keyword
https://read.qxmd.com/read/36904025/antiphotoaging-and-skin-protective-activities-of-ardisia-silvestris-ethanol-extract-in-human-keratinocytes
#21
JOURNAL ARTICLE
Lei Huang, Long You, Nur Aziz, Seung Hui Yu, Jong Sub Lee, Eui Su Choung, Van Dung Luong, Mi-Jeong Jeon, Moonsuk Hur, Sarah Lee, Byoung-Hee Lee, Han Gyung Kim, Jae Youl Cho
Ardisia silvestris is a traditional medicinal herb used in Vietnam and several other countries. However, the skin-protective properties of A. silvestris ethanol extract (As-EE) have not been evaluated. Human keratinocytes form the outermost barrier of the skin and are the main target of ultraviolet (UV) radiation. UV exposure causes skin photoaging via the production of reactive oxygen species. Protection from photoaging is thus a key component of dermatological and cosmetic products. In this research, we found that As-EE can prevent UV-induced skin aging and cell death as well as enhance the barrier effect of the skin...
March 3, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/36903948/anti-oxidative-and-anti-aging-effects-of-ethanol-extract-of-the-officinal-breynia-breynia-vitis-idaea-in-vitro
#22
JOURNAL ARTICLE
Chae Yun Shin, Jiwon Jang, Hwa Pyoung Lee, Sang Hee Park, Masphal Kry, Omaliss Keo, Byoung-Hee Lee, Wooram Choi, Sarah Lee, Jae Youl Cho
The skin is the largest organ of the human body, and it is also the one most exposed to external environmental contaminants. The skin is the body's first defense against harmful environmental stimuli, including ultraviolet B (UVB) rays and hazardous chemicals. Therefore, proper care of the skin is required to prevent skin-related diseases and age-related symptoms. In this study, we analyzed anti-aging and anti-oxidative effects of Breynia vitis-idaea ethanol extract (Bv-EE) in human keratinocytes and dermal fibroblasts...
March 1, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/36771069/anti-photoaging-effect-of-phaseolus-angularis-l-extract-on-uvb-exposed-hacat-keratinocytes-and-possibilities-as-cosmetic-materials
#23
JOURNAL ARTICLE
Sarang Oh, Shengdao Zheng, Minzhe Fang, Myeongju Kim, Arce Defeo Bellere, Jeehaeng Jeong, Tae-Hoo Yi
Phaseolus angularis L. is widely cultivated and is considered a superfood because of its nutritious protein and starch contents. Nevertheless, P. angularis 's effects on skin photoaging are unknown. The aim of this study was to research the effects of P. angularis seed extract (PASE) on photoaging in human keratinocytes (HaCaT) damaged by UVB radiation so as to find out whether PASE can be used as an effective anti-photoaging ingredient in cosmetic products. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) radical scavenging, and reactive oxygen species (ROS) assays...
February 1, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36704879/novel-cell-culture-system-for-monitoring-cells-during-continuous-and-variable-negative-pressure-wound-therapy
#24
JOURNAL ARTICLE
Toshifumi Yamashiro, Toshihiro Kushibiki, Yoshine Mayumi, Masato Tsuchiya, Miya Ishihara, Ryuichi Azuma
BACKGROUND: Although the clinical efficacy of negative-pressure wound therapy (NPWT) is well known, many of its molecular biological mechanisms remain unresolved, mainly due to the difficulty and paucity of relevant in vitro studies. We attempted to develop an in vitro cell culture system capable of real-time monitoring of cells during NPWT treatment. MATERIALS AND METHODS: A novel negative-pressure cell culture system was developed by combining an inverted microscope, a stage-top incubator, a sealed metal chamber for cell culture, and an NPWT treatment device...
January 2023: Skin Research and Technology
https://read.qxmd.com/read/36527388/the-mineralocorticoid-receptor-modulates-timing-and-location-of-genomic-binding-by-glucocorticoid-receptor-in-response-to-synthetic-glucocorticoids-in-keratinocytes
#25
JOURNAL ARTICLE
Elena Carceller-Zazo, Lisa M Sevilla, Omar Pons-Alonso, Álvaro Chiner-Oms, Larbi Amazit, Thi An Vu, Géraldine Vitellius, Say Viengchareun, Iñaki Comas, Yan Jaszczyszyn, Montserrat Abella, Andrea Alegre-Martí, Eva Estébanez-Perpiñá, Marc Lombès, Paloma Pérez
Glucocorticoids (GCs) exert potent antiproliferative and anti-inflammatory properties, explaining their therapeutic efficacy for skin diseases. GCs act by binding to the GC receptor (GR) and the mineralocorticoid receptor (MR), co-expressed in classical and non-classical targets including keratinocytes. Using knockout mice, we previously demonstrated that GR and MR exert essential nonoverlapping functions in skin homeostasis. These closely related receptors may homo- or heterodimerize to regulate transcription, and theoretically bind identical GC-response elements (GRE)...
January 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/36461623/lncrna-wakmar2-regulates-expression-of-cldn1-to-affect-skin-barrier-through-recruiting-c-fos
#26
JOURNAL ARTICLE
Yunhua Tu, Li Wang, Xiaoli Wang, Wenjuan Wu, Ying Tu, Dandan Zou, Yuanyuan Deng, Jue Qi, Can Cao, Dan Xu, Yanjie Chai, Yun Zhu, Juan Zhang, Jun Sun, Fan Lai, Li He
BACKGROUND: Chronic actinic dermatitis (CAD) is an immune-mediated photo-allergic skin disease. In the clinic, the treatment of this disease is hampered by the lack of proper understanding of the skin barrier dysfunction mechanism. OBJECTIVE: To illuminate the mechanism of skin barrier dysfunction in CAD. METHODS: Transcriptome sequencing and protein profiling were used to detect skin barrier injury-related genes. RNA pull down, a promoter-reporter gene assay, and chromatin isolation by RNA purification-sequencing were used to elucidate the effect of WAKMAR2 in skin barrier functionality...
December 2, 2022: Contact Dermatitis
https://read.qxmd.com/read/36297328/-moringa-concanensis-l-alleviates-dncb-induced-atopic-dermatitis-like-symptoms-by-inhibiting-nlrp3-inflammasome-mediated-il-1%C3%AE-in-balb-c-mice
#27
JOURNAL ARTICLE
Kyeong-Min Kim, So-Yeon Kim, Tamanna Jahan Mony, Ho Jung Bae, Seung-Hyuk Choi, Yu-Yeong Choi, Ju-Yeon An, Hyun-Jeong Kim, Ye Eun Cho, Kandhasamy Sowndhararajan, Se Jin Park
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, dry skin and redness on the face and inside elbows or knees. Most patients with AD are children and youths, but it can also develop in adults. In the therapeutic aspect, treatment with corticosteroids for AD has several side effects, such as weight loss, atrophy and acne. In the current study, we examined the anti-inflammatory effect of Moringa concanensis leaves on HaCaT keratinocytes and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like symptoms in BALB/c mice...
September 30, 2022: Pharmaceuticals
https://read.qxmd.com/read/36278711/-trichosanthes-kirilowii-extract-promotes-wound-healing-through-the-phosphorylation-of-erk1-2-in-keratinocytes
#28
JOURNAL ARTICLE
Minho Kim, Jae-Goo Kim, Ki-Young Kim
The proliferation of keratinocytes is one of the important steps in the wound-healing process, which is regulated by various signals. Prior studies have shown that Trichosanthes kirilowii extract has the ability to promote angiogenesis. Therefore, in this study, we tested the wound-healing efficacy of Trichosanthes kirilowii extract with respect to promoting keratinocyte proliferation. A total of 100 μg/mL of Trichosanthes kirilowii extract treatment improved 145.38% of keratinocyte proliferation compared with DMSO-treated control in an MTT assay and increased 238...
October 7, 2022: Biomimetics
https://read.qxmd.com/read/36103110/rosa-davurica-inhibits-skin-photoaging-via-regulating-mapk-ap-1-nf-%C3%AE%C2%BAb-and-nrf2-ho-1-signaling-in-uvb-irradiated-hacats
#29
JOURNAL ARTICLE
Minzhe Fang, Hyun-Myung Lee, Sarang Oh, Shengdao Zheng, A D Bellere, Minseon Kim, Junhui Choi, Myeongju Kim, Duna Yu, Tae-Hoo Yi
Rosa davurica is widely used to treat various kinds of diseases because of its high antioxidant, antiviral and anti-inflammatory activities. This use of plant-based materials as medicine is called phytomedicine and has been widely practiced since time immemorial. However, the pharmacological mechanism of R. davurica in skin photoaging is not yet fully understood. Therefore, this study was carried out to evaluate the recovery effects of R. davurica leaf extracts (RDE) in UVB-irradiated human skin keratinocytes (HaCaTs) and investigate whether RDE is a potential therapeutic agent against skin photoaging...
September 14, 2022: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/35964097/cd147-mediates-epidermal-malignant-transformation-through-the-rsk2-ap-1-pathway
#30
JOURNAL ARTICLE
Xu Zhang, Yeye Guo, Ta Xiao, Jie Li, Aiyuan Guo, Li Lei, Chong Jin, Qi Long, Juan Su, Mingzhu Yin, Hong Liu, Chao Chen, Zhe Zhou, Susi Zhu, Juan Tao, Shuo Hu, Xiang Chen, Cong Peng
BACKGROUND: Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumors, the role of CD147 in epidermal malignant transformation in vivo remains unclear. METHODS: Epidermal CD147-overexpression or knockout (EpiCD147-OE or EpiCD147-KO ) transgenic mouse models were generated for in vivo study. RNA-sequencing and q-PCR were performed to identify the differentially expressed genes...
August 13, 2022: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/35932049/rhein-promotes-the-proliferation-of-keratinocytes-by-targeting-oestrogen-receptors-for-skin-ulcer-treatment
#31
JOURNAL ARTICLE
Ning Xu, Yuanran Chen, Dongjie Guo, Yu Deng, Wanjun Guo, Xin Liu, Yi Wang, Hanzhi Lu, Aijun Liu, Jianyong Zhu, Fulun Li
BACKGROUND: The Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional Chinese Medicines (TCM) in the treatment of delayed diabetic wounds. Previous research has shown that the SJHY formula has significant anti-inflammatory and wound-healing effects, but the precise mechanism remains unknown. The purpose of this study was to evaluate the effects of rhein, a compound extracted from SJHY formula, in keratinocytes and to investigate the underlying mechanisms. METHODS: Microscale thermophoresis (MST) technology was used to confirm that rhein binds directly to oestrogen receptors (ERs)...
August 5, 2022: BMC complementary medicine and therapies
https://read.qxmd.com/read/35881108/stress-signaling-and-stat1-activation-characterize-the-keratinocytic-gene-expression-pattern-in-hidradenitis-suppurativa
#32
JOURNAL ARTICLE
V G Frings, L Jopp, M Srivastava, D Presser, M Goebeler, M Schmidt
BACKGROUND: The pathogenetic factors generating the innate immune signal necessary for T cell activation, initiation and chronification of Hidradenitis suppurativa (HS, also known as Acne inversa) are still poorly understood. Emerging evidence suggests that a defective keratinocyte function critically contributes to HS disease development and progression. OBJECTIVES: To elucidate the role of keratinocytes in HS lesion formation, we compared the transcriptomes of lesional and perilesional epidermis isolated from HS patients by RNA sequencing (RNA Seq)...
July 26, 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/35684259/antiphotoaging-effects-of-damiana-turnera-diffusa-leaves-extract-via-regulation-ap-1-and-nrf2-are-signaling-pathways
#33
JOURNAL ARTICLE
Minseon Kim, Lee-Keun Ha, Sarang Oh, Minzhe Fang, Shengdao Zheng, Arce D Bellere, Jeehaeng Jeong, Tae-Hoo Yi
Damiana ( Turnera di ffusa ), of the family Passifloraceae, has been widely studied for its pharmacological effects, especially for antioxidant and antibacterial actions. However, there are limited scientific findings describing its antiphotoaging effects on the skin. In the present study, the underlying molecular mechanisms of the protective effect of Damiana were investigated in keratinocytes (HaCaTs) and normal human dermal fibroblasts (HDFs) subject to UVB irradiation. The mRNA expression of matrix metalloproteinases (MMPs) and procollagen type I was determined by reverse transcription-polymerase chain reaction...
May 31, 2022: Plants (Basel, Switzerland)
https://read.qxmd.com/read/35660310/potential-anti-skin-aging-effect-of-a-peptide-ayape-isolated-from-isochrysis-zhanjiangensis-on-uvb-induced-hacat-cells-and-h-2-o-2-induced-bj-cells
#34
JOURNAL ARTICLE
Yuan-Lin He, Liyuan Lin, Haiyan Zheng, Yinhuan Mo, Chunxia Zhou, Shengli Sun, Pengzhi Hong, Zhong-Ji Qian
AYAPE (Ala-Tyr-Ala-Pro-Glu) is a pentapeptide isolated from Isochrysis zhanjiangensis, previous studies have proved that this pentapeptide has antioxidant and inflammatory activities. In this study, we determined the anti-skin aging bioactivity of AYAPE with UVB-induced human immortalized keratinocytes (HaCaT) and H2 O2 -induced human skin fibroblasts (BJ cells) as models. The results showed that AYAPE against UVB-induced photoaging on HaCaT cells via alleviating DNA damage, reducing intracellular reactive oxygen (ROS) levels, down regulating phosphorylation of proteins in MAPK/AP-1 signaling pathways...
May 26, 2022: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/35645796/role-of-phytochemicals-in-skin-photoprotection-via-regulation-of-nrf2
#35
REVIEW
Anyamanee Chaiprasongsuk, Uraiwan Panich
Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and effective preventive and therapeutic strategies for various diseases including skin photoaging and photodamage-related skin problems including abnormal pigmentation and inflammation. Exploring the roles of phytochemicals in mitigating ultraviolet radiation (UVR)-induced skin damage is thus of importance to offer insights into medicinal and ethnopharmacological potential for development of novel and effective photoprotective agents...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35637486/alpinetin-promotes-hair-regeneration-via-activating-hair-follicle-stem-cells
#36
JOURNAL ARTICLE
Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei, Ying Xiao
BACKGROUND: Alopecia affects millions of individuals globally, with hair loss becoming more common among young people.  Various traditional Chinese medicines (TCM) have been used clinically for treating alopecia, however, the effective compounds and underlying mechanism are less known. We sought to investigate the effect of Alpinetin (AP), a compound extracted from Fabaceae and Zingiberaceae herbs, in hair regeneration. METHODS: Animal model for hair regeneration was mimicked by depilation in C57BL/6J mice...
May 31, 2022: Chinese Medicine
https://read.qxmd.com/read/35560767/4-aminopyridine-promotes-cutaneous-reinnervation-and-accelerates-wound-healing
#37
JOURNAL ARTICLE
M G Jagadeeshaprasad, Prem Kumar Govindappa, Amanda Nelson, Mark D Noble, John Elfar
Skin wound healing is a tightly orchestrated process between epithelial, dermal, neuronal and vascular cells, all working in concert to restore tissue integrity and skin barrier function. Here, we report the therapeutic regenerative effects of FDA-approved 4-aminopyridine (4-AP) to promote skin wound healing by accelerating re-epithelialization, wound induced hair neogenesis (WIHN), dermal collagen deposition, angiogenesis, and reinnervation. We demonstrate that 4-AP enhanced wound closure by promoting keratinocyte proliferation and migration as well as collagen deposition through myofibroblast differentiation...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35336655/inhibitory-effect-of-lotusine-on-solar-uv-induced-matrix-metalloproteinase-1-expression
#38
JOURNAL ARTICLE
Tae-Kyeong Ryu, Eunmiri Roh, Han-Seung Shin, Jong-Eun Kim
Solar ultraviolet (sUV) radiation remains a major cause of skin aging. Nelumbo nucifera (lotus) is a well-known edible plant widely grown in Asia, including Korea, China, and Japan. The lotus consists of flowers, leaves, stems, and seeds, and all parts reportedly possess nutritional and medical values. Traditionally, lotus flowers, leaves, stems, and seeds have been used as antidiarrheal agents, diuretics, antipyretics, and antimicrobial and antihyperlipidemic agents. In addition, the Nelumbo nucifera lotus embryo has been shown to possess sedative and antipyretic properties and can relieve hemostatic thirst and treat eye diseases...
March 14, 2022: Plants (Basel, Switzerland)
https://read.qxmd.com/read/35316219/uvb-mediated-dna-damage-induces-matrix-metalloproteinases-to-promote-photoaging-in-an-ahr-and-sp1-dependent-manner
#39
JOURNAL ARTICLE
Daniel J Kim, Akiko Iwasaki, Anna L Chien, Sewon Kang
It is currently thought that UVB radiation drives photoaging of the skin primarily by generating ROS. In this model, ROS purportedly activates activator protein-1 to upregulate MMPs 1, 3, and 9, which then degrade collagen and other extracellular matrix components to produce wrinkles. However, these MMPs are expressed at relatively low levels and correlate poorly with wrinkles, suggesting that another mechanism distinct from ROS and MMP1/3/9 may be more directly associated with photoaging. Here we show that MMP2, which degrades type IV collagen, is abundantly expressed in human skin, increases with age in sun-exposed skin, and correlates robustly with aryl hydrocarbon receptor (AhR), a transcription factor directly activated by UV-generated photometabolites...
May 9, 2022: JCI Insight
https://read.qxmd.com/read/35008862/anti-inflammatory-antioxidant-moisturizing-and-antimelanogenesis-effects-of-quercetin-3-o-%C3%AE-d-glucuronide-in-human-keratinocytes-and-melanoma-cells-via-activation-of-nf-%C3%AE%C2%BAb-and-ap-1-pathways
#40
JOURNAL ARTICLE
Anh Thu Ha, Laily Rahmawati, Long You, Mohammad Amjad Hossain, Jong-Hoon Kim, Jae Youl Cho
Quercetin 3-O-β-D-glucuronide (Q-3-G), the glucuronide conjugate of quercetin, has been reported as having anti-inflammatory properties in the lipopolysaccharide-stimulated macrophages, as well as anticancer and antioxidant properties. Unlike quercetin, which has been extensively described to possess a wide range of pharmacological activities including skin protective effects, the pharmacological benefits and mechanisms Q-3-G in the skin remained to be elucidated. This study focused on characterizing the skin protective properties, including anti-inflammatory and antioxidant properties, of Q-3-G against UVB-induced or H2 O2 -induced oxidative stress, the hydration effects, and antimelanogenesis activities using human keratinocytes (HaCaT) and melanoma (B16F10) cells...
December 31, 2021: International Journal of Molecular Sciences
keyword
keyword
165816
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.