keyword
https://read.qxmd.com/read/38018548/diminished-hand-grip-strength-and-cirrhosis-prevalence-and-associated-factors
#21
JOURNAL ARTICLE
Carolina Pretti Tumang de Andrade, Lara Ferrari Dalcumune, Núbia Mesquita Fiorese, Livia Zardo Trindade, Felipe Bertollo Ferreira, Mariana Poltronieri Pacheco
BACKGROUND: Sarcopenia is a syndrome characterized by progressive and generalized loss of muscle mass and strength, observed to varying degrees in patients with various chronic conditions. In cirrhotic patients, it reflects protein-energy malnutrition due to metabolic protein imbalance and is associated with worsened prognosis and reduced post-liver transplantation survival. OBJECTIVE: To evaluate the epidemiological distribution of diminished hand grip (HG) strength in cirrhotic patients at an outpatient clinic of Santa Casa de Misericórdia in Vitória-ES, Brazil, seeking its association with liver function and cirrhosis complications...
2023: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38016243/prevalence-of-and-associated-factors-for-sarcopenia-in-patients-with-liver-cirrhosis-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Shuyue Tuo, Yee Hui Yeo, Rachel Chang, Zhang Wen, Qiuju Ran, Longbao Yang, Qing Fan, Junxiu Kang, Jiaojiao Si, Yi Liu, Haitao Shi, Yong Li, Jia Yuan, Na Liu, Shejiao Dai, Xiaoyan Guo, Jinhai Wang, Fanpu Ji, Xinxing Tantai
BACKGROUND: Sarcopenia is associated with poor outcomes in patients with cirrhosis. However, the prevalence of and associated factors for developing sarcopenia in this population remain to be determined. OBJECTIVES: This study aimed to summarize the prevalence, characteristics, and associated factors of sarcopenia in patients with cirrhosis. METHODS: Electronic searches were performed from inception to June 9, 2022 to identify the eligible studies...
November 14, 2023: Clinical Nutrition
https://read.qxmd.com/read/37881635/sarcopenia-in-liver-cirrhosis-perspectives-from-epigenetics-and-microbiota
#23
REVIEW
Jia-Qi Xu, Yu-Ke Pan, Jie-Xin Zhang, Shi-Xue Dai, Li-Shu Xu
Sarcopenia is characterized by the loss of muscle mass and function. It is well known that sarcopenia is often associated with aging, while in recent years, sarcopenia comorbid with chronic diseases such as cirrhosis has attracted widespread attention, whose underlying molecular mechanisms remain unclear. Since cirrhosis and sarcopenia are assumed to be closely interrelated in terms of pathogenesis, this review innovatively discussed the role of epigenetic modifications and microecological dysregulation in sarcopenia in the context of liver cirrhosis...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37867493/coexistence-of-muscle-atrophy-and-high-subcutaneous-adipose-tissue-radiodensity-predicts-poor-prognosis-in-hepatocellular-carcinoma
#24
JOURNAL ARTICLE
Masatsugu Ohara, Goki Suda, Risako Kohya, Takashi Sasaki, Tomoka Yoda, Sonoe Yoshida, Qingjie Fu, Zijian Yang, Shunichi Hosoda, Osamu Maehara, Shunsuke Ohnishi, Yoshimasa Tokuchi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Koji Ogawa, Naoya Sakamoto
INTRODUCTION: We aimed to assess the prognostic implications of muscle atrophy and high subcutaneous adipose tissue (SAT) radiodensity in patients with hepatocellular carcinoma (HCC). METHODS: In this retrospective study, muscle atrophy was assessed using the psoas muscle index (PMI) obtained from computed tomography. SAT radiodensity was evaluated based on radiodensity measurements. Survival and multivariate analyses were performed to identify factors associated with prognosis...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37837304/the-association-of-testosterone-with-sarcopenia-and-frailty-in-chronic-liver-disease
#25
REVIEW
Lampros Chrysavgis, Magdalini Adamantou, Anna Angelousi, Evangelos Cholongitas
BACKGROUND: Testosterone is an important anabolic hormone responsible for maintaining body composition and muscle mass and circulates mostly albumin-bound, or sex hormone binding globulin (SHBG)-bound or free in the plasma. Of these fractions, the latter is bioactive and exerts the androgenic effects on male population. Liver cirrhosis, the advanced stage of any chronic liver disease characterized by permanent distortions to the hepatic architecture, disrupts the hypothalamic-pituitary-gonadal axis, leading to diminished levels of free testosterone and hypogonadism...
October 14, 2023: European Journal of Clinical Investigation
https://read.qxmd.com/read/37827533/reduced-muscle-strength-is-closely-linked-to-computed-tomography-defined-myosteatosis-among-inpatients-with-cirrhosis
#26
JOURNAL ARTICLE
Chao Sun, Tianming Zhao, Wanting Yang, Gaoyue Guo, Han Wang, Chaoqun Li, Yangyang Hui, Binxin Cui, Xiaoyu Wang, Xiaofei Fan, Xingliang Zhao
BACKGROUND: Myosteatosis indicates pathological fat infiltration in muscles and is regarded as a distinct disease from sarcopenia. This muscular condition exhibits a link to muscle fiber disarrangement coinciding with disrupted muscle contractility and weakened mechanical action, mirrored as decreased muscle quality. However, the relationship between handgrip strength (HGS) and computed tomography-defined myosteatosis among cirrhosis is unclear. We aimed to investigate the association between HGS and myosteatosis and determine gender-specific cutoffs regarding HGS to identify myosteatotic subjects...
October 12, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37771367/cirrhosis-related-sarcopenia-may-not-resolve-after-liver-transplantation
#27
JOURNAL ARTICLE
Sara Brown, Brooks Richardson, Erin Bouquet, Elise Reid, Evan Mercer, Michael Goncalves, Ashley Spann, Jeffrey Annis, Evan Brittain, Anthony Dreher, Sophoclis Alexopoulos, James C Slaughter, Heidi J Silver, Manhal Izzy
BACKGROUND & AIMS: Sarcopenia has significant burden in cirrhosis and has been shown to worsen short-term post-liver transplantation (LT). This study aims to evaluate the long-term change in sarcopenia post-LT along with its associations and predictors. METHODS: A retrospective study of adult patients who underwent LT at a tertiary centre between 1/1/2009 and 12/31/2018. Relevant demographic and clinical data were collected. Skeletal muscle index (SMI) was calculated using standard of care computerised tomography (CT) scans pre- and post-LT...
November 2023: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/37767786/altered-gut-microbiome-bile-acid-composition-and-metabolome-in-sarcopenia-in-liver-cirrhosis
#28
JOURNAL ARTICLE
Benard Aliwa, Angela Horvath, Julia Traub, Nicole Feldbacher, Hansjörg Habisch, Günter Fauler, Tobias Madl, Vanessa Stadlbauer
BACKGROUND: Sarcopenia in liver cirrhosis is associated with low quality of life and high mortality risk. The pathogenesis has yet to be fully understood. We hypothesized that gut microbiome, bile acid (BA) composition and metabolites differ between cirrhotic patients with and without sarcopenia and contribute to pathogenesis. METHODS: Cirrhotic patients with (n = 78) and without (n = 38) sarcopenia and non-cirrhotic controls with (n = 39) and without (n = 20) sarcopenia were included in this study...
September 28, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/37760177/isolation-and-biological-evaluation-of-alfa-mangostin-as-potential-therapeutic-agents-against-liver-fibrosis
#29
JOURNAL ARTICLE
Yi-Jen Liao, Chun-Ya Lee, Yuh-Ching Twu, Fat-Moon Suk, Tzu-Chieh Lai, Ya-Ching Chang, Yi-Cheng Lai, Jing-Wei Yuan, Hong-Ming Jhuang, Huei-Ruei Jian, Li-Chia Huang, Kuang-Po Chen, Ming-Hua Hsu
The increased proliferation and activation of hepatic stellate cells (HSCs) are associated with liver fibrosis development. To date, there are no FDA-approved drugs for the treatment of liver cirrhosis. Augmentation of HSCs apoptosis is one of the resolutions for liver fibrosis. In this study, we extracted α-mangostin (1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one) from the fruit waste components of mangosteen pericarp. The isolated α-mangostin structure was determined and characterized with nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) and compared with those known compounds...
September 11, 2023: Bioengineering
https://read.qxmd.com/read/37739726/effect-of-probiotics-on-nutritional-status-biochemical-parameters-and-disease-severity-in-cirrhotic-patients-referred-for-liver-transplantation-a-randomised-double-blind-placebo-controlled-trial
#30
JOURNAL ARTICLE
Gokulapriya Ramachandran, Biju Pottakkat, Sharbari Basu, Pazhanivel Mohan
INTRODUCTION: Probiotics have been shown to be effective in many diseases. However, their effects on the nutritional status in patients with cirrhosis is uncertain. AIM: We aimed to study the effect of probiotics on nutritional status, biochemical parameters, and liver disease severity in patients with cirrhosis referred for liver transplantation. METHODS: A randomised, double-blind, placebo-controlled study was conducted from July 2021-October 2022...
October 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/37735907/impact-of-sarcopenia-on-the-survival-of-patients-undergoing-liver-transplantation-for-decompensated-liver-cirrhosis
#31
JOURNAL ARTICLE
Da Zhou, Donghua Zhang, Chenghao Zeng, Li Zhang, Xuejin Gao, Xinying Wang
BACKGROUND: Patients with decompensated cirrhosis (DC) are prone to skeletal muscle loss, namely, sarcopenia, before liver transplantation (LT). While sarcopenia is reportedly associated with adverse outcomes after LT, these findings are limited owing to mixed diseases and retrospective data. We investigated the association between sarcopenia and 1-year overall survival (OS) in patients with DC after LT and established and validated a prediction model for postoperative OS based on sarcopenia...
September 21, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/37695087/bioimpedance-analysis-predicts-the-etiology-of-cirrhosis-in-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Hashem B El-Serag, Ghida Akhdar, Aaron P Thrift, Michelle Luster, Saira Khaderi, Abeer Alsarraj, Hao Duong, Fasiha Kanwal
BACKGROUND: Obesity is associated with an increased risk of developing cirrhosis. However, body mass index (BMI) and waist-to-hip ratio (WHR) may not be indicative of body composition parameters that predispose to cirrhosis. Bioimpedance analysis (BIA) is a noninvasive cost-efficient method for more detailed estimation of body composition. METHODS: We examined patients with cirrhosis who underwent BIA as part of enrollment into a prospective cohort study. We examined the correlation between BIA variables, BMI, and WHR...
October 1, 2023: Hepatology Communications
https://read.qxmd.com/read/37693267/nutritional-management-of-a-liver-transplant-candidate
#33
REVIEW
Saurabh Mishra, Madhumita Premkumar
Nearly two-thirds of patients with cirrhosis suffer from malnutrition resulting from multiple contributory factors such as poor intake, accelerated starvation, catabolic milieu, and anabolic resistance. Nutritional assessment and optimization are integral to adequate management of a liver transplant (LT) candidate. A detailed nutritional assessment should be done at baseline in all potential transplant candidates with periodic reassessments. Sarcopenia is defined as a reduction in muscle mass, function, and/or performance...
2023: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/37661093/muscle-mass-adjusted-for-body-weight-is-associated-with-significant-liver-fibrosis-in-young-adults-with-nonalcoholic-fatty-liver-disease-a-cross-sectional-study-from-a-korean-military-hospital
#34
JOURNAL ARTICLE
Jaejun Lee, Seongjoo Na, Taeyun Kim, Seong-Woo Lee, Myoung Jung Kim, Chang In Han, Si Hyun Bae
BACKGROUND: Sarcopenia has been associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the correlation between liver fibrosis and muscle mass in young adults with NAFLD. METHODS: We conducted a retrospective review of 88 Korean soldiers <35 years of age who underwent bioelectrical impedance analysis and liver stiffness measurements. A FibroScan-aspartate aminotransferase score >0.35 was used to determine the presence of liver fibrosis...
September 4, 2023: Journal of obesity & metabolic syndrome
https://read.qxmd.com/read/37643935/nonalcoholic-fatty-liver-disease-and-adult-growth-hormone-deficiency-an-under-recognized-association
#35
REVIEW
Yutaka Takahashi
Growth hormone (GH) plays an essential role not only in promoting growth in children, but also in many important metabolic processes in adults. One of the major metabolic functions of GH is its stimulatory effects on the liver in generating approximately 80% of circulating insulin-like growth factor 1 (IGF-1). Adult growth hormone deficiency (GHD) is an established clinical entity defined as a defect in endogenous GH secretion that is frequently associated with central obesity, loss of muscle mass, decreased bone mass, and impaired quality of life...
August 16, 2023: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/37571273/detection-of-sarcopenia-in-patients-with-liver-cirrhosis-using-the-bioelectrical-impedance-analysis
#36
JOURNAL ARTICLE
Dorotea Bozic, Ivica Grgurevic, Bisera Mamic, Vesna Capkun, Josipa Bilandzic-Ivisic, Tomislav Ivanovic, Ivona Bozic, Ivan Zaja, Kristian Podrug, Zeljko Puljiz, Zdravko Perko, Ivana Mikolasevic
Bioelectrical impedance analysis (BIA) is a body composition assessment method. We aimed to determine its accuracy in the detection of sarcopenia in patients with liver cirrhosis (LC), using skeletal muscle index (SMI) at the level of third lumbar vertebra (L3-SMI) obtained using multislice computed tomography as the reference method. Patients with LC were enrolled in the period October 2019-March 2022 and follow-ups were conducted until January 2023. Their BIA parameters were compared against L3-SMI, and BIA cut-off values were proposed using AUROC analysis...
July 27, 2023: Nutrients
https://read.qxmd.com/read/37547031/evaluation-of-the-nutritional-status-of-patients-with-liver-cirrhosis
#37
JOURNAL ARTICLE
Barbara Janota, Aneta Krupowicz, Kinga Noras, Ewa Janczewska
BACKGROUND: Progressive malnutrition coexists with liver diseases, particularly in patients with cirrhosis. Early diagnosis of malnutrition in patients with advanced stages of chronic liver disease and the implementation of appropriate nutritional treatment for malnourished patients should be an integral part of the therapeutic process. AIM: To evaluate the nutritional status of patients with various severities of advanced liver fibrosis, using various nutritional status parameters...
July 27, 2023: World Journal of Hepatology
https://read.qxmd.com/read/37545638/sarcopenia-in-cirrhosis-prospects-for-therapy-targeted-to-gut-microbiota
#38
REVIEW
Roman Maslennikov, Aliya Alieva, Elena Poluektova, Yury Zharikov, Andrey Suslov, Yana Letyagina, Ekaterina Vasileva, Anna Levshina, Evgenii Kozlov, Vladimir Ivashkin
Decreased muscle mass and function, also known as sarcopenia, is common in patients with cirrhosis and is associated with a poor prognosis. Although the pathogenesis of this disorder has not been fully elucidated, a disordered gut-muscle axis probably plays an important role. Decreased barrier function of the gut and liver, gut dysbiosis, and small intestinal bacterial overgrowth (SIBO) can lead to increased blood levels of ammonia, lipopolysaccharides, pro-inflammatory mediators, and myostatin. These factors have complex negative effects on muscle mass and function...
July 21, 2023: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/37482521/a-prospective-study-on-the-differential-association-of-sarcopenia-and-frailty-with-health-outcomes-in-cirrhotic-patients
#39
JOURNAL ARTICLE
Jia Luo, Dawei Yang, Zhengyu Xu, Dai Zhang, Min Li, Yuanyuan Kong, Xiaoming Wang, Xiaojuan Ou, Yu Wang, Xinyan Zhao, Shan Shan, Zhenghan Yang, Jidong Jia
BACKGROUND: To investigate the joint impact of sarcopenia and frailty on mortality and the development of decompensation in cirrhosis. METHODS: Sarcopenia was assessed using the skeletal muscle mass index (SMI) by computed tomography, whereas frailty was measured using the Fried Frailty Phenotype (FFP). Cox proportional hazard regression and competing risks analysis were used to evaluate their association with adverse outcomes. RESULTS: The prevalence of sarcopenia and frailty was 29...
July 21, 2023: Digestive and Liver Disease
https://read.qxmd.com/read/37443613/hemoglobin-and-endotoxin-levels-predict-sarcopenia-occurrence-in-patients-with-alcoholic-cirrhosis
#40
JOURNAL ARTICLE
Akihiko Shibamoto, Tadashi Namisaki, Junya Suzuki, Takahiro Kubo, Satoshi Iwai, Fumimasa Tomooka, Soichi Takeda, Yuki Fujimoto, Takashi Inoue, Misako Tanaka, Aritoshi Koizumi, Nobuyuki Yorioka, Takuya Matsuda, Shohei Asada, Yuki Tsuji, Yukihisa Fujinaga, Norihisa Nishimura, Shinya Sato, Hiroaki Takaya, Koh Kitagawa, Kosuke Kaji, Hideto Kawaratani, Takemi Akahane, Akira Mitoro, Hitoshi Yoshiji
Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then divided into two groups: alcoholic cirrhosis (AC; n = 149) and nonalcoholic cirrhosis (NAC; n = 302). Endotoxin activity (EA) levels were measured with an EA assay. Group AC showed significantly higher platelet counts ( p = 0...
June 29, 2023: Diagnostics
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