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Keywords Mechanism for stress related h...

Mechanism for stress related hair loss

https://read.qxmd.com/read/38539861/lercanidipine-s-antioxidative-effect-prevents-noise-induced-hearing-loss
#1
JOURNAL ARTICLE
Zhaoqi Guo, E Tian, Sen Chen, Jun Wang, Jingyu Chen, Weijia Kong, Debbie C Crans, Yisheng Lu, Sulin Zhang
Noise-induced hearing loss (NIHL) is a prevalent form of adult hearing impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties against such damage, the ability of third-generation dihydropryidines like lercanidipine to mitigate NIHL remains unclear.We utilized glucose oxidase (GO)-treated OC1 cell lines and cochlear explants to evaluate the protective influence of lercanidipine on hair cells...
March 7, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38397748/oxidative-stress-plays-an-important-role-in-glutamatergic-excitotoxicity-induced-cochlear-synaptopathy-implication-for-therapeutic-molecules-screening
#2
JOURNAL ARTICLE
Anissa Rym Saidia, Florence François, François Casas, Ilana Mechaly, Stéphanie Venteo, Joseph T Veechi, Jérôme Ruel, Jean-Luc Puel, Jing Wang
The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed early in several auditory pathologies (e.g., noise-induced or ototoxic drug-induced or age-related hearing loss). It has been suggested that glutamate excitotoxicity may be an inciting element in the degenerative cascade observed in these pathological cochlear conditions. Moreover, oxidative damage induced by free hydroxyl radicals and nitric oxide may dramatically enhance cochlear damage induced by glutamate excitotoxicity...
January 25, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38334784/the-human-opa1-delttag-mutation-induces-adult-onset-and-progressive-auditory-neuropathy-in-mice
#3
JOURNAL ARTICLE
Corentin Affortit, Carolanne Coyat, Anissa Rym Saidia, Jean-Charles Ceccato, Majida Charif, Emmanuelle Sarzi, Frédéric Flamant, Romain Guyot, Chantal Cazevieille, Jean-Luc Puel, Guy Lenaers, Jing Wang
Dominant optic atrophy (DOA) is one of the most prevalent forms of hereditary optic neuropathies and is mainly caused by heterozygous variants in OPA1, encoding a mitochondrial dynamin-related large GTPase. The clinical spectrum of DOA has been extended to a wide variety of syndromic presentations, called DOAplus, including deafness as the main secondary symptom associated to vision impairment. To date, the pathophysiological mechanisms underlying the deafness in DOA remain unknown. To gain insights into the process leading to hearing impairment, we have analyzed the Opa1delTTAG mouse model that recapitulates the DOAplus syndrome through complementary approaches combining morpho-physiology, biochemistry, and cellular and molecular biology...
February 9, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38219076/m1-polarization-of-macrophages-promotes-stress-induced-hair-loss-via-interleukin-18-and-interleukin-1%C3%AE
#4
JOURNAL ARTICLE
Xing Xiao, Ying Gao, Lingchen Yan, Cuncan Deng, Wang Wu, Xiaofang Lu, Qiumei Lu, Wenwei Zhong, Yunsheng Xu, Changhua Zhang, Wei Chen, Bihui Huang
Stress-induced hair loss is a prevalent health concern, with mechanisms that remain unclear, and effective treatment options are not yet available. In this study, we investigated whether stress-induced hair loss was related to an imbalanced immune microenvironment. Screening the skin-infiltrated immune cells in a stressed mouse model, we discovered a significant increase in macrophages upon stress induction. Clearance of macrophages rescues mice from stress-induced hair shedding and depletion of hair follicle stem cells (HFSCs) in the skin, demonstrating the role of macrophages in triggering hair loss in response to stress...
January 14, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38071436/neurotensin-counteracts-hair-growth-inhibition-induced-by-chronic-restraint-stress
#5
JOURNAL ARTICLE
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Stress has been considered as a potential trigger for hair loss through the neuroendocrine-hair follicle (HF) axis. Neurotensin (NTS), a neuropeptide, is known to be dysregulated in the inflammatory-associated skin diseases. However, the precise role of NTS in stress-induced hair loss is unclear. To investigate the function and potential mechanisms of NTS in stress-induced hair growth inhibition, we initially detected the expression of neurotensin receptor (Ntsr) and NTS in the skin tissues of stressed mice by RNA-sequencing and ELISA...
December 9, 2023: Experimental Dermatology
https://read.qxmd.com/read/37927722/stress-related-hair-loss-among-the-general-population-in-al-majma-ah-saudi-arabia-a-cross-sectional-study
#6
JOURNAL ARTICLE
Abdulaziz S Alanazi, Waleed A Alsalhi, Waleed K Alghuyaythat, Abdulrahman N Almutairi, Mohanned A Almazrou, Jehad A Alabdulminaim, Elsadig Y Mohamed
Background Hair loss is a prevalent concern affecting individuals worldwide, often attributed to various factors including genetics, hormonal changes, and stress. This study aims to investigate the prevalence of stress-related hair loss among the general population in Al Majma'ah, Saudi Arabia, and hair loss association with sociodemographic characteristics and risk factors. Methods A cross-sectional study was conducted involving 1080 participants. Data were collected through a structured questionnaire that encompassed sociodemographic factors, stress levels, psychosocial factors, and habits related to hair care and lifestyle...
October 2023: Curēus
https://read.qxmd.com/read/37901149/promotion-of-hair-regrowth-in-androgenetic-alopecia-with-supplemented-erzhi-wan-exploring-its-mechanism-using-network-pharmacology-and-molecular-docking
#7
JOURNAL ARTICLE
Chen Ji, Jun Ma, Chengcheng Feng, Hongliu Zhu, Yanwei Gao, Jun Huang, Hui Shen, Yuegang Wei
PURPOSE: Supplemented Erzhi Wan (SEZW) is a Traditional Chinese Medicine commonly used in the treatment of androgenetic alopecia (AGA). This study aims to verify the effectiveness of SEZW for the treatment of AGA in mice and explore the potential molecular mechanisms underlying its function using network pharmacology and molecular docking. METHODS: Forty mice were divided into five groups: Control, AGA-model, AGA-Positive, SEZW Low Dose, and SEZW High Dose. Hair regrowth in mice was evaluated by scoring hair on days 0, 14, and 28 post-treatment and weighing mouse hair on day 28 post-treatment...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/37579646/potential-roles-for-lncrna-mirg-foxp1-in-an-arhl-model-created-using-c57bl-6j-mice
#8
JOURNAL ARTICLE
Xiaoqin Luo, Yaqin Hu, Xiaoqing Zhou, Chanyuan Zhang, Menglong Feng, Ting Yang, Wei Yuan
Age-related hearing loss (ARHL) is associated with hair cell apoptosis, but the underlying mechanism of hair cell apoptosis remains unclear. Here, we investigated the expression profiles of long noncoding RNAs (lncRNAs) and mRNAs in an ARHL model created with C57BL/6 J mice using RNA sequencing and found that the expression of several lncRNAs was significantly correlated with apoptosis-associated mRNAs in the cochlear tissues of old mice compared to young mice. We found that lncRNA Mirg was upregulated in the cochlear tissues of old mice compared to young mice and its overexpression promoted apoptosis in House Ear Institute-Organ of Corti 1 (HEI-OC1)...
August 9, 2023: Hearing Research
https://read.qxmd.com/read/37503854/space-station-like-composite-nanoparticles-for-co-delivery-of-multiple-natural-compounds-from-chinese-medicine-and-hydrogen-in-combating-sensorineural-hearing-loss
#9
JOURNAL ARTICLE
Wenbin Xiao, Kerui He, Chong Yu, Zeming Zhou, Liye Xia, Shibao Xie, Hanqi Li, Ming Zhang, Zhifeng Zhang, Pei Luo, Lu Wen, Gang Chen
Ototoxic drugs such as aminoglycoside antibiotics and cisplatin (CDDP) can cause sensorineural hearing loss (SNHL), which is closely related to oxidative stress and the acidification of the inner ear microenvironment. Effective treatment of SNHL often requires multifaceted approach due to the complex pathology, and drug combination therapy is expected to be at the forefront of modern hearing loss treatment. Here, space-station-like composite nanoparticles (CCC@mPP NPs) with pH/oxidation dual responsiveness and multidrug simultaneous delivery capability were constructed and then loaded with various drugs including panax notoginseng saponins (PNS), tanshinone IIA (TSIIA), and ammonia borane (AB) to provide robust protection against SNHL...
July 28, 2023: Molecular Pharmaceutics
https://read.qxmd.com/read/37476961/ros-related-disruptions-to-cochlear-hair-cell-and-stria-vascularis-consequently-leading-to-radiation-induced-sensorineural-hearing-loss
#10
JOURNAL ARTICLE
Gao Yiming, Wu Fan, He Wuhui, Cai Ziyi, Pang Jiaqi, Zheng Yiqing
AIMS: Radiation-induced sensorineural hearing loss (RISNHL) is one of the major side effects of radiotherapy (RT) for head and neck cancers. Currently, no effective clinical treatment or prevention is available for RISNHL. This study thus aimed to investigate the cochlear pathology so that the underlying mechanisms of RISNHL may be elucidated, consequently paving the way for potential protective strategies to be developed. RESULTS: Functional and morphological impairment in the stria vascularis (SV) was observed after irradiation (IR), as indicated by endocochlear potential (EP) reduction, hyperpermeability and SV atrophy...
July 21, 2023: Antioxidants & Redox Signaling
https://read.qxmd.com/read/37229201/impact-of-brahman-genetics-on-skin-histology-characteristics-with-implications-for-heat-tolerance-in-cattle
#11
JOURNAL ARTICLE
Raluca G Mateescu, Kaitlyn M Sarlo Davila, Aakilah S Hernandez, Andrea Nunez Andrade, Gabriel A Zayas, Eduardo E Rodriguez, Serdal Dikmen, Pascal A Oltenacu
Cattle lose heat predominantly through cutaneous evaporation at the skin-hair coat interface when experiencing heat stress. Sweating ability, sweat gland properties, and hair coat properties are a few of the many variables determining the efficacy of evaporative cooling. Sweating is a significant heat dissipation mechanism responsible for 85% of body heat loss when temperatures rise above 86⁰F. The purpose of this study was to characterize skin morphological parameters in Angus, Brahman, and their crossbred cattle...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37167889/role-of-mitochondrial-dysfunction-and-oxidative-stress-in-sensorineural-hearing-loss
#12
REVIEW
Winston J T Tan, Lei Song
Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological mechanisms underlying SNHL remain unclear, an overwhelming body of evidence implicates mitochondrial dysfunction and oxidative stress playing a central etiological role. With its high metabolic demands, the cochlea, particularly the sensory hair cells, stria vascularis, and spiral ganglion neurons, is vulnerable to the damaging effects of mitochondrial reactive oxygen species (ROS)...
July 2023: Hearing Research
https://read.qxmd.com/read/37138925/stress-in-wildlife-comparison-of-the-stress-response-among-domestic-captive-and-free-ranging-animals
#13
REVIEW
Mina Cansu Karaer, Nina Čebulj-Kadunc, Tomaž Snoj
The stress response, which involves joint activity of the nervous and endocrine systems, is one of the basic adaptive mechanisms that ensures the survival of the individual. The activation of the sympathetic nervous system, the sympathetic-adrenal-medullary axis, and the hypothalamic-pituitary-adrenal axis enables organisms to respond to endogenous and exogenous challenges. Repeated short-term stress leads to long-term stress, which disrupts physiological homeostasis. Unlike domestic animals, wild animals are not protected from environmental and weather influences or treated for diseases...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37120472/hearing-and-ageing
#14
JOURNAL ARTICLE
Mariapia Guerrieri, Roberta Di Mauro, Stefano Di Girolamo, Arianna Di Stadio
Age-related hearing loss (ARHL), or presbycusis, occurs in most mammals, humans included, with a different age of onset and magnitude of loss. It is associated with two major symptoms: loss of sensitivity to sound, especially for high pitches, and a reduced ability to understand speech in background noise. This phenomenon involves both the peripheral structures of the inner ear and the central acoustic pathways. Several mechanisms have been identified as pro-ageing in the human cochlea. The main one is the oxidative stress...
2023: Sub-cellular Biochemistry
https://read.qxmd.com/read/37100013/piceatannol-protects-against-age-related-hearing-loss-by-inhibiting-cellular-pyroptosis-and-inflammation-through-regulated-caspase11-gsdmd-pathway
#15
JOURNAL ARTICLE
Xu Yang, Yanlin Wu, Menglian Zhang, Lingyu Zhang, Tianhao Zhao, Weiwei Qian, Mengmei Zhu, Xinya Wang, Qiannuo Zhang, Jiaqiang Sun, Liuyi Dong
Age-related hearing loss (ARHL) is a common issue associated with aging. One of the typical causes of hearing loss is the damage to inner ear hair cells. In addition, oxidative stress and inflammation contribute to ARHL. To avoid excessive inflammatory responses, non-classical scorch death pathway by cell membrane lipopolysaccharide (LPS) activates of caspase-11. Piceatannol (PCT) is also known for anti-tumor, antioxidant and anti-inflammatory effects; however, the protective effect of piceatannol (PCT) on ARHL is unclear...
April 24, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37063286/mitochondrial-redox-system-a-key-target-of-antioxidant-therapy-to-prevent-acquired-sensorineural-hearing-loss
#16
REVIEW
Jeong-In Baek, Ye-Ri Kim, Kyu-Yup Lee, Un-Kyung Kim
Noise (noise-induced hearing loss), and ototoxic drugs (drug-induced ototoxicity), and aging (age-related hearing loss) are the major environmental factors that lead to acquired sensorineural hearing loss. So far, there have been numerous efforts to develop protective or therapeutic agents for acquired hearing loss by investigating the pathological mechanisms of each types of hearing loss, especially in cochlear hair cells and auditory nerves. Although there is still a lack of information on the underlying mechanisms of redox homeostasis and molecular redox networks in hair cells, an imbalance in mitochondrial reactive oxygen species (ROS) levels that enhance oxidative stress has been suggested as a key pathological factor eventually causing acquired sensorineural hearing loss...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36959542/tmem30a-is-essential-for-hair-cell-polarity-maintenance-in-postnatal-mouse-cochlea
#17
JOURNAL ARTICLE
Yazhi Xing, Kun Peng, Qian Yi, Dongzhen Yu, Haibo Shi, Guang Yang, Shankai Yin
BACKGROUND: Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is critical to maintain cellular stability and homeostasis. Transmembrane protein 30A (TMEM30A) is the β-subunit of P4-ATPase. Loss of P4-ATPase function causes sensorineural hearing loss and visual dysfunction in human. However, the function of TMEM30A in the auditory system is unclear. METHODS: P4-ATPase subtype expression in the cochlea was detected by immunofluorescence staining and quantitative real-time polymerase chain reaction (qRT-PCR) at different developmental stages...
March 23, 2023: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/36731645/%C3%AE-aminobutyric-acid-promotes-the-inhibition-of-hair-growth-induced-by-chronic-restraint-stress
#18
JOURNAL ARTICLE
Xuewen Wang, Yixin Su, Zhenying Cai, Yaohan Xu, Xia Wu, Mus'ab Al Rudaisat, Chunting Hua, Siji Chen, Lihua Lai, Hao Cheng, Yinjing Song, Qiang Zhou
Stress plays a critical role in hair loss, although the underlying mechanisms are largely unknown. γ-aminobutyric acid (GABA) has been reported to be associated with stress; however, whether it affects stress-induced hair growth inhibition is unclear. This study aimed to investigate the potential roles and mechanisms of action of GABA in chronic restraint stress (CRS)-induced hair growth inhibition. We performed RNA-seq analysis and found that differentially expressed genes (DEGs) associated with neuroactive ligand-receptor interaction, including genes related to GABA receptors, significantly changed after mice were treated with CRS...
March 15, 2023: Life Sciences
https://read.qxmd.com/read/36525891/mitochondrial-form-and-function-in-hair-cells
#19
REVIEW
James D B O'Sullivan, Anwen Bullen, Zoë F Mann
Hair cells (HCs) are specialised sensory receptors residing in the neurosensory epithelia of inner ear sense organs. The precise morphological and physiological properties of HCs allow us to perceive sound and interact with the world around us. Mitochondria play a significant role in normal HC function and are also intricately involved in HC death. They generate ATP essential for sustaining the activity of ion pumps, Ca2+ transporters and the integrity of the stereociliary bundle during transduction as well as regulating cytosolic calcium homoeostasis during synaptic transmission...
November 25, 2022: Hearing Research
https://read.qxmd.com/read/36430990/the-molecular-mechanism-of-natural-products-activating-wnt-%C3%AE-catenin-signaling-pathway-for-improving-hair-loss
#20
REVIEW
Dong Wook Shin
Hair loss, or alopecia, is a dermatological disorder that causes psychological stress and poor quality of life. Drug-based therapeutics such as finasteride and minoxidil have been clinically used to treat hair loss, but they have limitations due to their several side effects in patients. To solve this problem, there has been meaningful progress in elucidating the molecular mechanisms of hair growth and finding novel targets to develop therapeutics to treat it. Among various signaling pathways, Wnt/β-catenin plays an essential role in hair follicle development, the hair cycle, and regeneration...
November 11, 2022: Life
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