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Xueke Sun, Jiao Sun, Biao Dong, Gaosheng Huang, Li Zhang, Wanhui Zhou, Jiekai Lv, Xinran Zhang, Min Liu, Lin Xu, Xue Bai, Wen Xu, Yudan Yang, Xiuling Song, Hongwei Song
Accurate treatment of photothermal therapy (PTT) is crucial to avoid the unnecessary injury of normal cells and tissues. Therefore the real-time temperature monitoring in the PTT process has drawn more and more attention in recent years. Herein, we designed and prepared one kind of lanthanide (Ln3+ )-doped up-conversion nanocomposites with multi-functions, which can not only provide temperature feedback in PTT process, but also play the photodynamic therapy (PDT) function for the synergistic effect of tumor therapy...
February 14, 2019: Biomaterials
Chaoli Wang, Peng Chen, Youbei Qiao, Yuan Kang, Songyan Guo, Danfeng Wu, Jian Wang, Hong Wu
With the increase in antibiotic resistance, the development of new antibacterial agents is urgent. Photosensitizers with no detectable resistance are promising antibacterial agents. However, most photosensitizers are insoluble, structurally unstable and ineffective against Gram-negative bacteria due to their negatively charged cell wall that hinder their use. In this study, a novel bacteria-activated photosensitizer ionic liquid was designed and assembled to improve the solubility, stability and antibacterial ability of photodynamic therapy...
February 15, 2019: Biomaterials Science
Yuxia Tang, Ying Liu, Shouju Wang, Ying Tian, Yanjun Li, Zhaogang Teng, Guangming Lu
Nanocarriers for drug delivery have made great progress in the treatment of cancer, but the dense extracellular collagen of tumors has greatly limited the efficiency of drug delivery. In this study, losartan is used to deplete tumor collagen and improve the delivery efficiency and photodynamic therapeutic efficacy of chlorine 6 (Ce6)-loaded periodic mesoporous organosilica nanoplatform (Ce6-PMO) for breast cancer. After pretreatment with losartan in vivo, the tumor collagen I fraction is significantly reduced by 53% compared to that of mice pretreated with saline...
January 28, 2019: Drug Delivery and Translational Research
Si-Han Chen, Wan-Wen Huang, Khalilalrahman Dehvari, Yong-Chien Ling, Anil V Ghule, Shen-Long Tsai, Jia-Yaw Chang
Photo-activated therapy is a non-invasive and promising medical technology for the treatment of cancers. Herein, we present Ce6-HA-CIS phototherapeutic nanohybrids composed of Cu-In-S (CIS) heterostructured nanorod (HS-rod), chlorin e6 (Ce6), and hyaluronic acid (HA) for the use in targeted photodynamic/photothermal therapy (PDT/PTT). In the Ce6-HA-CIS nanohybrids, the CIS HS-rod was investigated as a PTT agent to convert light into thermal energy, with Ce6 acting as a PDT agent to generate singlet oxygen (1 O2 )...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
Xiaoqiu Xu, Huijie An, Dinglin Zhang, Hui Tao, Yin Dou, Xiaohui Li, Jun Huang, Jianxiang Zhang
Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibility of the nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with a luminescent donor (luminol) and a fluorescent acceptor [chlorin e6 (Ce6)] for in vivo luminescence imaging and photodynamic therapy in deep tissues...
January 2019: Science Advances
Lihong Sun, Mengmeng Hou, Lei Zhang, Dongxiang Qian, Qingquan Yang, Zhigang Xu, Yuejun Kang, Peng Xue
Taking advantage of the mesoporous structure of bismuth sulfide nanostars (Bi2 S3 NSs), a chemotherapeutic drug of doxorubicin (DOX) and a photosensitizer of chlorin e6 (Ce6) were concurrently loaded in the PEGylated Bi2 S3 NSs to formulate a multifunctional nanocomplex (BPDC NSs) for tumor theranostics. BPDC NSs have excellent photothermal conversion efficiency and a capacity of yielding reactive oxygen species (ROS) upon laser irradiation, and can realize on-demand drug release by either pH-activation or thermal induction...
January 14, 2019: Nanomedicine: Nanotechnology, Biology, and Medicine
Peishan Li, Li Liu, Qianglan Lu, Shan Yang, Lifang Yang, Yu Cheng, Yidan Wang, Siyu Wang, Yilin Song, Fengping Tan, Nan Li
Recently, we developed ultrasmall molybdenum disulfide (MoS2) quantum dots for computed tomography (CT) and multispectral optoacoustic tomography (MSOT) image-guided phuotothermal therapy (PTT). But, due to the rapid body elimination and the limited blood circulation time, the tumor uptake of the dots is low. In our study, this problem was solved via designing an amino modified biodegradable nanomaterial based on MoS2 quantum dots doped disulfide-based SiO2 nanoparticles (denoted MoS2@ss-SiO2) for multimodal application...
January 17, 2019: ACS Applied Materials & Interfaces
Shan Sun, Jingqin Chen, Kai Jiang, Zhongdi Tang, Yuhui Wang, Zhongjun Li, Chengbo Liu, Aiguo Wu, Hengwei Lin
Photo-mediated cancer therapy, mainly including photothermal therapy (PTT) and photodynamic therapy (PDT), have received tremendous attention in recently years thanks to their noninvasive and stimuli-responsive features. The single mode of PTT or PDT, however, shows obvious drawbacks, either requiring high power laser irradiation to generate enough heat or only providing limited efficacy due to the hypoxia nature inside tumors. In addition, the reported synergistic PTT/PDT usually utilized two excitation sources to separately activate PTT and PDT, and the problem of high power laser irradiation for PTT was still not well solved...
January 16, 2019: ACS Applied Materials & Interfaces
Changwei Ji, Ahu Yuan, Liu Xu, Feifei Zhang, Shiwei Zhang, Xiaozhi Zhao, Guangxiang Liu, Wei Chen, Hongqian Guo
Prostate cancer is one of the leading causes of death in men worldwide. Photodynamic therapy (PDT) is a new emerging and promising strategy for the treatment of prostate cancer. PDT uses a combination of light and a photosensitizer (PS) to kill cancer cells. However, most photosensitizers (PS) accumulate in normal tissues, in particular the skin and eyes, and can be activated by sunlight, causing severe side effects such as prolonged skin photosensitivity that have limited the clinical application of PDT. Herein, a novel strategy is presented to overcome these limitations using Indocyanine green (ICG) as an activatable PDT agent...
February 1, 2019: Journal of Biomedical Nanotechnology
Xiaolin Sun, Lin Wang, Christopher D Lynch, Xueke Sun, Xue Li, Manlin Qi, Cui Ma, Chunyan Li, Biao Dong, Yanmin Zhou, Hockin H K Xu
OBJECTIVES: The objectives of this study were to: (1) develop the multifunctional nanoparticles containing Chlorin e6 (Ce6), Coumarin 6 (C6) and Fe3 O4 nanoparticles (NPs); and (2) investigate the inhibitory effects of the nanoparticles via antibacterial photodynamic therapy (aPDT) against three species of periodontitis-related pathogens for the first time. MATERIALS AND METHODS: Ce6 and C6 were co-loaded into the Fe3 O4 -silane core-shell structure to form multifunctional nanoparticles (denoted "Fe3 O4 -silane@Ce6/C6 MNPs")...
December 26, 2018: Journal of Dentistry
Chaemin Lim, Junseong Moon, Taehoon Sim, Woong Roeck Won, Eun Seong Lee, Yu Seok Youn, Kyung Taek Oh
Photo-Chemo combination therapy has been intensively investigated for treatment of cancers, especially multidrug resistance cancer. However, antagonistic interactions between chemo-drugs and photosensitizers are frequently reported, and drugs doses and treatment sequences have been changed to overcome the problems. We observed the antagonistic effect by a decrease in singlet oxygen generation from the photosensitizer when Dox was in close physical proximity. To control the distance between Dox and the photosensitizer, we developed a novel pH-sensitive poly ionomer complex system composed of PEG-PLL(-g-Ce6) [Chlorin e6 grafted poly(ethylene glycol)-poly(l-lysine)] and PEG-PLL(-g-DMA)-PLA [2,3-dimethylmaleic anhydride grafted poly(ethylene glycol)-poly(l-lysine)-poly(lactic acid)] and evaluated this system with regard to singlet oxygen generation and antiproliferative activity against MCF-7/Dox cells...
December 25, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Junxia Wang, Xinyu He, Song Shen, Ziyang Cao, Xianzhu Yang
The extremely inefficient endosomal escape and intracellular release are the central barriers for effective nanocarrier-mediated RNA interference (RNAi) therapeutics. Accelerating endosomal escape and triggering intracellular release with red or near-infrared light are of particular interest due to its spatiotemporal controllability, great tissue penetration, and minimal phototoxicity. As a proof-of-concept, we explored an innovative siRNA delivery system, TKPEI-Ce6, that is prepared by the linking reaction of branched polyethylenimine, a reactive oxygen species (ROS)-labile crosslinker, poly(ethylene glycol), and chlorin e6 (Ce6)...
December 24, 2018: ACS Applied Materials & Interfaces
James Mitchell, Naveena Yanamala, Yi Lei Tan, Eric E Gardner, Kalyan C Tirupula, Fernanda Balem, Mordechai Sheves, Daniel Nietlispach, Judith Klein-Seetharaman
The chlorophyll-derivative chlorin e6 (Ce6) identified in the retinas of deep-sea ocean fish is proposed to play a functional role in red bioluminescence detection. Fluorescence and 1 H NMR spectroscopy studies with the bovine dim-light photoreceptor, rhodopsin, indicate that Ce6 weakly binds to it with μM affinity. Absorbance spectra prove that red light sensitivity enhancement is not brought about by a shift in the absorbance maximum of rhodopsin. 19 F NMR experiments with samples where 19 F labels are either placed at the cytoplasmic binding site or incorporated as fluorinated retinal, indicate that the cytoplasmic domain is highly perturbed by binding, while little to no changes are detected near the retinal...
December 24, 2018: Photochemistry and Photobiology
Chaoqun You, Zhiguo Gao, Mingxin Wang, Hongshuai Wu, Peijing An, Senlin Wang, Yu Sun, Baiwang Sun, Xiangyang Zhang
Lipid-polymer hybrid nanoparticle was suggested to be a new and promising drug delivery agent due to the suitable particle size and controllable release. However, the low drug loading capacity has been a critical problem in the improvement of the nano-carrier systems. At present work, we have designed and developed smart nanoparticles with cholesterol-cisplatin (IV) conjugate contained to enhance the drug loading capacity. The predesigned drug delivery system showed enhanced synergistic effect through co-delivery of cisplatin and Ce6 and the drug released in a controllable way due to the polyaniline mediated photothermal conversion...
February 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
Xiao Wu, Peijian Yan, Zhaohui Ren, Yifan Wang, Xiujun Cai, Xiang Li, Renren Deng, Gaorong Han
The efficacy of dynamic therapy for solid tumors suffers daunting challenges induced by tumor hypoxia. Herein, we report a biocompatible nanosystem containing Fe(OH)3-modified upconversion nanoparticles (UCNPs) for promoted synergetic chemo- and photo- dynamic therapy with the modulation of tumor hypoxia. In the system, UCNPs convert 808 nm-NIR excitation to visible photon energy which stimulates Ce6 photosensitizers to generate toxic reactive oxygen species (ROS) by consumption of dissolved oxygen in cancer cells...
December 17, 2018: ACS Applied Materials & Interfaces
Lei Liu, Hong-Jun Xie, Li-Min Mu, Rui Liu, Zhan-Bo Su, Yi-Nuo Cui, Ying Xie, Wan-Liang Lu
Background: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect. Methods: Functional chlorin gold nanorods (Ce6-AuNR@SiO2 -d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). The nanostructure was developed by synthesizing Au nanorods as the photothermal conversion material, and by coating the pegylated mesoporous SiO2 as the shell for entrapping photosensitizer Ce6 and for linking the D-type cell penetrating peptide (d-CPP)...
2018: International Journal of Nanomedicine
Anthony P Neumann, Garret Suen
Members of the genus Fibrobacter are cellulose-degrading bacteria and common constituents of the gastrointestinal microbiota of herbivores. Although considerable phylogenetic diversity is observed among members of this group, few functional differences explaining the distinct ecological distributions of specific phylotypes have been described. In this study, we sequenced and performed a comparative analysis of whole genomes from 38 novel Fibrobacter strains against the type strains for the two formally described Fibrobacter species F...
December 12, 2018: MSphere
Qian Li, Lihong Sun, Mengmeng Hou, Qiubing Chen, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Environmental stimuli, including pH, light and temperature, have been utilized for activating controlled drug delivery to achieve efficient antitumor therapeutics while minimizing undesirable side effects. In this study, a multifunctional nanoplatform based on hollow mesoporous copper sulfide nanoparticles (H-CuS NPs) was developed by loading the interior cavity of the NPs with a drug-loaded phase change material (PCM, 1-tetradecanol). Doxorubicin (DOX) and chlorin e6 (Ce6) were selected as the model chemotherapeutic drug and photosensitizer, respectively, which were encapsulated in H-CuS NPs via the PCM to form H-CuS@PCM/DOX/Ce6 (HPDC) NPs...
December 12, 2018: ACS Applied Materials & Interfaces
Zhenlu Yang, Jun Wen, Qing Wang, Yanjiao Li, Ying Zhao, Ying Tian, Xiaofen Wang, Xiongfeng Cao, Yunlei Zhang, Guangming Lu, Zhaogang Teng, Longjiang Zhang
Real-time monitoring of oxygen consumption is beneficial to predict treatment response and optimize therapeutic protocols for photodynamic therapy (PDT). In this work, we first demonstrate that deformable hollow mesoporous organosilica nanoparticles (HMONs) can be used to load [(Ru(dpp)3)]Cl2 for detecting oxygen (denoted as HMON-[(Ru(dpp)3)]Cl2). This nanoprobe shows significantly improved biocompatibility and high cellular uptake. In-vitro eperiments demonstrate that the HMON-[(Ru(dpp)3)]Cl2 can sensitively detect oxygen changes between 1 %-20 %...
December 10, 2018: ACS Applied Materials & Interfaces
Xiaoling Wang, Xumei Ouyang, Jinliang Chen, Ying Hu, Xiaoyi Sun, Zhenwei Yu
AIM: A photomedicine consisting of a core for photothermal therapy, a photosensitizer for photodynamic therapy, and a cancer-targeting moiety was fabricated to improve photosensitizer selectivity and antitumor efficiency. MATERIALS & METHODS: Hyaluronic acid-decorated polydopamine nanoparticles with conjugated chlorin e6 (HA-PDA-Ce6) were synthesized and characterized. Cell uptake, phototoxicity, penetration, distribution and therapeutic effects were evaluated...
December 4, 2018: Nanomedicine
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