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https://read.qxmd.com/read/30769345/the-impact-of-interventions-by-pharmacists-collected-in-a-computerised-physician-order-entry-context-a-prospective-observational-study-with-a-10-year-reassessment
#1
Marie-Caroline Loustalot, Sarah Berdot, Pierre Sabatier, Pierre Durieux, Germain Perrin, Alexandre Karras, Brigitte Sabatier
AIMS OF THE STUDY: This study assesses clinical interventions by pharmacists prospectively collected from medical and surgical wards, notably the acceptance of interventions, computerised physician order entry (CPOE)related problems, the potential impact of interventions on patient safety evaluated by a multidisciplinary committee, and their evolution over the 10 years since a first assessment. METHODS: A prospective observational study covering 13 months was conducted in a French teaching hospital with a patient information system that integrates an electronic health record (EHR) with a CPOE...
February 11, 2019: Swiss Medical Weekly
https://read.qxmd.com/read/30769297/risk-of-recurrence-of-mood-disorders-during-pregnancy-and-the-impact-of-medication-a-systematic-review
#2
REVIEW
Anja W M M Stevens, Peter J J Goossens, Elise A M Knoppert-van der Klein, Stasja Draisma, Adriaan Honig, Ralph W Kupka
BACKGROUND: Mood disorders can be difficult to treat during pregnancy. There is still lack of evidence whether pregnancy influences their natural course and whether continuation of pharmacotherapy, despite potential risks for the unborn child, is beneficial in preventing recurrence of mood episodes during pregnancy. METHODS: Systematic review conducted according to the PRISMA guidelines, searching Pubmed, PsycINFO, Embase and Cochrane databases up till January 9th, 2018...
February 7, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30769247/risk-factors-for-perforated-appendicitis-in-the-acute-care-surgery-era-minimizing-the-patient-s-delayed-presentation-factor
#3
Narong Kulvatunyou, Steven A Zimmerman, Bellal Joseph, Randall S Friese, Lynn Gries, Terence O'Keeffe, John A Stroster, Andrew L Tang
BACKGROUND: Numerous factors contribute to advanced disease or increased complications in patients with acute appendicitis (AA). This study aimed to identify risk factors associated with AA perforation, including the effect of system time (ST) delay, after controlling for patient time (PT) delay. In this study, PT was controlled (to less than or equal to 24 h) to better understand the effect of ST delay on AA perforation. METHODS: Medical records of patients who underwent surgery for AA at a tertiary referral hospital from October 2009 through September 2013 were reviewed...
February 12, 2019: Journal of Surgical Research
https://read.qxmd.com/read/30769227/effects-of-adjuvant-tamoxifen-over-three-decades-on-breast-cancer-free-and-distant-recurrence-free-interval-among-premenopausal-women-with-oestrogen-receptor-positive-breast-cancer-randomised-in-the-swedish-sbii-2pre-trial
#4
M Ekholm, P O Bendahl, M Fernö, B Nordenskjöld, O Stål, L Rydén
AIMS: The primary aim was to compare 2 years of adjuvant tamoxifen versus no systemic treatment in premenopausal patients with oestrogen receptor (ER)-positive tumours, regarding breast cancer-free interval (BCFi) and distant recurrence-free interval (D-RFi), with 30 years of follow-up and for specified intervals. Moreover, we aimed to investigate the effects of adjuvant tamoxifen on the incidence of secondary malignancies and survival after distant recurrence. METHODS: Premenopausal patients with primary breast cancer were randomised to 2 years of tamoxifen (n = 277) or no systemic treatment (n = 287), irrespective of ER status...
February 12, 2019: European Journal of Cancer
https://read.qxmd.com/read/30769194/barriers-to-allogeneic-hematopoietic-stem-cell-transplant-for-human-t-cell-lymphotropic-virus-1-associated-adult-t-cell-lymphoma-leukemia-in-the-united-states-experience-from-a-large-cohort-in-a-major-tertiary-center
#5
Diego Adrianzen Herrera, Noah Kornblum, Ana Acuna-Villaorduna, R Alejandro Sica, Urvi Shah, Moya Butler, Nivetha Vishnuvardhan, Nishi Shah, Lizamarie Bachier-Rodriguez, Olga Derman, Aditi Shastri, Ioannis Mantzaris, Amit K Verma, Ira Braunchweig, Murali Janakiram
In the United States (U.S.), Adult T-Cell Lymphoma-Leukemia (ATLL) carries a dismal prognosis and mainly affects immigrants from Human T-Cell Lymphotropic Virus 1 (HTLV-1) endemic areas. Allogeneic Hematopoietic Stem Cell Transplant (alloHSCT) can be effective and is recommended as an upfront treatment in the NCCN guidelines. We studied the barriers to alloHSCT in one of the largest ATLL populations in the U.S. Comprehensive chart and donor registry reviews were conducted for 88 ATLL patients treated at Montefiore Medical Center from 2003 to 2018...
February 12, 2019: Biology of Blood and Marrow Transplantation
https://read.qxmd.com/read/30769161/antioxidants-bronchopulmonary-dysplasia-beating-the-system-or-beating-a-dead-horse
#6
REVIEW
Gaston Ofman, Trent E Tipple
Preterm birth is a primary cause of worldwide childhood mortality. Bronchopulmonary dysplasia, characterized by impaired alveolar and lung vascular development, affects 25-50% of extremely low birth weight (BW; <1 kg) infants. Abnormalities in lung function persist into childhood in affected infants and are second only to asthma in terms of childhood respiratory disease healthcare costs. While advances in the medical care of preterm infants have reduced mortality, the incidence of BPD has not decreased in the past 10 years...
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30769059/routine-postoperative-cardiac-testing-is-unnecessary-following-carotid-endarterectomy
#7
Arthelma C Tyson, Shailraj Parikh, Kuldeep Singh, Saqib Zia, Jonathan S Deitch, Jonathan A Schor
BACKGROUND: Routine laboratory testing to rule out myocardial infarction (MI) after carotid endarterectomy (CEA) is common in many centers. Its utility in this patient population has not been thoroughly investigated. We hypothesize that routine testing for MI in post-CEA patients is of low-yield and not cost-effective. METHODS: A retrospective review of 291 consecutive CEAs from February, 2011 to July, 2015 was performed. Two patients were excluded: one for postoperative non-cardiac death and one for preoperative MI...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30769055/polytetrafluoroethylene-is-a-safe-and-effective-interposition-conduit-for-caval-reconstruction-after-resection-of-primary-leiomyosarcoma-of-the-inferior-vena-cava
#8
Aravind G Kalluri, Ashish K Jain, Heron E Rodriguez, Mark K Eskandari
BACKGROUND: Primary leiomyosarcoma of the inferior vena cava (IVC) is a rare soft tissue sarcoma. Techniques for caval reconstruction after tumor resection vary widely. Our single-center experience serves as one of the largest reviews of caval reconstruction using polytetrafluoroethylene (PTFE) interposition grafts published in the past 10 years. METHODS: We conducted a single-center retrospective review of all patients who had undergone surgical resection of IVC leiomyosarcomas since January 1, 2007...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30768762/patterns-and-clinical-consequences-of-discontinuing-hiv-preexposure-prophylaxis-during-primary-care
#9
Douglas Krakower, Kevin M Maloney, Victoria E Powell, Ken Levine, Chris Grasso, Kathy Melbourne, Julia L Marcus, Kenneth H Mayer
INTRODUCTION: Discontinuations of HIV preexposure prophylaxis (PrEP) by at-risk individuals could decrease the effectiveness of PrEP. Our objective was to characterize patterns of, reasons for, and clinical outcomes associated with PrEP discontinuations in primary care. METHODS: We conducted medical chart reviews for patients prescribed PrEP during 2011 to 2014 at a Boston community health centre specializing in healthcare for sexual and gender minorities. Patients were followed through 2015...
February 2019: Journal of the International AIDS Society
https://read.qxmd.com/read/30768755/age-of-introduction-of-complementary-feeding-and-overweight-in-adolescence-and-adulthood-a-systematic-review
#10
Cybele Sodré Araújo, Priscila Ribas de Farias Costa, Valterinda Alves de Oliveira Queiroz, Monica Leila Portela Santos, Emile Pereira Miranda, Jacqueline Costa Dias Pitangueira, Ana Marlucia de Oliveira Assis
Recent studies on early infant feeding suggest that the type of diet and age of starting complementary foods may have a positive correlation with overweight in adolescence and adulthood. This study aimed to systematically review the evidence on the relationship between the age of introduction of complementary feeding and excess weight in adolescence and adulthood. PROSPERO: CRD42017067764. The PRISMA standards were used as a reference. Articles were researched on Medline via PubMed, Web of Science, Embase, Lilacs, Ovid and Scopus, between June and December 2017...
February 15, 2019: Maternal & Child Nutrition
https://read.qxmd.com/read/30768617/baseline-high-sensitivity-c-reactive-protein-predicts-the-risk-of-incident-ankylosing-spondylitis-results-of-a-community-based-prospective-study
#11
Jinmei Su, Liufu Cui, Wenhao Yang, Huijing Shi, Cheng Jin, Rong Shu, Hongfen Li, Xiaofeng Zeng, Shouling Wu, Xiang Gao
BACKGROUND: A hospitalized-based cohort study suggested that elevated C-reactive protein (CRP) levels are associated with radiographic sacroiliitis progression in ankylosing spondylitis (AS) patients. However, data from community-based populations are limited. OBJECTIVE: We sought to determine the association between elevated CRP levels and AS diagnosis in a prospective community-based study of 129,681 Chinese adults over a follow-up period of 8 years. METHODS: We measured the plasma CRP concentration at baseline and every 2 years thereafter with the high-sensitivity (hs)-CRP test...
2019: PloS One
https://read.qxmd.com/read/30768579/increased-acute-postoperative-wound-problems-following-spinal-fusion-in-overweight-patients-with-adolescent-idiopathic-scoliosis
#12
Ryan D Snowden, Vincent W Prusick, Donna J Oeffinger, Henry J Iwinski, Ryan D Muchow
This study assessed the rate of adverse wound events in individuals with adolescent idiopathic scoliosis who underwent a posterior spinal fusion and sought to determine if obesity was related to the rate of adverse wound events. A retrospective review of patients with adolescent idiopathic scoliosis that underwent posterior spinal fusion between 2001 and 2013 was performed. Preoperative, perioperative, and postoperative data, including wound adverse events, were obtained through medical record review. Using the Center for Disease Control BMI criteria, participants were grouped into overweight/obese (BMI%≥85 percentile) or healthy/underweight (BMI%<85 percentile) groups...
February 13, 2019: Journal of Pediatric Orthopedics. Part B
https://read.qxmd.com/read/30768558/the-promising-future-of-drones-in-prehospital-medical-care-and-its-application-to-battlefield-medicine
#13
Jonathan Braun Bsc, S David Gertz, Ariel Furer, Tarif Bader, Hagay Frenkel, Jacob Chen, Elon Glassberg, Dean Nachman
Unmanned aerial vehicles (UAV), commonly referred to as drones, have been made widely available in recent years leading to an exponential growth in their roles and applications. The rapidly developing field of medical drones is on the verge of revolutionizing pre-hospital medicine enabling advanced healthcare delivery to once-inaccessible patients. The aim of this review is to clarify the basic technical properties of currently available medical drones and review recent advances and their usefulness in military and civilian healthcare missions...
February 13, 2019: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/30768444/use-of-supervised-exercise-during-recovery-following-sports-related-concussion
#14
Michael Popovich, Andrea Almeida, Jeremiah Freeman, James T Eckner, Bara Alsalaheen, Matthew Lorincz, Andrew Sas
OBJECTIVE: To assess the safety of supervised exercise (SE) in acute sport-related concussion (SRC) and its influence on recovery. DESIGN: Retrospective cohort study. SETTING: University SRC clinic at a tertiary care center. PATIENTS: One hundred ninety-four consecutive new patient charts were reviewed. Patients were included if they were seen within 30 days of sustaining a SRC, and their medical records included all required data elements...
February 12, 2019: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://read.qxmd.com/read/30768188/prevalence-underlying-causes-and-preventability-of-sepsis-associated-mortality-in-us-acute-care-hospitals
#15
Chanu Rhee, Travis M Jones, Yasir Hamad, Anupam Pande, Jack Varon, Cara O'Brien, Deverick J Anderson, David K Warren, Raymund B Dantes, Lauren Epstein, Michael Klompas
Importance: Sepsis is present in many hospitalizations that culminate in death. The contribution of sepsis to these deaths, and the extent to which they are preventable, is unknown. Objective: To estimate the prevalence, underlying causes, and preventability of sepsis-associated mortality in acute care hospitals. Design, Setting, and Participants: Cohort study in which a retrospective medical record review was conducted of 568 randomly selected adults admitted to 6 US academic and community hospitals from January 1, 2014, to December 31, 2015, who died in the hospital or were discharged to hospice and not readmitted...
February 1, 2019: JAMA network open
https://read.qxmd.com/read/30767965/barriers-to-lung-cancer-screening-with-low-dose-computed-tomography
#16
Fang Lei, Eunice Lee
PROBLEM IDENTIFICATION: Despite lung cancer screening guidelines and insurance coverage changes, rates of lung cancer screening with low-dose computed tomography remain suboptimal among the eligible population in the United States. LITERATURE SEARCH: Electronic literature databases, including PubMed, CINAHL®, PsycINFO, and Google Scholar, were searched. DATA EVALUATION: After applying filter information and inclusion and exclusion criteria, 10 articles were reviewed...
March 1, 2019: Oncology Nursing Forum
https://read.qxmd.com/read/30767943/a-review-of-clinical-poster-presentations-at-the-sixth-biennial-pediatric-anesthesia-neurodevelopment-assessment-panda-symposium
#17
Manon Haché, Tom G Hansen, Ruth Graham, Jamie W Sinton, Phillip S Adams, Carol Garber, Lynne Maxwell, Teeda Pinyavat
Clinical researchers studying the long-term neurocognitive effects of anesthetic and sedative agents on children continue to struggle with identifying a phenotype for anesthetic neurotoxicity, the window of vulnerability, and the toxicity threshold in terms of concentration and duration. The Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) symposium at Columbia University included a moderated poster presentation session where 4 investigators presented their latest contributions to the landscape of clinical anesthetic neurotoxicity research...
January 2019: Journal of Neurosurgical Anesthesiology
https://read.qxmd.com/read/30767931/report-on-the-sixth-pediatric-anesthesia-neurodevelopmental-assessment-panda-symposium-anesthesia-and-neurodevelopment-in-children
#18
Jennifer J Lee, Lena S Sun, Richard J Levy
On April 14 and 15, 2018, the Sixth Biennial Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium convened at Columbia University Medical Center and New York Presbyterian/Morgan Stanley Children's Hospital of New York. Since its inception over 10 years ago, the PANDA Symposium has served as a key forum for clinicians, researchers, and other major stakeholders to gather and review the current state of preclinical and clinical research related to anesthetic neurotoxicity in the developing brain...
January 2019: Journal of Neurosurgical Anesthesiology
https://read.qxmd.com/read/30767816/viral-oncolytic-immunotherapy-in-the-war-on-cancer-infection-control-considerations
#19
Elizabeth V Robilotti, Asmita Kumar, Michael S Glickman, Mini Kamboj
Oncolytic viral immunotherapy is an emerging treatment modality for cancer that exploits in vivo replication and other viral properties to enhance immune killing of malignant cells. The potential for horizontal transmission of native or engineered oncolytic viruses creates several unique infection control challenges. In 2015, talimogene laherparepvec (TVEC) became the first agent in this class to gain FDA approval for treatment of melanoma, and several others are being developed. Although some data on the transmissibility of TVEC are available from clinical studies, the aftermarket or real-world experience remains limited...
February 15, 2019: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/30767742/structure-and-function-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-in-atherosclerosis
#20
Lei Zhang, Zahid Hussain, Zhuanqin Ren
BACKGROUND: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH. OBJECTIVE: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH...
February 14, 2019: Current Drug Targets
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