keyword
https://read.qxmd.com/read/37129027/dorzolamide-suppresses-pkc%C3%AE-tirap-p38-mapk-signaling-axis-to-dampen-the-inflammatory-response
#21
JOURNAL ARTICLE
Sajjan Rajpoot, Ashutosh Kumar, Vadim Gaponenko, Teresa Lm Thurston, Dolly Mehta, Syed M Faisal, Kam Yj Zhang, Hem C Jha, Gajanan N Darwhekar, Mirza S Baig
Background: Sepsis is a syndrome due to microbial infection causing impaired multiorgan function. Its underlying cause is immune dysfunction and macrophages play an essential role. Methods: TIRAP interaction with PKCδ in macrophage was studied, revealing downstream signaling by Western blot and quantitative reverse transcriptase PCR. Dorzolamide (DZD) disrupting TIRAP-PKCδ interaction was identified by virtual screening and validated in vitro and in septic mice. Results: The study highlights the indispensable role of TIRAP-PKCδ in p38 MAPK-activation, NF-κB- and AP-1-mediated proinflammatory cytokines expression, whereas DZD significantly attenuated the signaling...
April 27, 2023: Future Medicinal Chemistry
https://read.qxmd.com/read/37108435/transcriptional-activation-of-a-pro-inflammatory-response-nf-%C3%AE%C2%BAb-ap-1-il-1%C3%AE-by-the-vibrio-cholerae-cytotoxin-vcc-monomer-through-the-mapk-signaling-pathway-in-the-thp-1-human-macrophage-cell-line
#22
JOURNAL ARTICLE
Julio Rodrigo Escartín-Gutiérrez, Mariana Ponce-Figueroa, Miguel Ángel Torres-Vega, Leopoldo Aguilar-Faisal, Paula Figueroa-Arredondo
This study describes, to some extent, the VCC contribution as an early stimulation of the macrophage lineage. Regarding the onset of the innate immune response caused by infection, the β form of IL-1 is the most important interleukin involved in the onset of the inflammatory innate response. Activated macrophages treated in vitro with VCC induced the activation of the MAPK signaling pathway in a one-hour period, with the activation of transcriptional regulators for a surviving and pro-inflammatory response, suggesting an explanation inspired and supported by the inflammasome physiology...
April 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37011419/the-ethanol-extract-of-cyperus-exaltatus-var-iwasakii-exhibits-cell-cycle-dysregulation-erk1-2-p38-mapk-akt-phosphorylation-and-reduced-mmp-9-mediated-metastatic-capacity-in-prostate-cancer-models-in-vitro-and-in-vivo
#23
JOURNAL ARTICLE
Hoon Kim, Byungdoo Hwang, Seongbin Cho, Woo Jung Kim, Soon Chul Myung, Yung Hyun Choi, Wun-Jae Kim, Sanghyun Lee, Sung-Kwon Moon
BACKGROUND: Prostate cancer is the second most common cause of cancer death worldwide in men. The development of novel and highly efficient therapeutic strategies is strongly recommended to treat prostate cancer. Cyperaceae are an ecologically and economically important family of plants with several pharmacological effects. However, the biological efficacy of Cyperus exaltatus var. iwasakii (CE) is unknown. PURPOSE: This study aimed to investigate the antitumor effect of the ethanol extract of CE against prostate cancer...
March 30, 2023: Phytomedicine
https://read.qxmd.com/read/36958385/withametelin-a-steroidal-lactone-isolated-from-datura-innoxa-attenuates-stz-induced-diabetic-neuropathic-pain-in-rats-through-inhibition-of-nf-kb-mapk-signaling
#24
JOURNAL ARTICLE
Adnan Khan, Bushra Shal, Ashraf Ullah Khan, Muhammad Waleed Baig, Ihsan Ul Haq, Salman Khan
Diabetic neuropathic pain is one of the microvascular complications of diabetes mellitus characterized by symmetrical pain and sensory abnormalities. A steroidal lactone isolated from the datura innoxa plant, withametelin (WMT), exhibited significant neuroprotective, anti-inflammatory, antioxidant, and anticancer properties. The current study aimed to investigate anti-neuropathic pain activity and the molecular mechanism of WMT against streptozotocin (STZ)-induced diabetic neuropathy. Rats were given a single injection of STZ (60 mg/kg, intraperitoneally (i...
March 21, 2023: Food and Chemical Toxicology
https://read.qxmd.com/read/36828198/commensal-bacillus-siamensis-lf4-induces-antimicrobial-peptides-expression-via-tlrs-and-nlrs-signaling-pathways-in-intestinal-epithelial-cells-of-lateolabrax-maculatus
#25
JOURNAL ARTICLE
Zi-Yan Liu, Hong-Ling Yang, Cheng-Ye Wei, Guo-He Cai, Ji-Dan Ye, Chun-Xiao Zhang, Yun-Zhang Sun
Antimicrobial peptides (AMPs) play an important role in modulating intestinal microbiota, and our previous study showed that autochthonous Baccilus siamensis LF4 could shape the intestinal microbiota of spotted seabass (Lateolabrax maculatus). In the present study, a spotted seabass intestinal epithelial cells (IECs) model was used to investigate whether autochthonous B. siamensis LF4 could modulate the expression of AMPs in IECs. And then, the IECs were treated with active, heat-inactivated LF4 and its supernatant to illustrate their AMPs inducing effects and the possible signal transduction mechanisms...
February 22, 2023: Fish & Shellfish Immunology
https://read.qxmd.com/read/36771069/anti-photoaging-effect-of-phaseolus-angularis-l-extract-on-uvb-exposed-hacat-keratinocytes-and-possibilities-as-cosmetic-materials
#26
JOURNAL ARTICLE
Sarang Oh, Shengdao Zheng, Minzhe Fang, Myeongju Kim, Arce Defeo Bellere, Jeehaeng Jeong, Tae-Hoo Yi
Phaseolus angularis L. is widely cultivated and is considered a superfood because of its nutritious protein and starch contents. Nevertheless, P. angularis 's effects on skin photoaging are unknown. The aim of this study was to research the effects of P. angularis seed extract (PASE) on photoaging in human keratinocytes (HaCaT) damaged by UVB radiation so as to find out whether PASE can be used as an effective anti-photoaging ingredient in cosmetic products. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) radical scavenging, and reactive oxygen species (ROS) assays...
February 1, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36746125/mapk-ap-1-signaling-pathway-is-involved-in-the-protection-mechanism-of-bone-marrow-mesenchymal-stem-cells-derived-exosomes-against-ultraviolet-induced-photoaging-in-human-dermal-fibroblasts
#27
JOURNAL ARTICLE
Tingting Yan, Lining Huang, Yunling Yan, Yiping Zhong, Heng Xie, Xiaohua Wang
INTRODUCTION: The role of bone marrow mesenchymal stem cells derived exosomes (BMSCs-exo) in skin photoaging was explored in human dermal fibroblasts (HDFs). The underlying mechanism was further explored. METHODS: HDFs were exposed to UVB irradiation to establish the cell photodamage models. The cell viability, and levels of oxidative stress-related factors were tested. ELISA was done to detect TNF-α, IL-6 and IL-1β concentration. Western blot was applied for protein examination...
February 6, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36610522/bisphenol-a-exposure-inhibits-vascular-smooth-muscle-cell-responses-involvement-of-proliferation-migration-and-invasion
#28
JOURNAL ARTICLE
Hoon Kim, Hongbum Park, Byungdoo Hwang, Soobin Kim, Yung Hyun Choi, Wun-Jae Kim, Sung-Kwon Moon
Previous studies have associated bisphenol A (BPA) with malignant tumor formation, infertility, and atherosclerosis in vitro and in vivo. However, the precise mechanisms through which BPA affects the cardiovascular system under normal conditions remain unclear. Therefore, this study investigated the biological mechanisms through which BPA affects the responses of aortic vascular smooth muscle cells (VSMCs). BPA treatment inhibited the proliferative activity of VSMCs and induced G2 /M-phase cell cycle arrest via stimulation of the ATM-CHK2-Cdc25C-p21WAF1 -Cdc2 cascade in VSMCs...
January 4, 2023: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/36559293/alpinetin-suppresses-zika-virus-induced-interleukin-1%C3%AE-production-and-secretion-in-human-macrophages
#29
JOURNAL ARTICLE
Nitwara Wikan, Saranyapin Potikanond, Phateep Hankittichai, Phatarawat Thaklaewphan, Sathit Monkaew, Duncan R Smith, Wutigri Nimlamool
Zika virus (ZIKV) infection has been recognized to cause adverse sequelae in the developing fetus. Specially, this virus activates the excessive release of IL-1β causing inflammation and altered physiological functions in multiple organs. Although many attempts have been invested to develop vaccine, antiviral, and antibody therapies, development of agents focusing on limiting ZIKV-induced IL-1β release have not gained much attention. We aimed to study the effects of alpinetin (AP) on IL-1β production in human macrophage upon exposure to ZIKV...
December 14, 2022: Pharmaceutics
https://read.qxmd.com/read/36527784/pattern-recognition-receptor-mediated-innate-immune-response-requires-a-rif-dependent-pathway
#30
JOURNAL ARTICLE
Xiaoxia Tian, Kathleen Nanding, Xueyao Dai, Qian Wang, Junyu Wang, Morigen, Lifei Fan
Small GTPases play critical roles in cell morphology, movement, and adhesion by dynamic regulation of actin cytoskeleton. The small Rho GTPase Rif/RhoF (Rho in filopodia) regulates the formation of filopodia and stress fibers in cells. Rif is highly expressed in a number of cell types in the immune system; however, it's role in immune system function is unclear. In this research, we found that Rif expression is necessary for NF-κB activation in primary immune cells, and mature dendritic cell (mature DCs) induced from Bone Marrow-Derived Dendritic Cells (BMDCs) isolated from Rif knock out (Rif KO) mice displayed impaired degradation of I-κBα, as well as reduced TNF-α secretion and p38 MAPK phosphorylation under LPS stimulation...
December 15, 2022: Journal of Autoimmunity
https://read.qxmd.com/read/36499473/preparation-of-cpd-photolyase-nanoliposomes-derived-from-antarctic-microalgae-and-their-effect-on-uvb-induced-skin-damage-in-mice
#31
JOURNAL ARTICLE
Changfeng Qu, Nianxu Li, Tianlong Liu, Yingying He, Jinlai Miao
UVB radiation is known to trigger the block of DNA replication and transcription by forming cyclobutane pyrimidine dimer (CPD), which results in severe skin damage. CPD photolyase, a kind of DNA repair enzyme, can efficiently repair CPDs that are absent in humans and mice. Although exogenous CPD photolyases have beneficial effects on skin diseases, the mechanisms of CPD photolyases on the skin remain unknown. Here, this study prepared CPD photolyase nanoliposomes (CPDNL) from Antarctic Chlamydomonas sp. ICE-L, which thrives in harsh, high-UVB conditions, and evaluated their protective mechanisms against UVB-induced damage in mice...
December 2, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36415572/investigation-of-immunostimulatory-effects-of-heat-treated-lactiplantibacillus-plantarum-lm1004-and-its-underlying-molecular-mechanism
#32
JOURNAL ARTICLE
Won-Young Bae, Woo-Hyun Jung, So Lim Shin, Seulgi Kwon, Minn Sohn, Tae-Rahk Kim
Postbiotics are defined as probiotics inactivated by heat, ultraviolet radiation, sonication, and other physical or chemical stresses. Postbiotics are more stable than probiotics, and these properties are advantageous for food additives and pharmacological agents. This study investigated the immunostimulatory effects of heat-treated Lactiplantibacillus plantarum LM1004 (HT-LM1004). Cellular fatty acid composition of L. plantarum LM1004 isolated form kimchi was analyzed by gas chromatography-mass spectrometry detection system...
November 2022: Food science of animal resources
https://read.qxmd.com/read/36373826/hiv-tat-conjugated-histone-h3-peptides-induce-tumor-cell-death-via-cellular-stress-responses
#33
JOURNAL ARTICLE
Qian Xu, Feimei Zhu, Yixuan Pan, Yanlin Ren, Jingyu Li, Ning Huang, Keyun Liu, Yi Wang
Histone H3 is a nucleosome scaffold protein that is involved in a variety of intracellular processes. Aberrant modification of H3 is important in carcinogenesis. In contrast, free histones in cells can act as stimuli to trigger cellular immune responses and cell death. In this study, we linked cell-penetrating peptide HIV Tat to a histone H3 fragment to achieve intracellular delivery in tumor cells. We found that Tat-conjugated histone polypeptides localized to nuclei of lung and breast cancer cells and caused cell death...
November 14, 2022: Human Gene Therapy
https://read.qxmd.com/read/36219321/nuciferine-attenuates-lipopolysaccharide-stimulated-inflammatory-responses-by-inhibiting-p38-mapk-atf2-signaling-pathways
#34
JOURNAL ARTICLE
Sung-Min Kim, Eun-Jung Park, Hae-Jeung Lee
Nuciferine, isolated from Nelumbo nucifera (commonly known as lotus) leaves, has been shown to have beneficial effects, including antioxidant, anti-obesity, anti-diabetic, and anti-inflammatory properties. However, little is known about the mechanism of nuciferine action on the inflammatory response. This study aimed to investigate the anti-inflammatory effects of nuciferine and its underlying molecular mechanisms in lipopolysaccharide (LPS)-stimulated murine macrophages. In this study, nuciferine reduced LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2 ) production and mRNA expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2...
October 11, 2022: Inflammopharmacology
https://read.qxmd.com/read/36206994/modulatory-effects-of-curcumin-on-singapore-grouper-iridovirus-infection-associated-apoptosis-and-autophagy-in-vitro
#35
JOURNAL ARTICLE
Yuexuan Wang, Suifeng Xu, Chengzong Han, Youhua Huang, Jingguang Wei, Shina Wei, Qiwei Qin
Singapore grouper iridovirus (SGIV) with high pathogenicity can cause great economic losses to aquaculture industry. Thus, it is of urgency to find effective antiviral strategies to combat SGIV. Curcumin has been demonstrated effective antiviral activity on SGIV infection. However, the molecular mechanism behind this action needs to be further explanations. In view of the fact that apoptosis (type I programmed cell death) and autophagy (type II programmed cell death) were key regulators during SGIV infection, we aimed to investigate the relevance between antiviral activity of curcumin and SGIV-associated programmed and clarify the role of potential signaling pathways...
October 4, 2022: Fish & Shellfish Immunology
https://read.qxmd.com/read/36142785/mlk3-regulates-inflammatory-response-via-activation-of-ap-1-pathway-in-hek293-and-raw264-7-cells
#36
JOURNAL ARTICLE
Anh Thu Ha, Jae Youl Cho, Daewon Kim
Inflammation is a critically important barrier found in innate immunity. However, severe and sustained inflammatory conditions are regarded as causes of many different serious diseases, such as cancer, atherosclerosis, and diabetes. Although numerous studies have addressed how inflammatory responses proceed and what kinds of proteins and cells are involved, the exact mechanism and protein components regulating inflammatory reactions are not fully understood. In this paper, to determine the regulatory role of mixed lineage kinase 3 (MLK3), which functions as mitogen-activated protein kinase kinase kinase (MAP3K) in cancer cells in inflammatory response to macrophages, we employed an overexpression strategy with MLK3 in HEK293 cells and used its inhibitor URMC-099 in lipopolysaccharide (LPS)-treated RAW264...
September 17, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36139814/cynanoside-f-controls-skin-inflammation-by-suppressing-mitogen-activated-protein-kinase-activation
#37
JOURNAL ARTICLE
Mara Melissa Duarte Fleitas, Seon Sook Kim, Nam Kyoung Kim, Su Ryeon Seo
Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by severe itching and dry skin. Currently, the incidence of AD due to excessive activation of immune cells by various environmental factors is increasing worldwide, and research on inflammatory response inhibitors with fewer side effects is continuously needed. Cynanoside F (CF) is one of the pregnane-type compounds in the root of Cynanchum atratum , an oriental medicinal herb that has been shown to have antioxidant, antitumor, and anti-inflammatory effects...
September 1, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36130829/th17-derived-cytokines-synergistically-enhance-il-17c-production-by-the-colonic-epithelium
#38
JOURNAL ARTICLE
Stephanie M Swedik, Abson Madola, Michelle A Cruz, Braulio J Llorens-Bonilla, Alan D Levine
Tightly regulated communication between the gastrointestinal epithelium and immune cells in the underlying lamina propria is critical for immune homeostasis and inflammation. IL-17C, produced by epithelial cells after exposure to inflammatory stimuli, facilitates cell-to-cell communication by promoting inflammatory responses in Th17 cells. In this study, we demonstrate that Th17-derived cytokines TNF-α, IL-17A, and IL-22 synergistically enhance IL-17C expression in both human-transformed colonic epithelial cell lines and primary non-inflammatory bowel disease colonic epithelial spheroids...
September 21, 2022: Journal of Immunology
https://read.qxmd.com/read/36115602/23-o-acetylshengmanol-3-o-%C3%AE-l-arabinoside-alleviates-lipopolysaccharide-induced-acute-lung-injury-through-inhibiting-i%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-and-mapk-ap-1-signaling-pathways
#39
JOURNAL ARTICLE
Chunyan Chen, Lin Li, Xiaomei Liu, Deqin Zhang, Yang Liu, Yuhong Li
ETHNOPHARMACOLOGICAL RELEVANCE: Cimicifuga foetida L. is a well-established traditional Chinese medicine with heat-clearing and detoxifying effects and has good therapeutic effect on oral mucosal ulcer and pharyngitis. The rhizome of this herb is rich in triterpenoid glycosides, including 23-O-acetylshengmanol-3-o-α-L-arabinoside (DA). AIM OF THE STUDY: Whether and how DA attenuates acute lung injury (ALI) are unclear. Accordingly, we focused on its anti-inflammatory effects and underlying molecular mechanisms in lipopolysaccharide (LPS)-stimulated ALI mice and RAW264...
September 14, 2022: Journal of Ethnopharmacology
https://read.qxmd.com/read/36115169/anemoside-b4-prevents-chronic-obstructive-pulmonary-disease-through-alleviating-cigarette-smoke-induced-inflammatory-response-and-airway-epithelial-hyperplasia
#40
JOURNAL ARTICLE
Huimiao Ma, Ziye Zhou, Lanying Chen, Lingling Wang, Qi Muge
BACKGROUND: Cigarette smoke (CS) is one of the major risk factors for chronic obstructive pulmonary disease (COPD) and increases the risk of lung cancer (LC). Anemoside B4 (B4) is the main bioactive ingredient in Pulsatilla chinensis (P. chinensis), a traditional medicinal herb for various diseases. It has a wide range of anti-inflammatory, anti-oxidation and anti-cancer activities. However, in recent years, there is no relevant literature report on the therapeutic effect of B4 on COPD, and the anti-inflammatory and inhibitory effects of anemoside B4 on basal cell hyperplasia in CS-induced COPD have not been clearly established...
September 2, 2022: Phytomedicine
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