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Macular perfusion

Massimo Lorusso, Virginia Milano, Eleni Nikolopoulou, Luisa Micelli Ferrari, Maria Vittoria Cicinelli, Giuseppe Querques, Tommaso Micelli Ferrari
BACKGROUND AND OBJECTIVE: To quantify and compare the vessel density (VD) in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP), as well as the size of the foveal avascular zone (FAZ) in patients with proliferative diabetic retinopathy (PDR) before and after panretinal photocoagulation (PRP). PATIENTS AND METHODS: This prospective clinical study was conducted in the Department of Ophthalmology, Miulli Hospital Acquaviva delle Fonti, Italy...
March 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Acner Camino, Yali Jia, Jeffrey Yu, Jie Wang, Liang Liu, David Huang
Frequently, when imaging retinal vasculature with optical coherence tomography angiography (OCTA) in diseased eyes, there are unavoidable obstacles to the propagation of light such as vitreous floaters or the pupil boundary. These obstacles can block the optical coherence tomography (OCT) beam and impede the visualization of the underlying retinal microcirculation. Detecting these shadow artifacts is especially important in the quantification of metrics that assess retinal disease progression because they might masquerade as regional perfusion loss...
March 1, 2019: Biomedical Optics Express
Tudor C Tepelus, Sheena Song, Enrico Borrelli, Muneeswar G Nittala, Elmira Baghdasaryan, SriniVas R Sadda, Vikas Chopra
PRéCIS:: By using OCT-A, we observed a reduction of the superficial macular, peripapillary, and optic nerve, as well as the choriocapillaris in eyes with low tension glaucoma, compared with normal controls. PURPOSE: To investigate macular and optic disc vascular parameters in patients with low tension glaucoma (LTG) using optical coherence tomography angiography (OCTA). METHODS: In this cross-sectional study, images were prospectively acquired from both eyes of 26 patients with clinically-diagnosed LTG and 22 age-matched volunteers with normal healthy eyes using the Zeiss swept-source (SS) OCTA (Plex Elite 9000, Carl Zeiss Meditec)...
March 18, 2019: Journal of Glaucoma
Gisung Son, Yoon Jeon Kim, Yu Sub Sung, Bumwoo Park, June-Gone Kim
BACKGROUND/AIM: To analyse ultrawide-field fluorescein angiography (UWF-FA) images of diabetic retinopathy using a novel software that automatically calculates microaneurysm (MA) and non-perfusion area. METHODS: Two hundred UWF-FA images of treatment-naïve diabetic retinopathy (38 proliferative diabetic retinopathy and 162 non-proliferative diabetic retinopathy) from 120 patients (mean age 54.22; 80 male) were analysed using novel software to determine the number of MAs, area of capillary non-perfusion (ischaemic index) and number of neovascularisations...
March 14, 2019: British Journal of Ophthalmology
M Ouederni, H Sassi, F Nefaa, A Kharroubi, N Kellil, M Cheour
INTRODUCTION: The purpose of our study was to describe the microvascular abnormalities on OCT-angiography in eyes with branch retinal vein occlusion (BRVO), to measure the surface of the foveal avascular zone (FAZ) and the capillary density, and to establish anatomic-functional correlations. METHODS: We conducted an observational prospective study in the ophthalmology department of Habib Thameur Hospital in Tunis, which included 17 eyes of patients with unilateral BRVO...
March 7, 2019: Journal Français D'ophtalmologie
Hong Wang, Xun Xu, Xiaodong Sun, Yingyan Ma, Tao Sun
PURPOSE: To explore macular perfusion changes in patients with rhegmatogenous retinal detachment (RRD) involved the macula following successful surgery and to evaluate the correlation between macular blood flow density and visual outcomes using optical coherence tomography angiography (OCTA). METHODS: This retrospective study included 14 eyes (14 patients) with macular-off RRD that underwent a standard three-port 23-gauge pars plana vitrectomy (PPV) and intraocular gas tamponade combined with phacoemulsification, aspiration, and intraocular lens implantation...
February 22, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Ying Lin, Hong Jiang, Yi Liu, Giovana Rosa Gameiro, Giovanni Gregori, Chuanhui Dong, Tatjana Rundek, Jianhua Wang
Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. The RTP was calculated as the blood flow supplying the macular area (ϕ 2.5 mm) divided by the perfused tissue volume of the inner retina from the inner limiting membrane to the outer plexiform layer...
February 1, 2019: Investigative Ophthalmology & Visual Science
Bingyao Tan, Jacqueline Chua, Veluchamy Amutha Barathi, Mani Baskaran, Anita Chan, Emily Lin, Marcus Ang, Gerd Klose, Leopold Schmetterer
The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. We analyzed different algorithms to quantify flow voids in non-human primates that can be easily implemented into clinical research...
January 1, 2019: Biomedical Optics Express
Javier Pascual-Prieto, Barbara Burgos-Blasco, Mario Ávila Sánchez-Torija, Jose Ignacio Fernández-Vigo, Pedro Arriola-Villalobos, Maria Aranzazu Barbero Pedraz, Julian García-Feijoo, Jose M Martínez-de-la-Casa
OBJECTIVE: To evaluate the potential utility of perfusion density measurements to discriminate patients with arterial hypertension by cardiovascular risk category. METHODS: In this cross-sectional study, one eye per subject was evaluated (N = 73). The study cohort was divided into three groups according to the clinical criteria established by the European Guidelines for Arterial Hypertension: 26 controls, 24 patients with low cardiovascular risk, and 23 patients with very high cardiovascular risk...
February 17, 2019: European Journal of Ophthalmology
Dao-Yi Yu, Stephen J Cringle, Paula K Yu, Chandrakumar Balaratnasingam, Andrew Mehnert, Marinko V Sarunic, Dong An, Er-Ning Su
The central role of the cardiovascular system is to maintain adequate capillary perfusion. The spatially and temporally heterogeneous nature of capillary perfusion has been reported in some organs. However, such heterogeneous perfusion properties have not been sufficiently explored in the retina. Arguably, spatial and temporal heterogeneity of capillary perfusion could be more predominant in the retina than that in other organs. This is because the retina is one of the highest metabolic demand neural tissues yet it has a limited blood supply due to optical requirements...
February 13, 2019: Progress in Retinal and Eye Research
Shih-Chun Chao, Shang-Jung Yang, Hung-Chi Chen, Chi-Chin Sun, Chin-Hsin Liu, Chia-Yi Lee
Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. The ophthalmic data including best-corrected visual acuity, spherical equivalent, intraocular pressure, central corneal thickness, central foveal thickness, visual field deviation, retinal nerve fiber layers thickness, and ganglion cell complex thickness were obtained from medical documents...
2019: Journal of Ophthalmology
Alexander Barash, Toco Y P Chui, Patricia Garcia, Richard B Rosen
PURPOSE: Intravitreal injections acutely and temporarily increase intraocular pressure (IOP), and this may have cumulative long-term effects including an increased risk for glaucoma surgery. This study was designed to measure retinal perfusion density changes on optical coherence tomography (OCT) angiography and OCT thickness alterations associated with acutely increased IOP after intravitreal injections. METHODS: Retrospective observational clinical study of 40 eyes (39 patients) with various retinopathies from October 2016 to June 2017 at a tertiary care retina clinic in NYC...
February 11, 2019: Retina
Caleb Busch, Taku Wakabayashi, Tatsuhiko Sato, Yoko Fukushima, Chikako Hara, Nobuhiko Shiraki, Andrew Winegarner, Kentaro Nishida, Hirokazu Sakaguchi, Kohji Nishida
We investigated changes in retinal vascular area and the foveal avascular zone (FAZ) after intravitreal aflibercept in diabetic macular edema (DME) and the association of these changes with visual outcomes. The retinal vascular area in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) and the FAZ area were measured using optical coherence tomography angiography (OCTA) in 23 eyes of 23 patients with DME, before and after intravitreal aflibercept. Overall, there was no significant change in retinal vascular area or FAZ...
February 7, 2019: Scientific Reports
Seoung Hyun An, Woo Jin Jeong
PURPOSE: To investigate the effect of early-scatter laser photocoagulation on the formation of collateral vessels in branch retinal vein occlusion. METHODS: The medical records of 40 cases (40 patients) of branch retinal vein occlusion with macular edema were retrospectively reviewed. Of them, 23 patients were treated with intravitreal bevacizumab injection and 17 patients underwent intravitreal bevacizumab injection with additional laser treatment. Early-scatter laser photocoagulation was applied for capillary non-perfusion areas, regardless of retinal neovascularization...
February 5, 2019: European Journal of Ophthalmology
Delu Song, Yoshiyasu Ueda, Rupak Bhuyan, Imran Mohammed, Takashi Miwa, Damodar Gullipali, Hangsoo Kim, Lin Zhou, Ying Song, Hannah Schultz, Albert Bargoud, Joshua L Dunaief, Wen-Chao Song
Single-nucleotide polymorphisms and rare mutations in factor H (FH; official name, CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thrombotic microangiopathy. Mice with the FH W1206R mutation (FHR/R ) share features with human atypical hemolytic uremic syndrome. Herein, we report that FHR/R mice exhibited retinal vascular occlusion and ischemia. Retinal fluorescein angiography demonstrated delayed perfusion and vascular leakage in FHR/R mice. Optical coherence tomography imaging of FHR/R mice showed retinal degeneration, edema, and detachment...
February 1, 2019: American Journal of Pathology
Jiahui Wu, Rani T Sebastian, Colin J Chu, Freia McGregor, Andrew D Dick, Lei Liu
AIMS: To evaluate retinal vasculature changes in primary open angle glaucoma (POAG) and whether the functional visual loss correlates with parameters obtained using optical coherence tomography angiography (OCTA). MATERIALS AND METHODS: OCT and OCTA images were collected from 116 POAG eyes and 40 normal eyes in a prospective, cross-sectional observational study. Glaucomatous eyes were further divided into three groups according to a Glaucoma Staging System. Measurements of macular vessel density, ganglion cell complex (GCC), and disc retinal nerve fibre layer (RNFL) thickness were compared among groups...
December 21, 2018: Current Eye Research
Jia Qin, Nicholas Rinella, Qinqin Zhang, Hao Zhou, Jessica Wong, Michael Deiner, Austin Roorda, Travis C Porco, Ruikang K Wang, Daniel M Schwartz, Jacque L Duncan
Purpose: To compare cone spacing and choriocapillaris (CC) perfusion adjacent to geographic atrophy (GA) in patients with age-related macular degeneration (AMD) and age-similar normal eyes. Methods: Subjects were imaged using adaptive optics scanning laser ophthalmoscopy (AOSLO), fundus autofluorescence (FAF), and swept-source optical coherence tomography angiography. The GA border was identified using FAF images; CC flow void was analyzed in 1° regions extending from the GA border...
December 3, 2018: Investigative Ophthalmology & Visual Science
Maged Alnawaiseh, Friederike Schubert, Peter Heiduschka, Nicole Eter
PURPOSE: To evaluate the correlation between the flow density measured by optical coherence tomography angiography and functional parameters in patients with retinitis pigmentosa. METHODS: Twenty eyes of 20 patients with retinitis pigmentosa and 21 eyes of 21 healthy subjects were prospectively included in this study. Optical coherence tomography angiography was performed using RTVue XR Avanti with AngioVue (Optovue Inc). The macula was imaged with a 6 × 6-mm scan, whereas for the optic nerve head a 4...
January 2019: Retina
Grace M Richter, Ryuna Chang, Betty Situ, Zhongdi Chu, Bruce Burkemper, Alena Reznik, Sahar Bedrood, Amir H Kashani, Rohit Varma, Ruikang K Wang
Purpose: To compare the diagnostic ability of the vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) in differentiating primary open-angle glaucoma (POAG) from healthy eyes. Methods: POAG patients and healthy subjects underwent 6 × 6-mm scans centered on the macula and optic nerve head. Commercially available automatic segmentation created en face images from SD-OCTA of the superficial retinal layer (SRL) of the macular (m) and peripapillary (cp) regions...
November 2018: Translational Vision Science & Technology
Acner Camino, Miao Zhang, Liang Liu, Jie Wang, Yali Jia, David Huang
Purpose: Quantification of optical coherence tomography angiography (OCTA) is confounded by the prevalence of bulk motion. We have previously developed a regression-based bulk motion subtraction (rb-BMS) algorithm that estimates bulk motion velocity and corrects for its effect on flow signal. Here, we aim to investigate its ability to improve the reliability of capillary density (CD) quantification. Methods: Two spectral-domain systems (70-kHz Avanti/AngioVue and 68-kHz Cirrus/AngioPlex) acquired 6 × 6-mm OCTA scans...
November 2018: Translational Vision Science & Technology
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