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Vitamin C And Pain

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https://read.qxmd.com/read/30777056/a-genetic-variant-of-cyp2r1-identified-in-a-cat-with-type-1b-vitamin-d-dependent-rickets-a-case-report
#1
Takahiro Teshima, Sena Kurita, Takashi Sasaki, Hirotaka Matsumoto, Ayaka Niina, Daijiro Abe, Nobuo Kanno, Hidekazu Koyama
BACKGROUND: Vitamin D-dependent rickets is rare in animals and humans. Several types of this condition are associated with genetic variants related to vitamin D metabolism. This is the first report of type 1B vitamin D-dependent rickets in a cat. CASE PRESENTATION: Here, we describe the case of a 3-month-old female domestic short-haired cat previously fed on commercial kitten food that presented at our clinic with seizures, lethargy, and generalized pain. Serum and ionized calcium concentrations and 1,25-dihydroxycholecalciferol in this cat were low, and radiographs showed skeletal demineralization and abnormally wide growth plates on the long bones...
February 18, 2019: BMC Veterinary Research
https://read.qxmd.com/read/30755720/towards-precision-medicine-for-pain-diagnostic-biomarkers-and-repurposed-drugs
#2
A B Niculescu, H Le-Niculescu, D F Levey, K Roseberry, K C Soe, J Rogers, F Khan, T Jones, S Judd, M A McCormick, A R Wessel, A Williams, S M Kurian, F A White
We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of pain. For discovery, we used a powerful within-subject longitudinal design. We were successful in identifying blood gene expression biomarkers that were predictive of pain state, and of future emergency department (ED) visits for pain, more so when personalized by gender and diagnosis...
February 12, 2019: Molecular Psychiatry
https://read.qxmd.com/read/30746054/denosumab-related-osteonecrosis-of-jaw-a-case-report
#3
Marco Vinícius de Sales Lima, Jaqueline Rizzato, Daniella Varzea Gracindo Marques, Dárcio Kitakawa, Felipe da Silva Peralta, Alexandre Prado Scherma, Luis Felipe C S Carvalho
Background: This case report shows an affected postmenopausal patient with medicaments related osteonecrosis of the jaw injury associated with increased use of bisphosphonates and Prolia® (denosumab) for the treatment of osteoporosis. The mechanism of action of the receptor activates the denosumab of the nuclear-kB factor binding and makes nuclear-kB Factor, reducing bone volume and reabsorption in the trabecular and cortical bones and, consequently, decreasing an incidence of fractures and maintaining a bone formation...
October 2018: Journal of Oral & Maxillofacial Research
https://read.qxmd.com/read/30684966/association-of-25-hydroxyvitamin-d-with-hdl-cholesterol-and-other-cardiovascular-risk-biomarkers-in-subjects-with-non-cardiac-chest-pain
#4
Mohammad J Alkhatatbeh, Noor A Amara, Khalid K Abdul-Razzak
BACKGROUND: Chest pain is a serious symptom that is routinely investigated as a sign of coronary artery disease. Non-cardiac chest pain (NCCP) is indistinguishable from ischemic chest pain and both are considered serious and receive similar medical investigations. Although NCCP is not associated with cardiovascular diseases (CVDs), patients with NCCP may become anxious and frightened from developing coronary events. So, it will be valuable to improve modifiable cardiovascular risk factors in such subjects to reduce fear from CVDs...
January 26, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/30677009/scurvy-outbreak-among-south-sudanese-adolescents-and-young-men-kakuma-refugee-camp-kenya-2017-2018
#5
Mija Ververs, Jesse Wambugu Muriithi, Ann Burton, John Wagacha Burton, Allison Oman Lawi
Scurvy is a relatively rare micronutrient deficiency disease that can occur among refugees dependent on food aid (1). Inadequate access to fresh fruits and vegetables in refugee camps can result in scurvy (2,3). Kakuma Refugee Camp in Kenya's Turkana District is home to 148,000 refugees, mostly from Somalia and South Sudan, who receive food assistance. In August 2017, a number of South Sudanese adolescent and young adult male refugees were evaluated at a health clinic in the camp for calf pain, chest pain, and gingival swelling...
January 25, 2019: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/30670251/pediatric-perioperative-measures-of-sleep-pain-anxiety-and-anesthesia-emergence-a-healing-touch-proof-of-concept-randomized-clinical-trial
#6
Laura E James, Michele M Gottschlich, Judith K Nelson, Lois C Cone, John E McCall
BACKGROUND AND PURPOSE: The purpose of this study was to determine the impact of healing touch (HT) on sleep, anxiety, anesthesia emergence and pain. METHODS: HT, sham HT, control with an aide (CP) and control groups without the presence of an aide (CNP), underwent polysomnography (PSG) preoperatively. The Yale Preoperative Anxiety Scale (YPAS) score was obtained preoperatively before medications were given and in the preoperative surgery area. Sedation score, anesthesia emergence score and vital signs were recorded...
February 2019: Complementary Therapies in Medicine
https://read.qxmd.com/read/30617082/leading-a-meaningful-life-at-older-ages-and-its-relationship-with-social-engagement-prosperity-health-biology-and-time-use
#7
Andrew Steptoe, Daisy Fancourt
The sense that one is living a worthwhile and meaningful life is fundamental to human flourishing and subjective well-being. Here, we investigate the wider implications of feeling that the things one does in life are worthwhile with a sample of 7,304 men and women aged 50 and older (mean 67.2 y). We show that independently of age, sex, educational attainment, and socioeconomic status, higher worthwhile ratings are associated with stronger personal relationships (marriage/partnership, contact with friends), broader social engagement (involvement in civic society, cultural activity, volunteering), less loneliness, greater prosperity (wealth, income), better mental and physical health (self-rated health, depressive symptoms, chronic disease), less chronic pain, less disability, greater upper body strength, faster walking, less obesity and central adiposity, more favorable biomarker profiles (C-reactive protein, plasma fibrinogen, white blood cell count, vitamin D, high-density lipoprotein cholesterol), healthier lifestyles (physical activity, fruit and vegetable consumption, sleep quality, not smoking), more time spent in social activities and exercising, and less time spent alone or watching television...
January 22, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30588988/periarticular-calcification-mimicking-inflammatory-polyarthritis-in-chronic-kidney-disease
#8
Kumari Naidoo, Kwazi C Z Ndlovu, Girish M Mody
Periarticular calcification is a frequent radiographic manifestation in chronic kidney disease (CKD). However, clinical presentation as inflammatory periarthritis, tenosynovitis, and bursitis is unusual. A 34-year-old man with CKD on dialysis for three years presented with painful swollen joints. His adherence to regular dialysis, phosphate binders, Vitamin D supplements, and antihypertension therapy was poor. He had swelling of the right thumb, index, and little fingers; periarticular swelling of the left middle finger and right little toe; and extensor tenosynovitis of the wrists and right olecranon bursitis...
November 2018: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/30585516/protocatechuic-acid-protects-against-menadione-induced-liver-damage-by-up-regulating-nuclear-erythroid-related-factor-2
#9
O B Ibitoye, T O Ajiboye
Menadione (Vitamin K3 ) is an over-the-counter (OTC) drug used in the treatment of abdominal cramps, colitis, diarrhea, hay fever, hemorrahage, hypoprothrombinemia, and joint pains. In this study, we evaluated the protective influence of protocatechuic acid on menadione-induced hepatotoxicity in rats. Rats were randomized into five groups (A-E) of five rats each. Control rats orally received 1% dimethyl sulfoxide (DMSO) in distilled water (the vehicle for protocatechuic administration) for 7 days. In addition, control rats intraperioneally received olive oil (vehicle for menadione administration) on the 7th day...
December 26, 2018: Drug and Chemical Toxicology
https://read.qxmd.com/read/30582663/enhancing-carotenoid-biosynthesis-in-rice-endosperm-by-metabolic-engineering
#10
Yong-Sheng Tian, Bo Wang, Ri-He Peng, Jing Xu, Tong Li, Xiao-Yan Fu, Ai-Sheng Xiong, Jian-Jie Gao, Quan-Hong Yao
Most cereal grains contain small amounts of dietary carotenoids. Thus, vitamin A deficiency (VAD) is common in third-world countries where the nutrition (of the population) depends on a single staple crop such as rice. Thus, considerable research effort has been dedicated to achieving sustainable and economical production of carotenoids in crops (Paine et al., 2012). Plant carotenoids are isoprenoid-derived molecules, and isoprenoids are produced via the mevalonate (MVA) or plastidial 2-C-methyl-D-erythritol 4-phosphate (MEP) routes, both giving rise to isopentenyl diphosphate (IPP) (Hemmerlin et al...
December 24, 2018: Plant Biotechnology Journal
https://read.qxmd.com/read/30581189/vitamin-d-deficiency-harms-patients-with-coronary-heart-disease-by-enhancing-inflammation
#11
Yongxing Liu, Wanzhong Peng, Ya Li, Bingxun Wang, Jiancai Yu, Zesheng Xu
BACKGROUND Vitamin D (VD) deficiency and local inflammation of plaque are potential new risk factors and prevention goals for coronary heart disease (CHD). MATERIAL AND METHODS This study included 135 CHD patients and 45 chest tightness or chest pain patients (control group). Basic clinical data and serum 25-OH-VD, TNF-α, IL-6, IL-8, and IL-1β of the 2 groups were compared by SPSS 25.0. A CHD rat model was used to explore the potential molecular mechanisms. RESULTS The serum 25-OH-VD level in the control group was significantly higher compared to the CHD group, and decreased with the worsening of the CHD condition...
December 24, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30569495/small-fiber-neuropathy-expanding-the-clinical-pain-universe
#12
REVIEW
Maurice Sopacua, Janneke G J Hoeijmakers, Ingemar S J Merkies, Giuseppe Lauria, Stephen G Waxman, Catharina G Faber
Small-fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to a significant reduction in quality of life. According to international criteria, the diagnosis is established by the assessment of intraepidermal nerve fiber density and/or quantitative sensory testing. SFN is mainly associated with autoimmune diseases, sodium channel gene variants, diabetes mellitus, and vitamin B12 deficiencies, although in more than one half of patients no etiology can be identified...
December 19, 2018: Journal of the Peripheral Nervous System: JPNS
https://read.qxmd.com/read/30559614/clinical-observations-plasma-retinol-concentrations-and-in-vitro-lymphocyte-functions-in-children-with-sickle-cell-disease
#13
Solo R Kuvibidila, Renée Gardner, Maria Velez, Raj Warrier
Background: Children with sickle cell disease (SCD) often have infections, growth deficits, and impaired immunity, problems that also are observed in individuals with a vitamin A deficiency (plasma retinol concentration <20 μg/dL). The goal of this study was to investigate the association between vitamin A, health status, and the in vitro immune function of children with SCD. Methods: Fifty-nine children (40 SS, 11 SC, and 8 Sβthalassemia [Sβthal ] hemoglobin genotypes) 9 months to 18 years old were investigated for plasma levels of retinol, retinol binding protein, C-reactive protein, alpha-1-acid glycoprotein, lymphocyte proliferation, and interleukin (IL)-2 activity in supernatant of phytohemagglutinin-treated lymphocytes...
2018: Ochsner Journal
https://read.qxmd.com/read/30465254/neurological-and-electroneurography-findings-in-patients-with-systemic-sclerosis-and-symptoms-of-neuropathic-pain-in-extremities
#14
Predrag Ostojic, Sladjana Knezevic-Apostolski, Nada Djurovic, Biljana Stojic, Katarina Jankovic, Daniela Bartolovic
OBJECTIVE: To analyze neurological and electroneurography (ENG) findings in patients with systemic sclerosis (SSc) and symptoms of neuropathic pain in upper and lower extremities. PATIENTS AND METHODS: Using the PainDetect questionnaire, 42 consecutive patients with SSc (38 women and 4 men) were screened for the presence of neuropathic pain in upper and/or lower extremities. Patients with previously diagnosed diabetes or other metabolic diseases, malignancy, other autoimmune disorders, or any neurological or psychiatric disease, were not included...
November 21, 2018: Acta Neurologica Belgica
https://read.qxmd.com/read/30433798/nociceptive-behavior-induced-by-chemotherapeutic-paclitaxel-and-beneficial-role-of-antioxidative-pathways
#15
H Miao, J Xu, D Xu, X Ma, X Zhao, L Liu
Paclitaxel is used for the treatment of several types of cancers. However, one of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy. In this study we examined the engagement of antioxidative signal pathway of the dorsal root ganglion (DRG) in mechanical and thermal hypersensitivity evoked by paclitaxel. Behavioral test was performed to determine mechanical and thermal sensitivity in rats. Western Blot analysis and ELISA were used to examine expression of Nrf2-antioxidant response element (ARE) and superoxide dismutases (SOD); and the levels of products of oxidative stress in the DRG...
October 23, 2018: Physiological Research
https://read.qxmd.com/read/30410835/rare-fungal-infection-linked-to-a-case-of-juvenile-arthritis
#16
Karin Ried, Peter Fakler
Juvenile arthritis with unknown disease etiology is also known as juvenile idiopathic arthritis. Symptoms include joint pain, swelling, and stiffness, and standard treatment involves immunosuppressant medication. Here we present a case of juvenile idiopathic arthritis with severe malnutrition and worsening of symptoms, which restrained a nine-year-old girl to a wheelchair with minimal movement capacity and low energy during standard immunosuppressant therapies over the course of three years. Our innovative Pathogen Blood Test combining cytology-based microscopy and genetic analysis using a pan-fungal primer assay and sequencing identified a systemic fungal infection with Sagenomella species, closely related to Aspergillus , and a soil-dwelling highly pathogenic fungus, which had previously been linked to a fatal veterinary case of arthritis and malnutrition...
August 29, 2018: Curēus
https://read.qxmd.com/read/30374635/scurvy-an-unusual-complication-of-paediatric-cancer-treatment
#17
Iain Irvine, Triona Walshe, Michael Capra, Roisin Hayes
Scurvy is a disease that is rarely encountered in modern medicine. A condition that was classically associated with sailors, its incidence has decreased dramatically since the discovery of its association with vitamin C deficiency. We present the case of a 2-year-old boy, whose treatment for neuroblastoma was complicated by gastrointestinal disease, which necessitated enteral feeding. While still undergoing treatment, he started to complain about increasing pain in his lower limbs, which appeared to be markedly tender on palpation...
October 29, 2018: Skeletal Radiology
https://read.qxmd.com/read/30373022/industrial-use-of-pepper-capsicum-annum-l-derived-products-technological-benefits-and-biological-advantages
#18
REVIEW
N Baenas, M Belović, N Ilic, D A Moreno, C García-Viguera
The recovery of pepper phytochemicals present an interesting strategy in pursuit of new bioactive compounds and natural ingredients for agro-food, cosmetic and pharma industry uses, as replacements for the synthetic compounds and also in the valorisation of plant's by-products. Besides being used as a condiment, providing characteristic pungency, colour and flavour, the new pepper-derived ingredients could be used for the preservation and extension of industrial products' lifespan, as well as additives or technological ingredients with antioxidant and antimicrobial activities...
February 15, 2019: Food Chemistry
https://read.qxmd.com/read/30321947/role-of-anti-oxidant-vitamin-c-in-post-operative-pain-relief-in-foot-and-ankle-trauma-surgery-a-prospective-randomized-trial
#19
Sumit Kumar Jain, Mohammad Yahya Dar, Sanjeev Kumar, Arun Yadav, Stephen R Kearns
BACKGROUND: Post-operative pain may adversely affect a patient's quality of life. Studies have shown that vitamin C, being an anti-oxidant and neuro-modulating agent, can help to reduce pain in a variety of clinical settings. The objective of this randomized controlled trial was to assess the effectiveness of vitamin C in reducing post-operative pain, analgesia requirements and improving functional outcome. METHODS: Patients with isolated foot and ankle trauma, who had undergone surgery, were randomly assigned to receive either vitamin C 500mg or a placebo tablet twice a day...
May 24, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://read.qxmd.com/read/30319419/metabolomics-driven-elucidation-of-cellular-nitrate-tolerance-reveals-ascorbic-acid-prevents-nitroglycerin-induced-inactivation-of-xanthine-oxidase
#20
Elizabeth Rose Axton, Eleonso Cristobal, Jaewoo Choi, Cristobal L Miranda, Jan Frederik Stevens
Glyceryl trinitrate (GTN) has found widespread use for the treatment of angina pectoris, a pathological condition manifested by chest pain resulting from insufficient blood supply to the heart. Metabolic conversion of GTN, a nitric oxide (NO) pro-drug, into NO induces vasodilation and improves blood flow. Patients develop tolerance to GTN after several weeks of continuous use, limiting the potential for long-term therapy. The mechanistic cause of nitrate tolerance is relatively unknown. We developed a cell culture model of nitrate tolerance that utilizes stable isotopes to measure metabolism of 15 N3 -GTN into 15 N-nitrite...
2018: Frontiers in Pharmacology
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