keyword
https://read.qxmd.com/read/38456238/anti-pollutant-effect-of-oleic-acid-against-urban-particulate-matter-is-mediated-via-regulation-of-ahr-and-trpv1-mediated-signaling-in-vitro
#1
JOURNAL ARTICLE
Seoyoung Choi, Seyoung Yang, Ji Woong Kim, Kitae Kwon, Sae Woong Oh, Eunbi Yu, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Jeong Kyun Yoo, Su Young Kim, Young Soo Kim, Jae Youl Cho, Jongsung Lee
Urban Particulate Matter (UPM) induces skin aging and inflammatory responses by regulating skin cells through the transient receptor potential vanilloid 1 (TRPV1). Although oleic acid, an unsaturated free fatty acid (FFA), has some functional activities, its effect on UPM-induced skin damage has not been elucidated. Here, we investigated signaling pathways on how oleic acid is involved in attenuating UPM induced cell damage. UPM treatment increased XRE-promoter luciferase activity and increased translocation of AhR to the nucleus, resulting in the upregulation of CYP1A1 gene...
March 8, 2024: Environmental Toxicology
https://read.qxmd.com/read/38415391/anti-inflammatory-antioxidative-and-moisturizing-effects-of-oxyceros-horridus-lour-ethanol-extract-in-human-keratinocytes-via-the-p38-signaling-pathway
#2
JOURNAL ARTICLE
Natasha Christabella Sutopo, Laily Rahmawati, Lei Huang, Masphal Kry, Phourin Chhang, Sarah Lee, Byoung-Hee Lee, Jae Youl Cho
Skin is the largest and outermost organ in the human body; it serves as a vital defense mechanism against various external threats. Therefore, it is crucial to maintain its health through protection against harmful substances and adequate moisture levels. This study investigates the anti-inflammatory, antioxidant, and moisturizing properties of Oxyceros horridus Lour. (Oh-EE) in human keratinocytes. Oh-EE demonstrates potent antioxidant activity and effectively protects against oxidative stress induced by external stimuli such as UVB radiation and H2O2...
February 28, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38379292/1-kestose-blocks-uvb-induced-skin-inflammation-and-promotes-type-i-procollagen-synthesis-via-regulating-mapk-ap-1-nf-%C3%AE%C2%BAb-and-tgf-%C3%AE-smad-pathway
#3
JOURNAL ARTICLE
Jihye Baek, Jong-Hwa Kim, Jiwon Park, Do Hyun Kim, Soonok Sa, Jung-Sook Han, Wonyong Kim
Solar UVB irradiation cause skin photoaging by inducing the high expression of matrix metalloproteinase (MMPs) to inhibit the expression of Type1 procollagen synthesis. 1-kestose, a natural trisaccharide, has been indicated to show a cytoprotective role in UVB radiation-induced-HaCaT cells. However, few studies have confirmed the anti-aging effects. In the present study, we evaluated the anti-photoaging and pathological mechanism of 1-kestose using Human keratinocytes (HaCaT) cells. The results found that 1-kestose pretreatment remarkably reduced UVB-generated reactive oxygen species (ROS) accumulation in HaCaT cells...
February 22, 2024: Journal of Microbiology and Biotechnology
https://read.qxmd.com/read/38350816/topical-application-of-activator-protein-1-inhibitor-t-5224-suppresses-inflammation-and-improves-skin-barrier-function-in-a-murine-atopic-dermatitis-like-dermatitis
#4
JOURNAL ARTICLE
Minori Sasakura, Hitoshi Urakami, Kota Tachibana, Kenta Ikeda, Ken-Ichi Hasui, Yoshihiro Matsuda, Ko Sunagawa, Daisuke Ennishi, Shuta Tomida, Shin Morizane
BACKGROUND: Selective activator protein (AP)-1 inhibitors are potentially promising therapeutic agents for atopic dermatitis (AD) because AP-1 is an important regulator of skin inflammation. However, few studies have investigated the effect of topical application of AP-1 inhibitors in treating inflammatory skin disorders. METHODS: Immunohistochemistry was conducted to detect phosphorylated AP-1/c-Jun expression of skin lesions in AD patients. In the in vivo study, 1 % T-5224 ointment was topically applied for 8 days to the ears of 2,4 dinitrofluorobenzene challenged AD-like dermatitis model mice...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/38284293/tanshinone-iia-a-component-of-the-self-made-xiao-yin-decoction-ameliorates-psoriasis-by-inhibiting-il-17-il-23-and-ptgs2-nf-%C3%AE%C2%BAb-ap-1-pathways
#5
JOURNAL ARTICLE
Lei Fu, Meijiao Li, Peng Wang, Lang Chen, Jianqiu Huang, Hui Zhang
BACKGROUND: Psoriasis is a persistent inflammatory dermatological disorder. Tanshinone IIA (tan-IIA) is a biologically active compound in the self-made Xiao-Yin decoction (SMXYD) and exhibits diverse biological properties, such as anti-proliferative and anti-inflammatory effects. The objective of this investigation was to assess the potential of tan-IIA as a therapeutic agent against psoriasis. METHODS: Network pharmacology was employed to ascertain the active constituents and potential pathways associated with SMXYD and psoriasis...
February 2024: Skin Research and Technology
https://read.qxmd.com/read/38237728/ap-2%C3%AE-ap-2%C3%AE-transcription-factors-are-key-regulators-of-epidermal-homeostasis
#6
JOURNAL ARTICLE
Hui Zhang, Jackelyn R Raymundo, Kathleen E Daly, Wenjuan Zhu, Bill Senapati, Hanyu Zhong, Arjun R Ahilan, Alexander G Marneros
AP-2 transcription factors regulate ectodermal development but their roles for epidermal homeostasis in the adult skin are unknown. We find that AP-2α is the predominant AP-2 family member in adult epidermis, followed by AP-2β. Through inactivation of AP-2α, AP-2β, or both in keratinocytes we assessed the effects of a gradient of epidermal AP-2 activity on skin function. We find that (1) loss of AP-2β in keratinocytes is compensated for by AP-2α, (2) loss of AP-2α impairs terminal keratinocyte differentiation and hair morphogenesis, and (3) the combined loss of AP-2α/AP-2β results in more severe skin and hair abnormalities...
January 16, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38139186/fisetin-inhibits-uva-induced-expression-of-mmp-1-and-mmp-3-through-the-nox-ros-mapk-pathway-in-human-dermal-fibroblasts-and-human-epidermal-keratinocytes
#7
JOURNAL ARTICLE
Hye-Yeon Jang, Gi-Beum Kim, Jeong-Mi Kim, Sang Yull Kang, Hyun-Jo Youn, Jinny Park, Su Yeon Ro, Eun-Yong Chung, Kwang-Hyun Park, Jong-Suk Kim
Fisetin is a flavonoid found in plants and has been reported to be effective in various human diseases. However, the effective mechanisms of ultraviolet-A (UVA)-mediated skin damage are not yet clear. In this study, we investigated the protective mechanisms of fisetin regarding UVA-induced human dermal fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) damages. Fisetin showed a cytoprotective effect against UVA irradiation and suppressed matrix metalloproteinases (MMPs), MMP-1, and MMP-3 expression...
December 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38125354/identification-of-potential-mir%C3%A2-155-target-genes-in-epidermal-immune-microenvironment-of-atopic-dermatitis-patients-and-their-inflammatory-effects-on-hacat-cells
#8
JOURNAL ARTICLE
Xiaochen Wang, Lu Chen, Xiaoqing Chen, Chang Liu, Wenhong Qiu, Kaiwen Guo
Atopic dermatitis (AD) is a common inflammatory skin condition and the leading cause of morbidity associated with skin conditions worldwide. For the majority of patients, AD is a lifelong disease that cannot be cured completely. Therefore, in the present study, differentially expressed genes (DEGs) in the epidermal immune microenvironment were screened using bioinformatic techniques. Subsequently, an in vitro cellular model was constructed to investigate the role of microRNA (miR)-155 in immune infiltration during AD...
January 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38105942/ap-2%C3%AE-ap-2%C3%AE-transcription-factors-are-key-regulators-of-epidermal-homeostasis
#9
Hui Zhang, Jackelyn Raymundo, Kathleen E Daly, Wenjuan Zhu, Bill Senapati, Alexander G Marneros
AP-2 transcription factors regulate ectodermal development but their roles for epidermal homeostasis in the adult skin are unknown. We find that AP-2α is the predominant AP-2 family member in adult epidermis, followed by AP-2β. Through inactivation of AP-2α, AP-2β, or both in keratinocytes we assessed the effects of a gradient of epidermal AP-2 activity on skin function. We find that (1) loss of AP-2β in keratinocytes is compensated for by AP-2α, (2) loss of AP-2α impairs terminal keratinocyte differentiation and hair morphogenesis, and (3) the combined loss of AP-2α/AP-2β results in more severe skin and hair abnormalities...
December 4, 2023: bioRxiv
https://read.qxmd.com/read/38097025/anti-oxidative-anti-apoptotic-and-anti-inflammatory-activities-of-connarus-semidecandrus-jack-ethanol-extract-in-uvb-irradiated-human-keratinocytes
#10
JOURNAL ARTICLE
Lei Huang, Ji Hye Kim, Long You, Sang Hee Park, Jianmei Zhang, Chae Yun Shin, Natasha Christabella Sutopo, Hye-Woo Byun, Keo Omaliss, Kry Masphal, Jino Son, Ga Ryun Kim, Byoung-Hee Lee, Jong-Hoon Kim, Jongsung Lee, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Connarus semidecandrus Jack (Family: connaraceae) is a medicinal plant known for its wide distribution throughout Southeast Asia. Renowned for its diverse therapeutic properties, it has been traditionally used for treating fever, skin irritation, and colic. AIM OF THE STUDY: Numerous individuals suffer from skin issues, including wrinkles, hyperpigmentation, and inflammation, due to environmental factors. Although many drugs are available to treat skin problems, chemical drugs have many shortcomings and side effects...
December 12, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37870674/weizmannia-coagulans-extracellular-proteins-reduce-skin-acne-by-inhibiting-pathogenic-bacteria-and-regulating-tlr2-traf6-mediated-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways
#11
JOURNAL ARTICLE
Yongtao Zhang, Yanbing Jiang, Jingsha Zhao, Qiuting Mo, Changtao Wang, Dongdong Wang, Meng Li
As a probiotic, Weizmannia coagulans (W. coagulans) is often used in food and medicine to regulate intestinal flora and exert anti-inflammatory effects. In this study, the anti-acne efficacy and mechanism of extracellular proteins (YTCY-EPs) from W. coagulans YTCY strain are analyzed. The main components of YTCY-EPs, extracted and separated from the fermentation broth, are peptides ranging from 1.51 to 11.44 kDa, accounting for about 80%. Among the peptides identified by LC/MS-MS, YTCY_A-F possess the properties of antimicrobial peptides, while YTCY_1-4 possess antioxidative properties...
October 23, 2023: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/37849425/liquiritin-targeting-th17-cells-differentiation-and-abnormal-proliferation-of-keratinocytes-alleviates-psoriasis-via-nf-%C3%AE%C2%BAb-and-ap-1-pathway
#12
JOURNAL ARTICLE
Dandan Guo, Qianqian Wang, Aifang Li, Shuxuan Li, Baiyan Wang, Yalan Li, Juan Yuan, Tao Guo, Shuying Feng
Psoriasis is a common immune-mediated inflammatory skin disease, caused by disturbed interactions between keratinocytes and immune cells. Chinese medicine shows potential clinical application for its treatment. Liquiritin is a flavone compound extracted from licorice and shows potential antitussive, antioxidant and antiinflammatory effects, and therefore may have potential as a psoriasis therapeutic. The aim of this work was to examine the possible roles that liquiritin may have in treating psoriasis. HaCaT cells were stimulated by TNF-α with or without liquiritin, harvested for analysis by western blots and RT-qPCR, and the cellular supernatants were collected and analyzed by ELISA for cytokines...
October 17, 2023: Phytotherapy Research: PTR
https://read.qxmd.com/read/37727996/protective-effect-of-helianthus-annuus-seed-byproduct-extract-on-ultraviolet-radiation-induced-injury-in-skin-cells
#13
JOURNAL ARTICLE
Xiaoying Mo, Xiaochun Chen, Xiaojiao Pan, Yantong Lu, Guangjuan Pan, Jielan Xie, Zhenzhen Pan, Li Li, Hui Tian, Yaohua Li
Helianthus annuus seed byproduct is a residual product obtained after seed oil extraction. The present study investigated the preventive and repair effects of the H. annuus seed byproduct ethanol extract (HSE) on ultraviolet radiation (UVR)-induced injury in human immortalized keratinocytes (HaCaTs) and human skin fibroblasts (HSFs). Results revealed that the total phenolic acid and oligosaccharide content in HSE was >50%. HSE had a stronger preventive effect on UVR-induced injury than the repair effect...
September 20, 2023: Photochemistry and Photobiology
https://read.qxmd.com/read/37454069/wound-healing-effects-of-asparagus-lucidus-lindl-extract-through-the-phosphorylation-of-erk1-2
#14
JOURNAL ARTICLE
Minho Kim, Ki-Young Kim
BACKGROUND: Skin is the outermost part of the human body and is essential in maintaining body homeostasis. In the event of skin injury, rapid wound repair is crucial to protect the body. In this study, we investigated the wound-healing properties of Asparagus lucidus Lindl extract by promoting keratinocyte proliferation. METHODS: To evaluate the effect of Asparagus lucidus Lindl extract on skin regeneration, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to measure keratinocyte proliferation, while an in vitro wound-healing assay was performed to evaluate wound closure through keratinocyte re-epithelialization...
July 15, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37447040/higenamine-reduces-fine-dust-induced-matrix-metalloproteinase-mmp-1-in-human-keratinocytes
#15
JOURNAL ARTICLE
DongHyeon Kim, JeaHyeok Yun, Eunmiri Roh, Han-Seung Shin, Jong-Eun Kim
Environmental pollutants such as fine dust are increasingly linked to premature skin aging. In this study, we investigated the protective effects of higenamine, a natural plant alkaloid, against fine-dust-induced skin aging in human keratinocytes (HaCaT cells). We found that higenamine significantly attenuated fine-dust-induced expression of matrix metalloproteinase-1 (MMP-1), a key enzyme involved in collagen degradation. Furthermore, higenamine was found to modulate fine-dust-induced AP-1 and NF-κB transactivation, which are crucial factors for MMP-1 transcription...
June 28, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37299400/-hydrangea-serrata-hot-water-extract-and-its-major-ingredient-hydrangenol-improve-skin-moisturization-and-wrinkle-conditions-via-ap-1-and-akt-pi3k-pathway-upregulation
#16
JOURNAL ARTICLE
Ji Hye Yoon, Sang Hee Park, Si Eun Yoon, Seong Yoon Hong, Jun Bae Lee, Jongsung Lee, Jae Youl Cho
Hydrangea serrata is a plant grown in Korea and Japan with a particular natural compound, hydrangenol. H. serrata has been researched for its anti-fungal properties, and ability to attenuate allergies and promote muscle growth. Its ability to reduce skin dryness is poorly understood. For that reason, we investigated whether H. serrata hot water extracts (Hs-WE) can moisturize keratinocytes. In clinical studies (Approval Code: GIRB-21929-NY and approval Date: 5 October 2021), skin wrinkles and skin moisturizing levels were improved in subjects applying 0...
May 24, 2023: Nutrients
https://read.qxmd.com/read/37236445/transcriptomics-reveals-key-regulatory-pathways-and-genes-associated-with-skin-diseases-induced-by-face-paint-usage
#17
JOURNAL ARTICLE
Bin Wang, Zhaohao Zheng, Ling Chen, Wenhui Zhang, Yujie He, Bing Wu, Rong Ji
The use of face paint cosmetics can cause skin diseases in opera performers due to the presence of heavy metals and other toxic ingredients in the cosmetics. However, the underlying molecular mechanism for these diseases remains unknown. Here we examined the transcriptome gene profile of human skin keratinocytes exposed to artificial sweat extracts of face paints, and identified the key regulatory pathways and genes, using RNA sequencing technique. Bioinformatics analyses suggested that the face paint exposure induced the differentially expression of 1531 genes and enriched inflammation-relevant TNF and IL-17 signaling pathways after just 4 h of exposure...
May 24, 2023: Science of the Total Environment
https://read.qxmd.com/read/37232735/antiphotoaging-effect-of-ages-blocker%C3%A2-in-uvb-irradiated-cells-and-skh-hr-1-hairless-mice
#18
JOURNAL ARTICLE
JaeIn Jung, Yean-Jung Choi, JinHee Yoo, Su-Young Choi, EunJi Kim
Chronic exposure to ultraviolet (UV) radiation is a major cause of photoaging. It involves extrinsic aging, wrinkle formation, and skin dehydration, and leads to excessive production of active oxygen that adversely affects the skin. Here, we investigated the antiphotoaging effect of AGEs BlockerTM (AB), which comprises Korean mint aerial part and fig and goji berry fruits. Compared to its individual components, AB was more potent at increasing the expression of collagen and hyaluronic acid and decreasing MMP-1 expression in UVB-irradiated Hs68 fibroblasts and HaCaT keratinocytes...
May 9, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37076760/protective-effect-and-mechanism-research-of-phyllanthus-emblica-linn-fruit-extract-on-uv-induced-photodamage-in-keratinocytes
#19
JOURNAL ARTICLE
Liping Qu, Feifei Wang, Yueyue Chen
Ultraviolet (UV) irradiation causes acute and chronic cutaneous effects that may result in photodamage and photoaging. Epidermis keratinocytes, as the closest surface of skin, are susceptible to damage from UV rays. Phyllanthus emblica Linn. fruit (PE) extract, as a medicine and food dual-use plant, contains high levels of polyphenols and possesses multiple pharmacological properties. The present study investigated common and different molecular mechanisms and signaling pathway activations of UVA and UVB stimulated cell damage and photoprotective effect of PE extract against UVA and UVB by Methyl Thiazolyl Tetrazolium (MTT) method, Elisa assay, flow cytometry, differentially expressed genes analysis and western blot analysis...
April 19, 2023: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/36927117/management-of-acne-vulgaris-with-trifarotene
#20
REVIEW
Jerry Tan, Rajeev Chavda, Hilary Baldwin, Brigitte Dreno
Topical retinoids have an essential role in treatment of acne. Trifarotene, a topical retinoid selective for retinoic acid receptor (RAR) γ, is the most recent retinoid approved for treatment of acne. RAR-γ is the most common isoform of RARs in skin, and the strong selectivity of trifarotene for RAR-γ translates to efficacy in low concentration. Trifarotene, like other topical retinoids, acts by increasing keratinocyte differentiation and decreasing proliferation, which reduces hyperkeratinization...
March 16, 2023: Journal of Cutaneous Medicine and Surgery
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