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JOURNAL ARTICLE
Vera J E van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K Amarasinghe, Brian L Mark, Marjolein Kikkert, Sachdev S Sidhu
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses-including SARS-CoV, MERS-CoV, and SARS-CoV-2-is the papain-like protease (PLpro). PLpro cleaves part of the viral replicase polyproteins into non-structural protein subunits, which are essential to the viral replication cycle. Additionally, PLpro can cleave both ubiquitin and the ubiquitin-like protein ISG15 from host cell substrates as a mechanism to evade innate immune responses during infection...
December 22, 2022: PLoS Pathogens
#22
JOURNAL ARTICLE
Yukino N Strong, Angel Li, Michael E White, Abrahim N Razzak, Danyon J Anderson, Alan D Kaye, Edwin W Herron, Nazih P Khater, Elyse C Bradley, Ivan Urits
Dhat syndrome is a culture-bound psychiatric syndrome most commonly found in the Indian subcontinent. It has been characterized as the experiential fear of losing semen through ejaculation, nocturnal emission, or other means. While Dhat syndrome is common in the Indian subcontinent, given the lack of representativeness, generalizability, and closer connection to Ayurvedic system, there have been limited studies or recognition of symptoms among healthcare providers around the world. In this review, we describe Dhat syndrome, its epidemiology, risk factors, comorbidities, diagnosis, treatment, and its management...
2022: Health Psychology Research
#23
Tanuja Bhardwaj, Lokesh Shekhawat, Viju P D
No abstract text is available yet for this article.
November 2022: Indian Journal of Psychological Medicine
#24
JOURNAL ARTICLE
Mohit Kumar Shahi, Adarsh Tripathi, Astha Singh, Sujita Kumar Kar, Anil Nischal, Shweta Singh, Pronob Kumar Dalal
Background: Dhat syndrome (DS) is considered a culture-bound syndrome of South East Asia. It is often associated with multiple sexual and psychiatric comorbidities. We aimed to assess the quality of life (QoL) and disability in patients of DS with and without comorbidity. Methods: This cross-sectional study included 117 patients with DS and 117 matched controls. DS was diagnosed based on the International Classification of Diseases , 10 version, Diagnostic Criteria for Research diagnostic criteria...
September 2022: Indian Journal of Psychological Medicine
#25
Dennis Bomansang Daliri, Agani Afaya, William H F Koomson, Emmanuel Akatibo
The rarity and close resemblance to other mental health conditions of dissociative fugue make it difficult to diagnose. Akin to a culture-bound syndrome, most African countries have their local explanation for this unique presentation and therefore people may not seek evidence-based health care but rather may resort to faith-based-treatment which may not give the best results. This is the case of a 39-year-old man who has experienced about five episodes of dissociative fugue over nine years. This case points out the comorbidities associated with the condition...
2022: Case Reports in Psychiatry
#26
JOURNAL ARTICLE
Quentin Thomas, Marialetizia Motta, Thierry Gautier, Maha S Zaki, Andrea Ciolfi, Julien Paccaud, François Girodon, Odile Boespflug-Tanguy, Thomas Besnard, Jennifer Kerkhof, Haley McConkey, Aymeric Masson, Anne-Sophie Denommé-Pichon, Benjamin Cogné, Eva Trochu, Virginie Vignard, Fatima El It, Lance H Rodan, Mohammad Ayman Alkhateeb, Rami Abou Jamra, Laurence Duplomb, Emilie Tisserant, Yannis Duffourd, Ange-Line Bruel, Adam Jackson, Siddharth Banka, Meriel McEntagart, Anand Saggar, Joseph G Gleeson, David Sievert, Hyunwoo Bae, Beom Hee Lee, Kisang Kwon, Go Hun Seo, Hane Lee, Anjum Saeed, Nadeem Anjum, Huma Cheema, Salem Alawbathani, Imran Khan, Jorge Pinto-Basto, Joyce Teoh, Jasmine Wong, Umar Bin Mohamad Sahari, Henry Houlden, Kristina Zhelcheska, Melanie Pannetier, Mona A Awad, Marion Lesieur-Sebellin, Giulia Barcia, Jeanne Amiel, Julian Delanne, Christophe Philippe, Laurence Faivre, Sylvie Odent, Aida Bertoli-Avella, Christel Thauvin, Bekim Sadikovic, Bruno Reversade, Reza Maroofian, Jérôme Govin, Marco Tartaglia, Antonio Vitobello
The transmembrane protein TMEM147 has a dual function: first at the nuclear envelope, where it anchors lamin B receptor (LBR) to the inner membrane, and second at the endoplasmic reticulum (ER), where it facilitates the translation of nascent polypeptides within the ribosome-bound TMCO1 translocon complex. Through international data sharing, we identified 23 individuals from 15 unrelated families with bi-allelic TMEM147 loss-of-function variants, including splice-site, nonsense, frameshift, and missense variants...
October 6, 2022: American Journal of Human Genetics
#27
JOURNAL ARTICLE
Shucheng Zheng, Fanjuan Meng, Dongli Li, Lingke Liu, Di Ge, Qing Wang, Haipeng Liu
Sirtuin 1 (SIRT1), a member of the class III lysine deacetylases, exhibits powerful functional diversity in physiological processes and disease occurrences. However, the potential molecular mechanism underlying the role of SIRT1 during viral infection in crustaceans is poorly understood. Herein, SIRT1 was functionally characterized from the red claw crayfish Cherax quadricarinatus , which possesses typically conserved deacetylase domains and strong evolutionary relationships across various species. Moreover, gene knockdown of Cq SIRT1 in crayfish haematopoietic tissue (Hpt) cell culture inhibited white spot syndrome virus (WSSV) late envelope gene vp28 transcription...
August 6, 2022: Viruses
#28
JOURNAL ARTICLE
Julie Wagner, Angela Bermúdez-Millán, S Megan Berthold, Thomas Buckley, Orfeu M Buxton, Richard Feinn, Sengly Kong, Theanvy Kuoch, Lindsay Master, Mary Scully, Kagnica Seng
AIMS: This paper reports secondary data analysis of associations between psychological distress and health behaviors among Cambodian Americans. METHODS: Data are from baseline assessments from a diabetes prevention trial. All participants met criteria for depression and were free of diabetes. Participants (n=191) completed surveys, a food frequency assessment, and wore sleep and physical activity actigraphy devices for 7 days. A factor analysis of symptoms of post-traumatic stress, baksbat (a Cambodian culture-bound syndrome), depression, and anxiety yielded a single factor named 'psychological distress'...
August 20, 2022: Stress and Health: Journal of the International Society for the Investigation of Stress
#29
EDITORIAL
Bonnie N Kaiser, Lesley Jo Weaver
No abstract text is available yet for this article.
August 2022: Transcultural Psychiatry
#30
JOURNAL ARTICLE
Ann Cavers, Matthias Christian Kugler, Yesim Ozguler, Arshed Fahad Al-Obeidi, Gulen Hatemi, Beatrix M Ueberheide, Didar Ucar, Olivier Manches, Johannes Nowatzky
OBJECTIVES: The endoplasmic reticulum aminopeptidase ( ERAP1 ) haplotype Hap10 encodes for a variant allotype of the endoplasmic reticulum (ER)-resident peptide-trimming aminopeptidase ERAP1 with low enzymatic activity. This haplotype recessively confers the highest risk for Behçet's diseases (BD) currently known, but only in carriers of HLA-B*51 , the classical risk factor for the disease. The mechanistic implications and biological consequences of this epistatic relationship are unknown...
November 2022: Annals of the Rheumatic Diseases
#31
JOURNAL ARTICLE
Xinghua Ren, Siyi Zhang, Yongyan Yang, Annie Song, Feng Liang, Yiying Zhang, Yuanlin Dong, Xu Wu, Zhongcong Xie
BACKGROUND: Ketamine is an intravenous anesthetic. However, whether ketamine can induce neurotoxicity and neurobehavioral deficits remains largely unknown. Delirium is a syndrome of acute brain dysfunction associated with anesthesia and surgery in patients, and tau protein may contribute to postoperative delirium. Finally, ketamine may affect the function of the endosome, the key organelle for tau release from neurons. Therefore, we set out to determine the effects of ketamine on delirium-like behavior in mice and on tau trafficking in cultured cells...
July 25, 2022: Anesthesia and Analgesia
#32
JOURNAL ARTICLE
Alaa F Nahhas, Thomas J Webster
Herein, we designed a nano peptide that contains three important motifs for targeting the chemotrypsin-like cysteine protease (3CLpro ) which is the enzyme responsible for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication. The novel nano peptide contains the Nap Phe-Phe motif that is responsible for peptide self-assembly, an octapeptide (Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe) motif where the enzyme recognizes the substrate and induces enzyme sensitivity, and a tetrapeptide motif which is positively charged containing the peptide (Lys)₄ that facilitates penetration into a cell...
April 1, 2022: Journal of Biomedical Nanotechnology
#33
JOURNAL ARTICLE
Boris Simonetti, James L Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A Lewis, Kate J Heesom, Deborah K Shoemark, Andrew D Davidson, Brett M Collins, Tambet Teesalu, Yohei Yamauchi, Peter J Cullen
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans -Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex promoting exit 1 (ESCPE-1). Using this methodology, we identify Neuropilin-1 (NRP1), a recently characterized host factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as a cargo directly bound and trafficked by ESCPE-1...
June 21, 2022: Proceedings of the National Academy of Sciences of the United States of America
#34
JOURNAL ARTICLE
Jiao Wang, Mingrui Xiong, Yu Fan, Chengyu Liu, Qing Wang, Dong Yang, Yangmian Yuan, Yixue Huang, Shun Wang, Yu Zhang, Shuxuan Niu, Junqiu Yue, Hua Su, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang
Rationale: Ischemia-reperfusion (IR) induced acute kidney injury (AKI) causes serious clinical problems associated with high morbidity and mortality. Mecp2 is a methyl-CpG binding protein, its mutation or deletion causes a neurodevelopment disease called Rett syndrome. Notably, some Rett syndrome patients present urological dysfunctions. It remains unclear whether and how Mecp2 affects AKI. Methods: Renal tubular cell specific Mecp2 deletion mice challenged with IR injury were used to investigate the effects of Mecp2 on renal tubular damage, function, cell death, fibrosis and inflammation...
2022: Theranostics
#35
JOURNAL ARTICLE
Ting Geng, Yifan Sun, Lin Cheng, Yuming Cao, Ming Zhang, Zhidan Hong, Ling Ma, Yuanzhen Zhang
An association between endometriosis and luteinized unruptured follicle syndrome (LUFs) has long been identified. Although inactivating mutation of luteinizing hormone/choriogonadotropin receptor (LHGCR) results in LUFs, whether LHCGR contributes to promoting LUFs in endometriosis remains elusive. To investigate the effect of LHCGR signaling in the development of endometriosis-associated LUFs and dissect the underlying mechanism in vivo mouse endometriosis model was established to measure the effect on ovarian folliculogenesis...
2022: Frontiers in Endocrinology
#36
REVIEW
Nancy Ortiz-Mendoza, Eva Aguirre-Hernández, Itzi Fragoso-Martínez, María Eva González-Trujano, Francisco A Basurto-Peña, Martha J Martínez-Gordillo
Salvia is the most diverse genus within the mint family (Lamiaceae), many of its species are well-known due to their medicinal and culinary uses. Most of the ethnopharmacological and phytochemical studies on Salvia are centred on species from the European and Asian clades. However, studies about the most diverse clade, the Neotropical sages ( Salvia subgenus Calosphace ; 587 spp.), are relatively scarce. This review aims to compile the information on the traditional medicinal uses, pharmacological and phytochemistry properties of the Neotropical sages...
2022: Frontiers in Pharmacology
#37
S M Yasir Arafat, Firoj Mondal, Sabina Ghimire
Dhat syndrome is a culture-bound syndrome in which patients believe that they pass Dhat (semen) with their urine, feces, sweat, and saliva that causes lethargy, apathy, dysphoria, and depression. Here, we report a case of a 47-year-old man who presented with complaints of burning sensation in the whole body, especially in the pubic region, and insomnia for the last 5 years. This case could be enlightening for clinicians in South Asia in daily clinical practice and family physicians in Western countries where immigrants from Dhat syndrome prevailing countries could present with complex cultural myths and superstitious beliefs...
May 2022: Journal of General and Family Medicine
#38
JOURNAL ARTICLE
Jacopo Pruccoli, Angela La Tempa, Valentina Francia, Paola Gualandi, Elisabetta Malaspina, Filomena Moscano, Francesca Rossi, Leonardo Sacrato, Paola Rucci, Antonia Parmeggiani
PURPOSE: Cultural and environmental factors have frequently been implicated in the pathogenesis of Eating Disorders (ED). Although ED have been considered as "Western culture-bound syndromes", increasing rates of ED among non-Western groups are being documented. The present study aims to investigate treatment and clinical outcomes among first-generation immigrant children and adolescents (FGI) (patients born abroad) and second-generation immigrant youth (SGI, patients born in Italy) with Anorexia Nervosa (AN)...
March 2022: Rivista di Psichiatria
#39
REVIEW
Chengyuan Liang, Nan Hui, Yuzhi Liu, Guaiping Qiao, Juan Li, Lei Tian, Xingke Ju, Minyi Jia, Hong Liu, Wenqiang Cao, Pengcheng Yu, Han Li, Xiaodong Ren
Background: In December 2019, a novel coronavirus, SARS-CoV-2 caused a series of acute atypical respiratory diseases worldwide. However, there is still a lack of drugs with clear curative effects, and the clinical trial research of vaccines has not been completely finished. Purpose: LH capsules are approved TCM patent medicine that are widely used for the treatment of respiratory tract infectious diseases caused by colds and flu. On April 12, 2020, LH capsules and granules were officially repurposed by the China Food and Drug Administration (CFDA) for patients with mild COVID-19 based on their safety and efficacy demonstrated through multicentre, randomized, controlled clinical trials...
May 2021: Phytomed Plus
#40
JOURNAL ARTICLE
Yoko Ino, Mayuko Nishi, Yutaro Yamaoka, Kei Miyakawa, Sundararaj Stanleyraj Jeremiah, Makoto Osada, Yayoi Kimura, Akihide Ryo
Phosphorylation of viral proteins serves as a regulatory mechanism during the intracellular life cycle of infected viruses. There is therefore a pressing need to develop a method to efficiently purify and enrich phosphopeptides derived from viral particles in biological samples. In this study, we utilized Phos-tag technology to analyze the functional phosphorylation of the nucleocapsid protein (N protein; NP) of severe respiratory syndrome coronavirus 2 (SARS-CoV-2). Viral particles were collected from culture supernatants of SARS-CoV-2-infected VeroE6/TMPRSS2 cells by ultracentrifugation, and phosphopeptides were purified by Phos-tag magnetic beads for LC-MS/MS analysis...
January 27, 2022: Journal of Proteomics
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