keyword
https://read.qxmd.com/read/38097025/anti-oxidative-anti-apoptotic-and-anti-inflammatory-activities-of-connarus-semidecandrus-jack-ethanol-extract-in-uvb-irradiated-human-keratinocytes
#1
JOURNAL ARTICLE
Lei Huang, Ji Hye Kim, Long You, Sang Hee Park, Jianmei Zhang, Chae Yun Shin, Natasha Christabella Sutopo, Hye-Woo Byun, Keo Omaliss, Kry Masphal, Jino Son, Ga Ryun Kim, Byoung-Hee Lee, Jong-Hoon Kim, Jongsung Lee, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Connarus semidecandrus Jack (Family: connaraceae) is a medicinal plant known for its wide distribution throughout Southeast Asia. Renowned for its diverse therapeutic properties, it has been traditionally used for treating fever, skin irritation, and colic. AIM OF THE STUDY: Numerous individuals suffer from skin issues, including wrinkles, hyperpigmentation, and inflammation, due to environmental factors. Although many drugs are available to treat skin problems, chemical drugs have many shortcomings and side effects...
December 12, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37762273/protective-effects-of-%C3%AE-carotene-like-compounds-against-acute-uvb-induced-skin-damage
#2
JOURNAL ARTICLE
Liping Zhang, Shaoxin Liang, Zhi Zhang, Kai Wang, Junhan Cao, Mengke Yao, Ling Qin, Changfeng Qu, Jinlai Miao
The previous study successfully established an expression strain of ζ-carotene-like compounds (CLC) and demonstrated its remarkable antioxidant activity, which exhibited resistance to photodamage caused by UVB radiation on the skin following gavage administration. The objective of this study was to investigate the impact and mechanism of CLC on UVB-induced skin damage through topical application. Cell viability, anti-apoptotic activity, ROS scavenging ability, the inhibition of melanin synthesis, the regulation of inflammatory factors and collagen deposition were assessed in cells and mice using qRT-PCR, WB, Elisa assays, immunohistochemistry staining and biochemical kits, etc...
September 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36915215/de-novo-design-of-a-novel-aie-fluorescent-probe-tailored-to-autophagy-visualization-via-ph-manipulation
#3
JOURNAL ARTICLE
Xueyan Huang, Fei Chen, Yeshuo Ma, Fan Zheng, Yanpeng Fang, Bin Feng, Shuai Huang, Hongliang Zeng, Wenbin Zeng
BACKGROUND: Macroautophagy is an essential cellular self-protection mechanism, and defective autophagy has been considered to contribute to a variety of diseases. During the process, cytoplasmic components are transported via autophagosomes to acidic lysosomes for metabolism and recycling, which represents application niches for lysosome-targeted fluorescent probes. Additionally, in view of the complexity of the autophagy pathway, it entails more stringent requirements for probes suitable for monitoring autophagy...
March 13, 2023: Biomaterials Research
https://read.qxmd.com/read/35986572/anti-melanogenic-effects-of-glucosylceramides-and-elasticamide-derived-from-rice-oil-by-products-in-melanoma-cells-melanocytes-and-human-skin
#4
JOURNAL ARTICLE
Kenchi Miyasaka, Yoshiaki Manse, Akari Yoneda, Shogo Takeda, Norihito Shimizu, Wakana Yamada, Toshio Morikawa, Hiroshi Shimoda
Glucosylceramides (GlcCer), which are present in many edible plants, suppress melanin production in mouse melanocytes. Rice GlcCer consist of multiple molecules that comprise different types of sphingoid bases as well as diverse lengths and stereotypes of free fatty acids. Adjacent to the GlcCer fraction, there are free ceramides (Cer) as minor constituents. However, the anti-melanogenic activities of individual GlcCer and Cer remain unknown. Therefore, we herein isolated 13 GlcCer and elasticamide, a Cer [AP] from the gummy by-products of rice bran oil, and examined their anti-melanogenic activities...
October 2022: Journal of Food Biochemistry
https://read.qxmd.com/read/35645796/role-of-phytochemicals-in-skin-photoprotection-via-regulation-of-nrf2
#5
REVIEW
Anyamanee Chaiprasongsuk, Uraiwan Panich
Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and effective preventive and therapeutic strategies for various diseases including skin photoaging and photodamage-related skin problems including abnormal pigmentation and inflammation. Exploring the roles of phytochemicals in mitigating ultraviolet radiation (UVR)-induced skin damage is thus of importance to offer insights into medicinal and ethnopharmacological potential for development of novel and effective photoprotective agents...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35009097/in-vitro-photoprotective-anti-inflammatory-moisturizing-and-antimelanogenic-effects-of-a-methanolic-extract-of-chrysophyllum-lucentifolium-cronquist
#6
JOURNAL ARTICLE
Chaoran Song, Laura Rojas Lorz, Jongsung Lee, Jae Youl Cho
UVB exposure causes DNA mutation and ROS generation, which lead to skin photoaging, skin wrinkling, skin sagging, and uneven skin pigmentation. ROS activate the NF-κB and MAPK signaling pathways leading to production of inflammatory molecules such as COX-2, collagen-degrading proteins such as matrix metalloproteinases (MMPs), and moisture-deficiency-related proteins such as hyaluronidases (HYALs). UVB exposure also induces irregular skin pigmentation though melanin overproduction, related to CREB transcription factor activity and transcription of melanogenesis genes...
December 28, 2021: Plants (Basel, Switzerland)
https://read.qxmd.com/read/35008862/anti-inflammatory-antioxidant-moisturizing-and-antimelanogenesis-effects-of-quercetin-3-o-%C3%AE-d-glucuronide-in-human-keratinocytes-and-melanoma-cells-via-activation-of-nf-%C3%AE%C2%BAb-and-ap-1-pathways
#7
JOURNAL ARTICLE
Anh Thu Ha, Laily Rahmawati, Long You, Mohammad Amjad Hossain, Jong-Hoon Kim, Jae Youl Cho
Quercetin 3-O-β-D-glucuronide (Q-3-G), the glucuronide conjugate of quercetin, has been reported as having anti-inflammatory properties in the lipopolysaccharide-stimulated macrophages, as well as anticancer and antioxidant properties. Unlike quercetin, which has been extensively described to possess a wide range of pharmacological activities including skin protective effects, the pharmacological benefits and mechanisms Q-3-G in the skin remained to be elucidated. This study focused on characterizing the skin protective properties, including anti-inflammatory and antioxidant properties, of Q-3-G against UVB-induced or H2 O2 -induced oxidative stress, the hydration effects, and antimelanogenesis activities using human keratinocytes (HaCaT) and melanoma (B16F10) cells...
December 31, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33673204/base-excision-repair-ap-endonucleases-like-genes-modulate-dna-damage-response-and-virulence-of-the-human-pathogen-cryptococcus-neoformans
#8
JOURNAL ARTICLE
Rayssa Karla de Medeiros Oliveira, Fabián Andrés Hurtado, Pedro Henrique Gomes, Luiza Lassi Puglia, Fernanda Fonsêca Ferreira, Kunal Ranjan, Patrícia Albuquerque, Márcio José Poças-Fonseca, Ildinete Silva-Pereira, Larissa Fernandes
Pathogenic microbes are exposed to a number of potential DNA-damaging stimuli during interaction with the host immune system. Microbial survival in this situation depends on a fine balance between the maintenance of DNA integrity and the adaptability provided by mutations. In this study, we investigated the association of the DNA repair response with the virulence of Cryptococcus neoformans , a basidiomycete that causes life-threatening meningoencephalitis in immunocompromised individuals. We focused on the characterization of C...
February 12, 2021: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/32459880/clinical-evaluation-method-for-blue-light-456-nm-protection-of-skin
#9
JOURNAL ARTICLE
Hong Li Jo, Yuchul Jung, Byung-Fhy Suh, Eunbyul Cho, Kyungtae Kim, Eunjoo Kim
BACKGROUND: Blue light from electronic devices enriched with a peak at 456 nm affects circadian rhythm and antioxidant balance of skin, necessitating the study of photoprotection against the 456-nm blue light. AIMS: This study aims to report that blue light (456 nm) can cause skin pigmentation and proposes a new clinical evaluation method for blue light (456 nm) protection based on the skin pigmentation level. PATIENTS/METHODS: We developed a clinical device (ABC deviceTM ) that emits blue light (peak = 456 nm)...
September 2020: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/32328122/photoaging-protective-effects-of-ranunculus-bulumei-methanol-extract
#10
JOURNAL ARTICLE
Yo Han Hong, Ji Hye Kim, Jae Youl Cho
Ultraviolet B (UVB) radiation is the main cause of photoaging processes including cellular senescence, skin drying, collagen degradation, melanogenesis, and inflammation. These responses occur because UVB induces a change in expression of aging-related genes through regulation of signal pathways such as that of mitogen-activated protein kinases- (MAPKs-) activator protein 1 (AP-1). Ranunculus bulumei , which is used as an herb in Indonesia, belongs to the Ranunculaceae family, which has been reported to perform various physiological effects including antioxidant and anti-inflammation...
2020: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/31074886/antiphotoaging-and-antimelanogenesis-properties-of-ginsenoside-c-y-a-ginsenoside-rb2-metabolite-from-american-ginseng-pdd-ginsenoside
#11
JOURNAL ARTICLE
Xiao-Yi Liu, Yong-Kun Xiao, Eunson Hwang, Jeong Jee Haeng, Tae-Hoo Yi
Ginsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound-Y (C-Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB-irradiated NHDFs and its potential for use as an antihyperpigmentation agent through ginsenoside C-Y as a functional food and cosmetic ingredient. Ginsenoside C-Y is a natural antioxidant isolated from the American ginseng PDD-ginsenoside. Our data showed that ginsenoside C-Y block UVB-exposed ROS, restrict MMP-1 production and promote procollagen type I synthesis...
November 2019: Photochemistry and Photobiology
https://read.qxmd.com/read/30849679/p44-42-mapk-signaling-is-a-prime-target-activated-by-phenylethyl-resorcinol-in-its-anti-melanogenic-action
#12
JOURNAL ARTICLE
Mingyeong Kang, See-Hyoung Park, Se Jung Park, Sae Woong Oh, Ju Ah Yoo, Kitae Kwon, Jangsoon Kim, Eunbi Yu, Jae Youl Cho, Jongsung Lee
BACKGROUND: Melanin plays a crucial role in protecting human skin against exposure to ultraviolet (UV) radiation. However, its overproduction induces hyperpigmentation disorders of the skin. PURPOSE: To investigate effects of phenylethyl resorcinol as one resorcinol derivative on melanogenesis and its mechanisms using B16F10 mouse melanoma cells and human epidermal melanocytes. METHODS: Effects of phenylethyl resorcinol on melanogenesis and its mechanism of action were examined using several in vitro assays (i...
May 2019: Phytomedicine
https://read.qxmd.com/read/30571966/dietary-enzyme-treated-hibiscus-syriacus-l-protects-skin-against-chronic-uvb-induced-photoaging-via-enhancement-of-skin-hydration-and-collagen-synthesis
#13
JOURNAL ARTICLE
Jung-Eun Yang, Hien T T Ngo, Eunson Hwang, Seul A Seo, Sul Woong Park, Tae-Hoo Yi
Exposure of skin to UVB radiation is associated with skin thickening, erythema, deep wrinkles, and marked losses of elasticity, resilience, and hydration. To find effective anti-aging materials, scientists have studied not only natural nutritional sources, but also biotransformed metabolites. Although Hibiscus syriacus L., the national flower of Korea has been used extensively throughout history, it has not yet been examined for possible anti-aging effects. In this study, skin anti-aging effects of H. syriacus L...
February 15, 2019: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/29443872/ap-1-kif13a-blocking-peptides-impair-melanosome-maturation-and-melanin-synthesis
#14
JOURNAL ARTICLE
Cécile Campagne, Léa Ripoll, Floriane Gilles-Marsens, Graça Raposo, Cédric Delevoye
Melanocytes are specialized cells that generate unique organelles called melanosomes in which melanin is synthesized and stored. Melanosome biogenesis and melanocyte pigmentation require the transport and delivery of melanin synthesizing enzymes, such as tyrosinase and related proteins (e.g., TYRP1), from endosomes to maturing melanosomes. Among the proteins controlling endosome-melanosome transport, AP-1 together with KIF13A coordinates the endosomal sorting and trafficking of TYRP1 to melanosomes. We identify here β1-adaptin AP-1 subunit-derived peptides of 5 amino acids that block the interaction of KIF13A with AP-1 in cells...
February 14, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/26226650/the-dual-roles-of-armigeres-subalbatus-prophenoloxidase-v-in-parasite-melanization-and-egg-chorion-melanization-in-the-mosquito-ar-subalbatus
#15
JOURNAL ARTICLE
I-Y Tsao, J-W Chen, C-J Li, H-L Lo, B M Christensen, C-C Chen
Phenoloxidases (POs) play key roles in various physiological functions in insects, e.g., cuticular sclerotization, wound healing, egg tanning, cuticle formation and melanotic encapsulaction of pathogens. Previously, we identified five POs, designated As-pro-PO I-V, from the mosquito Armigeres subalbatus and demonstrated that the functions of As-pro-PO I, II and III, were associated with filarial parasite melanization, blood feeding and cuticle formation, respectively. In the present study, we delineate the dual functions of As-pro-PO V...
September 2015: Insect Biochemistry and Molecular Biology
https://read.qxmd.com/read/25682620/anti-skin-aging-benefits-of-exopolymers-from-aureobasidium-pullulans-sm2001
#16
JOURNAL ARTICLE
Kyung Hu Kim, Soo Jin Park, Ji Eun Lee, Young Joon Lee, Chang Hyun Song, Seong Hun Choi, Sae Kwang Ku, Su Jin Kang
BACKGROUND: There have been many attempts to search for affordable and effective functional cosmetic ingredients, especially from natural sources. OBJECTIVES: As research into developing a functional cosmetic ingredient, we investigated whether exopolymers from Aureobasidium pullulans SM2001 (E-AP-SM2001) exert antioxidant, antiwrinkle, whitening, and skin moisturizing effects. METHODS: Antioxidant effects of E-AP-SM2001 were determined by measuring free radical scavenging capacity and superoxide dismutase (SOD)-like activity...
September 2014: Journal of Cosmetic Science
https://read.qxmd.com/read/25386046/nf-%C3%AE%C2%BAb-ap-1-targeted-inhibition-of-macrophage-mediated-inflammatory-responses-by-depigmenting-compound-ap736-derived-from-natural-1-3-diphenylpropane-skeleton
#17
JOURNAL ARTICLE
Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang-Soo Baek, Muhammad Jahangir Hossen, Woo Seok Yang, Yong Kim, Jun Ho Kim, Sungjae Yang, Jeong-Hwan Kim, Yung Hyup Joo, Chang Seok Lee, Joonho Choi, Hong-Ju Shin, Sungyoul Hong, Song Seok Shin, Jae Youl Cho
AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. The effects of AP736 on various inflammatory events such as nitric oxide (NO)/prostaglandin (PG) E2 production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264...
2014: Mediators of Inflammation
https://read.qxmd.com/read/23247405/cell-type-specific-rab32-and-rab38-cooperate-with-the-ubiquitous-lysosome-biogenesis-machinery-to-synthesize-specialized-lysosome-related-organelles
#18
REVIEW
Jarred J Bultema, Santiago M Di Pietro
Lysosome-related organelles (LROs) exist in specialized cells to serve specific functions and typically co-exist with conventional lysosomes. The biogenesis of LROs is known to utilize much of the common protein machinery used in the transport of integral membrane proteins to lysosomes. Consequently, an outstanding question in the field has been how specific cargoes are trafficked to LROs instead of lysosomes, particularly in cells that simultaneously produce both organelles. One LRO, the melanosome, is responsible for the production of the pigment melanin and has long been used as a model system to study the formation of specialized LROs...
January 2013: Small GTPases
https://read.qxmd.com/read/23151809/inhibitory-effects-of-asterina-pectinifera-extracts-on-melanin-biosynthesis-through-tyrosinase-activity
#19
JOURNAL ARTICLE
Min-Ho Jeong, Kwang-Mo Yang, Jung-Ki Kim, Byung-Hyouk Nam, Gi-Yong Kim, Sang-Wha Lee, Su-Yeong Seo, Wol-Soon Jo
The control of melanogenesis is an important strategy in the treatment of abnormal skin pigmentation for cosmetic purposes. The aim of the present study was to investigate the anti-melanogenic effect of Asterina pectinifera (A. pectinifera) extracts by cell-free mushroom tyrosinase assay, cellular tyrosinase assay, melanin content assay and the analysis of related protein expression in melan-a cells. A. pectinifera was extracted with 80% methanol (80-MAP) and further fractionated with hexane (He-AP) and ethyl acetate (EA-AP)...
January 2013: International Journal of Molecular Medicine
https://read.qxmd.com/read/23084991/bloc-3-mutated-in-hermansky-pudlak-syndrome-is-a-rab32-38-guanine-nucleotide-exchange-factor
#20
JOURNAL ARTICLE
Andreas Gerondopoulos, Lars Langemeyer, Jin-Rui Liang, Andrea Linford, Francis A Barr
Hermansky-Pudlak syndrome (HPS) is a human disease characterized by partial loss of pigmentation and impaired blood clotting. These symptoms are caused by defects in the biogenesis of melanosomes and platelet dense granules, often referred to as lysosome-related organelles. Genes mutated in HPS encode subunits of the biogenesis of lysosome-related organelles complexes (BLOCs). BLOC-1 and BLOC-2, together with the AP-3 clathrin adaptor complex, act at early endosomes to sort components required for melanin formation and melanosome biogenesis away from the degradative lysosomal pathway toward early stage melanosomes...
November 20, 2012: Current Biology: CB
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