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Osteopenia treatments

Mads Hvid Poulsen, Morten Frost, Bo Abrahamsen, Oke Gerke, Steen Walter, Lars Lund
OBJECTIVE: To analyze the prevalence of osteoporosis during androgen deprivation therapy (A.D.T.). BACKGROUND: Treatment and prognosis of prostate cancer necessitate management of long-term consequences of A.D.T., including accelerated bone loss resulting in osteoporosis; osteoporotic fractures are associated with excess morbidity and mortality. PATIENTS AND METHODS: Patients with prostate cancer awaiting initiation of A.D.T. were consecutively included from the daily clinic...
February 19, 2019: Scandinavian Journal of Urology
Mike T Wei, An K Le, Matthew S Chang, Holden Hsu, Pauline Nguyen, Jian Q Zhang, Chris Wong, Clifford Wong, Ramsey Cheung, Mindie H Nguyen
BACKGROUND: Recent studies have suggested a potential increase in the incidence of osteoporosis for patients receiving tenofovir disoproxil fumarate (TDF), but this issue remains controversial. METHODS: Retrospective cohort study of 1,224 Asian chronic hepatitis B (CHB) patients >18 years without baseline osteopenia/osteoporosis seen at four U.S. centers from 2008-2016. Patients were categorized into three groups-treatment naive patients who initiated therapy with TDF (1) or entecavir (ETV) (2), or untreated patients (3)...
February 18, 2019: Journal of Medical Virology
Daranporn Triwongwaranat, Rattapon Thuangtong, Sittiroj Arunkajohnsak
Hair pigmentation is regulated by follicular melanogenesis, in which the process consists of melanin formation and transfer to keratinocytes in the hair shaft. Human hair follicles contain two types of melanin: the brown-black eumelanin and yellow-red pheomelanin. Eumelanin is commonly present in black and brown hair while pheomelanin is found in auburn and blonde hair. Hair follicle melanogenesis is under cyclical control and is concurrently coupled to hair growth. Many factors including intrinsic and extrinsic factors affect the follicular melanogenesis...
February 15, 2019: International Journal of Dermatology
Irene E G van Hellemond, Carolien H Smorenburg, Petronella G M Peer, Astrid C P Swinkels, Caroline M Seynaeve, Maurice J C van der Sangen, Judith R Kroep, Hiltje De Graaf, Aafke H Honkoop, Frans L G Erdkamp, Franchette W P J van den Berkmortel, Maaike de Boer, Wilfred K de Roos, Sabine C Linn, Alexander L T Imholz, Vivianne C G Tjan-Heijnen
The phase III DATA study investigates the efficacy of adjuvant anastrozole (6 versus 3 year) in postmenopausal women with breast cancer previously treated with 2-3 years of tamoxifen. This planned side-study assessed patterns of care regarding detection and treatment of osteopenia/osteoporosis, and trends in bone mineral density (BMD) during and after therapy. We registered all BMD measurements and bisphosphonate-use. Time to osteopenia/osteoporosis was analysed by Kaplan Meier methodology. For the trend in T-scores we used linear mixed models with random patients effects...
February 12, 2019: International Journal of Cancer. Journal International du Cancer
Marion Geoffroy, Isabelle Charlot-Lambrecht, Jan Chrusciel, Isabelle Gaubil-Kaladjian, Ana Diaz-Cives, Jean-Paul Eschard, Jean-Hugues Salmon
INTRODUCTION: Bariatric surgery is used to treat severe obesity. We aimed to investigate the incidence of clinically significant bone mineral density (BMD) loss at 6 and 12 months after bariatric surgery. METHODS: Observational study performed in a specialized center for the treatment of obesity at the University Hospital of Reims, France. Surface BMD was measured by dual x-ray absorptiometry (DEXA). A reduction of > 0.03 g/cm2 was considered clinically significant...
February 7, 2019: Obesity Surgery
Kanthi Shankar, Sakthibalan M, Priyanka Raizada, Rashmi Jain
Introduction: Many factors influence bone health, but osteoporosis is viewed as a calcium deficiency disorder in which bone is resorbed to maintain the serum calcium levels. Dietary calcium supplements have been recommended for the prevention of osteoporosis in the elderly. Many forms of dietary calcium supplements are widely available in market, but products containing calcium citrate and calcium carbonate are the most common. Calcium lysinate, a new form of calcium preparation, may have a better absorption and can be a better calcium supplement...
July 2018: Journal of Orthopaedic Case Reports
Behzad Javaheri, Eleanor Herbert, Mark Hopkinson, Ahmed Al-Jazzar, Andrew A Pitsillides
Glucocorticoid-induced secondary osteoporosis is the most predictable side-effect of this anti-inflammatory. One of the main mechanisms by which glucocorticoids achieve such deleterious outcome in bone is by antagonizing Wnt/β-catenin signalling. Sclerostin, encoded by Sost gene, is the main negative regulator of the pro-formative and anti-resorptive role of the Wnt signaling pathway in the skeleton. We hypothesized that the partial inactivation of sclerostin function by genetic manipulation will rescue the osteopenia induced by high endogenous glucocorticoid levels...
January 18, 2019: American Journal of Pathology
Yili Zhang, Yan Chai, Xiaojie Pan, Hao Shen, Xu Wei, Yanming Xie
Purpose: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis. Methods: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Meta-analyses and trial sequential analyses (TSA) were conducted using RevMan 5.3 and TSA 0.9. Results: Fifteen randomized controlled trials involving a total of 857 patients were included in the analyses...
2019: Clinical Interventions in Aging
P Kumar, N K Singh, A Gargeshwari, R S, R Jha
Alteration in the process of bone remodelling results in conditions like osteopenia and osteoporosis in which the bones become susceptible to fracture. The functioning of middle ear bones in such individuals were assessed in this study and it was found that the middle ear bones are equally susceptible to micro-fractures and can cause reduction in the transmission of sound energy. INTRODUCTION: Alteration in the process of bone remodelling or increase in the number of osteoclasts cells as it occurs in osteoporosis and osteopenia are likely to affect the middle ear bones in the same way it affects the skeletal bones...
January 16, 2019: Osteoporosis International
Francisco Miguel Conesa, Patricia Llamas-Granda, Ane Larrañaga-Vera, Tuere Wilder, Raquel Largo, Gabriel Herrero-Beaumont, Bruce Cronstein, Aránzazu Mediero
Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, a common antiviral in HIV treatment, also leads to increases in bone catabolism markers and decreased bone mineral density (BMD) in children and young adults. In murine models and human cell lines, tenofovir inhibits ATP release and decreases extracellular adenosine levels. Adenosine, and adenosine A2A receptor, inhibits osteoclast formation, and increasing local adenosine concentration with dipyridamole, an agent that blocks adenosine cellular uptaken, stimulates new bone formation as well as rhBMP-2...
January 15, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Gemma Tatangelo, Jennifer Watts, Karen Lim, Catherine Connaughton, Julie Abimanyi-Ochom, Fredrik Borgström, Geoff C Nicholson, Catherine Shore-Lorenti, Amanda L Stuart, Sandra Iuliano-Burns, Ego Seeman, Richard Prince, Lyn March, Marita Cross, Tania Winzenberg, Laura L Laslett, Gustavo Duque, Peter R Ebeling, Kerrie M Sanders
Osteoporosis and osteopenia are increasingly prevalent conditions among older adults. Not only do the fractures associated with poor bone health have significant health consequences for the individual, but also their economic impact is placing increasing financial burden on governments and society. This study aimed to determine the direct economic cost of osteoporosis, osteopenia, and fractures among Australians aged 50 years and older in 2017. This study uses previous Australian data on the incidence and prevalence of osteoporosis and osteopenia together with recent Australian data on health service utilization after fracture to provide an estimate of the economic burden of osteoporosis...
January 7, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
K Anjaneyulu, Kumar Mr Bhat, S R Srinivasa, R A Devkar, T Henry
Background: The current strategies to prevent and treat menopausal osteoporosis are hormone replacement therapy (HRT). However, the long-term use of hormone replacement therapy is limited due to its side-effects. Alternately, use of phytoestrogens has been implicated. Trigonella foenum graecum (TFG) seeds are rich in phytoestrogen and known traditional medicine to treat menopause induced hyperlipidemia. Therefore, in this study, we evaluated the role of dietary TFG seed extract on bone structure and mechanical properties in ovariectomized rats...
November 2018: Ethiopian Journal of Health Sciences
V Frighi, A Morovat, T M Andrews, F Rana, M T Stephenson, S J White, E Fower, J Roast, G M Goodwin
BACKGROUND: People with intellectual disabilities (IDs) have very high rates of osteoporosis and fractures, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in people with IDs previously treated for vitamin D deficiency (1) long-term adherence to vitamin D supplementation and (2) bone mineral density (BMD), as an indicator for risk of fractures, according to vitamin D supplementation and other factors. METHOD: We recorded height, weight, medical, pharmacological, dietary and lifestyle assessment...
December 19, 2018: Journal of Intellectual Disability Research: JIDR
Kari Wagner, Scott Wagner, Apryl Susi, Gregory Gorman, Elizabeth Hisle-Gorman
OBJECTIVE: To evaluate the impact of prematurity on fracture by age 5, controlling for medications and comorbidities of prematurity. STUDY DESIGN: We performed a retrospective cohort study of infants born in Military Treatment Facilities in 2009-2010 with ≥5 years of follow-up care. Gestational age, low birth weight, comorbidities of prematurity (osteopenia, necrotizing enterocolitis, chronic lung disease, and cholestasis) and fractures were identified by International Classification of Disease, 9th Edition, codes...
December 7, 2018: Journal of Pediatrics
Carlos J Padilla Colón, Irma L Molina-Vicenty, María Frontera-Rodríguez, Alejandra García-Ferré, Bernabejoel Ponce Rivera, Gerardo Cintrón-Vélez, Sebastián Frontera-Rodríguez
Aging is the result of different functional changes leading to a substantial reduction of all human capabilities. A variety of anatomical and physiological changes occur with advancing age. These changes are more evident in the elderly population. There are various methods to measure muscle and bone mass loss, but the dual X-ray absorptiometry (DXA) is considered one of the most efficient. The elderly population (65 years and older) has been increasing throughout the years. Loss of muscle mass (sarcopenia) and loss bone mass (osteopenia or osteoporosis) with advancing age, when untreated, represent a major public health problem for the elderly population and may result in loss of independence in later life...
2018: Journal of Biomedicine
Fernando Mendoza-Moreno, Manuel Díez-Alonso, Enrique Ovejero-Merino, Ana Sánchez-Gollarte, Ricardo Alvarado-Hurtado, Belén Matías-García, Ángel Rodríguez-Pascual, Carlos Medina-Reinoso, Tomás Ratia-Jiménez, Francisco Hernández-Merlo, Javier Granell-Vicent
AIM: To analyze the effect of the surgery in bone mineral density (BMD) and to study the value of preoperative clinical and analytical factors as predictors of bone increase. MATERIAL AND METHODS: Prospective observational study. Postmenopausal women who were operated for primary hyperparathyroidism were included. A bone densitometry of the lumbar spine and femoral neck and analytical determinations (parathyroid hormone [PTH], alkaline phosphatase, albumin, phosphate, creatinine, 25-hydroxy-vitamin D3, creatinine clearance, and calciuria) were performed previous to the intervention and after 12 months from surgery...
November 9, 2018: Journal of Clinical Densitometry
Judith F Baumhauer, Timothy Daniels, Mark Glazebrook
Synthetic cartilage implant surgery is an excellent option for the patient with great toe arthritis and good alignment of the toe who wishes to retain first metatarsophalangeal motion and obtain 90% improved pain relief and function. Patients with osteoporosis, osteopenia, or bone defects from surgery or disease may not maintain the implant position due to poor bone quality, resulting in less than desired outcomes. Despite this being a straightforward surgery, patients need to be aware that the pain relief may not begin until 3+ months after surgery because this procedure does require bone resection and implant placement...
January 2019: Orthopedic Clinics of North America
Katarzyna J Jerzak, Jacques Raphael, Danielle N Desautels, Phillip S Blanchette, Ivan Tyono, Kathleen I Pritchard
Aromatase inhibitors (AIs) play an important role in the adjuvant treatment of hormone receptor-positive breast cancer, but they are associated with bone loss and increased fracture risk. Although several guidelines for the management of osteoporosis and osteopenia exist, their algorithms do not account for the use of AIs. In this article, we describe the role of bone-targeted therapies, specifically for managing early breast cancer, by reviewing their bone-specific and cancer-specific benefits.
November 15, 2018: Oncology (Williston Park, NY)
(no author information available yet)
[This corrects the article on p. 593 in vol. 6, PMID: 21206758.].
2018: Therapeutics and Clinical Risk Management
Nan Li, Yan Jiang, Shuli He, Zhen Zhao, Jing Sun, Mei Li, Ou Wang, Xiaoping Xing, Weibo Xia
This study aimed to explore the therapeutic efficacy and safety of alfacalcidol among Chinese postmenopausal women (age >65 years) with osteoporosis or osteopenia.A total of 62 postmenopausal women with osteoporosis or osteopenia (>65 years) were recruited from urban residential community of Beijing. The patients daily took oral calcium and alfacalcidol (Alpha D3, 1 μg) for 9 months. Safety and efficacy assessments were performed at baseline and regular intervals. Alfacalcidol was adjusted to a daily dose of 0...
November 2018: Medicine (Baltimore)
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