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Barret Rush, Clark Fruhstofer, Keith R Walley, Leo Anthony Celi, Mayur Brahmania
BACKGROUND: Patients with end-stage liver disease (ESLD) have a reduced life expectancy and a significant symptom burden. Our aim is to determine if inpatient palliative care (PC) referral for patients with ESLD is associated with decreased hospital readmission rates. METHODS: The 2013 US Nationwide Readmission Database (NRD) was used for the current analysis. The NRD allows for longitudinal analysis of all patient hospital admissions across 22 states. Patients ≥18 years of age with a diagnosis of ESLD with at least two decompensating events were included in the analysis...
February 13, 2019: BMJ Supportive & Palliative Care
Sarah E Rudasill, Yas Sanaiha, Alexandra L Mardock, Habib Khoury, Hanning Xing, James W Antonios, James A McKinnell, Peyman Benharash
BACKGROUND: Rising rates of hospitalization for infective endocarditis (IE) have been increasingly tied to rising injection drug use (IDU) associated with the opioid epidemic. OBJECTIVES: This study analyzed recent trends in IDU-IE hospitalization and characterized outcomes and readmissions for IDU-IE patients. METHODS: The authors evaluated the National Readmissions Database (NRD) for IE cases between January 2010 and September 2015. Patients were stratified by IDU status and surgical versus medical management...
February 12, 2019: Journal of the American College of Cardiology
Alen Džubur, Malik Ejubović, Almir Fajkić, Amela Dervišević, Azra Durak Nalbantić, Ajla Avdić Agić, Amela Džubur, Mevludin Mekić
Aim To assess triglyceride - to high-density lipoprotein cholesterol (TG/HDL)-C ratio in patients with acute coronary syndrome (ACS) and to verify its association with renal dysfunction. Methods A cross sectional study included 85 ACS patients divided in two groups with (ACS - RD) and without (ACS-nRD) presence of renal dysfunction, and 35 healthy subjects. Blood pressure, blood glucose, C-reactive protein, urea, creatinine, eGFR and serum lipids levels (total cholesterol, triglycerides, LDL-C, HDL-C) was measured in all participants...
February 1, 2019: Medicinski Glasnik
Mariska Wesseling, Lode Bosmans, Christophe Van Dijck, Jos Vander Sloten, Roel Wirix-Speetjens, Ilse Jonkers
To account for proximal femoral deformities in children with cerebral palsy (CP), subject-specific musculoskeletal models are needed. Non-rigid deformation (NRD) deforms generic onto personalized bone geometry and thereby transforms the muscle points. The goal of this study was to determine to what extent the models and simulation outcomes in CP patients differ when including subject-specific detail using NRD or Magnetic Resonance Imaging (MRI)-based models. The NRD models slightly overestimated hip contact forces compared to MRI models and differences in muscle point positions and moment arm lengths (MALs) remained, although differences were smaller than for the generic model...
January 22, 2019: Computer Methods in Biomechanics and Biomedical Engineering
Ravi B Pavurala, Daniel Li, Kyle Porter, Sara A Mansfield, Darwin L Conwell, Somashekar G Krishna
BACKGROUND: While cholecystectomy (CCY) is the standard of care for gallstone-related acute cholecystitis, percutaneous cholecystostomy-tube (CCYT-tube) is an alternative option in patients with significant comorbid conditions. We sought to identify immediate and longitudinal hospital outcomes of patients who underwent CCYT-tube placement and determine predictors of CCYT-tube placement and eventual CCY on a national level in the US. METHODS: We identified all adults (age ≥ 18 years) with a primary diagnosis of acute calculous cholecystitis from January to November 2013 in the Nationwide Readmissions Database (NRD)...
January 2, 2019: Surgical Endoscopy
Katherine L Bailey, Natalie Merchant, Young-Ji Seo, David Elashoff, Peyman Benharash, Jane Yanagawa
BACKGROUND: Readmission after surgery is an established surrogate indicator of quality of care. We aimed to compare short-term readmission rates and patient outcomes between open, video-assisted thoracoscopic (VATS), and robotic lobectomies in the Nationwide Readmissions Database (NRD). METHODS: Adults who underwent open, VATS, or robotic lobectomy for lung cancer from 2010 to 2014 were evaluated. Propensity-matched analysis was used to assess differences in readmission characteristics, GDP-adjusted cost, and mortality...
January 2, 2019: World Journal of Surgery
Yusuke Morita, Tetsuya Haruna, Yoshisumi Haruna, Eisaku Nakane, Yuhei Yamaji, Hideyuki Hayashi, Michiya Hanyu, Moriaki Inoko
BACKGROUND: Readmissions after in-hospital cardiopulmonary resuscitation (ICPR) are common and contribute to increased health care utilization and costs. This study aimed to estimate the burden and patterns of 30-day readmission after ICPR from the US Nationwide Readmission Database (NRD). METHODS: Using International Classification of Diseases-Ninth Revision-Clinical Modification codes, patients who underwent ICPR in the 2014 NRD were included. The incidence, predictors, causes, and costs of 30-day readmission were analyzed with discharge weights to obtain national estimates...
December 16, 2018: Resuscitation
Rohan M Shah, Qianzi Zhang, Subhasis Chatterjee, Faisal Cheema, Gabriel Loor, Scott A Lemaire, Matthew J Wall, Joseph S Coselli, Todd K Rosengart, Ravi K Ghanta
BACKGROUND: Readmissions adversely affect hospital reimbursement and quality measures. We aimed to evaluate the incidence, cost, and risk factors for readmission following Coronary Artery Bypass Grafting (CABG). METHODS: We queried the National Readmissions Database (NRD) and isolated patients who underwent CABG from 2013-2014. We determined the top reasons for readmission and compared demographics, comorbidities, in-hospital outcomes, and costs between readmitted and non-readmitted patients...
December 13, 2018: Annals of Thoracic Surgery
Salil V Deo, Sajjad Raza, Salah E Altarabsheh, Vaishali S Deo, Yakov E Elgudin, Shayan Marsia, Stephen Mitchell, Carolyn Chang, Ankur Kalra, Sahil Khera, Dhaval Kolte, Marco Costa, Daniel Simon, Alan H Markowitz, Soon J Park, Joseph F Sabik
BACKGROUND: Re-admission is an important source of patient dissatisfaction and increased hospital costs. A simple calculator to determine the probability of re-admission may help guide patient dismissal planning. METHODS: Using the national readmissions database (NRD), we identified admissions for isolated primary coronary artery bypass (CABG) and stratified them according to 30-day readmission. Including pre, intra and postoperative variables, we prepared a logistic regression model to determine the probability for re-admission...
November 29, 2018: Heart, Lung & Circulation
David Shau, Neeta Shenvi, Kirk Easley, Melissa Smith, Thomas Bradbury, George Guild
BACKGROUND: Medicaid payer status has been shown to affect risk-adjusted outcomes and resource utilization across multiple medical specialties. The purpose of this study was to examine resource utilization via readmission rates, length of stay, and total cost specific to Medicaid payer status following primary total hip arthroplasty. METHODS: The Nationwide Readmissions Database (NRD) was utilized to identify patients who underwent total hip arthroplasty in 2013 as well as corresponding "Medicaid" or "non-Medicaid" payer status...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
Dan-Dan Zhang, Gan Lu, Xuan-Feng Zhu, Ling-Ling Zhang, Jia Gao, Li-Cheng Shi, Jian-Hua Gu, Jian-Nan Liu
Background: Neural respiratory drive (NRD) using diaphragm electromyography through an invasive transesophageal multi-electrode catheter can be used as a feasible clinical physiological parameter in patients with chronic obstructive pulmonary disease (COPD) to provide useful information on the treatment response. However, it remains unknown whether the surface diaphragm electromyogram (EMGdi) could be used to identify the deterioration of clinical symptoms and to predict the necessity of hospitalization in acute exacerbation of COPD (AECOPD) patients...
December 5, 2018: Chinese Medical Journal
Junya Mizoi, Natsumi Kanazawa, Satoshi Kidokoro, Fuminori Takahashi, Feng Qin, Kyoko Morimoto, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki
Plants have evolved complex systems to rapidly respond to severe stress conditions, such as heat, cold, and dehydration. DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2A (DREB2A) is a key transcriptional activator that induces many heat- and drought-responsive genes, increases tolerance to both heat and drought stress, and suppresses plant growth in Arabidopsis thaliana DREB2A expression is induced by stress, but stabilization of the DREB2A protein in response to stress is essential for activating the expression of downstream stress-inducible genes...
November 28, 2018: Journal of Biological Chemistry
Stephanie Doupnik, Jonathan Rodean, Bonnie T Zima, Tumaini R Coker, Diana Worsley, Kris P Rehm, James C Gay, Matt Hall, Steve Marcus
OBJECTIVE: To inform resource allocation toward a continuum of care for youth at risk of suicide, we examined unplanned 30-day readmissions after pediatric hospitalization for either suicide ideation (SI) or suicide attempt (SA). METHODS: We conducted a retrospective cohort study of a nationally representative sample of 133,516 hospitalizations for SI or SA among 6- to 17-year-olds to determine prevalence, risk factors, and characteristics of 30-day readmissions using the 2013 and 2014 Nationwide Readmissions Dataset (NRD)...
November 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Jonas Boström, Dean G Brown, Robert J Young, György M Keserü
This corrects the article DOI: 10.1038/nrd.2018.116.
November 28, 2018: Nature Reviews. Drug Discovery
Zain H Rizvi, Rocco Ferrandino, Quang Luu, Jeffrey D Suh, Marilene B Wang
BACKGROUND: Transsphenoidal pituitary surgery has evolved into a safe procedure with shorter hospitalizations, yet unplanned readmissions remain a quality measure for which there is a paucity of data. We sought to examine rates, timing, etiologic factors, and costs surrounding readmission after transsphenoidal pituitary surgery. METHODS: The Nationwide Readmissions Database (NRD) was queried for patients who underwent transsphenoidal pituitary between January 2013 and November 2013...
November 23, 2018: International Forum of Allergy & Rhinology
Spyridon N Karras, Theocharis Koufakis, Andrea Petróczi, Dirk Folkerts, Maria Kypraiou, Hilda Mulrooney, Declan P Naughton, Angeliki Persynaki, Pantelis Zebekakis, Dimitrios Skoutas, Kalliopi Kotsa
OBJECTIVES: Christian Orthodox fasting (COF), a periodical vegetarian subset of the Mediterranean diet, has been proven to exert beneficial effects on human health. Athonian fasting is a pescetarian COF variation, where red meat is strictly restricted throughout the year. Previous studies have examined the COF nutritional synthesis and health effects in general population fasters (GF) and Athonian monks (AM), separately. The aim of this study is to comparatively evaluate the characteristics and effects of this nutritional advocacy between the two populations...
July 24, 2018: Nutrition
Rushikesh Shah, Emad Qayed
OBJECTIVES: Gastrointestinal (GI) bleeding is a major comorbidity in patients with left ventricular assist devices (LVADs). The study aim was to estimate the rate of hospital readmissions for GI bleeding in patients with LVADs using a nationally representative database. Additionally, we evaluated the etiologies, costs, endoscopy utilization, mortality, and predictors of GI bleeding readmissions in these patients. METHODS: We analyzed data from the National Readmissions Database (NRD) from 2010 through 2014...
November 2018: Southern Medical Journal
Luke K Kim, Ilhwan Yeo, Jim W Cheung, Rajesh V Swaminathan, S Chiu Wong, Konstantinos Charitakis, Oluwayemisi Adejumo, John Chae, Robert M Minutello, Geoffrey Bergman, Harsimran Singh, Dmitriy N Feldman
Background Readmission after ST-segment-elevation myocardial infarction ( STEMI ) poses an enormous economic burden to the US healthcare system. Efforts to prevent readmissions should be based on understanding the timing and causes of these readmissions. This study aimed to investigate contemporary causes, timing, and cost of 30-day readmissions after STEMI . Methods and Results All STEMI hospitalizations were selected in the Nationwide Readmissions Database ( NRD ) from 2010 to 2014. The 30-day readmission rate as well as the primary cause and cost of readmission were examined...
September 18, 2018: Journal of the American Heart Association
Srikanth Yandrapalli, Wilbert S Aronow, William H Frishman
Background: Influenza epidemics are a major health care concern in the US. Influenza related complications can increase in-hospital complications, and readmissions following a hospitalization for influenza. We sought to determine the 30-day readmission rate, etiologies, outcomes, and healthcare burden of 30-day readmissions in adults hospitalized for influenza. Methods: The 2014 US National Readmissions Database (NRD) was retrospectively analyzed to identify patients ≥18 years of age hospitalized for influenza and discharged between January and November 2014...
August 2018: Annals of Translational Medicine
Jun Tang, Laura Pearce, Jill O'Donnell-Tormey, Vanessa M Hubbard-Lucey
This corrects the article DOI: 10.1038/nrd.2018.167.
October 26, 2018: Nature Reviews. Drug Discovery
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