2.5) has been implicated in lung injury and various cancers, yet its precise mechanistic role remains elusive. To elucidate the key signaling pathways underpinning PM2.5-induced lung cancer progression, we embarked on a study examining the impact of PM2.5 both in vitro and in vivo. Lung cancer cell lines, A549 and H157, were employed for the in vitro investigations. Overexpression or knockdown techniques targeting the hnRNPA2B1 protein were implemented. Lung cancer cells were treated with a medium containing PM2...
March 7, 2024: IUBMB Life
https://read.qxmd.com/read/38434617/the-biological-interplay-between-air-pollutants-and-mirnas-regulation-in-cancer
#10
REVIEW
Alessandro Giammona, Sofia Remedia, Danilo Porro, Alessia Lo Dico, Gloria Bertoli
Air pollution, especially fine particulate matter (PM2.5, with an aerodynamic diameter of less than 2.5 μm), represents a risk factor for human health. Many studies, regarding cancer onset and progression, correlated with the short and/or long exposition to PM2.5. This is mainly mediated by the ability of PM2.5 to reach the pulmonary alveoli by penetrating into the blood circulation. This review recapitulates the methodologies used to study PM2.5 in cellular models and the downstream effects on the main molecular pathways implicated in cancer...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38432370/metals-nonmetals-and-metalloids-in-cigarette-smoke-as-hazardous-compounds-for-human-health
#11
JOURNAL ARTICLE
Héctor Morillas, Euler Gallego-Cartagena, Settakorn Upasen
Cigarette smoke contains many chemicals that are harmful to both smokers and non-smokers. Breathing just a little cigarette smoke can be harmful. There are >7000 chemicals in cigarette smoke, at least 250 are known to be harmful and many of them can cause cancer. Currently, many studies reported the types of harmful organic compounds in cigarette smoke; instead, there are almost no works that describe the presence of inorganic compounds. In this work, a cost-effective self-made passive sampler (SMPS) was tested as a tool to collect different types of particulate matter (PM) from cigarette smoke containing metals as hazardous compounds (HCs)...
March 1, 2024: Science of the Total Environment
https://read.qxmd.com/read/38429521/source-analysis-and-health-risk-assessment-of-polycyclic-aromatic-hydrocarbon-pahs-in-total-suspended-particulate-matter-tsp-from-bengbu-china
#12
JOURNAL ARTICLE
Danchen Wu, Liu Chen, Zhijing Ma, Dalin Zhou, Le Fu, Mengmeng Liu, Tianer Zhang, Jing Yang, Quan Zhen
The polycyclic aromatic hydrocarbon (PAH) concentrations in total suspended particulate matter (TSP) samples collected from October, 2021 to September, 2022 were analyzed to clarify the pollution characteristics and sources of 16 PAHs in the atmospheric TSP in Bengbu City. The ρ(PAHs) concentrations ranged from 1.71 to 43.85 ng/m3 and higher concentrations were detected in winter, followed by spring, autumn, and summer. The positive matrix factorization analysis revealed that, in spring and summer, PAH pollution was caused mainly by industrial emissions, gasoline and diesel fuel combustion, whereas in autumn and winter, it was coal, biomass and natural gas combustion...
March 1, 2024: Scientific Reports
https://read.qxmd.com/read/38418158/the-impact-of-pm-2-5-on-radiation-induced-pneumonitis-in-patients-with-breast-cancer
#13
JOURNAL ARTICLE
Dong-Yun Kim, In Ah Kim, Bum-Sup Jang
BACKGROUND/AIM: Exposure to particulate matter (PM) air pollution is known to adversely affect respiratory disease, but no study has examined its effect on radiation-induced pneumonitis (RIP) in patients with breast cancer. PATIENTS AND METHODS: We conducted a retrospective review of 2,736 patients with breast cancer who received postoperative radiation therapy (RT) between 2017 and 2020 in a single institution. The distance between the PM measurement station and our institution was only 3...
2024: In Vivo
https://read.qxmd.com/read/38409078/differential-pulmonary-toxicity-and-autoantibody-formation-in-genetically-distinct-mouse-strains-following-combined-exposure-to-silica-and-diesel-exhaust-particles
#14
JOURNAL ARTICLE
Lisa Mf Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen Aj Vanoirbeek, Kenneth Michael Pollard, Manosij Ghosh, Peter Hm Hoet
BACKGROUND: Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects. This study investigates the separate and combined effects of occupational-level silica and ambient-level DEP on lung injury, inflammation, and autoantibody formation in two genetically distinct mouse strains, thereby aiming at understanding the interplay between genetic susceptibility, particulate exposure, and disease outcomes...
February 27, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38408818/fine-particle-trace-elements-at-a-mountain-site-in-southern-china-source-identification-transport-and-health-risks
#15
JOURNAL ARTICLE
Jiaoping Xing, Runping Ding, Feifeng Chen, Linyu Peng, Wenhua Wang, Xiaoyan Song, Qing Ye, Yuanqiu Liu
Trace elements in atmospheric particulate matter play a significant role in air quality, human health, and biogeochemical cycles. In this study, the trace elements (Ca, Al, K, Fe, Na, Mg, Zn, Pb, Mn, Ti, Cu, Cr, Sr, Ni) in PM2.5 samples collected at the summit of Mt. Lushan were analyzed to quantify their abundance, source, transport, and health risks. During the whole sampling period, the major trace elements was Ca, Al, and K. While the trace metals with the lowest concentrations were Sr, Ni, Rb, and Cd. The trace elements were influenced by air mass transport routes, exhibiting an increasing trend of crustal elements in the northwesterly airmass and anthropogenic elements (Zn, Mn, Cu, and Ni) in the easterly air masses...
July 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38393244/effects-of-pm-10-airborne-particles-from-different-regions-of-a-megacity-on-in-vitro-secretion-of-cytokines-by-a-monocyte-line-during-different-seasons
#16
JOURNAL ARTICLE
Noemi Meraz-Cruz, Natalia Manzano-León, Daniel Eduardo Sandoval-Colin, María Del Carmen García de León Méndez, Raúl Quintana-Belmares, Laura Sevilla Tapia, Alvaro R Osornio-Vargas, Miatta A Buxton, Marie S O'Neill, Felipe Vadillo-Ortega
Several epidemiological studies have demonstrated that particulate matter (PM) in air pollution can be involved in the genesis or aggravation of different cardiovascular, respiratory, perinatal, and cancer diseases. This study assessed the in vitro effects of PM10 on the secretion of cytokines by a human monocytic cell line (THP-1). We compared the chemotactic, pro-inflammatory, and anti-inflammatory cytokines induced by PM10 collected for two years during three different seasons in five different Mexico City locations...
February 15, 2024: Toxics
https://read.qxmd.com/read/38390149/fine-particulate-matter-from-brick-kilns-site-and-roadside-in-lahore-pakistan-insight-into-chemical-composition-oxidative-potential-and-health-risk-assessment
#17
JOURNAL ARTICLE
Mushtaq Ahmad, Jing Chen, Sirima Panyametheekul, Qing Yu, Asim Nawab, Muhammad Tariq Khan, Yuepeng Zhang, Syed Weqas Ali, Worradorn Phairuang
BACKGROUND: Human health is seriously threatened by particulate matter (PM) pollution, which is a major environmental problem. A better indicator of biological responses to PM exposure than its mass alone is the PM "oxidative potential (OP)," or ability to oxidize target molecules. When reactive oxygen species (ROS) are generated in the OP in excess of the antioxidant capacity of body due to PM components such metals and organic species, it causes inflammation, deoxyribonucleic acid (DNA), proteins, and lipids damage...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38373277/nontargeted-identification-of-organic-components-in-fine-particulate-matter-related-to-lung-tumor-metastasis-based-on-an-adverse-outcome-pathway-strategy
#18
JOURNAL ARTICLE
Shaoyang Ji, Yuqiong Guo, Jinjian Ding, Wenjun Hong, Zhipeng Yan, Zhihong Cai, Huifeng Yue, Xinghua Qiu, Nan Sang
Emerging studies implicate fine particulate matter (PM2.5 ) and its organic components (OCs) as urgent hazard factors for lung cancer progression in nonsmokers. Establishing the adverse outcome pathway (AOP)-directed nontargeted identification method, this study aimed to explore whether PM2.5 exposure in coal-burning areas promoted lung tumor metastasis and how we identify its effective OCs to support traceability and control of regional PM2.5 pollution. First, we used a nude mouse model of lung cancer for PM2...
February 19, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38366656/pm2-5-vegetation-density-and-childhood-cancer-a-case-control-registry-based-study-from-texas-1995-2011
#19
JOURNAL ARTICLE
Lindsay A Williams, David Haynes, Jeannette M Sample, Zhanni Lu, Ali Hossaini, Laura A McGuinn, Thanh T Hoang, Philip J Lupo, Michael E Scheurer
BACKGROUND: Air pollution is positively associated with some childhood cancers while greenness is inversely associated with some adult cancers. The interplay between air pollution and greenness in childhood cancer etiology is unclear. We estimated the association between early life air pollution and greenness exposure and childhood cancer in Texas (1995-2011). METHODS: We included 6,101 cancer cases and 109,762 controls (aged 0-16 years). We linked residential birth address to census tract annual average particulate matter ≤2...
February 15, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38361599/temporal-patterns-of-cancer-burden-in-asia-1990-2019-a-systematic-examination-for-the-global-burden-of-disease-2019-study
#20
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Cancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. METHODS: The age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study...
February 2024: Lancet Reg Health Southeast Asia
keyword
keyword
165876
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.