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Hepatitis c screening

S Ashwin Kumar, P V Krishnam Raju, K V T Gopal, T Narayana Rao
Background: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. Materials and Methods: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls...
January 2019: Indian Dermatology Online Journal
K Leber, J M M B Otten, A C T M Depla, D P M Brandjes, F N Lauw
BACKGROUND: Patients with a chronic hepatitis B virus (HBV) infection or patients who have recovered from an HBV infection are at risk for HBV reactivation (HBVr), especially if they need treatment with chemotherapy. International guidelines recommend routine HBV screening for all patients starting with chemotherapy. This study evaluates the implementation of a routine HBV screening protocol. METHODS: A retrospective study was performed between January 2015 and October 2016 at the Medical Centre Slotervaart Amsterdam...
January 2019: Netherlands Journal of Medicine
Dominique Thabut, Christophe Bureau, Richard Layese, Valérie Bourcier, Maryam Hammouche, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Odile Goria, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle-Bladou, Thông Dao, Christophe Pilette, Christine Silvain, Christos Christidis, Dominique Capron, Brigitte Bernard-Chabert, Sophie Hillaire, Vincent Di Martino, Angela Sutton, Etienne Audureau, Françoise Roudot-Thoraval, Pierre Nahon, Pierre Nahon, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Hélène Fontaine, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Vincent Leroy, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Sebastien Dharancy, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Dominique Capron, Gérard Thiefin, Sophie Hillaire, Vincent Di Martino
BACKGROUND & AIMS: Management of patients with cirrhosis includes endoscopic screening and surveillance to detect esophageal varices (EV) and prevent bleeding. However, the Baveno VI guidelines recommend avoiding endoscopies for patients with liver stiffness measurements below 20 kPa and platelet counts above 150,000 (favorable Baveno VI status) and endoscopic assessment of patients with higher levels of liver stiffness and platelet counts (unfavorable Baveno VI status). We aimed to validate the Baveno VI guidelines, evaluating outcomes of patients in the ANRS-CO12 CirVir cohort with compensated cirrhosis associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, with or without a sustained response to antiviral therapy...
February 12, 2019: Gastroenterology
Tiffany C Edwards, Nagraj Mani, Bruce Dorsey, Ramesh Kakarla, Rene Rijnbrand, Michael J Sofia, John E Tavis
We recently developed a screening system capable of identifying and evaluating inhibitors of the Hepatitis B virus (HBV) ribonuclease H (RNaseH), which is the only HBV enzyme not targeted by current anti-HBV therapies. Inhibiting the HBV RNaseH blocks synthesis of the positive-polarity DNA strand, causing early termination of negative-polarity DNA synthesis and accumulation of RNA:DNA heteroduplexes. We previously reported inhibition of HBV replication by N-hydroxyisoquinolinediones (HID) and N-hydroxypyridinediones (HPD) in human hepatoma cells...
February 12, 2019: Antiviral Research
Rhondalyn C McLean, Peter P Reese, Michael Acker, Pavan Atluri, Christian Bermudez, Lee Goldberg, Peter L Abt, Emily A Blumberg, Vivianna M Van Deerlin, K Rajender Reddy, Roy D Bloom, Richard Hasz, Lawrence Suplee, Anna Sicilia, Ashley Woodards, Muhammad Nauman Zahid, Katharine J Bar, Paige Porrett, Matthew Levine, Nicole Hornsby, Caren Gentile, Jennifer Smith, David S Goldberg
The advent of direct-acting antiviral therapy for hepatitis C virus (HCV) has generated tremendous interest in transplanting organs from HCV-infected donors. We conducted a single-arm trial of orthotopic heart transplantation (OHT) from HCV-infected donors into uninfected recipients, followed by elbasvir/grazoprevir treatment after recipient HCV was first detected (NCT03146741; sponsor: Merck). We enrolled OHT candidates aged 40-65 years; LVAD support and liver disease were exclusions. We accepted hearts from HCV-genotype 1 donors...
February 15, 2019: American Journal of Transplantation
Angela Park, Rachel Gonzalez, Maggie Chartier, Shari Rogal, Vera Yakovchenko, David Ross, Timothy R Morgan
The national effort to redesign care using Lean management strategies, develop local and regional teams, and centralize support allowed VA to maximize available resources to achieve higher rates of testing and treatment of patients with hepatitis C virus than that of any other health care system in the US.
July 2018: Federal Practitioner: for the Health Care Professionals of the VA, DoD, and PHS
Afrodite Psaros Einberg, Anna-Theresia Ekman, Stefan Söderhäll, Charlotta Millbourn, Karin Lindahl, Arja Harila-Saari, Björn Fischler
BACKGROUND: Childhood cancer survivors treated before 1992, when blood donor screening for hepatitis C virus (HCV) infection was introduced, are at risk of transfusion-transmitted HCV infection. A national HCV screening campaign targeting blood transfusion recipients was launched in Sweden in 2007-2010. The aims of this study were to, among adult childhood cancer survivors in Stockholm County, investigate the prevalence of HCV infection, the natural course of infection, treatment outcome and anti-HCV testing frequency before, during and after the screening campaign and finally to actively screen the untested ones...
February 14, 2019: Acta Oncologica
Sathish Kumar, Rina Barouch-Bentov, Fei Xiao, Stanford Schor, Szuyuan Pu, Elise Biquand, Albert Lu, Brett D Lindenbach, Yves Jacob, Caroline Demeret, Shirit Einav
The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT-0 component) binding and envelopment. Nevertheless, the ubiquitin signaling that governs NS2 ubiquitination remained unknown. Here, we map the NS2 interactome with the ubiquitin proteasome system (UPS) via mammalian cell-based screens. NS2 interacts with E3 ligases, deubiquitinases, and ligase regulators, some of which are candidate proviral or antiviral factors...
February 12, 2019: Cell Reports
Tiffany Wu, Peter G Konyn, Austin W Cattaneo, Sammy Saab
Chronic hepatitis C viral (HCV) infection continues to carry a high burden of disease despite recent and emerging advancements in treatment. The persistently high prevalence of HCV is attributed to the rising opioid epidemic, with a history of injection drug use as the primary risk factor for infection. As a result, the epidemiology of HCV-infected individuals is changing. Previously a disease of "Baby Boomers," males, and non-Hispanic blacks, the new generation of patients with HCV includes younger adults from 20 to 39 years of age, both men and women similarly represented, and non-Hispanic whites...
February 13, 2019: Digestive Diseases and Sciences
Rui-Feng Yang, Yan Liu, Cai-Yan Zhao, Ya-Xing Ding, Yu Chen, Ya-Dong Wang, Zhong-Ping Duan
Recent advance in the direct-acting antivirals (DAAs) offers the potentials to eradicate hepatitis C virus (HCV) worldwide and makes universal screening more urgent. A point-of-care (POC) oral anti-HCV assay, the Fortune assay, was developed and its performance was evaluated. Individuals with or without HCV infection were recruited in three Centers. Paired oral and serum samples were tested using the Fortune and InTec anti-HCV assays. The Kehua serum anti-HCV assay served as a supplemental test to verify the discordant results...
2019: PloS One
Y K Wang, X C Chen, J B Wang, X Duan, S J Zhou, J Yang, T Yang, R H Ye, Y C Yang, S T Yao, S Duan, N He
Objective: To understand the characteristics on major strain subtypes of hepatitis C virus among HIV/HCV co-infected patients, so as to explore the molecular transmission clusters and related risk factors of HCV strains. Methods: A total of 336 newly reported HIV-infected patients were diagnosed as HIV/HCV co-infection in Dehong Dai and Jingpo autonomous prefecture (Dehong) in 2016. We used Nested PCR to amplify CE1 and NS5B genes among 318 samples with plasma levels above 200 μl, before using the combining phylogenetic tree and constructing molecular propagation network method to analyze the related data...
February 10, 2019: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Zhigang Zheng, Jinying Lin, ZhenZhen Lu, Jinming Su, Jianjun Li, Guangjie Tan, Chongxing Zhou, Wenkui Geng
To evaluate the mortality risk in the HIV-positive population, we conducted an observational cohort study involving routine data collection of HIV-positive patients who presented at HIV clinics and multiple treatment centers throughout Guangxi province, Southern China in 2011. The patients were screened for tuberculosis (TB) and tested for hepatitis B (HBV) and C (HCV) virus infections yearly. Following the registration, the cohort was followed up for a 60-month period till the end-point (December 31, 2015)...
2019: PloS One
Zhiguo Zhao, Dan Gao, Tie Ma, Liping Zhang
MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epidermal growth factor receptor (EGFR) were enhanced in tissues with low miR-141 expression but were reduced by miR-141 overexpression, and there was a significant negative correlation between EGFR and miR-141 levels in HNSCC tissues ( P < 0...
February 8, 2019: Aging
Tadayuki Kumagai, Hiroshi Terashima, Hajime Uchida, Akinari Fukuda, Mureo Kasahara, Motomichi Kosuga, Torayuki Okuyama, Tomoyuki Tsunoda, Ayano Inui, Tomoo Fujisawa, Aya Narita, Yoshikatsu Eto, Masaya Kubota
BACKGROUND: Niemann-Pick type C (NPC) is a lysosomal lipid storage disease with mutation of NPC1/NPC2 genes, which transport lipids in the endosome and lysosome, and various neurological symptoms. NPC patients also develop hepatosplenomegaly or liver disorder in the neonatal period, and 10% suffer severe liver failure. Neonatal hemochromatosis (NH) is a liver disorder characterized by hepatic and extrahepatic siderosis. Although the etiology of NH is unclear, recent reports suggest that the gestational alloimmune mechanism is the cause of NH...
February 5, 2019: Brain & Development
Natalie E Chichetto, Michael W Plankey, Alison G Abraham, David S Sheps, Nicole Ennis, Xinguang Chen, Kathleen M Weber, Steven Shoptaw, Robert C Kaplan, Wendy S Post, Robert L Cook
BACKGROUND: The relationship between alcohol consumption and atherosclerosis has not been sufficiently examined among people living with HIV (PLWH). METHODS: We analyzed data from PLWH in the Women's Interagency HIV Study (WIHS; n=1164) and the Multicenter AIDS Cohort Study (MACS; n=387) with no history of cardiovascular disease (CVD). Repeated measures of intima-media thickness of the right common carotid artery (CCA-IMT) were assessed using B-mode ultrasound from 2004-2013...
February 8, 2019: Alcoholism, Clinical and Experimental Research
Hidenori Kamio, Toshitaka Uchiyama, Hitoshi Kanno, Yoshiko Onoe, Kayoko Saito, Shingo Kameoka, Takako Kamio, Takahiro Okamoto
AIM: The aim of this study was to identify pharmacogenomic biomarkers to predict tegafur-uracil (UFT)-induced liver dysfunction. PATIENTS & METHODS:  A total of 68 patients, who were administered UFT, were evaluated using a two-step pharmacogenomics analysis. RESULTS: The first screening revealed the association between five SNPs and UFT-induced hepatic dysfunction. In the second step, SLCO1B1 (rs4149056) was found to be the only SNP associated with UFT treatment-related elevation of aspartate aminotransferase (odds ratio: C/C vs T/T = 7...
February 8, 2019: Pharmacogenomics
Mahmood Alawainati, Jawad Khamis, Muneer Abdulla, Saeed Alsaeed
Background: There are multiple aetiologies for dyspnea in patients with liver disease, including pneumonia, pulmonary embolism, hepatic hydrothorax, portopulmonary syndrome, and hepatopulmonary syndrome. The aim of this paper is to emphasize the importance of early diagnosis and management of hepatopulmonary syndrome. Case Presentation: We report a case of a 65-year-old male who was known to have chronic hepatitis C presented with one-year history of shortness of breath and cyanosis...
2019: Case Reports in Hepatology
John S Lambert, Ross Murtagh, Dee Menezes, Austin O'Carroll, Carol Murphy, Walter Cullen, Tina McHugh, Gordana Avramovic, Willard Tinago, Marie Claire Van Hout
BACKGROUND: Hepatitis C virus (HCV) is one of the main causes of chronic liver disease worldwide. Prevalence of HCV in homeless populations ranges from 3.9 to 36.2%. The HepCheck study sought to investigate and establish the characterisation of HCV burden among individuals who attended an intensified screening programme for HCV in homeless services in Dublin, Ireland. METHODS: The HepCheck study was conducted as part of a larger European wide initiative called HepCare Europe...
February 7, 2019: BMC Infectious Diseases
Jessica L Childs-Disney, Tuan Tran, Balayeshwanth R Vummidi, Sai Pradeep Velagapudi, Hafeez S Haniff, Yasumasa Matsumoto, Gogce Crynen, Mark R Southern, Avik Biswas, Zi-Fu Wang, Timothy L Tellinghuisen, Matthew D Disney
Many RNAs cause disease; however, RNA is rarely exploited as a small-molecule drug target. Our programmatic focus is to define privileged RNA motif small-molecule interactions to enable the rational design of compounds that modulate RNA biology starting from only sequence. We completed a massive, library-versus-library screen that probed over 50 million binding events between RNA motifs and small molecules. The resulting data provide a rich encyclopedia of small-molecule RNA recognition patterns, defining chemotypes and RNA motifs that confer selective, avid binding...
October 11, 2018: Chem
François Girardin, Natalie Hearmon, Erika Castro, Francesco Negro, Lucy Eddowes, Laurent Gétaz, Hans Wolff
Background: Hepatitis C virus (HCV) amongst people living in detention (PLD) is typically high in many countries including Switzerland, where it is estimated that the HCV prevalence rate is between 5.7% and 6.2%. In Switzerland, the existing screening strategy involves routine screening of PLD who indicate they are from HCV high-risk populations based on questionnaire responses upon entry to the detention center, rather than an offer to screen all PLD. Methods: A cost-effectiveness analysis from a Swiss healthcare provider perspective was conducted by combining a five-year decision tree screening model with results from a Markov model of HCV treatment outcomes...
February 2, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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